NO950974L - Nye N,N,N',N'-tetrasubstituert-1,2-etandiaminderivatforbindelser - Google Patents

Nye N,N,N',N'-tetrasubstituert-1,2-etandiaminderivatforbindelser

Info

Publication number
NO950974L
NO950974L NO950974A NO950974A NO950974L NO 950974 L NO950974 L NO 950974L NO 950974 A NO950974 A NO 950974A NO 950974 A NO950974 A NO 950974A NO 950974 L NO950974 L NO 950974L
Authority
NO
Norway
Prior art keywords
substituted
tetra
new
derivative compounds
fluorophenylmethylene
Prior art date
Application number
NO950974A
Other languages
English (en)
Other versions
NO950974D0 (no
Inventor
Rafael Foquet
Santiago Gubert
Jose Ortiz
Aurelio Sacristan
Josep M Castello
Original Assignee
Ferrer Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferrer Int filed Critical Ferrer Int
Publication of NO950974D0 publication Critical patent/NO950974D0/no
Publication of NO950974L publication Critical patent/NO950974L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/29—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C07C215/30—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C225/04—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated
    • C07C225/06—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated and acyclic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Nye N, N,N',N'-tetrasubstituert-l,2-etandiamlnforblnd- elser av den generelle formel: hvor X er en karbonyl (CO)-, hydroksymetylen (CHOH)- eller p-fluorfenylmetylen (p-F-C^I^-CHj-gruppe, R er en benzylgruppe som eventuelt er substituert i p- stillingen med et halogen, eller R er en 2-pyrImldinyl- gruppe forutsatt at X Ikke samtidig kan være p- fluorfenylmetylen (p-F-C6H4-CH) og R kan Ikke være en usubstltuert benzylgruppe; samt deres farmasøytiske akseptable addisjonssalter. Disse forbindelsene er potensielt nyttige i behand- lingen av a-reseptorrelaterte sykdommer i nerve- systemet .
NO950974A 1993-07-19 1995-03-14 Nye N,N,N',N'-tetrasubstituert-1,2-etandiaminderivatforbindelser NO950974L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES09301616A ES2074946B1 (es) 1993-07-19 1993-07-19 Nuevos compuestos derivados de la 1,2-etanodiamina-n,n,n',n'-tetrasustituida.
PCT/EP1994/002363 WO1995003270A1 (en) 1993-07-19 1994-07-18 New n,n,n',n'-tetrasubstituted-1,2-ethanediamine derivative compounds

Publications (2)

Publication Number Publication Date
NO950974D0 NO950974D0 (no) 1995-03-14
NO950974L true NO950974L (no) 1995-03-14

Family

ID=8282595

Family Applications (1)

Application Number Title Priority Date Filing Date
NO950974A NO950974L (no) 1993-07-19 1995-03-14 Nye N,N,N',N'-tetrasubstituert-1,2-etandiaminderivatforbindelser

Country Status (19)

Country Link
US (1) US5561135A (no)
EP (1) EP0660819B1 (no)
JP (1) JPH08503962A (no)
KR (1) KR950703515A (no)
AT (1) ATE159511T1 (no)
AU (1) AU670716B2 (no)
CA (1) CA2144758A1 (no)
DE (1) DE69406406T2 (no)
DK (1) DK0660819T3 (no)
ES (1) ES2074946B1 (no)
FI (1) FI951277L (no)
GR (1) GR3025941T3 (no)
MX (1) MX9403011A (no)
NO (1) NO950974L (no)
NZ (1) NZ271076A (no)
PH (1) PH30969A (no)
TW (1) TW262460B (no)
WO (1) WO1995003270A1 (no)
ZA (1) ZA943035B (no)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007047978A2 (en) 2005-10-21 2007-04-26 Braincells, Inc. Modulation of neurogenesis by pde inhibition
EP2314289A1 (en) 2005-10-31 2011-04-27 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
EP2021000A2 (en) 2006-05-09 2009-02-11 Braincells, Inc. Neurogenesis by modulating angiotensin
US7678808B2 (en) 2006-05-09 2010-03-16 Braincells, Inc. 5 HT receptor mediated neurogenesis
WO2008030651A1 (en) 2006-09-08 2008-03-13 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE757408A (fr) * 1969-10-13 1971-04-13 Thomae Gmbh Dr K Nouveaux butanols tertiaires a constituants basiques
FR2279383A1 (fr) * 1974-04-25 1976-02-20 Synthelabo Nouveaux derives tetrasubstitues des alcoylene-diamines, leurs sels, leur preparation et les medicaments qui en contiennent
US4605655A (en) * 1984-03-06 1986-08-12 Bristol-Myers Company Antipsychotic 1-fluorophenylbutyl-4-(2-pyrimidinyl)piperazine derivatives
US4588728A (en) * 1985-03-27 1986-05-13 Burroughs Wellcome Co. Treatment of drug induced psychosis
US4709094A (en) * 1986-07-10 1987-11-24 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon Sigma brain receptor ligands and their use
US4929734A (en) * 1987-03-31 1990-05-29 Warner-Lambert Company Tetrahydropyridine oxime compounds
IT1205124B (it) * 1987-06-05 1989-03-15 Simens Soteta Italiana Medicin Composto attivo nella terapia carciovascolare
US4981870A (en) * 1989-03-07 1991-01-01 Pfizer Inc. Use of 4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine derivatives in the treatment of psychosis, inflammation and as immunosuppressants
US5109002A (en) * 1989-09-08 1992-04-28 Du Pont Merck Pharmaceutical Company Antipsychotic 1-cycloalkylpiperidines
US5149817A (en) * 1990-03-05 1992-09-22 Shionogi & Co., Ltd. Teirahydropyridine derivatives
US5116995A (en) * 1990-05-25 1992-05-26 Taisho Pharmaceutical Co., Ltd. Carbazole compounds
JP2935541B2 (ja) * 1990-06-28 1999-08-16 サントリー株式会社 縮合複素環化合物
US5086054A (en) * 1990-07-31 1992-02-04 Sri International Novel arylcycloalkanepolyalkylamines
DE4032767A1 (de) * 1990-10-16 1992-04-30 Basf Ag Phenylpiperidinoylamine und diese enthaltende arzneimittel
ES2086464T3 (es) * 1990-12-19 1996-07-01 Kali Chemie Pharma Gmbh Compuestos de alquilaminoalquil-amina y -eter, asi como procedimientos y productos intermedios para su preparacion y medicamentos que contienen estos compuestos.
US5162341A (en) * 1991-02-22 1992-11-10 Du Pont Merck Pharmaceutical Company Use of sigma receptor antagonists for treatment of amphetamine abuse
FR2675799B1 (fr) * 1991-04-24 1993-12-24 Synthelabo Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique.

Also Published As

Publication number Publication date
NO950974D0 (no) 1995-03-14
MX9403011A (es) 1995-01-31
FI951277A0 (fi) 1995-03-17
FI951277A7 (fi) 1995-03-17
EP0660819A1 (en) 1995-07-05
EP0660819B1 (en) 1997-10-22
GR3025941T3 (en) 1998-04-30
ES2074946B1 (es) 1996-06-16
ATE159511T1 (de) 1997-11-15
ES2074946A1 (es) 1995-09-16
FI951277L (fi) 1995-03-17
DE69406406T2 (de) 1998-05-20
PH30969A (en) 1997-12-23
AU7459094A (en) 1995-02-20
AU670716B2 (en) 1996-07-25
DK0660819T3 (da) 1998-01-12
DE69406406D1 (de) 1997-11-27
WO1995003270A1 (en) 1995-02-02
CA2144758A1 (en) 1995-02-02
ZA943035B (en) 1995-05-02
US5561135A (en) 1996-10-01
TW262460B (no) 1995-11-11
JPH08503962A (ja) 1996-04-30
KR950703515A (ko) 1995-09-20
NZ271076A (en) 1996-03-26

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