NO944722L - 3- (Phenylalkylaminoalkyloxy) -5-phenylpyrazole compounds and methods and intermediates for their preparation, and drugs containing these compounds - Google Patents

3- (Phenylalkylaminoalkyloxy) -5-phenylpyrazole compounds and methods and intermediates for their preparation, and drugs containing these compounds

Info

Publication number
NO944722L
NO944722L NO944722A NO944722A NO944722L NO 944722 L NO944722 L NO 944722L NO 944722 A NO944722 A NO 944722A NO 944722 A NO944722 A NO 944722A NO 944722 L NO944722 L NO 944722L
Authority
NO
Norway
Prior art keywords
compounds
phenylalkylaminoalkyloxy
preparation
intermediates
methods
Prior art date
Application number
NO944722A
Other languages
Norwegian (no)
Other versions
NO944722D0 (en
Inventor
Wolfgang Kehrbach
Michael Mlinaric
Dieter Ziegler
Reinhard Bruckner
Willi Bielenberg
Original Assignee
Kali Chemie Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kali Chemie Pharma Gmbh filed Critical Kali Chemie Pharma Gmbh
Publication of NO944722D0 publication Critical patent/NO944722D0/en
Publication of NO944722L publication Critical patent/NO944722L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • C07D271/07—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C07D231/20—One oxygen atom attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/12—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/08—1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Det er beskrevet 3-(fenylalkyl- aminoalkyloksy)-5-fenylpyrazolylforbin- delser med hjertefrekvenssenkende virkninger og deres fremstilling. For- bindelsene har den generelle formel I hvor substituentene har de i beskrivel- sen angitte betydninger.3- (Phenylalkylaminoalkyloxy) -5-phenylpyrazolyl compounds having heart rate lowering effects and their preparation are disclosed. The compounds have the general formula I wherein the substituents have the meanings given in the description.

NO944722A 1993-12-08 1994-12-07 3- (Phenylalkylaminoalkyloxy) -5-phenylpyrazole compounds and methods and intermediates for their preparation, and drugs containing these compounds NO944722L (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4341749A DE4341749A1 (en) 1993-12-08 1993-12-08 3- (Phenylalkylaminoalkyloxy) -5-phenylpyrazole compounds and methods and intermediates for their preparation and medicaments containing these compounds

Publications (2)

Publication Number Publication Date
NO944722D0 NO944722D0 (en) 1994-12-07
NO944722L true NO944722L (en) 1995-06-09

Family

ID=6504420

Family Applications (1)

Application Number Title Priority Date Filing Date
NO944722A NO944722L (en) 1993-12-08 1994-12-07 3- (Phenylalkylaminoalkyloxy) -5-phenylpyrazole compounds and methods and intermediates for their preparation, and drugs containing these compounds

Country Status (19)

Country Link
EP (1) EP0663395B1 (en)
JP (1) JP3492433B2 (en)
KR (1) KR950017965A (en)
CN (1) CN1109051A (en)
AT (1) ATE201200T1 (en)
AU (1) AU7769494A (en)
CA (1) CA2137446A1 (en)
CZ (1) CZ303194A3 (en)
DE (2) DE4341749A1 (en)
ES (1) ES2156135T3 (en)
FI (1) FI945750L (en)
HU (1) HUT68518A (en)
IL (1) IL111539A0 (en)
NO (1) NO944722L (en)
NZ (1) NZ264883A (en)
PL (1) PL306155A1 (en)
RU (1) RU94045839A (en)
SK (1) SK150694A3 (en)
ZA (1) ZA949537B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9422708D0 (en) * 1994-11-10 1995-01-04 Zeneca Ltd Herbicides
FR2773153A1 (en) * 1997-12-29 1999-07-02 Rhone Poulenc Agrochimie NEW FUNGICIDE COMPOUNDS
EP1829873A1 (en) * 2006-03-02 2007-09-05 Laboratorios Del Dr. Esteve, S.A. Pyrrazole derivatives as sigma receptors antagonists
EP1829866A1 (en) * 2006-03-02 2007-09-05 Laboratorios Del Dr. Esteve, S.A. Sigma receptor inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1001161A (en) * 1972-05-05 1976-12-07 Burton K. Wasson 5-(3-substituted amino-2-hydroxypropoxy)1,3-disubstituted pyrazoles and method of preparation
DE2828529A1 (en) * 1978-06-29 1980-01-17 Kali Chemie Pharma Gmbh NEW 5-PHENYLPYRAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS
FR2479219A1 (en) * 1980-04-01 1981-10-02 Nativelle Sa Ets AMINO-ALCOXY PYRAZOLES, PROCESS FOR THEIR PREPARATION, AND MEDICAMENTS CONTAINING SAME
FR2513996A1 (en) * 1981-10-02 1983-04-08 Nativelle Sa Ets PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THERAPEUTIC APPLICATION
DE3424586A1 (en) * 1984-07-04 1986-01-09 Kali-Chemie Pharma Gmbh, 3000 Hannover 3-AMINOCARBONYLMETHOXY-5-PHENYL-PYRAZOLE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF, AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
DE4040632A1 (en) * 1990-12-19 1992-06-25 Kali Chemie Pharma Gmbh PHENYL ALKYLAMINOALKYL COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF AND THE COMPOUND CONTAINING THE SAME COMPOUNDS

Also Published As

Publication number Publication date
CN1109051A (en) 1995-09-27
CZ303194A3 (en) 1995-08-16
ATE201200T1 (en) 2001-06-15
HU9403458D0 (en) 1995-02-28
ZA949537B (en) 1995-08-11
FI945750A7 (en) 1995-06-09
SK150694A3 (en) 1995-07-11
FI945750A0 (en) 1994-12-07
ES2156135T3 (en) 2001-06-16
PL306155A1 (en) 1995-06-12
JP3492433B2 (en) 2004-02-03
NO944722D0 (en) 1994-12-07
CA2137446A1 (en) 1995-06-09
EP0663395B1 (en) 2001-05-16
RU94045839A (en) 1996-09-27
NZ264883A (en) 1995-12-21
DE4341749A1 (en) 1995-06-14
EP0663395A1 (en) 1995-07-19
IL111539A0 (en) 1995-01-24
FI945750L (en) 1995-06-09
JPH07196622A (en) 1995-08-01
KR950017965A (en) 1995-07-22
HUT68518A (en) 1995-06-28
AU7769494A (en) 1995-06-15
DE59409756D1 (en) 2001-06-21

Similar Documents

Publication Publication Date Title
NO971471L (en) New carboxamides with fungicidal activity
NO20075066L (en) Pharmaceutical composition containing isoflavones
NO992821L (en) Ketobenzamides as Calpain Inhibitors
AU6613896A (en) Chemical compounds
NO996269L (en) Quinoline-indole antimicrobial agents, as well as the use and mixtures thereof
IL130260A (en) 3-thiocarbamoylpyrazole derivatives as pesticides
NO996108L (en) 9 oksinerytromycinderivater
AU6703300A (en) Fungicides
NO990662L (en) Thrombin inhibitors
NO991761L (en) New piperidine cotocarboxylic acid derivatives, their preparation and use
ATE180781T1 (en) CRYSTALLINE TIAGABINE HYDROCHLORIDE MONOHYDRATE, ITS PREPARATION AND USE
NO975975L (en) Vitronectin receptor antagonists, preparation and use thereof
NO934196L (en) N, N-disubstituted arylcycloalkylamines, their salts, drugs containing these compounds, their use and process for their preparation
DK0659427T3 (en) 2-Phenyl-3-azoylbenzothiophenes to increase thrombomodulin expression
NO20001934L (en) 3-Substituted tetrahydropyridopyrimidinone derivatives, their preparation and use
NO20004273L (en) Streptogramin derivatives, their preparation and preparations containing the compounds
NO922934L (en) CYCLOHEXANE AND TETRAHYDROPYRANDER DERIVATIVES
NO20022123L (en) Oxoxazole derivatives for use as inhibitors of phosphodiesterase VII
NO991734L (en) Pyrazolinones for the treatment of potency disorders
NO953892L (en) Imidazoloquinoxalinone derivatives as EAA antagonists
NO990914L (en) Amorphous benzothiophenes, methods of preparation and methods of use
NO944722L (en) 3- (Phenylalkylaminoalkyloxy) -5-phenylpyrazole compounds and methods and intermediates for their preparation, and drugs containing these compounds
NO20001758L (en) Methods and compositions for the treatment of arthritis
DE69426021D1 (en) Xamonelin tartrate
NO971424L (en) Novel heterocyclic substituted imidazoloquinoxalinones, their preparation and use