NO940928L - Nye 2-tiosubstituerte karbapenemer - Google Patents

Nye 2-tiosubstituerte karbapenemer

Info

Publication number
NO940928L
NO940928L NO940928A NO940928A NO940928L NO 940928 L NO940928 L NO 940928L NO 940928 A NO940928 A NO 940928A NO 940928 A NO940928 A NO 940928A NO 940928 L NO940928 L NO 940928L
Authority
NO
Norway
Prior art keywords
thio
new
substituted carbapenems
carbapenems
substituted
Prior art date
Application number
NO940928A
Other languages
English (en)
Other versions
NO940928D0 (no
NO311939B1 (no
Inventor
Yang-I Lin
Panayota Bitha
Subas Sakya
Timothy W Strohmeyer
Karen Bush
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of NO940928D0 publication Critical patent/NO940928D0/no
Publication of NO940928L publication Critical patent/NO940928L/no
Publication of NO311939B1 publication Critical patent/NO311939B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/14—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65611—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system (X = CH2, O, S, NH) optionally with an additional double bond and/or substituents, e.g. penicillins and analogs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO19940928A 1993-03-16 1994-03-15 Nye 2-tiosubstituerte karbapenemer, anvendelse derav og farmasöytisk blanding NO311939B1 (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3368493A 1993-03-16 1993-03-16

Publications (3)

Publication Number Publication Date
NO940928D0 NO940928D0 (no) 1994-03-15
NO940928L true NO940928L (no) 1994-09-19
NO311939B1 NO311939B1 (no) 2002-02-18

Family

ID=21871845

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19940928A NO311939B1 (no) 1993-03-16 1994-03-15 Nye 2-tiosubstituerte karbapenemer, anvendelse derav og farmasöytisk blanding

Country Status (19)

Country Link
US (4) US5602118A (no)
EP (1) EP0617036A3 (no)
JP (1) JPH06321948A (no)
KR (1) KR100353751B1 (no)
CN (3) CN1041633C (no)
AU (1) AU676877B2 (no)
CA (1) CA2118961A1 (no)
CZ (1) CZ290494B6 (no)
FI (1) FI106718B (no)
HU (2) HUT67741A (no)
IL (1) IL108939A0 (no)
NO (1) NO311939B1 (no)
NZ (1) NZ260102A (no)
PL (1) PL179558B1 (no)
RU (1) RU2130457C1 (no)
SG (2) SG91908A1 (no)
SK (1) SK31694A3 (no)
TW (1) TW474937B (no)
ZA (1) ZA941828B (no)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69942571D1 (de) * 1998-04-23 2010-08-26 Dentsply Detrey Gmbh Lagerungsbeständige polymerisierbare Zusammensetzung
ATE386546T1 (de) * 1998-08-04 2008-03-15 Takeda Schering Plough Animal Stabilisierte ölige zubereitung von tobicillin (beta-lactam-antibiotika)
US6162924A (en) 1999-04-09 2000-12-19 Eastman Chemical Company Process for halohydrin preparation
EP1282445A2 (en) * 2000-03-21 2003-02-12 Atherogenics, Inc. N-substituted dithiocarbamates for the treatment of biological disorders
US6649756B2 (en) 2000-07-13 2003-11-18 Wyeth, Five Giralda Farms Process improvement in the preparation of (4r, 5s, 6s)-3-[[(2r,3r)-2-[[[(s)-2-amino-3-methyl-1-oxobutyl]amino]methyl]tetrahydro-3-furanyl]thio]-6-[(r)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
US20020049315A1 (en) * 2000-09-06 2002-04-25 Williams John M. Crystalline forms of carbapenem intermediates
US7232924B2 (en) * 2001-06-11 2007-06-19 Xenoport, Inc. Methods for synthesis of acyloxyalkyl derivatives of GABA analogs
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US7186855B2 (en) 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US6818787B2 (en) * 2001-06-11 2004-11-16 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US20050152887A1 (en) * 2004-01-14 2005-07-14 Doctor's Signature Sales And Marketing International Corp. [Dba Life Force International Protonic formulation
KR100621782B1 (ko) * 2004-06-14 2006-09-19 한국과학기술연구원 1-베타메틸카바페넴 유도체 및 이의 제조방법
CA2620675C (en) * 2005-09-22 2015-04-14 Meiji Seika Kaisha, Ltd. Metallo-.beta.-lactamase inhibitors
US8119667B2 (en) * 2005-12-29 2012-02-21 Schering-Plough Animal Health Corporation Carbonates of fenicol antibiotics
TW200815442A (en) * 2006-04-28 2008-04-01 Kaneka Corp Improved method for the crystallization of intermediates of carbapenem antibiotics
WO2008012371A1 (en) * 2006-07-28 2008-01-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Process for the preparation of amorphous and crystalline forms of candesartan cilexetil using column chromatography
US20110046101A1 (en) * 2008-03-17 2011-02-24 Dmitrienko Gary I Bate-lactamase inhibitors
US20110118462A1 (en) * 2009-11-18 2011-05-19 Guangzhou Baiyunshan Pharmaceutical Co., Ltd. Guangzhou Baiyunshan Pharmaceutical Factory N-heterocyclic substituent-containing antibiotic, preparation and use thereof
CA2929742C (en) 2013-12-04 2022-09-20 Evotec International Gmbh Sulfoximine substituted quinazolines for pharmaceutical compositions
DE102015011861B4 (de) 2015-09-10 2018-03-01 Rudolf Schindler Neue cyclische Carboxamide als NMDA NR2B Rezeptor Inhibitoren
JP7213173B2 (ja) 2016-03-16 2023-01-26 オーキッド ファーマ リミテッド カルバペネム化合物

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2656362A (en) * 1951-07-05 1953-10-20 Allied Lab Inc Preparation of 2-halogenated tetrahydrothiophene 1, 1-dioxides
GB1441177A (en) * 1973-12-13 1976-06-30 Beheer Bv Pfw Sulphur-containing flavouring agents
CS176325B1 (no) * 1975-01-31 1977-06-30
US4347368A (en) * 1977-10-19 1982-08-31 Merck & Co., Inc. 3-Substituted-6-substituted-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
US4232036A (en) * 1978-10-24 1980-11-04 Merck & Co., Inc. 6-, 1- and 2-Substituted-1-carbadethiapen-2-em-3-carboxylic acids
EP0010317B1 (en) * 1978-10-24 1983-12-21 Merck & Co. Inc. 6-, 1- and 2-substituted-1-carbapen-2-em-3-carboxylic acids, processes for the preparation of such compounds and pharmaceutical composition comprising such compounds
US4260627A (en) * 1978-10-24 1981-04-07 Merck & Co., Inc. 1-, 6- And 2-substituted-1-carba-2-penem-3-carboxylic acids
US4341706A (en) * 1980-10-10 1982-07-27 Merck & Co., Inc. Process for the preparation of carbapenem antibiotics
US4745188A (en) * 1980-11-21 1988-05-17 Merck & Co., Inc. Process for preparing 3-substituted-6-substituted-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
EP0060612A1 (en) * 1981-02-04 1982-09-22 Beecham Group Plc Process for the preparation of azabicyclo(3.2.0)-hept-2-ene derivatives
NZ201471A (en) * 1981-08-10 1985-09-13 Merck & Co Inc Antibacterial compositions containing penems and dipeptidase inhibitors
US4552873A (en) * 1981-08-19 1985-11-12 Sankyo Company Limited Carbapenem compounds, and compositions containing them
CA1283906C (en) * 1983-05-09 1991-05-07 Makoto Sunagawa .beta.-LACTAM COMPOUNDS AND PRODUCTION THEREOF
US4539332A (en) * 1983-11-14 1985-09-03 Merck & Co., Inc. 2,5-Diaryl tetrahydrofurans and analogs thereof as PAF-antagonists
JPS60202886A (ja) * 1984-03-27 1985-10-14 Sankyo Co Ltd １―置換カルバペネム―３―カルボン酸誘導体
US4696923A (en) * 1984-04-23 1987-09-29 Merck & Co., Inc. 6-[1-hydroxyethyl]-2-SR8 -1-methyl-1-carbadethiapen-2-em-3-carboxylic acids
US4820817A (en) * 1984-09-10 1989-04-11 Merck & Co., Inc. Process for preparing 3-substituted-6-substituted-7-oxo-1-azabicycl(3.2.0)-hept-2-ene-2-carboxylic acid
CA1281720C (en) * 1984-11-08 1991-03-19 Makoto Sunagawa Carbapenem compounds and production thereof
JPH075463B2 (ja) * 1985-03-09 1995-01-25 サントリー株式会社 抗菌剤
US4665169A (en) * 1985-09-11 1987-05-12 Bristol-Myers Company Carbapenem antibiotics
ATE108798T1 (de) * 1988-11-08 1994-08-15 Daiichi Seiyaku Co Carbapenemderivate.
MX20084A (es) * 1989-03-28 1993-03-01 Pfizer Derivados de 2 -carbapenem antibacterianos
US5321020A (en) * 1989-03-28 1994-06-14 Pfizer Inc. Antibacterial 2-carbapenem derivatives
CA2022382A1 (en) * 1989-08-02 1991-02-03 Susumu Nakagawa Piperidylthiocarbapenem derivatives
DE69034150T2 (de) * 1989-10-24 2005-08-25 Isis Pharmaceuticals, Inc., Carlsbad 2'-Modifizierte Oligonukleotide
WO1991009860A1 (fr) * 1989-12-28 1991-07-11 Banyu Pharmaceutical Co., Ltd. Nouveau derive de carbapenem
CA2037767A1 (en) * 1990-03-23 1991-09-24 Mark D. Wittman Conversion of amines to hydroxylamines
US5116833A (en) * 1990-10-19 1992-05-26 Bristol-Myers Squibb Company Antibiotic c-3 dithioacetal-substituted carbapenem compounds, compositions, and methods of use thereof
JPH04368386A (ja) * 1991-06-18 1992-12-21 Sankyo Co Ltd １−メチルカルバペネム−３−カルボン酸の製造法
GB9202298D0 (en) * 1992-02-04 1992-03-18 Ici Plc Antibiotic compounds

Also Published As

Publication number Publication date
CN1482122A (zh) 2004-03-17
CZ290494B6 (cs) 2002-08-14
EP0617036A3 (en) 1998-01-14
SG91908A1 (en) 2002-10-15
JPH06321948A (ja) 1994-11-22
US5744465A (en) 1998-04-28
NO940928D0 (no) 1994-03-15
AU676877B2 (en) 1997-03-27
ZA941828B (en) 1994-10-18
IL108939A0 (en) 1994-06-24
FI941215A0 (fi) 1994-03-15
NZ260102A (en) 1996-05-28
KR100353751B1 (ko) 2003-02-25
SK31694A3 (en) 1994-10-05
KR940021555A (ko) 1994-10-19
FI106718B (fi) 2001-03-30
US5602118A (en) 1997-02-11
US5750735A (en) 1998-05-12
CN1136208C (zh) 2004-01-28
CN1041633C (zh) 1999-01-13
SG77541A1 (en) 2001-01-16
HU9400724D0 (en) 1994-06-28
AU5783194A (en) 1994-09-22
PL179558B1 (pl) 2000-09-29
CA2118961A1 (en) 1994-09-17
US5623081A (en) 1997-04-22
HU211883A9 (en) 1995-12-28
NO311939B1 (no) 2002-02-18
HUT67741A (en) 1995-04-28
EP0617036A2 (en) 1994-09-28
CN1104214A (zh) 1995-06-28
RU2130457C1 (ru) 1999-05-20
FI941215L (fi) 1994-09-17
CZ58694A3 (en) 1995-10-18
TW474937B (en) 2002-02-01
CN1223261A (zh) 1999-07-21

Similar Documents

Publication Publication Date Title
FI943084A7 (fi) Uusia sulfonyyliaminopyrimidiinejä
FI945690L (fi) Substituoitu N-piperidino-3-pyratsolikarboksamidi
NO940928L (no) Nye 2-tiosubstituerte karbapenemer
FI940154L (fi) Substituoidut dialkyylitioeetterit
DE69406617D1 (de) Schalter
FI932094A0 (fi) Kylningsapparat i kranens vaexel
DE59403503D1 (de) Substituierte 1-Aryltriazolinone
FI932732A0 (fi) Rotorkonstruktion i en tvaolindningselektricitetsmaskin
FI932264A0 (fi) Gapformare i en pappersmaskin
FI956304L (fi) Substituoidut aryltioalkyylitiopyridiinit
NO940195L (no) Nye forbindelser
BR9405830A (pt) Oxazois substituidos
FI962301L (fi) Substituoidut aminoalkyyliaminopyridiinit
FI930927A0 (fi) Banformningsparti i en pappersmaskin
NO942051D0 (no) Nye tiosemikarbazontioner
NO952939D0 (no) Nye substituerte tiosemikarbazontioner
FI945872L (fi) Kanisteri
KR950003963U (ko) 가로등용 기둥
FI930419A0 (fi) Foerfarande foer kompensering av maetfel i en lutningsindikator
BR9301563A (pt) Generoso - bem bolado
FI833U1 (fi) Dammfilter foer vaedringsluckor i foenster
FI1435U1 (fi) Foer synskadande avsett hjaelpdon i elspisvred
FI933617A0 (fi) Anordning i en stoetborrmaskin
FI934019A0 (fi) Foerfarande foer stoerningsmaetning i en basstation
FI934136A0 (fi) Lastoeverfoeringsanordning i vaexelflak

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees