NO952288L - Benzazepinon-derivater - Google Patents
Benzazepinon-derivaterInfo
- Publication number
- NO952288L NO952288L NO952288A NO952288A NO952288L NO 952288 L NO952288 L NO 952288L NO 952288 A NO952288 A NO 952288A NO 952288 A NO952288 A NO 952288A NO 952288 L NO952288 L NO 952288L
- Authority
- NO
- Norway
- Prior art keywords
- lower alkyl
- aryl
- alkyl
- alkylene
- alkoxy
- Prior art date
Links
- AYQMNFRCBKOMIA-UHFFFAOYSA-N 1-benzazepin-2-one Chemical class O=C1C=CC=C2C=CC=CC2=N1 AYQMNFRCBKOMIA-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 16
- 125000003118 aryl group Chemical group 0.000 abstract 9
- 125000003545 alkoxy group Chemical group 0.000 abstract 6
- 125000002947 alkylene group Chemical group 0.000 abstract 5
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 3
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000005529 alkyleneoxy group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- -1 amino, amino Chemical group 0.000 abstract 1
- 125000005161 aryl oxy carbonyl group Chemical group 0.000 abstract 1
- 125000004391 aryl sulfonyl group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Det er beskrevet substituerte 3-amlno-l-arylalkyl-benzazepln-2-oner med generell formel (I), hvor Ar betyr aryl; * står for -O- eller -S(0)n- og n betyr O, l eller 2; Xj betyr q-Cg-alkylen eller står for en direkte binding; RJ betyr hydrogen, lavere alkyl, aryl-lavere alkyl eller acyl; R2 betyr lavere alkyl, hydroksy lavere alkyl, lavere alkoksy lavere alkyl, aryl lavere alkoksy lavere alkyl, aryl-lavere alkyl eller C3-C7-cykloalkyl-lavere alkyl; R3 betyr karboksy; lavere alkoksykarbonyl; lavere alkoksy-lavere alkoksykarbonyl; aryl lavere alkoksykarbonyl; aryloksykarbonyl; karbamoyl; karbamoyl, som er monosubstltuert (1) med hydroksy, lavere alkansulfonyl, halogen lavere alkansulfonyl eller arylsulfonyl, monosubstltuert eller uavhengig av hverandre dlsubstituert (il) med lavere alkyl, lavere alkenyl, lavere alklnyl, fenyl lavere alkyl eller er dlsubstltuert (111) med lavere alkylen eller lavere alkylen-Zj-lavere alkylen, hvorved ZA står for O, S eller KH; 6-tetrazolyl; P02H2: PO^ eller SO^; ringen A hhv. aromatiske rester er uavhengig av hverandre usubsti- tuerte eller enkelt- eller flersubstltuerte med substltuenter valgt fra gruppen bestående av lavere alkyl, aryl lavere alkyl, lavere alkoksy lavere alkyl, lavere alkoksy, lavere alkoksy-lavere alkoksy, aryl lavere alkoksy, C3-C7-cykloalkyl, C3-C7-cykloalkyl-lavere alkyl, nitro, halogen, trlfluormetyl, amlno, emino som er mono- eller uavhengig av hverandre dlsubstltuert med lavere alkyl, aryl lavere alkyl eller aryl eller dlsubstltuert med lavere alkylen, lavere alkylenoksy lavere alkylen; eller et salt derav; fremgangsmåter for fremstilling derav; deres anvendelse samt farmasøytiske preparater som Inneholder forbindelser med formel (I) eller farmasøytisk anvendbare salter derav.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH380192 | 1992-12-11 | ||
| PCT/EP1993/003426 WO1994013651A1 (de) | 1992-12-11 | 1993-12-06 | Benzazepinon-derivate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO952288L true NO952288L (no) | 1995-06-09 |
| NO952288D0 NO952288D0 (no) | 1995-06-09 |
Family
ID=4263742
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO952288A NO952288D0 (no) | 1992-12-11 | 1995-06-09 | Benzazepinon-derivater |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5610153A (no) |
| EP (1) | EP0673371A1 (no) |
| JP (1) | JPH08505374A (no) |
| KR (1) | KR950704280A (no) |
| AU (1) | AU685768B2 (no) |
| CA (1) | CA2151384A1 (no) |
| FI (1) | FI952803A0 (no) |
| HU (1) | HUT72330A (no) |
| NO (1) | NO952288D0 (no) |
| NZ (1) | NZ258889A (no) |
| WO (1) | WO1994013651A1 (no) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9423172D0 (en) * | 1994-11-17 | 1995-01-04 | Wellcom Foundation The Limited | Hypolipidemic benzothiazepines |
| JPH11506760A (ja) * | 1995-06-07 | 1999-06-15 | メルク エンド カンパニー インコーポレーテッド | 新規なｎ−（２，４−ジオキソ−２，３，４，５−テトラヒドロ−１ｈ−１，５−ベンゾジアゼピン−３イル）−３−アミド |
| CN1304000C (zh) | 1998-12-23 | 2007-03-14 | 诺瓦提斯公司 | 缬沙坦在制备用于治疗肺癌的药物中的用途 |
| US6211217B1 (en) | 1999-03-16 | 2001-04-03 | Novartis Ag | Method for reducing pericardial fibrosis and adhesion formation |
| GB9914745D0 (en) * | 1999-06-24 | 1999-08-25 | Knoll Ag | Therapeutic agents |
| US7291639B2 (en) * | 2001-06-20 | 2007-11-06 | Wyeth | Aryloxy-acetic acid compounds useful as inhibitors of plasminogen activator inhibitor-1 (PAI-1) |
| KR100710547B1 (ko) * | 2002-01-02 | 2007-04-24 | 에스케이 주식회사 | (ｓ)-3-아미노-2,3,4,5-테트라히드로-2-옥소-1Ｈ-벤자제핀-1-아세트산 및 이의 에스테르 화합물의 제조방법 |
| KR100710548B1 (ko) | 2002-12-26 | 2007-04-24 | 에스케이 주식회사 | (ｓ)-3-아미노-2,3,4,5-테트라히드로-2-옥소-1Ｈ-1-벤자제핀-1-아세트산 및 이의 에스테르 화합물의 제조방법 |
| EP1604656A1 (en) | 2004-06-09 | 2005-12-14 | Schwarz Pharma Ag | Novel use of peptide compounds for treating amyotrophic lateral sclerosis (ALS) |
| WO2019246541A1 (en) * | 2018-06-21 | 2019-12-26 | Dana-Farber Cancer Institute, Inc. | Inhibitors of egfr and methods of use thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0072352B1 (de) * | 1981-08-11 | 1986-03-05 | Ciba-Geigy Ag | Benzazepin-2-one, Verfahren zu ihrer Herstellung, pharmazeutische Präparate die diese Verbindungen enthalten, sowie die Verbindungen zur therapeutischen Verwendung |
| US4477464A (en) * | 1983-02-10 | 1984-10-16 | Ciba-Geigy Corporation | Hetero-benzazepine derivatives and their pharmaceutical use |
| IL72523A (en) * | 1983-08-12 | 1988-06-30 | Takeda Chemical Industries Ltd | 3-amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine derivatives,their production and pharmaceutical compositions containing them |
-
1993
- 1993-12-06 AU AU56967/94A patent/AU685768B2/en not_active Expired - Fee Related
- 1993-12-06 NZ NZ258889A patent/NZ258889A/en unknown
- 1993-12-06 WO PCT/EP1993/003426 patent/WO1994013651A1/de not_active Ceased
- 1993-12-06 US US08/454,106 patent/US5610153A/en not_active Expired - Fee Related
- 1993-12-06 KR KR1019950702385A patent/KR950704280A/ko not_active Withdrawn
- 1993-12-06 HU HU9501693A patent/HUT72330A/hu unknown
- 1993-12-06 CA CA002151384A patent/CA2151384A1/en not_active Abandoned
- 1993-12-06 JP JP6513760A patent/JPH08505374A/ja active Pending
- 1993-12-06 EP EP94902689A patent/EP0673371A1/de not_active Withdrawn
-
1995
- 1995-06-09 NO NO952288A patent/NO952288D0/no unknown
- 1995-12-06 FI FI952803A patent/FI952803A0/fi not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| US5610153A (en) | 1997-03-11 |
| NZ258889A (en) | 1997-02-24 |
| HUT72330A (en) | 1996-04-29 |
| FI952803A7 (fi) | 1995-06-07 |
| EP0673371A1 (de) | 1995-09-27 |
| FI952803A0 (fi) | 1995-06-07 |
| AU685768B2 (en) | 1998-01-29 |
| HU9501693D0 (en) | 1995-08-28 |
| WO1994013651A1 (de) | 1994-06-23 |
| AU5696794A (en) | 1994-07-04 |
| NO952288D0 (no) | 1995-06-09 |
| CA2151384A1 (en) | 1994-06-23 |
| JPH08505374A (ja) | 1996-06-11 |
| KR950704280A (ko) | 1995-11-17 |
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