NO934477L - PEG hydrazone and PEG oxime-binding reagents and protein derivatives thereof - Google Patents

PEG hydrazone and PEG oxime-binding reagents and protein derivatives thereof

Info

Publication number
NO934477L
NO934477L NO934477A NO934477A NO934477L NO 934477 L NO934477 L NO 934477L NO 934477 A NO934477 A NO 934477A NO 934477 A NO934477 A NO 934477A NO 934477 L NO934477 L NO 934477L
Authority
NO
Norway
Prior art keywords
peg
water
polymeric reagents
soluble polymeric
hydrazone
Prior art date
Application number
NO934477A
Other languages
Norwegian (no)
Other versions
NO934477D0 (en
Inventor
David E Wright
Original Assignee
Ortho Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Pharma Corp filed Critical Ortho Pharma Corp
Publication of NO934477D0 publication Critical patent/NO934477D0/en
Publication of NO934477L publication Critical patent/NO934477L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/333—Polymers modified by chemical after-treatment with organic compounds containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/04—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers only
    • C08G65/06—Cyclic ethers having no atoms other than carbon and hydrogen outside the ring
    • C08G65/16—Cyclic ethers having four or more ring atoms
    • C08G65/20—Tetrahydrofuran

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)

Abstract

Det blir beskrevet fremgangsmåter og forbindelser for modifisering av polypeptider med PEG eller andre vannoppløsellge organiske polymerer. Nye vannoppløselige polymerreagenser blir fremskaffet. De vannoppløsellge polymerreagensene omfatter hydrazln, hydrazinkarboksylat, semlkarbazld, tiosemikarbazid, karbonsyredlhydrazld, karbazid, tiokarbazid og arylhydrazidderivater så vel som oksylaminderivater av vannoppløsellge organiske polymerer, slik som poly- etylenglykol, polypropylenglykol, polyoksyetylert polyol, heparln, heparlnfragmenter, dekstran, poly- sakkarider, polyaminosyrer og polyvlnylalkohol. Det ble også fremskaffet aktuelle peptider som er derlvatisert ved foreliggende vannoppløselige polymer- reagenser . Det ble også beskrevet sett for modifisering av polypeptider med foreliggende vannoppløselige polymer- reagenser .Methods and compounds for modifying polypeptides with PEG or other water-soluble organic polymers are described. New water-soluble polymeric reagents are provided. The water-soluble polymeric reagents include hydrazine, hydrazine carboxylate, semicarbazide, thiosemicarbazide, carboxylic acid dihydrazide, carbazide, thiocarbazide and arylhydrazide derivatives as well as oxyamine paraffinic acid, polyethylene glycol, polyethylene glycol, and polyvinyl alcohol. Relevant peptides were also obtained which are derivatized by the present water-soluble polymeric reagents. Kits were also described for modifying polypeptides with the present water-soluble polymeric reagents.

NO934477A 1992-12-09 1993-12-08 PEG hydrazone and PEG oxime-binding reagents and protein derivatives thereof NO934477L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98773992A 1992-12-09 1992-12-09
US4505293A 1993-04-07 1993-04-07

Publications (2)

Publication Number Publication Date
NO934477D0 NO934477D0 (en) 1993-12-08
NO934477L true NO934477L (en) 1994-06-10

Family

ID=26722325

Family Applications (1)

Application Number Title Priority Date Filing Date
NO934477A NO934477L (en) 1992-12-09 1993-12-08 PEG hydrazone and PEG oxime-binding reagents and protein derivatives thereof

Country Status (5)

Country Link
JP (1) JPH07196925A (en)
KR (1) KR100254650B1 (en)
AU (1) AU5238393A (en)
FI (1) FI935485L (en)
NO (1) NO934477L (en)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6586398B1 (en) * 2000-04-07 2003-07-01 Amgen, Inc. Chemically modified novel erythropoietin stimulating protein compositions and methods
US20040082765A1 (en) * 2000-10-16 2004-04-29 Teruo Nakamura Peg-modified erythropoietin
US7214660B2 (en) * 2001-10-10 2007-05-08 Neose Technologies, Inc. Erythropoietin: remodeling and glycoconjugation of erythropoietin
US7173003B2 (en) 2001-10-10 2007-02-06 Neose Technologies, Inc. Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
US7247609B2 (en) 2001-12-18 2007-07-24 Universitat Zurich Growth factor modified protein matrices for tissue engineering
JPWO2003064462A1 (en) * 2002-02-01 2005-05-26 中外製薬株式会社 PEG-conjugated PTH or PEG-conjugated PTH derivative
DE10209821A1 (en) 2002-03-06 2003-09-25 Biotechnologie Ges Mittelhesse Coupling of proteins to a modified polysaccharide
DE10209822A1 (en) 2002-03-06 2003-09-25 Biotechnologie Ges Mittelhesse Coupling of low molecular weight substances to a modified polysaccharide
BR0314106A (en) * 2002-09-11 2005-07-19 Fresenius Kabi De Gmbh Hashed polypeptides, especially hashed erythropoietin
EP1400533A1 (en) * 2002-09-11 2004-03-24 Fresenius Kabi Deutschland GmbH HASylated polypeptides, especially HASylated erythropoietin
EP2055189A1 (en) 2003-04-09 2009-05-06 Neose Technologies, Inc. Glycopegylation methods and proteins/peptides produced by the methods
WO2005012484A2 (en) 2003-07-25 2005-02-10 Neose Technologies, Inc. Antibody-toxin conjugates
WO2005014655A2 (en) 2003-08-08 2005-02-17 Fresenius Kabi Deutschland Gmbh Conjugates of hydroxyalkyl starch and a protein
US20080305992A1 (en) 2003-11-24 2008-12-11 Neose Technologies, Inc. Glycopegylated erythropoietin
TWI417303B (en) 2004-03-11 2013-12-01 Fresenius Kabi De Gmbh Conjugates of hydroxyalkyl starch and a protein, prepared by reductive amination
WO2006010143A2 (en) 2004-07-13 2006-01-26 Neose Technologies, Inc. Branched peg remodeling and glycosylation of glucagon-like peptide-1 [glp-1]
US20080176790A1 (en) 2004-10-29 2008-07-24 Defrees Shawn Remodeling and Glycopegylation of Fibroblast Growth Factor (Fgf)
JP2008525473A (en) * 2004-12-22 2008-07-17 アンブレツクス・インコーポレイテツド Modified human growth hormone
US9029331B2 (en) 2005-01-10 2015-05-12 Novo Nordisk A/S Glycopegylated granulocyte colony stimulating factor
US20070154992A1 (en) 2005-04-08 2007-07-05 Neose Technologies, Inc. Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants
US20070105755A1 (en) 2005-10-26 2007-05-10 Neose Technologies, Inc. One pot desialylation and glycopegylation of therapeutic peptides
WO2007056191A2 (en) 2005-11-03 2007-05-18 Neose Technologies, Inc. Nucleotide sugar purification using membranes
ES2516694T3 (en) 2006-07-21 2014-10-31 Ratiopharm Gmbh Glycosylation of peptides through glycosylation sequences with O-binding
WO2008025856A2 (en) * 2006-09-01 2008-03-06 Novo Nordisk Health Care Ag Modified glycoproteins
US8969532B2 (en) 2006-10-03 2015-03-03 Novo Nordisk A/S Methods for the purification of polypeptide conjugates comprising polyalkylene oxide using hydrophobic interaction chromatography
KR20100016160A (en) 2007-04-03 2010-02-12 바이오제너릭스 에이지 Methods of treatment using glycopegylated g-csf
WO2008154639A2 (en) 2007-06-12 2008-12-18 Neose Technologies, Inc. Improved process for the production of nucleotide sugars
CA2710798A1 (en) 2007-12-28 2009-07-09 Kuros Biosurgery Ag Pdgf fusion proteins incorporated into fibrin foams
KR101582841B1 (en) 2008-02-27 2016-01-11 노보 노르디스크 에이/에스 Conjugated factor viii molecules
JPWO2009113578A1 (en) 2008-03-13 2011-07-21 味の素株式会社 Carbonyl compound removal material
US8067526B2 (en) 2009-03-27 2011-11-29 Nof Corporation Method for producing polyoxalkylene derivative
CN106110311A (en) * 2009-07-27 2016-11-16 百深公司 Blood coagulation protein conjugates
CN102497884A (en) * 2009-07-27 2012-06-13 巴克斯特国际公司 coagulation protein conjugates
KR101912335B1 (en) * 2009-07-27 2018-10-26 리폭센 테크놀로지즈 리미티드 Glycopolysialylation of non-blood coagulation proteins

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992016555A1 (en) * 1991-03-18 1992-10-01 Enzon, Inc. Hydrazine containing conjugates of polypeptides and glycopolypeptides with polymers

Also Published As

Publication number Publication date
AU5238393A (en) 1994-06-23
FI935485A7 (en) 1994-06-10
FI935485L (en) 1994-06-10
KR940014430A (en) 1994-07-18
NO934477D0 (en) 1993-12-08
FI935485A0 (en) 1993-12-08
JPH07196925A (en) 1995-08-01
KR100254650B1 (en) 2000-05-01

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