NO941905L - Fremgangsmåte for fremtilling av en prolinboronat-ester - Google Patents

Fremgangsmåte for fremtilling av en prolinboronat-ester

Info

Publication number: NO941905L
Authority: NO; Norway
Prior art keywords: boronic acid; protected; proline; ester; esters
Prior art date: 1991-11-22

Application number

NO941905A

Other languages

English (en)

Norwegian (no)

Other versions

NO941905D0 (no

Inventor

Roger Snow

Terence A Kelly

Julian Adams

Simon Coutts

Clark Perry

Original Assignee

Boehringer Ingelheim Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-11-22

Filing date

1994-05-20

Publication date

1994-07-14

1994-05-20 Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma

1994-05-20 Publication of NO941905D0 publication Critical patent/NO941905D0/no

1994-07-14 Publication of NO941905L publication Critical patent/NO941905L/no

Links

-1 Proline Boronate Ester Chemical class 0.000 title abstract 5
238000000034 method Methods 0.000 title abstract 4
238000002360 preparation method Methods 0.000 title abstract 2
RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 4
IBFLWIOFZGYDFZ-WCCKRBBISA-N OBO.OC(=O)[C@@H]1CCCN1 Chemical compound OBO.OC(=O)[C@@H]1CCCN1 IBFLWIOFZGYDFZ-WCCKRBBISA-N 0.000 abstract 3
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
150000002148 esters Chemical class 0.000 abstract 2
108090000765 processed proteins & peptides Proteins 0.000 abstract 2
MOILFCKRQFQVFS-BDNRQGISSA-N (1r,3s,4r,5r)-4,6,6-trimethylbicyclo[3.1.1]heptane-3,4-diol Chemical compound C1[C@@H]2C(C)(C)[C@H]1C[C@H](O)[C@@]2(O)C MOILFCKRQFQVFS-BDNRQGISSA-N 0.000 abstract 1
WADSQZHEAXPENM-UHFFFAOYSA-N 1h-pyrrol-2-ylboronic acid Chemical compound OB(O)C1=CC=CN1 WADSQZHEAXPENM-UHFFFAOYSA-N 0.000 abstract 1
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 abstract 1
ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical group [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 abstract 1
102000035195 Peptidases Human genes 0.000 abstract 1
108091005804 Peptidases Proteins 0.000 abstract 1
239000004365 Protease Substances 0.000 abstract 1
HISWWEXBLOFKSH-UHFFFAOYSA-N [Li]C1CCCN1 Chemical compound [Li]C1CCCN1 HISWWEXBLOFKSH-UHFFFAOYSA-N 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
229910052796 boron Inorganic materials 0.000 abstract 1
ZADPBFCGQRWHPN-UHFFFAOYSA-N boronic acid Chemical compound OBO ZADPBFCGQRWHPN-UHFFFAOYSA-N 0.000 abstract 1
125000005620 boronic acid group Chemical group 0.000 abstract 1
150000001735 carboxylic acids Chemical class 0.000 abstract 1
239000007795 chemical reaction product Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
150000002009 diols Chemical class 0.000 abstract 1
125000004185 ester group Chemical group 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 1
125000006239 protecting group Chemical group 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrrole Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

NO941905A 1991-11-22 1994-05-20 Fremgangsmåte for fremtilling av en prolinboronat-ester NO941905L (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US79614891A	1991-11-22	1991-11-22
US93619892A	1992-08-26	1992-08-26
PCT/US1992/009845 WO1993010127A1 (fr)	1991-11-22	1992-11-19	Procede de production d'un ester de prolineboronate

Publications (2)

Publication Number	Publication Date
NO941905D0 NO941905D0 (no)	1994-05-20
NO941905L true NO941905L (no)	1994-07-14

Family

ID=27121696

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO941905A NO941905L (no)	1991-11-22	1994-05-20	Fremgangsmåte for fremtilling av en prolinboronat-ester

Country Status (17)

Country	Link
EP (1)	EP0641347A1 (fr)
JP (1)	JPH07501078A (fr)
CN (1)	CN1073946A (fr)
AU (1)	AU661362B2 (fr)
CA (1)	CA2123128A1 (fr)
CZ (1)	CZ124494A3 (fr)
FI (1)	FI942345A0 (fr)
HU (1)	HUT67937A (fr)
IL (1)	IL103817A0 (fr)
MX (1)	MX9206628A (fr)
NO (1)	NO941905L (fr)
NZ (1)	NZ245207A (fr)
PT (1)	PT101079A (fr)
SI (1)	SI9200332A (fr)
SK (1)	SK59294A3 (fr)
TW (1)	TW232697B (fr)
WO (1)	WO1993010127A1 (fr)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6825169B1 (en)	1991-10-22	2004-11-30	Trustees Of Tufts College	Inhibitors of dipeptidyl-aminopeptidase type IV
US5965532A (en) *	1996-06-28	1999-10-12	Trustees Of Tufts College	Multivalent compounds for crosslinking receptors and uses thereof
US6040145A (en)	1997-05-07	2000-03-21	Tufts University	Potentiation of the immune response
US6100234A (en)	1997-05-07	2000-08-08	Tufts University	Treatment of HIV
ATE357509T1 (de)	1997-09-29	2007-04-15	Point Therapeutics Inc	Stimulierung von hämatopoietischen zellen im vitro
IL139247A0 (en)	1998-05-04	2001-11-25	Point Therapeutics Inc	Hematopoietic stimulation
JP2002517401A (ja) *	1998-06-05	2002-06-18	ポイントセラピューティクス，インコーポレイテッド	環状ボロプロリン化合物
US6979697B1 (en)	1998-08-21	2005-12-27	Point Therapeutics, Inc.	Regulation of substrate activity
US6890904B1 (en)	1999-05-25	2005-05-10	Point Therapeutics, Inc.	Anti-tumor agents
EP1259246A2 (fr) *	2000-02-25	2002-11-27	Novo Nordisk A/S	Inhibition de la degenerescence des cellules beta
WO2003063903A2 (fr) *	2002-02-01	2003-08-07	Probiodrug Ag	Modulation des lymphocytes t au moyen d'inhibiteurs de la dp iv
US7317109B2 (en)	2003-11-12	2008-01-08	Phenomix Corporation	Pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV
US7767828B2 (en)	2003-11-12	2010-08-03	Phenomix Corporation	Methyl and ethyl substituted pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV
SG134333A1 (en) *	2003-11-12	2007-08-29	Phenomix Corp	Heterocyclic boronic acid compounds
US7576121B2 (en)	2003-11-12	2009-08-18	Phenomix Corporation	Pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV
WO2005049022A2 (fr)	2003-11-17	2005-06-02	Novartis Ag	Utilisation de composes organiques
RU2766487C2 (ru)	2004-01-20	2022-03-15	Новартис Аг	Композиция и способ прямого прессования
TW200604137A (en)	2004-04-27	2006-02-01	Wyeth Corp	Coupling process for generating reactive boron-containing derivatives of n-substituted pyrrole-2-carbonitriles to produce biaryls
DOP2006000008A (es)	2005-01-10	2006-08-31	Arena Pharm Inc	Terapia combinada para el tratamiento de la diabetes y afecciones relacionadas y para el tratamiento de afecciones que mejoran mediante un incremento de la concentración sanguínea de glp-1
US7399869B2 (en)	2005-05-19	2008-07-15	Genentech, Inc.	Fibroblast activation protein inhibitor compounds and methods
US7825139B2 (en)	2005-05-25	2010-11-02	Forest Laboratories Holdings Limited (BM)	Compounds and methods for selective inhibition of dipeptidyl peptidase-IV
CN1331835C (zh) *	2005-10-18	2007-08-15	武汉大学	光活性β－羟基酮的制备方法
JP5270369B2 (ja) *	2005-12-19	2013-08-21	タフツユニバーシティー／トラスティーズオブタフツカレッジ	ソフトプロテアーゼ抑制剤およびそのプロソフト型
US7833730B2 (en)	2006-04-11	2010-11-16	Arena Pharmaceuticals, Inc.	Methods of using GPR119 to identify compounds useful for increasing bone mass in an individual
PE20071221A1 (es)	2006-04-11	2007-12-14	Arena Pharm Inc	Agonistas del receptor gpr119 en metodos para aumentar la masa osea y para tratar la osteoporosis y otras afecciones caracterizadas por masa osea baja, y la terapia combinada relacionada a estos agonistas
EP2108960A1 (fr)	2008-04-07	2009-10-14	Arena Pharmaceuticals, Inc.	Procédés d'utilisation d'un récepteur couplé à protéine G pour identifier les secrétagogues de peptide YY (PYY) et composés utiles dans le traitement des conditions modulées de secrétagogues BY (PYY) et composés utiles dans le traitement des conditions par PYY
EP2730579A1 (fr)	2008-06-17	2014-05-14	Millennium Pharmaceuticals, Inc.	Composés de borates esters et compositions pharmaceutiques contenant des composés
AR077642A1 (es)	2009-07-09	2011-09-14	Arena Pharm Inc	Moduladores del metabolismo y el tratamiento de trastornos relacionados con el mismo
CA2795513A1 (fr)	2010-04-06	2011-10-13	Arena Pharmaceuticals, Inc.	Modulateurs du recepteur de gpr119 et traitement de troubles associes
EP3323818A1 (fr)	2010-09-22	2018-05-23	Arena Pharmaceuticals, Inc.	Modulateurs du récepteur gpr119 et traitement de troubles associés
US20140018371A1 (en)	2011-04-01	2014-01-16	Arena Pharmaceuticals, Inc.	Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto
WO2012145361A1 (fr)	2011-04-19	2012-10-26	Arena Pharmaceuticals, Inc.	Modulateurs du récepteur gpr119 et traitement de troubles liés à celui-ci
US20140051714A1 (en)	2011-04-22	2014-02-20	Arena Pharmaceuticals, Inc.	Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto
US20140038889A1 (en)	2011-04-22	2014-02-06	Arena Pharmaceuticals, Inc.	Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto
WO2012170702A1 (fr)	2011-06-08	2012-12-13	Arena Pharmaceuticals, Inc.	Modulateurs du récepteur gpr119 et traitement de troubles associés à celui-ci
WO2013055910A1 (fr)	2011-10-12	2013-04-18	Arena Pharmaceuticals, Inc.	Modulateurs du récepteur gpr119 et traitement de troubles associés
WO2014074668A1 (fr)	2012-11-08	2014-05-15	Arena Pharmaceuticals, Inc.	Modulateurs de gpr119 et traitement de troubles associés à ceux-ci
US9523687B2 (en)	2014-02-28	2016-12-20	Institut Pasteur	Levels of CXCL 10/IP-10 forms and soluble CD26/DPPIV activity as early predictive biomarkers for HIV/SIV associated mucosal inflammation and progression towards AIDS
MA39964A (fr)	2014-05-20	2015-11-26	Millennium Pharm Inc	Inhibiteurs du protéasome contenant du bore destinés à être utilisés après une thérapie contre le cancer primaire
EA201791982A1 (ru)	2015-03-09	2020-02-17	Интекрин Терапьютикс, Инк.	Способы лечения неалкогольной жировой болезни печени и/или липодистрофии
WO2018162722A1 (fr)	2017-03-09	2018-09-13	Deutsches Institut Für Ernährungsforschung Potsdam-Rehbrücke	Inhibiteurs de dpp-4 à utiliser dans le traitement de fractures osseuses
JP2020515639A (ja)	2017-04-03	2020-05-28	コヒラス・バイオサイエンシズ・インコーポレイテッド	進行性核上性麻痺の処置のためのＰＰＡＲγアゴニスト
CN108047257B (zh) *	2017-12-17	2020-03-13	沧州普瑞东方科技有限公司	一种手性n-boc-吡咯烷-2-硼酸的制备工艺
CN111741939B (zh) *	2018-02-20	2026-04-17	大塚制药株式会社	制备4-二羟硼基苯丙氨酸的方法
CN110452258B (zh) *	2019-09-03	2021-01-01	上海馨远医药科技有限公司	一种二肽缬氨酸硼脯氨酸盐的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4935493A (en) *	1987-10-06	1990-06-19	E. I. Du Pont De Nemours And Company	Protease inhibitors
EP0528858B1 (fr) *	1990-04-14	1997-01-22	New England Medical Center Hospitals, Inc.	Inhibiteurs de dipeptidyl-aminopeptidase de type iv
GB9017694D0 (en) *	1990-08-13	1990-09-26	Sandoz Ltd	Improvements in or relating to organic chemistry

1992
- 1992-11-18 MX MX9206628A patent/MX9206628A/es unknown
- 1992-11-19 PT PT101079A patent/PT101079A/pt not_active Application Discontinuation
- 1992-11-19 SI SI19929200332A patent/SI9200332A/sl unknown
- 1992-11-19 SK SK592-94A patent/SK59294A3/sk unknown
- 1992-11-19 AU AU31368/93A patent/AU661362B2/en not_active Expired - Fee Related
- 1992-11-19 CZ CZ941244A patent/CZ124494A3/cs unknown
- 1992-11-19 CA CA002123128A patent/CA2123128A1/fr not_active Abandoned
- 1992-11-19 WO PCT/US1992/009845 patent/WO1993010127A1/fr not_active Ceased
- 1992-11-19 JP JP5509442A patent/JPH07501078A/ja active Pending
- 1992-11-19 HU HU9401350A patent/HUT67937A/hu unknown
- 1992-11-19 EP EP92925238A patent/EP0641347A1/fr not_active Withdrawn
- 1992-11-20 NZ NZ24520792A patent/NZ245207A/en unknown
- 1992-11-20 TW TW081109304A patent/TW232697B/zh active
- 1992-11-20 IL IL103817A patent/IL103817A0/xx unknown
- 1992-11-23 CN CN92113215A patent/CN1073946A/zh active Pending
1994
- 1994-05-20 NO NO941905A patent/NO941905L/no unknown
- 1994-05-20 FI FI942345A patent/FI942345A0/fi not_active Application Discontinuation

Also Published As

Publication number	Publication date
CN1073946A (zh)	1993-07-07
AU661362B2 (en)	1995-07-20
FI942345A7 (fi)	1994-05-20
HUT67937A (en)	1995-05-29
FI942345A0 (fi)	1994-05-20
AU3136893A (en)	1993-06-15
EP0641347A1 (fr)	1995-03-08
SK59294A3 (en)	1995-02-08
CA2123128A1 (fr)	1993-05-27
CZ124494A3 (en)	1995-07-12
MX9206628A (es)	1993-05-01
IL103817A0 (en)	1993-04-04
NO941905D0 (no)	1994-05-20
NZ245207A (en)	1994-07-26
PT101079A (pt)	1994-02-28
WO1993010127A1 (fr)	1993-05-27
JPH07501078A (ja)	1995-02-02
TW232697B (fr)	1994-10-21
HU9401350D0 (en)	1994-08-29
SI9200332A (en)	1993-06-30

Publication	Publication Date	Title
NO941905L (no)	1994-07-14	Fremgangsmåte for fremtilling av en prolinboronat-ester
KR100939598B1 (ko)	2010-02-01	붕소산 에스테르와 산 화합물의 합성
Snow et al.	1995	Boronic acid inhibitors of dipeptidyl peptidase IV: A new class of immunosuppressive agents
HK40066099B (en)	2024-06-14	Synthesis of boronic ester and acid compounds
HK40066099A (en)	2022-08-12	Synthesis of boronic ester and acid compounds
AU2018200981A1 (en)	2018-03-01	Synthesis of boronic ester and acid compounds
AU2011265442B2 (en)	2014-12-04	Synthesis of boronic ester and acid compounds
MXPA06011276A (en)	2007-04-20	Synthesis of boronic ester and acid compounds
HK1100004B (en)	2012-03-23	Synthesis of boronic ester and acid compounds
HK1163106A (en)	2012-09-07	Synthesis of bortezomib
AU2013202996A1 (en)	2013-05-02	Synthesis of boronic ester and acid compounds
HK1164320B (en)	2014-07-18	Synthesis of bortezomib