NO952482L - Peptider av borsyre, samt fremstilling derav - Google Patents

Peptider av borsyre, samt fremstilling derav

Info

Publication number
NO952482L
NO952482L NO952482A NO952482A NO952482L NO 952482 L NO952482 L NO 952482L NO 952482 A NO952482 A NO 952482A NO 952482 A NO952482 A NO 952482A NO 952482 L NO952482 L NO 952482L
Authority
NO
Norway
Prior art keywords
hydrogen atom
phenyl
preparation
boric acid
acid peptides
Prior art date
Application number
NO952482A
Other languages
English (en)
Other versions
NO952482D0 (no
Inventor
Guillaume De Nanteuil
Christine Lila
Philippe Gloanec
Michel Laubie
Tony Verbeuren
Serge Simonet
Alain Rubin
Original Assignee
Adir
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adir filed Critical Adir
Publication of NO952482D0 publication Critical patent/NO952482D0/no
Publication of NO952482L publication Critical patent/NO952482L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Det er beskrevet forbindelser av formel -OR< R.NH¿C¿CO¿A- A -co¿NH¿CH¿B; R1, OR, (I): (D hvor RI betegner et hydrogenatom, en acyl, alkoksykar- bonyl-, benzyloksykarbonyl-, fenoksykarbonyl-, eller lineær eller forgrenet C,-C6 alkylgruppe, substituert eller usubstituert, eller en R«S02- gruppe hvor R« betegner alkyl-, naftyl-, fenyl-, benzyl- eller morfolingruppe, R2 betegner et hydrogenatom eller en fenyl-, sub- stituert eller usubstituert benzyl-, tienylme- tyl-, (pyridyl)metyl-, difenylmetyl-, fluoren- yl-, naftylmetyl-, benzocyklobutyl-, (dicyklo- propylmetyl)metyl-, indanyl-, eller (Cj-C, cyk- loalkyljmetylgruppe, R'2 betegner et hydrogenatom, eller også betegner Rj og R'2 sammen CjHj-CH =, R3 angir enhver av gruppene ifølge beskrivelse, hver av R4 og Rj betegner et hydrogenatom eller en alkylgruppe, ^OR4 eller B\ danner en borsyreester av pinandiol, ^OR, A betegner den følgende gruppe: -N¿ hvor n og A2 er som definert i beskrivelsen, og er egnet som medikamenter.
NO952482A 1994-06-22 1995-06-21 Peptider av borsyre, samt fremstilling derav NO952482L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9407589A FR2721611B1 (fr) 1994-06-22 1994-06-22 Nouveaux dérivés peptidiques de l'acide boronique, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent .

Publications (2)

Publication Number Publication Date
NO952482D0 NO952482D0 (no) 1995-06-21
NO952482L true NO952482L (no) 1995-12-27

Family

ID=9464456

Family Applications (1)

Application Number Title Priority Date Filing Date
NO952482A NO952482L (no) 1994-06-22 1995-06-21 Peptider av borsyre, samt fremstilling derav

Country Status (13)

Country Link
US (1) US5585360A (no)
EP (1) EP0688788B1 (no)
JP (1) JP2862496B2 (no)
CN (1) CN1121077A (no)
AT (1) ATE199910T1 (no)
AU (1) AU686365B2 (no)
CA (1) CA2152205A1 (no)
DE (1) DE69520389D1 (no)
FI (1) FI953089A7 (no)
FR (1) FR2721611B1 (no)
NO (1) NO952482L (no)
NZ (1) NZ272401A (no)
ZA (1) ZA955176B (no)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6825169B1 (en) 1991-10-22 2004-11-30 Trustees Of Tufts College Inhibitors of dipeptidyl-aminopeptidase type IV
US5726159A (en) * 1994-03-04 1998-03-10 Eli Lilly And Company Antithrombotic agents
US5707966A (en) * 1994-03-04 1998-01-13 Eli Lilly And Company Antithrombotic agents
CA2143533A1 (en) * 1994-03-04 1995-09-05 Kenneth D. Kurz Antithrombotic agents
US5885967A (en) * 1994-03-04 1999-03-23 Eli Lilly And Company Antithrombotic agents
US5602101A (en) * 1994-03-04 1997-02-11 Eli Lilly And Company Antithrombotic agents
ZA951618B (en) * 1994-03-04 1996-08-27 Lilly Co Eli Antithrombotic agents
US5705487A (en) * 1994-03-04 1998-01-06 Eli Lilly And Company Antithrombotic agents
US5710130A (en) * 1995-02-27 1998-01-20 Eli Lilly And Company Antithrombotic agents
US5914319A (en) * 1995-02-27 1999-06-22 Eli Lilly And Company Antithrombotic agents
US5811402A (en) * 1996-03-22 1998-09-22 Eli Lilly And Company Antithrombotic diamides
US5965532A (en) 1996-06-28 1999-10-12 Trustees Of Tufts College Multivalent compounds for crosslinking receptors and uses thereof
US6194435B1 (en) 1996-10-11 2001-02-27 Cor Therapeutics, Inc. Lactams as selective factor Xa inhibitors
US6063794A (en) 1996-10-11 2000-05-16 Cor Therapeutics Inc. Selective factor Xa inhibitors
US6262047B1 (en) 1996-10-11 2001-07-17 Cor Therapeutics, Inc. Selective factor Xa inhibitors
US6369080B2 (en) 1996-10-11 2002-04-09 Cor Therapeutics, Inc. Selective factor Xa inhibitors
AU6896398A (en) 1997-04-14 1998-11-11 Cor Therapeutics, Inc. Selective factor xa inhibitors
AU741099B2 (en) * 1997-04-14 2001-11-22 Millennium Pharmaceuticals, Inc. Selective factor Xa inhibitors
NZ500353A (en) 1997-04-14 2002-02-01 Cor Therapeutics Inc Cyclic diaza compounds that are selective inhibitors of factor Xa
US6100234A (en) 1997-05-07 2000-08-08 Tufts University Treatment of HIV
US6040145A (en) 1997-05-07 2000-03-21 Tufts University Potentiation of the immune response
US6333321B1 (en) 1997-08-11 2001-12-25 Cor Therapeutics, Inc. Selective factor Xa inhibitors
US6218382B1 (en) 1997-08-11 2001-04-17 Cor Therapeutics, Inc Selective factor Xa inhibitors
US6228854B1 (en) 1997-08-11 2001-05-08 Cor Therapeutics, Inc. Selective factor Xa inhibitors
CA2304206A1 (en) 1997-09-29 1999-04-08 Point Therapeutics, Inc. Stimulation of hematopoietic cells in vitro
MY132924A (en) 1998-05-04 2007-10-31 Point Therapeutics Inc Hematopoietic stimulation
US6979697B1 (en) 1998-08-21 2005-12-27 Point Therapeutics, Inc. Regulation of substrate activity
US6890904B1 (en) 1999-05-25 2005-05-10 Point Therapeutics, Inc. Anti-tumor agents
CA2446282A1 (en) * 2001-05-30 2002-12-05 Novartis Ag 2-{[n-(2-amino-3-(heteroaryl or aryl)propionyl)-aminoacyl]-amino}-alkylboronic acid derivatives
US20060084592A1 (en) * 2002-09-09 2006-04-20 Trigen Limited Peptide boronic acid inhibitors
US20050119226A1 (en) * 2003-09-09 2005-06-02 Trigen Limited Methods for synthesizing organoboronic compounds and products thereof
US7112572B2 (en) * 2002-09-09 2006-09-26 Trigen Limited Multivalent metal salts of boronic acids
AU2003263343A1 (en) 2002-09-09 2004-03-29 Trigen Limited Boronic acid salts ant their use in the treatment of thromobis
US20050176651A1 (en) * 2002-09-09 2005-08-11 Trigen Limited Peptide boronic acids useful in making salts thereof
US20050282757A1 (en) * 2002-09-09 2005-12-22 Trigen Limited Peptide boronic acid compounds useful in anticoagulation
GB0405272D0 (en) * 2004-03-09 2004-04-21 Trigen Ltd Compounds
GB0507577D0 (en) 2005-04-14 2005-05-18 Novartis Ag Organic compounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5187157A (en) * 1987-06-05 1993-02-16 Du Pont Merck Pharmaceutical Company Peptide boronic acid inhibitors of trypsin-like proteases
GB9017694D0 (en) * 1990-08-13 1990-09-26 Sandoz Ltd Improvements in or relating to organic chemistry
US5288707A (en) * 1990-08-13 1994-02-22 Sandoz Ltd. Borolysine peptidomimetics
GB9024129D0 (en) * 1990-11-06 1990-12-19 Thrombosis Research Trust Inhibitors and substrates of thrombin
FR2701951B1 (fr) * 1993-02-24 1995-06-09 Adir Nouveaux derives peptidiques de l'acide boronique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
US5384410A (en) 1993-03-24 1995-01-24 The Du Pont Merck Pharmaceutical Company Removal of boronic acid protecting groups by transesterification
IL109319A0 (en) * 1993-04-27 1994-07-31 Du Pont Merck Pharma Amidino and guanidino substituted boronic acid compounds
IL111175A0 (en) * 1993-10-07 1994-12-29 Du Pont Merck Pharma Electrophilic peptide analogs as inhibitors of trypsin-like serine proteases and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
ZA955176B (en) 1996-02-08
NZ272401A (en) 1996-05-28
FR2721611A1 (fr) 1995-12-29
DE69520389D1 (de) 2001-04-26
FI953089A7 (fi) 1995-12-23
US5585360A (en) 1996-12-17
CN1121077A (zh) 1996-04-24
AU2180195A (en) 1996-01-04
AU686365B2 (en) 1998-02-05
JPH083187A (ja) 1996-01-09
EP0688788B1 (fr) 2001-03-21
FI953089A0 (fi) 1995-06-21
ATE199910T1 (de) 2001-04-15
CA2152205A1 (fr) 1995-12-23
EP0688788A1 (fr) 1995-12-27
FR2721611B1 (fr) 1996-09-27
JP2862496B2 (ja) 1999-03-03
NO952482D0 (no) 1995-06-21

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