NO951201L - Fremgangsmåte for fremstilling av taxanderivater - Google Patents

Fremgangsmåte for fremstilling av taxanderivater

Info

Publication number: NO951201L
Authority: NO; Norway
Prior art keywords: pct; vii; date; alkyl; alkenyl
Prior art date: 1992-10-05

Application number

NO951201A

Other languages

English (en)

Other versions

NO951201D0 (no

NO309089B1 (no

Inventor

Jean-Manuel Mas

Viviane Massonneau

Original Assignee

Rhone Poulenc Rorer Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-10-05

Filing date

1995-03-29

Publication date

1995-03-29

1995-03-29 Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa

1995-03-29 Publication of NO951201D0 publication Critical patent/NO951201D0/no

1995-03-29 Publication of NO951201L publication Critical patent/NO951201L/no

2000-12-11 Publication of NO309089B1 publication Critical patent/NO309089B1/no

Links

238000000034 method Methods 0.000 title abstract 2
DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 title abstract 2
125000003342 alkenyl group Chemical group 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
125000000453 2,2,2-trichloroethyl group Chemical group [H]C([H])(*)C(Cl)(Cl)Cl 0.000 abstract 1
YWLXLRUDGLRYDR-ZHPRIASZSA-N 5beta,20-epoxy-1,7beta,10beta,13alpha-tetrahydroxy-9-oxotax-11-ene-2alpha,4alpha-diyl 4-acetate 2-benzoate Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](O)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 YWLXLRUDGLRYDR-ZHPRIASZSA-N 0.000 abstract 1
OVMSOCFBDVBLFW-VHLOTGQHSA-N 5beta,20-epoxy-1,7beta,13alpha-trihydroxy-9-oxotax-11-ene-2alpha,4alpha,10beta-triyl 4,10-diacetate 2-benzoate Chemical compound O([C@@H]1[C@@]2(C[C@H](O)C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)O)C(=O)C1=CC=CC=C1 OVMSOCFBDVBLFW-VHLOTGQHSA-N 0.000 abstract 1
125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
230000010933 acylation Effects 0.000 abstract 1
238000005917 acylation reaction Methods 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
150000001412 amines Chemical group 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
150000001602 bicycloalkyls Chemical group 0.000 abstract 1
125000001309 chloro group Chemical group Cl* 0.000 abstract 1
125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
230000008030 elimination Effects 0.000 abstract 1
238000003379 elimination reaction Methods 0.000 abstract 1
230000032050 esterification Effects 0.000 abstract 1
238000005886 esterification reaction Methods 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epoxy Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Plural Heterocyclic Compounds (AREA)

NO951201A 1992-10-05 1995-03-29 FremgangsmÕte for fremstilling av taxanderivater NO309089B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9211741A FR2696458B1 (fr)	1992-10-05	1992-10-05	Procédé de préparation de dérivés du taxane.
PCT/FR1993/000967 WO1994007877A1 (fr)	1992-10-05	1993-10-04	Procede de preparation de derives du taxane

Publications (3)

Publication Number	Publication Date
NO951201D0 NO951201D0 (no)	1995-03-29
NO951201L true NO951201L (no)	1995-03-29
NO309089B1 NO309089B1 (no)	2000-12-11

Family

ID=9434119

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO951201A NO309089B1 (no)	1992-10-05	1995-03-29	FremgangsmÕte for fremstilling av taxanderivater

Country Status (24)

Country	Link
US (3)	US5616739A (no)
EP (1)	EP0663906B1 (no)
JP (1)	JP3014760B2 (no)
KR (1)	KR100311198B1 (no)
AT (1)	ATE146174T1 (no)
AU (1)	AU689080B2 (no)
CA (1)	CA2146250C (no)
CZ (1)	CZ283261B6 (no)
DE (1)	DE69306591T2 (no)
DK (1)	DK0663906T3 (no)
ES (1)	ES2095081T3 (no)
FI (1)	FI109793B (no)
FR (1)	FR2696458B1 (no)
GR (1)	GR3021997T3 (no)
HU (1)	HU226412B1 (no)
MX (1)	MX9305766A (no)
NO (1)	NO309089B1 (no)
NZ (1)	NZ256445A (no)
PL (1)	PL182284B1 (no)
RU (1)	RU2116303C1 (no)
SK (1)	SK280627B6 (no)
TW (1)	TW419472B (no)
WO (1)	WO1994007877A1 (no)
ZA (1)	ZA937318B (no)

Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2696464B1 (fr) *	1992-10-05	1994-11-10	Rhone Poulenc Rorer Sa	Nouveau procédé d'estérification de la baccatine III et de la désacétyl-10 baccatine III.
FR2697522B1 (fr) *	1992-10-30	1994-11-25	Rhone Poulenc Rorer Sa	Procédé de préparation de dérivés du taxane.
FR2698361B1 (fr) *	1992-11-20	1995-01-13	Rhone Poulenc Rorer Sa	Procédé de préparation d'un acide oxazolidine-1,3 carboxylique-5.
MX9307777A (es)	1992-12-15	1994-07-29	Upjohn Co	7-HALO-Y 7ß, 8ß-METANO-TAXOLES, USO ANTINEOPLASTICO Y COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN.
US5973160A (en) *	1992-12-23	1999-10-26	Poss; Michael A.	Methods for the preparation of novel sidechain-bearing taxanes
EP0982302B1 (en) *	1993-06-11	2004-04-14	PHARMACIA & UPJOHN COMPANY	Delta 6,7-taxols antineoplastic use and pharmaceutical compositions containing them
FR2706457B1 (fr) *	1993-06-16	1995-07-28	Rhone Poulenc Rorer Sa	Procédé de préparation d'un acide oxazolidinecarboxylique utile pour préparer des taxoïdes thérapeutiquement actifs.
US6005120A (en)	1993-07-20	1999-12-21	Florida State University	Tricyclic and tetracyclic taxanes
KR100354309B1 (ko) *	1993-11-12	2003-01-06	파마시아 앤드 업존 캄파니	피리미딘-티오알킬및알킬에테르화합물
IL127599A (en) *	1994-01-28	2004-06-01	Upjohn Co	Process for preparing isotaxol analogs
US5679807A (en) *	1995-01-30	1997-10-21	Hauser, Inc.	Preparation of taxol and docetaxel through primary amines
CA2170661A1 (en) *	1995-03-22	1996-09-23	John K. Thottathil	Novel methods for the preparation of taxanes using oaxzolidine intermediates
GB9512471D0 (en) *	1995-06-20	1995-08-23	Pharmacia Spa	Method for the preparation of taxol and its derivatives
US5688977A (en) *	1996-02-29	1997-11-18	Napro Biotherapeutics, Inc.	Method for docetaxel synthesis
NZ332475A (en) *	1996-05-08	2000-05-26	Upjohn Co	silylated baccatin derivatives, 3-(substituted amino)-3-phenyl-(2R,3S)-isoserinate derivatives, the oxazolidine ester thereof and other immediates used to prepare baccatin derivatives
US7288665B1 (en) *	1997-08-18	2007-10-30	Florida State University	Process for selective derivatization of taxanes
US6111144A (en)	1997-08-21	2000-08-29	Florida State University	Method for the synthesis of a taxane intermediate
WO1999032109A1 (en) *	1997-12-23	1999-07-01	Bristol-Myers Squibb Company	7-deoxy-6-nitrogen substituted paclitaxels
CA2385528C (en)	1999-10-01	2013-12-10	Immunogen, Inc.	Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
MXPA03002494A (es) *	2000-09-22	2004-05-24	Bristol Myers Squibb Co	Metodo para reducir toxicidad de quimio terapias combinadas.
US6891050B2 (en) *	2001-08-10	2005-05-10	Dabur India Limited	Process for the preparation of taxanes such as paclitaxel, docetaxel and structurally similar analogs
US6881852B2 (en) *	2002-02-05	2005-04-19	Dabur India Limited	Process of purification of paclitaxel and docetaxel
US7247738B2 (en) *	2002-05-07	2007-07-24	Dabur India Limited	Method of preparation of anticancer taxanes using 3-[(substituted-2-trialkylsilyl) ethoxycarbonyl]-5-oxazolidine carboxylic acids
US6900342B2 (en) *	2002-05-10	2005-05-31	Dabur India Limited	Anticancer taxanes such as paclitaxel, docetaxel and their structural analogs, and a method for the preparation thereof
US7351542B2 (en)	2002-05-20	2008-04-01	The Regents Of The University Of California	Methods of modulating tubulin deacetylase activity
JP4975964B2 (ja)	2002-06-26	2012-07-11	メディゲーネアクチエンゲゼルシャフト	脂肪親和性化合物から成る陽イオン性リポソームの製法
AU2003273671A1 (en) *	2002-10-09	2004-05-04	Phytogen Life Sciences, Inc.	Novel taxanes and methods related to use and preparation thereof
US6838569B2 (en)	2002-12-16	2005-01-04	Dabur India Limited	Process for preparation of paclitaxel trihydrate and docetaxel trihydrate
JP2007525188A (ja)	2003-05-16	2007-09-06	インターミューンインコーポレイテッド	合成ケモカイン受容体リガンドおよびその使用方法
US7407973B2 (en) *	2003-10-24	2008-08-05	Intermune, Inc.	Use of pirfenidone in therapeutic regimens
US7202370B2 (en) *	2003-10-27	2007-04-10	Conor Medsystems, Inc.	Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III
US7597884B2 (en)	2004-08-09	2009-10-06	Alios Biopharma, Inc.	Hyperglycosylated polypeptide variants and methods of use
CA2576030A1 (en) *	2004-08-09	2006-02-23	Alios Biopharma Inc.	Synthetic hyperglycosylated, protease-resistant polypeptide variants, oral formulations and methods of using the same
US7446126B2 (en) *	2004-10-08	2008-11-04	Indena S.P.A.	Semisynthesis process for the preparation of 10-deacetyl-N-debenzoyl-paclitaxel
EP1647552A1 (en) *	2004-10-08	2006-04-19	INDENA S.p.A.	Semisynthesis process for the preparation of 10-deacetyl-n-debenzoyl-paclitaxel
EP1712552A1 (en) *	2005-04-11	2006-10-18	INDENA S.p.A.	Semisynthesis process for the preparation of 10-deacetyl-n-debenzoyl-paclitaxel
WO2006089218A2 (en) *	2005-02-17	2006-08-24	The Board Of Trustees Of The Leland Stanford Junior University	Methods and compositions for modulating angiogenesis
AU2007226937A1 (en) *	2006-03-21	2007-09-27	Dr. Reddy's Laboratories Ltd.	Docetaxel polymorphs and processes
AU2007228984B2 (en)	2006-03-22	2012-05-03	Syncore Biotechnology Co., Ltd	Treatment of triple receptor negative breast cancer
ITMI20062479A1 (it) *	2006-12-21	2008-06-22	Indena Spa	Processo per la preparazione di secotassani
EP2296645B1 (en)	2008-05-22	2014-11-19	Galera Therapeutics, LLC	Combination antitumor therapy
KR101003822B1 (ko)	2008-06-20	2010-12-27	주식회사 셀트리온화학연구소	도세탁셀의 제조방법 및 도세탁셀의 제조를 위한 신규한중간체
WO2010005850A1 (en)	2008-07-08	2010-01-14	The J. David Gladstone Institutes	Methods and compositions for modulating angiogenesis
CN101735179B (zh) *	2008-11-19	2012-09-12	上海百灵医药科技有限公司	一种多烯紫杉醇的制备方法，其中间体及制备方法
EP2358693A4 (en) *	2008-11-20	2012-04-18	Reddys Lab Ltd Dr	PREPARATION OF DOCETAXEL
PL388144A1 (pl)	2009-05-29	2010-12-06	Przedsiębiorstwo Produkcyjno-Wdrożeniowe Ifotam Spółka Z Ograniczoną Odpowiedzialnością	Solwaty (2R,3S)-3-tert-butoksykarbonylamino-2-hydroksy-3-fenylopropionianu 4-acetoksy-2α-benzoiloksy -5β,20-epoksy-1,7β,10β-trihydroksy-9-okso-taks-11-en-13α-ylu, sposób ich otrzymywania i zastosowanie
JP6578206B2 (ja)	2012-07-19	2019-09-18	レッドウッドバイオサイエンス，インコーポレイテッド	Ｃｄ２２に特異的な抗体およびその使用方法
WO2014074218A1 (en)	2012-11-12	2014-05-15	Redwood Bioscience, Inc.	Compounds and methods for producing a conjugate
SI3300745T1 (sl)	2013-02-15	2020-01-31	The Regents Of The University Of California	Himerni antigenski receptor in postopki njihove uporabe
WO2014160185A2 (en)	2013-03-14	2014-10-02	The Board Of Trustees Of The Leland Stanford Junior University	Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof
CN105744935B (zh)	2013-11-27	2022-09-30	雷德伍德生物科技股份有限公司	肼基-吡咯并化合物及用于生成缀合物的方法
WO2015127137A1 (en)	2014-02-19	2015-08-27	Aldea Pharmaceuticals, Inc.	Mitochondrial aldehyde dehydrogenase 2 (aldh2) binding polycyclic amides and their use for the treatment of cancer
TW202214691A (zh)	2014-03-21	2022-04-16	美商艾伯維有限公司	抗-egfr抗體及抗體藥物結合物
WO2017083637A1 (en)	2015-11-12	2017-05-18	The Board Of Trustees Of The Leland Stanford Junior University	Cell-penetrating, guanidinium-rich oligophosphotriesters for drug and probe delivery
TWI760319B (zh)	2015-12-30	2022-04-11	杏國新藥股份有限公司	乳癌治療
EP3231421A1 (en)	2016-04-11	2017-10-18	Greenaltech, S.L.	Uses of a carotenoid in the treatment or prevention of stress induced conditions
CN109071634A (zh)	2016-04-26	2018-12-21	R.P.谢勒技术有限责任公司	抗体偶联物及其制备和使用方法
EP3463308B2 (en)	2016-06-01	2026-01-07	Servier IP UK Limited	Formulations of polyalkylene oxide-asparaginase and methods of making and using the same
WO2017214458A2 (en)	2016-06-08	2017-12-14	Abbvie Inc.	Anti-cd98 antibodies and antibody drug conjugates
TWI762487B (zh)	2016-06-08	2022-05-01	美商艾伯維有限公司	抗-b7-h3抗體及抗體藥物結合物
CA3027044A1 (en)	2016-06-08	2017-12-14	Abbvie Inc.	Anti-b7-h3 antibodies and antibody drug conjugates
BR112018075649A2 (pt)	2016-06-08	2019-04-09	Abbvie Inc.	anticorpos anti-b7-h3 e conjugados de fármaco de anticorpo
EP3468598A1 (en)	2016-06-08	2019-04-17	AbbVie Inc.	Anti-cd98 antibodies and antibody drug conjugates
TWI852903B (zh)	2017-01-05	2024-08-21	杏國新藥股份有限公司	胰臟癌治療
KR102905343B1 (ko)	2017-01-18	2025-12-29	바이오아트라, 인코퍼레이티드	Axl 또는 ror2에 대한 키메라 항원 수용체 및 이의 사용 방법
EP3388082A1 (en)	2017-04-13	2018-10-17	Galera Labs, LLC	Combination cancer immunotherapy with pentaaza macrocyclic ring complex
CN118652192A (zh)	2017-05-24	2024-09-17	德克萨斯州大学系统董事会	用于抗体药物缀合物的接头
IL276407B2 (en)	2018-01-31	2025-01-01	Galera Labs Llc	Combination cancer therapy with a pentase macrocyclic ring complex and a platinum-based anticancer agent
CA3095757A1 (en)	2018-04-06	2019-10-10	The Regents Of The University Of California	Methods of treating glioblastomas
EP3773632A4 (en)	2018-04-06	2022-05-18	The Regents of The University of California	METHODS OF TREATMENT OF EGFRVIII-EXPRESSING GLIOBLASTOMA
CN112368011A (zh)	2018-04-11	2021-02-12	俄亥俄州创新基金会	缓释微粒用于眼用药物递送的方法和组合物
MX2021000644A (es)	2018-07-18	2021-08-19	Manzanita Pharmaceuticals Inc	Conjugados para suministrar un agente contra el cancer a las celulas nerviosas, metodos de uso y metodos para la elaboracion de los mismos.
BR112021019701A2 (pt)	2019-04-02	2021-12-14	Kenjockety Biotechnology Inc	Anticorpos multiespecíficos para antígeno de câncer de bomba de efluxo e composições, reagentes, kits e métodos relacionados aos mesmos
BR112022013870A2 (pt)	2020-01-29	2022-09-13	Kenjockety Biotechnology Inc	Anticorpos anti-mdr1 e usos dos mesmos
WO2021247426A1 (en)	2020-06-04	2021-12-09	Kenjockety Biotechnology, Inc.	Anti-abcg2 antibodies and uses thereof
EP4161564A1 (en)	2020-06-04	2023-04-12	Kenjockety Biotechnology, Inc.	Abcg2 efflux pump-cancer antigen multi-specific antibodies and compositions, reagents, kits and methods related thereto
JP7747741B2 (ja)	2020-09-02	2025-10-01	ウィリアムロバートアラスーンリビングトラストデイテッドオーガスト 29, 2016	抗ａｂｃｃ１抗体及びその使用
EP4244257A1 (en)	2020-11-13	2023-09-20	Kenjockety Biotechnology, Inc.	Anti-mrp4 (encoded by abcc4 gene) antibodies and uses thereof
MX2023005979A (es)	2020-11-20	2023-08-11	Scherer Technologies Llc R P	Enlazadores de escisión doble de glicósido para conjugados de anticuerpo y fármaco.
AR124681A1 (es)	2021-01-20	2023-04-26	Abbvie Inc	Conjugados anticuerpo-fármaco anti-egfr
KR20240116829A (ko)	2021-12-13	2024-07-30	윌리엄 로버트 아라툰 리빙 트러스트 데이티드 어거스트 29, 2016	항-abcb1 항체
WO2023159220A1 (en)	2022-02-18	2023-08-24	Kenjockety Biotechnology, Inc.	Anti-cd47 antibodies

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5175315A (en) *	1989-05-31	1992-12-29	Florida State University	Method for preparation of taxol using β-lactam
US5136060A (en) *	1989-11-14	1992-08-04	Florida State University	Method for preparation of taxol using an oxazinone
US5015744A (en) *	1989-11-14	1991-05-14	Florida State University	Method for preparation of taxol using an oxazinone
MX9102128A (es) *	1990-11-23	1992-07-08	Rhone Poulenc Rorer Sa	Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene
US5319112A (en) *	1992-08-18	1994-06-07	Virgnia Tech Intellectual Properties, Inc.	Method for the conversion of cephalomannine to taxol and for the preparation of N-acyl analogs of taxol

1992
- 1992-10-05 FR FR9211741A patent/FR2696458B1/fr not_active Expired - Lifetime
1993
- 1993-09-21 MX MX9305766A patent/MX9305766A/es unknown
- 1993-10-01 ZA ZA937318A patent/ZA937318B/xx unknown
- 1993-10-02 TW TW082108117A patent/TW419472B/zh not_active IP Right Cessation
- 1993-10-04 AU AU51150/93A patent/AU689080B2/en not_active Expired
- 1993-10-04 DE DE69306591T patent/DE69306591T2/de not_active Expired - Lifetime
- 1993-10-04 RU RU95113717A patent/RU2116303C1/ru active
- 1993-10-04 CA CA002146250A patent/CA2146250C/fr not_active Expired - Lifetime
- 1993-10-04 SK SK436-95A patent/SK280627B6/sk not_active IP Right Cessation
- 1993-10-04 CZ CZ95841A patent/CZ283261B6/cs not_active IP Right Cessation
- 1993-10-04 HU HU9500971A patent/HU226412B1/hu unknown
- 1993-10-04 DK DK93921982.0T patent/DK0663906T3/da active
- 1993-10-04 WO PCT/FR1993/000967 patent/WO1994007877A1/fr not_active Ceased
- 1993-10-04 EP EP93921982A patent/EP0663906B1/fr not_active Expired - Lifetime
- 1993-10-04 PL PL93308241A patent/PL182284B1/pl unknown
- 1993-10-04 KR KR1019950701302A patent/KR100311198B1/ko not_active Expired - Lifetime
- 1993-10-04 NZ NZ256445A patent/NZ256445A/en not_active IP Right Cessation
- 1993-10-04 JP JP6508787A patent/JP3014760B2/ja not_active Expired - Lifetime
- 1993-10-04 ES ES93921982T patent/ES2095081T3/es not_active Expired - Lifetime
- 1993-10-04 AT AT93921982T patent/ATE146174T1/de active
- 1993-10-04 US US08/411,692 patent/US5616739A/en not_active Expired - Lifetime
1995
- 1995-03-29 NO NO951201A patent/NO309089B1/no not_active IP Right Cessation
- 1995-04-04 FI FI951595A patent/FI109793B/fi not_active IP Right Cessation
1996
- 1996-10-31 US US08/742,101 patent/US5677462A/en not_active Expired - Lifetime
- 1996-12-12 GR GR960402201T patent/GR3021997T3/el unknown
1997
- 1997-08-08 US US08/908,806 patent/US5869680A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
SK280627B6 (sk)	2000-05-16
EP0663906B1 (fr)	1996-12-11
NZ256445A (en)	1997-01-29
GR3021997T3 (en)	1997-03-31
CA2146250C (fr)	2003-03-11
FR2696458A1 (fr)	1994-04-08
JPH08501788A (ja)	1996-02-27
NO951201D0 (no)	1995-03-29
AU5115093A (en)	1994-04-26
WO1994007877A1 (fr)	1994-04-14
RU2116303C1 (ru)	1998-07-27
RU95113717A (ru)	1996-12-27
FI951595L (fi)	1995-04-04
US5616739A (en)	1997-04-01
AU689080B2 (en)	1998-03-26
MX9305766A (es)	1995-01-31
DK0663906T3 (da)	1996-12-30
CZ283261B6 (cs)	1998-02-18
CZ84195A3 (en)	1995-09-13
US5869680A (en)	1999-02-09
TW419472B (en)	2001-01-21
FR2696458B1 (fr)	1994-11-10
KR100311198B1 (ko)	2002-04-24
DE69306591T2 (de)	1997-04-17
PL308241A1 (en)	1995-07-24
PL182284B1 (pl)	2001-12-31
EP0663906A1 (fr)	1995-07-26
CA2146250A1 (fr)	1994-04-14
DE69306591D1 (de)	1997-01-23
NO309089B1 (no)	2000-12-11
FI109793B (fi)	2002-10-15
FI951595A0 (fi)	1995-04-04
SK43695A3 (en)	1995-08-09
HU9500971D0 (en)	1995-06-28
HU226412B1 (en)	2008-11-28
US5677462A (en)	1997-10-14
ES2095081T3 (es)	1997-02-01
KR950703546A (ko)	1995-09-20
JP3014760B2 (ja)	2000-02-28
ZA937318B (en)	1994-04-25
ATE146174T1 (de)	1996-12-15
HUT72679A (en)	1996-05-28

Legal Events

Date	Code	Title	Description
2013-11-11	MK1K	Patent expired

Publication	Publication Date	Title
NO951201D0 (no)	1995-03-29	Fremgangsmåte for fremstilling av taxanderivater
DE69308154D1 (de)	1997-03-27	Verfahren zur herstellung von taxan-derivaten
DE69307527D1 (de)	1997-02-27	Verfahren zur herstellung von taxan-derivaten
HUT72616A (en)	1996-05-28	Novel method of esterification of baccatine iii and 10-deacetylbaccatine iii