NO934218L - Inhibitorer av cathepsin g og elastase for forhindring av bindevevsned-brytning - Google Patents

Inhibitorer av cathepsin g og elastase for forhindring av bindevevsned-brytning

Info

Publication number
NO934218L
NO934218L NO934218A NO934218A NO934218L NO 934218 L NO934218 L NO 934218L NO 934218 A NO934218 A NO 934218A NO 934218 A NO934218 A NO 934218A NO 934218 L NO934218 L NO 934218L
Authority
NO
Norway
Prior art keywords
cathepsin
connective tissue
elastase
inhibitors
tissue degradation
Prior art date
Application number
NO934218A
Other languages
English (en)
Norwegian (no)
Other versions
NO934218D0 (no
Inventor
Michael R Angelastro
Philippe Bey
Niall S Doherty
Michael J Janusz
Shujaath Mehdi
Norton P Peet
Original Assignee
Merrell Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Publication of NO934218D0 publication Critical patent/NO934218D0/no
Publication of NO934218L publication Critical patent/NO934218L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/021—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Dental Preparations (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Vehicle Body Suspensions (AREA)
  • Transceivers (AREA)
  • Mobile Radio Communication Systems (AREA)
NO934218A 1991-05-23 1993-11-22 Inhibitorer av cathepsin g og elastase for forhindring av bindevevsned-brytning NO934218L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70449991A 1991-05-23 1991-05-23
PCT/US1992/003288 WO1992020357A1 (en) 1991-05-23 1992-04-21 Inhibitors of cathepsin g and elastase for preventing connective tissue degradation

Publications (2)

Publication Number Publication Date
NO934218D0 NO934218D0 (no) 1993-11-22
NO934218L true NO934218L (no) 1993-11-22

Family

ID=24829789

Family Applications (1)

Application Number Title Priority Date Filing Date
NO934218A NO934218L (no) 1991-05-23 1993-11-22 Inhibitorer av cathepsin g og elastase for forhindring av bindevevsned-brytning

Country Status (17)

Country Link
US (1) US5510333A (de)
EP (1) EP0587799B1 (de)
JP (1) JP3442075B2 (de)
AT (1) ATE181925T1 (de)
AU (1) AU655301B2 (de)
DE (1) DE69229552T2 (de)
DK (1) DK0587799T3 (de)
ES (1) ES2136091T3 (de)
FI (1) FI935172A0 (de)
GR (1) GR3031005T3 (de)
HU (1) HU217612B (de)
IL (1) IL101925A (de)
NO (1) NO934218L (de)
NZ (1) NZ242807A (de)
PT (1) PT100517B (de)
WO (1) WO1992020357A1 (de)
ZA (1) ZA923602B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5714470A (en) 1991-08-22 1998-02-03 Merrell Pharmaceuticals, Inc. Orally-active elastase inhibitors
ES2192190T3 (es) * 1992-04-10 2003-10-01 Abbott Lab Fragmentos proteicos tensioactivos pulmonares.
EP0644892A1 (de) * 1992-06-12 1995-03-29 Pfizer Inc. Inhibitoren für Angiotensin I-Chymasen inklusive der menschlichen Herzchymase
DE69522940T2 (de) * 1994-06-02 2002-04-04 Merrell Pharmaceuticals Inc., Cincinnati Acylierte enolderivate als vorläufdrogen von elastaseinhibitoren
NZ284766A (en) * 1994-06-02 1998-06-26 Merrell Pharma Inc Perfluoro amino ketones; medicaments as elastase inhibitors
US5804560A (en) * 1995-01-06 1998-09-08 Sibia Neurosciences, Inc. Peptide and peptide analog protease inhibitors
US5863902A (en) * 1995-01-06 1999-01-26 Sibia Neurosciences, Inc. Methods of treating neurodegenerative disorders using protease inhibitors
US5693515A (en) * 1995-04-28 1997-12-02 Arris Pharmaceutical Corporation Metal complexed serine protease inhibitors
DE19543750C2 (de) * 1995-11-24 1997-10-23 Crinos Industria Farmaco Cathepsin G inhibierende Aptamere
US6172044B1 (en) 1995-12-01 2001-01-09 Aventis Pharmaceuticals Inc. Acylated enol derivative of α-ketoesters and α-ketoamides
US5948886A (en) * 1996-11-20 1999-09-07 Hoechst Marion Roussel, Inc. Acylated enol derivatives of α-ketoesters and α-ketoamides
CA2251714A1 (en) * 1996-04-22 1997-10-30 Massachusetts Institute Of Technology Suppression of immune response via inhibition of cathepsin s
JP2002047256A (ja) * 2000-07-26 2002-02-12 Kanegafuchi Chem Ind Co Ltd α−アミノ−α´，α´，α´−トリハロケトン誘導体、α−アミノ−α´，α´，α´−トリハロアルコ−ル誘導体、及び、α−ヒドロキシ−β−アミノカルボン酸誘導体の製造法
WO2008054144A1 (en) * 2006-11-03 2008-05-08 Amorepacific Corporation Skin external composition containing cathepsin g inhibitors for preventing skin aging and the screening method for development of antiaging materials
US8883857B2 (en) 2012-12-07 2014-11-11 Baylor College Of Medicine Small molecule xanthine oxidase inhibitors and methods of use
JP7672641B2 (ja) 2019-09-17 2025-05-08 メレオ バイオファーマ ４ リミテッド 移植片拒絶反応、閉塞性細気管支炎症候群、及び移植片対宿主病の治療に使用するためのアルベレスタット
IL297211B2 (en) 2020-04-16 2025-12-01 Mereo Biopharma 4 Ltd Methods involving neutrophil elastase inhibitor alvelestat for treating respiratory disease mediated by alpha-1 antitrypsin deficiency
PH12022553378A1 (en) 2020-06-10 2024-03-25 Univ Leuven Kath Anti-viral compounds for treating coronavirus, picornavirus, and norovirus infections
AU2022306289A1 (en) 2021-07-09 2024-01-18 Aligos Therapeutics, Inc. Anti-viral compounds
WO2023043816A1 (en) 2021-09-17 2023-03-23 Aligos Therapeutics, Inc. Anti-viral compounds for treating coronavirus, picornavirus, and norovirus infections
KR20240090272A (ko) 2021-10-20 2024-06-21 메레오 바이오파마 4 리미티드 섬유화 치료에 사용하기 위한 호중구 엘라스테이스 억제제
WO2024254398A2 (en) * 2023-06-07 2024-12-12 Redd Pharmaceuticals, Inc. Modulation of neutrophil activation and neutrophil extracellular trap (net) formation

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3230275A1 (de) * 1982-08-14 1984-02-16 Bayer Ag, 5090 Leverkusen Elastaseinhibitoren, verfahren zu ihrer herstellung sowie diese enthaltende arzneimittel
DE3324534A1 (de) * 1983-07-07 1985-01-17 Ciba-Geigy Ag, Basel Modifizierte protease-inhibitoren, verfahren zu ihrer herstellung und daraus bereitete pharmazeutische mittel
US4629724A (en) * 1984-12-03 1986-12-16 E. R. Squibb & Sons, Inc. Amino acid ester and amide renin inhibitors
US4643991A (en) * 1984-12-18 1987-02-17 The University Of Kentucky Research Foundation Peptide elastase inhibitors and methods
US5055450A (en) * 1985-01-22 1991-10-08 Ici Americas Inc. Peptide derivatives
GB8600263D0 (en) * 1985-01-22 1986-02-12 Ici America Inc Peptide derivatives
CA1341029C (en) * 1985-02-04 2000-06-20 Michael Kolb Peptidase inhibitors
ATE71934T1 (de) * 1985-06-07 1992-02-15 Ici America Inc Selektionierte difluorverbindungen.
GB8613703D0 (en) * 1986-06-05 1986-07-09 Ici America Inc Difluoro peptide compounds
NZ223148A (en) * 1987-01-16 1989-10-27 Merrell Dow Pharma Peptide derivatives having peptidase inhibition activity
EP0307662A3 (de) * 1987-08-24 1990-07-25 Kabushiki Kaisha Vitamin Kenkyusyo Enkephalin-Analoge
EP0356595A1 (de) * 1988-09-01 1990-03-07 Merrell Dow Pharmaceuticals Inc. Peptidase-Hemmer
ZA897515B (en) * 1988-10-07 1990-06-27 Merrell Dow Pharma Novel peptidase inhibitors
ZA905737B (en) * 1989-07-26 1991-05-29 Merrell Dow Pharma Novel peptidase inhibitors
DE3938971A1 (de) * 1989-11-24 1991-05-29 Biotechnolog Forschung Gmbh Leukozytenelastase und kathepsin g blockierendes peptid, dna, vektor, wirtsorganismus und verfahren zu seiner gewinnung sowie pharmazeutisches praeparat

Also Published As

Publication number Publication date
US5510333A (en) 1996-04-23
HU217612B (hu) 2000-03-28
DE69229552D1 (de) 1999-08-12
FI935172A7 (fi) 1993-11-22
HUT65140A (en) 1994-04-28
JPH06508355A (ja) 1994-09-22
AU2184192A (en) 1992-12-30
EP0587799A4 (de) 1995-06-14
ES2136091T3 (es) 1999-11-16
DE69229552T2 (de) 1999-12-23
NO934218D0 (no) 1993-11-22
AU655301B2 (en) 1994-12-15
EP0587799B1 (de) 1999-07-07
NZ242807A (en) 1994-07-26
GR3031005T3 (en) 1999-12-31
IL101925A0 (en) 1992-12-30
EP0587799A1 (de) 1994-03-23
JP3442075B2 (ja) 2003-09-02
WO1992020357A1 (en) 1992-11-26
DK0587799T3 (da) 1999-11-22
IL101925A (en) 1996-03-31
ATE181925T1 (de) 1999-07-15
PT100517B (pt) 1999-06-30
ZA923602B (en) 1993-02-24
HU9303314D0 (en) 1994-03-28
PT100517A (pt) 1993-09-30
FI935172L (fi) 1993-11-22
FI935172A0 (fi) 1993-11-22

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Legal Events

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FC2A Withdrawal, rejection or dismissal of laid open patent application