NO942959L - Insulinpreparat - Google Patents

Insulinpreparat

Info

Publication number: NO942959L
Authority: NO; Norway
Prior art keywords: insulin; formulation; zinc; total; present
Prior art date: 1993-08-13

Application number

NO942959A

Other languages

English (en)

Norwegian (no)

Other versions

NO942959D0 (no

Inventor

James Arthur Hoffmann

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-08-13

Filing date

1994-08-09

Publication date

1995-02-14

1994-08-09 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1994-08-09 Publication of NO942959D0 publication Critical patent/NO942959D0/no

1995-02-14 Publication of NO942959L publication Critical patent/NO942959L/no

Links

NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 12
238000009472 formulation Methods 0.000 title abstract 7
239000000203 mixture Substances 0.000 title abstract 7
102000004877 Insulin Human genes 0.000 title abstract 6
108090001061 Insulin Proteins 0.000 title abstract 6
229940125396 insulin Drugs 0.000 title abstract 6
HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 abstract 2
239000011701 zinc Substances 0.000 abstract 2
229910052725 zinc Inorganic materials 0.000 abstract 2
101000976075 Homo sapiens Insulin Proteins 0.000 abstract 1
102000007327 Protamines Human genes 0.000 abstract 1
108010007568 Protamines Proteins 0.000 abstract 1
239000013078 crystal Substances 0.000 abstract 1
PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 abstract 1
230000005923 long-lasting effect Effects 0.000 abstract 1
229940048914 protamine Drugs 0.000 abstract 1
102000004169 proteins and genes Human genes 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
239000000725 suspension Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Diabetes (AREA)
Bioinformatics & Cheminformatics (AREA)
Endocrinology (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Inorganic Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Emergency Medicine (AREA)
Hematology (AREA)
Chemical Kinetics & Catalysis (AREA)
Dermatology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Obesity (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

NO942959A 1993-08-13 1994-08-09 Insulinpreparat NO942959L (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/106,106 US5534488A (en)	1993-08-13	1993-08-13	Insulin formulation

Publications (2)

Publication Number	Publication Date
NO942959D0 NO942959D0 (no)	1994-08-09
NO942959L true NO942959L (no)	1995-02-14

Family

ID=22309529

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO942959A NO942959L (no)	1993-08-13	1994-08-09	Insulinpreparat

Country Status (27)

Country	Link
US (1)	US5534488A (de)
EP (1)	EP0646379B1 (de)
JP (1)	JPH07149660A (de)
KR (1)	KR950005324A (de)
CN (1)	CN1109364A (de)
AT (1)	ATE207761T1 (de)
AU (1)	AU674975B2 (de)
BR (1)	BR9403204A (de)
CA (1)	CA2129763A1 (de)
CO (1)	CO4230235A1 (de)
CZ (1)	CZ193794A3 (de)
DE (1)	DE69428860T2 (de)
DK (1)	DK0646379T3 (de)
ES (1)	ES2164691T3 (de)
HU (1)	HUT67853A (de)
IL (1)	IL110581A0 (de)
NO (1)	NO942959L (de)
NZ (1)	NZ264197A (de)
PE (1)	PE14495A1 (de)
PH (1)	PH30757A (de)
PL (1)	PL177002B1 (de)
PT (1)	PT646379E (de)
RU (1)	RU2135205C1 (de)
TW (1)	TW326394B (de)
UA (1)	UA27874C2 (de)
YU (1)	YU50494A (de)
ZA (1)	ZA945939B (de)

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US5578238A (en) *	1992-10-30	1996-11-26	Lord Corporation	Magnetorheological materials utilizing surface-modified particles
YU18596A (sh) *	1995-03-31	1998-07-10	Eli Lilly And Company	Analogne formulacije monomernog insulina
US6531448B1 (en) *	1997-12-23	2003-03-11	Eli Lilly And Company	Insoluble compositions for controlling blood glucose
EP1396272A1 (de) *	1997-12-23	2004-03-10	Eli Lilly & Company	Unlöslische Insulin Zusammensetzungen zur Regelung der Blutglukose
US6956021B1 (en) *	1998-08-25	2005-10-18	Advanced Inhalation Research, Inc.	Stable spray-dried protein formulations
AU5454200A (en) *	1999-06-29	2001-01-31	Eli Lilly And Company	Protamine-free insoluble acylated insulin compositions
US7678364B2 (en)	1999-08-25	2010-03-16	Alkermes, Inc.	Particles for inhalation having sustained release properties
DE60120372T2 (de) *	2000-03-24	2007-07-05	Genentech Inc., San Francisco	Verwendung von insulin zur behandlung von knorpelkrankheiten
EP1247283B1 (de)	2000-10-06	2006-08-16	The Adviser - Defence Research & Development Organisation	Magnetosensitive flüssigkeit zusammenstellung und herstellungsverfahren
WO2002045102A1 (en) *	2000-11-29	2002-06-06	The Adviser Defence Research & Development Organisation, Ministry Of Defence, Government Of India	A magnetorheological fluid composition and a process for preparation thereof
CN100439397C (zh) *	2001-02-09	2008-12-03	基因技术股份有限公司	Igf-1的结晶
DE10114178A1 (de) *	2001-03-23	2002-10-10	Aventis Pharma Gmbh	Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität
EP1469827B1 (de)	2002-01-09	2017-12-27	Emisphere Technologies, Inc.	Polymorphe von natrium-4-(4-chlor-2-hydroxybenzoyl)aminobutanoat
DE10227232A1 (de) *	2002-06-18	2004-01-15	Aventis Pharma Deutschland Gmbh	Saure Insulinzubereitungen mit verbesserter Stabilität
RU2251426C1 (ru) *	2003-09-18	2005-05-10	Цыганков Владимир Владимирович	Способ получения инсулина из природного источника и инсулин
US7658721B2 (en) *	2004-01-16	2010-02-09	Biodel Inc.	Sublingual drug delivery device
US20080096800A1 (en) *	2004-03-12	2008-04-24	Biodel, Inc.	Rapid mucosal gel or film insulin compositions
US7279457B2 (en) *	2004-03-12	2007-10-09	Biodel, Inc.	Rapid acting drug delivery compositions
US20080085298A1 (en) *	2004-03-12	2008-04-10	Biodel, Inc.	Rapid Mucosal Gel or Film Insulin Compositions
US20080090753A1 (en)	2004-03-12	2008-04-17	Biodel, Inc.	Rapid Acting Injectable Insulin Compositions
CN102040535B (zh)	2004-05-06	2012-10-17	爱密斯菲尔科技公司	N-[8-(2-羟基苯甲酰基)氨基]辛酸一钠的晶体的多晶
NZ551241A (en) *	2004-05-14	2010-08-27	Emisphere Tech Inc	Aryl ketone compounds and compositions for delivering active agents
RU2527893C2 (ru)	2004-07-19	2014-09-10	Биокон Лимитед	Инсулин-олигомерные конъюгаты, их препараты и применения
EP1773376A4 (de)	2004-08-03	2009-07-01	Emisphere Tech Inc	Antidiabetische orale insulinbiguanidkombination
EP1781257B1 (de) *	2004-08-13	2018-12-19	Emisphere Technologies, Inc.	Pharmazeutische formulierungen mit mikropartikeln oder nanopartikeln eines zufuhrmittels
RU2288000C1 (ru) *	2005-04-27	2006-11-27	Институт нефтехимического синтеза им. А.В. Топчиева РАН (ИНХС РАН)	Раствор инсулина для перорального введения
US7713929B2 (en) *	2006-04-12	2010-05-11	Biodel Inc.	Rapid acting and long acting insulin combination formulations
US8084420B2 (en) *	2005-09-29	2011-12-27	Biodel Inc.	Rapid acting and long acting insulin combination formulations
EP2012817A2 (de) *	2006-04-12	2009-01-14	Biodel, Inc.	Insulinkombinationsformulierungen mit schneller wirkung und langzeitwirkung
EP3050568B1 (de)	2007-03-13	2020-12-02	JDS Therapeutics, LLC	Verfahren und zusammensetzungen zur verzögerten freisetzung von chrom
WO2008124522A2 (en) *	2007-04-04	2008-10-16	Biodel, Inc.	Amylin formulations
WO2009002867A2 (en)	2007-06-26	2008-12-31	Nutrition 21, Inc.	Multiple unit dosage form having a therapeutic agents in combination with a nutritional supplement
RU2453332C2 (ru)	2007-10-16	2012-06-20	Байокон Лимитид	Твердая фармацевтическая композиция (варианты) и способ контроля концентрации глюкозы с ее помощью, способ получения твердой фармацевтической композиции (варианты), таблетка (варианты) и способ получения амфорных частиц
EP2234644B1 (de) *	2008-01-04	2013-07-31	Biodel, Inc.	Insulinformulierungen zur insulinfreisetzung als funktion des gewebeglukosespiegels
RS59913B1 (sr)	2008-10-17	2020-03-31	Sanofi Aventis Deutschland	Kombinacija insulina i glp-1-agonista
US9060927B2 (en) *	2009-03-03	2015-06-23	Biodel Inc.	Insulin formulations for rapid uptake
CN102596175A (zh)	2009-07-06	2012-07-18	赛诺菲-安万特德国有限公司	含有甲硫氨酸的水性胰岛素制备物
PT3345593T (pt)	2009-11-13	2023-11-27	Sanofi Aventis Deutschland	Composição farmacêutica compreendendo despro36exendina- 4(1-39)-lys6-nh2 e metionina
MY180661A (en)	2009-11-13	2020-12-04	Sanofi Aventis Deutschland	Pharmaceutical composition comprising a glp-1 agonist, an insulin and methionine
PH12012501557A1 (en) *	2010-02-22	2012-10-22	Univ Case Western Reserve	Long-acting insulin analogue preparations in soluble and crystalline form
PL2611458T3 (pl)	2010-08-30	2017-02-28	Sanofi-Aventis Deutschland Gmbh	Zastosowanie AVE0010 do produkcji leku do leczenia cukrzycy typu 2
EP4070801A1 (de)	2011-03-01	2022-10-12	Nutrition 21, LLC	Zusammensetzungen aus insulin und chrom zur behandlung und vorbeugung von diabetes, hypoglykämie und verwandten erkrankungen
US9821032B2 (en)	2011-05-13	2017-11-21	Sanofi-Aventis Deutschland Gmbh	Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
TWI559929B (en)	2011-09-01	2016-12-01	Sanofi Aventis Deutschland	Pharmaceutical composition for use in the treatment of a neurodegenerative disease
EP3229828B1 (de)	2014-12-12	2023-04-05	Sanofi-Aventis Deutschland GmbH	Insulin-glargin/lixisenatid-fixierte verhältnisformulierung
TWI748945B (zh)	2015-03-13	2021-12-11	德商賽諾菲阿凡提斯德意志有限公司	第２型糖尿病病患治療
TW201705975A (zh)	2015-03-18	2017-02-16	賽諾菲阿凡提斯德意志有限公司	第２型糖尿病病患之治療
CA3014308A1 (en)	2016-02-11	2017-08-17	Nutrition 21, Llc	Chromium containing compositions for improving health and fitness

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US2626228A (en) *	1945-05-17	1953-01-20	Novo Terapeutisk Labor As	Method of producing crystalline insulin
US2882202A (en) *	1950-04-05	1959-04-14	Novo Terapeutisk Labor As	Insulin crystal preparations and methods of producing them
US2882203A (en) *	1951-06-26	1959-04-14	Novo Terapeutisk Labor As	Injectable insulin preparation with protracted effect
US2849370A (en) *	1953-06-04	1958-08-26	Novo Terapeutisk Labortorium A	Injectable insulin preparations with protracted effect and process of producing same
US3102077A (en) *	1953-08-19	1963-08-27	Christensen Henry Marinus	Preparation of insulin containing 2.75 to 8 percent zinc content
US2819999A (en) *	1953-11-13	1958-01-14	Novo Terapeutisk Labor As	Process for crystallization of insulin using freeze dried insulin as seeding material
US2799622A (en) *	1953-11-14	1957-07-16	Novo Terapeutisk Labor As	Process of producing insulin crystals of substantially uniform size and compositions thereof
US3060093A (en) *	1957-07-18	1962-10-23	Nordisk Insulinlab	Slowly acting insulin preparation in crystalline form and method of preparation
DE2933946A1 (de) *	1979-08-22	1981-03-12	Hoechst Ag, 6000 Frankfurt	Insulinkristallsuspension und verfahren zu ihrer herstellung.
DE3101382A1 (de) *	1981-01-17	1982-09-02	Hoechst Ag, 6000 Frankfurt	"verfahren zur herstellung von humanisulin oder dessen derivaten aus schweineinsulin oder dessen derivaten"
FI78616C (fi) *	1982-02-05	1989-09-11	Novo Industri As	Foerfarande foer framstaellning av en foer infusionsaendamaol avsedd stabiliserad insulinloesning, som har en foerhoejd zinkhalt.
SU1131507A1 (ru) *	1982-05-28	1984-12-30	Черновицкий Ордена Трудового Красного Знамени Государственный Университет	Способ получени инсулина
DE3511269A1 (de) *	1985-04-12	1986-10-09	Veb Berlin-Chemie, Ddr 1199 Berlin	Verfahren zur reinigung von insulin
PH23446A (en) *	1986-10-20	1989-08-07	Novo Industri As	Peptide preparations
DE3827533A1 (de) *	1988-08-13	1990-02-15	Hoechst Ag	Pharmazeutische zubereitung zur behandlung des diabetes mellitus

1993
- 1993-08-13 US US08/106,106 patent/US5534488A/en not_active Expired - Fee Related
1994
- 1994-08-04 HU HU9402287A patent/HUT67853A/hu unknown
- 1994-08-08 BR BR9403204A patent/BR9403204A/pt not_active Application Discontinuation
- 1994-08-08 IL IL11058194A patent/IL110581A0/xx not_active IP Right Cessation
- 1994-08-08 ZA ZA945939A patent/ZA945939B/xx unknown
- 1994-08-08 PE PE1994248043A patent/PE14495A1/es not_active Application Discontinuation
- 1994-08-08 NZ NZ264197A patent/NZ264197A/en unknown
- 1994-08-09 TW TW083107259A patent/TW326394B/zh active
- 1994-08-09 AT AT94305883T patent/ATE207761T1/de not_active IP Right Cessation
- 1994-08-09 RU RU94028671A patent/RU2135205C1/ru active
- 1994-08-09 UA UA94085696A patent/UA27874C2/uk unknown
- 1994-08-09 CA CA002129763A patent/CA2129763A1/en not_active Abandoned
- 1994-08-09 DE DE69428860T patent/DE69428860T2/de not_active Expired - Fee Related
- 1994-08-09 NO NO942959A patent/NO942959L/no not_active Application Discontinuation
- 1994-08-09 PH PH48764A patent/PH30757A/en unknown
- 1994-08-09 EP EP94305883A patent/EP0646379B1/de not_active Expired - Lifetime
- 1994-08-09 DK DK94305883T patent/DK0646379T3/da active
- 1994-08-09 PT PT94305883T patent/PT646379E/pt unknown
- 1994-08-09 ES ES94305883T patent/ES2164691T3/es not_active Expired - Lifetime
- 1994-08-09 PL PL94304600A patent/PL177002B1/pl unknown
- 1994-08-09 CO CO94035010A patent/CO4230235A1/es unknown
- 1994-08-09 KR KR1019940019550A patent/KR950005324A/ko not_active Abandoned
- 1994-08-10 CN CN94109082A patent/CN1109364A/zh active Pending
- 1994-08-10 YU YU50494A patent/YU50494A/sh unknown
- 1994-08-10 JP JP6188204A patent/JPH07149660A/ja not_active Withdrawn
- 1994-08-10 CZ CZ941937A patent/CZ193794A3/cs unknown
- 1994-08-12 AU AU70247/94A patent/AU674975B2/en not_active Ceased

Also Published As

Publication number	Publication date
DK0646379T3 (da)	2001-12-03
PH30757A (en)	1997-10-17
JPH07149660A (ja)	1995-06-13
ZA945939B (en)	1996-02-08
DE69428860D1 (de)	2001-12-06
EP0646379A1 (de)	1995-04-05
AU674975B2 (en)	1997-01-16
CO4230235A1 (es)	1995-10-19
KR950005324A (ko)	1995-03-20
AU7024794A (en)	1995-02-23
IL110581A0 (en)	1994-11-11
PE14495A1 (es)	1995-06-02
NZ264197A (en)	1997-01-29
US5534488A (en)	1996-07-09
PT646379E (pt)	2002-03-28
HU9402287D0 (en)	1994-09-28
EP0646379B1 (de)	2001-10-31
YU50494A (sh)	1997-01-08
CN1109364A (zh)	1995-10-04
RU2135205C1 (ru)	1999-08-27
CA2129763A1 (en)	1995-02-14
PL304600A1 (en)	1995-02-20
ES2164691T3 (es)	2002-03-01
TW326394B (en)	1998-02-11
UA27874C2 (uk)	2000-10-16
NO942959D0 (no)	1994-08-09
CZ193794A3 (en)	1995-03-15
PL177002B1 (pl)	1999-09-30
HUT67853A (en)	1995-05-29
DE69428860T2 (de)	2002-05-02
ATE207761T1 (de)	2001-11-15
BR9403204A (pt)	1995-04-18

Legal Events

Date	Code	Title	Description
2002-05-21	FC2A	Withdrawal, rejection or dismissal of laid open patent application

Publication	Publication Date	Title
DK0646379T3 (da)	2001-12-03	Insulinformulering
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AU2173988A (en)	1989-04-27	Stabilised human protein preparations
NO912281L (no)	1991-06-13	Isoformer av erythropoietin.
GB9108652D0 (en)	1991-06-12	Immunoreactive compounds
WO1994001006A3 (en)	1994-03-31	Composition for use as a food or food supplement
CA2015186A1 (en)	1990-10-24	Nutrient composition
AU8188087A (en)	1988-06-02	Variants of hirudin, their use and their preparation
EP0511903A3 (en)	1993-08-11	Conjugate of calcitonin and polyethylene glycol
AU2670495A (en)	1995-12-05	Ifn-beta liquid formulations
AU2198788A (en)	1989-03-16	Novel fluorinated derivatives of amino acids usable more particularly as surfactants or cosurfactants and preparations for biomedical use incorporating these derivatives
AU6406590A (en)	1991-04-28	Porcine lactoferrin amino acid and cdna sequence
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MD1714G2 (ro)	2002-03-31	Compoziţie terapeutică în formă de sirop, conţinând N-acetilcisteină
RU95113498A (ru)	1997-03-20	Линейные или циклические олигопептиды, обладающие сродством к опиоидным рецепторам, фармацевтическая композиция, способ лечения
ATE262307T1 (de)	2004-04-15	Verwendung von goldlegierungen für konstruktionselemente in der dentaltechnik
CA2153071A1 (en)	1994-07-21	Derivatized calcitonins
GR3007486T3 (de)	1993-07-30
EP0292302A3 (de)	1990-04-25	Menschliches Splenin
CA2247998A1 (en)	1997-09-04	Fragments of cr1 and their use
HU201445B (en)	1990-11-28	Herbicide composition containing sulfonyl-urea derivative as active component and glycinamide derivative as antidotum
TH17521A (th)	1996-01-23	สูตรผสมอินซูลิน