NO954878L - Pyrrolderivater - Google Patents

Pyrrolderivater

Info

Publication number
NO954878L
NO954878L NO954878A NO954878A NO954878L NO 954878 L NO954878 L NO 954878L NO 954878 A NO954878 A NO 954878A NO 954878 A NO954878 A NO 954878A NO 954878 L NO954878 L NO 954878L
Authority
NO
Norway
Prior art keywords
compounds
pyrrole
inflammation
pain
useful
Prior art date
Application number
NO954878A
Other languages
English (en)
Other versions
NO954878D0 (no
Inventor
Jim W Barnett
James P Dunn
Denis J Kertesz
Aaron B Miller
Jr David John Morgans
Chakk S Ramesha
C Elliott Sigal
Eric Brian Sjogren
David B Smith
Francisco X Talamas
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO954878D0 publication Critical patent/NO954878D0/no
Publication of NO954878L publication Critical patent/NO954878L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Det beskrives pyrrolderivater. Disse forbindelsene er anvendelige som antiinflammatoriske midler ved behandlingen av inflammasjon og smerte. Fremstillingen av disse forbindelsene, deres farmasøytisk akseptable salter samt farmasøytiske blandinger hvor disse forbindelsene inngår, er også beskrevet.
NO954878A 1994-12-01 1995-11-30 Pyrrolderivater NO954878L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/347,915 US5622948A (en) 1994-12-01 1994-12-01 Pyrrole pyridazine and pyridazinone anti-inflammatory agents

Publications (2)

Publication Number Publication Date
NO954878D0 NO954878D0 (no) 1995-11-30
NO954878L true NO954878L (no) 1996-06-03

Family

ID=23365840

Family Applications (1)

Application Number Title Priority Date Filing Date
NO954878A NO954878L (no) 1994-12-01 1995-11-30 Pyrrolderivater

Country Status (19)

Country Link
US (1) US5622948A (no)
EP (1) EP0714895A1 (no)
JP (1) JPH08208639A (no)
KR (1) KR960022506A (no)
CN (1) CN1066726C (no)
AR (1) AR001771A1 (no)
AU (1) AU3906295A (no)
BR (1) BR9505610A (no)
CA (1) CA2163490A1 (no)
CO (1) CO4650183A1 (no)
CZ (1) CZ316995A3 (no)
FI (1) FI955783A7 (no)
HU (1) HUT75117A (no)
IL (1) IL116139A0 (no)
MA (1) MA23735A1 (no)
NO (1) NO954878L (no)
PL (1) PL311536A1 (no)
TR (1) TR199501528A1 (no)
ZA (1) ZA9510027B (no)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5622948A (en) * 1994-12-01 1997-04-22 Syntex (U.S.A.) Inc. Pyrrole pyridazine and pyridazinone anti-inflammatory agents
US6231888B1 (en) 1996-01-18 2001-05-15 Perio Products Ltd. Local delivery of non steroidal anti inflammatory drugs (NSAIDS) to the colon as a treatment for colonic polyps
DE69716061T2 (de) * 1996-05-30 2003-08-14 F. Hoffmann-La Roche Ag, Basel Pyrrolderivate
CA2205757C (en) * 1996-05-30 2006-01-24 F. Hoffmann-La Roche Ag Pyridazinone derivatives and their use as inhibitors of prostaglandin g/h synthase i and ii(cox i and ii)
JP2003516925A (ja) * 1997-08-22 2003-05-20 アボット・ラボラトリーズ プロスタグランジンエンドペルオキシドｈシンターゼ生合成阻害剤としてのアリールピリダジノン
US6307047B1 (en) 1997-08-22 2001-10-23 Abbott Laboratories Prostaglandin endoperoxide H synthase biosynthesis inhibitors
US6525053B1 (en) 1997-08-22 2003-02-25 Abbott Laboratories Prostaglandin endoperoxide H synthase biosynthesis inhibitors
BR9812127A (pt) * 1997-08-22 2000-07-18 Abbott Lab Arilpiridazinonas como inibidores da biossìntese de prostagleina endoperóxido h sintase
AU749505B2 (en) * 1997-10-27 2002-06-27 Dr. Reddy's Laboratories Limited Novel tricyclic compounds and their use in medicine; process for their preparation and pharmaceutical compositions containing them
US6531152B1 (en) 1998-09-30 2003-03-11 Dexcel Pharma Technologies Ltd. Immediate release gastrointestinal drug delivery system
KR100666838B1 (ko) * 1998-10-27 2007-01-11 아보트 러보러터리즈 프로스타글란딘 엔도퍼옥사이드 ｈ 신타제 생합성 억제제 및 이를 포함하는 약제학적 조성물
US6632451B2 (en) 1999-06-04 2003-10-14 Dexcel Pharma Technologies Ltd. Delayed total release two pulse gastrointestinal drug delivery system
AU2002322720B2 (en) 2001-07-25 2008-11-13 Raptor Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
AU2003248907B2 (en) * 2002-07-11 2007-04-26 Merck & Co., Inc. Treatment of neuropathic pain with 6H-pyrrolo[3,4-d]pyridazine compounds
CN102379684B (zh) 2005-04-28 2014-11-19 普罗透斯数字保健公司 药物信息系统
GB0610680D0 (en) * 2006-05-31 2006-07-12 Istituto Di Ricerche D Biolog Therapeutic compounds
KR20090071598A (ko) 2006-09-18 2009-07-01 랩터 파마슈티컬 인코포레이티드 수용체 결합 단백질(ｒａｐ)-접합체 투여에 의한 간 질환의 치료
WO2009063244A1 (en) * 2007-11-15 2009-05-22 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Pyridazinone derivatives as parp inhibitors
EP2398500B1 (en) 2009-02-20 2019-03-13 2-BBB Medicines B.V. Glutathione-based drug delivery system
ES2942923T3 (es) 2009-05-06 2023-06-07 Laboratory Skin Care Inc Composiciones de administración dérmica que comprenden complejos de agente activo-partículas de fosfato de calcio y métodos de uso de las mismas
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
EP2527335B1 (en) 2011-04-26 2013-09-18 King Saud University Triazole compounds as anti-inflammatory agents
KR102233456B1 (ko) 2017-05-31 2021-03-29 주식회사 대웅제약 4-메톡시피롤 유도체의 중간체 제조 방법
KR102233455B1 (ko) 2017-06-21 2021-03-29 주식회사 대웅제약 4-메톡시피롤 유도체의 중간체 제조 방법
US20250042850A1 (en) * 2021-01-25 2025-02-06 Athos Therapeutics, Inc. Pharmaceutical compounds and methods of making and using the same

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Publication number Priority date Publication date Assignee Title
US2316942A (en) * 1937-12-27 1943-04-20 Schlumberger Well Surv Corp Apparatus for measuring temperatures in boreholes
US3726978A (en) * 1967-11-02 1973-04-10 Sandoz Ag Tetrahydropyridazines and pyridazinones as anti-inflammatory agents
US3586681A (en) * 1967-11-02 1971-06-22 Sandoz Ag 1,4,5,6-tetrahydropyridazines
US3752826A (en) * 1970-01-26 1973-08-14 Mcneilab Inc Aroyl substituted pyrroles
US4048191A (en) * 1975-06-27 1977-09-13 Mcneil Laboratories, Incorporated Halo-substituted 1-loweralkyl-5-aroylpyrrole-2-acetic acid compounds
US4089969A (en) * 1976-07-14 1978-05-16 Syntex (U.S.A.) Inc. 5-Aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof
JPS539788A (en) * 1976-07-14 1978-01-28 Syntex Inc 55aloyll1*22dihydroo3hh pyroro *1*22a* pyroll11 carboxylic acid derivative
US4247551A (en) * 1979-09-17 1981-01-27 Gruppo Lepetit S.P.A. N-Pyrrolyl-pyridazineamines and their use as antihypertensive agents
US4347187A (en) * 1980-10-20 1982-08-31 Syntex (U.S.A.) Inc. Process for preparing 5-aroyl 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids and novel intermediates therein
IT1150070B (it) * 1980-12-22 1986-12-10 Lepetit Spa Procedimento per preparare derivati n-pirrolipiridazinamminici
AU8509882A (en) * 1981-06-30 1983-01-06 Merck & Co., Inc. Tricyclic derivatives of substituted pyrrole acids
WO1983000863A1 (en) * 1981-09-11 1983-03-17 Diamond Shamrock Corp Antiinflammatory and analgetic 4-pyridylpyridazin(2h)-3-ones
US4816454A (en) * 1984-09-21 1989-03-28 Cassella Aktiengesellschaft 4,5-dihydro-3(2H)-pyridazinones and their pharmacological use
GB8501372D0 (en) * 1985-01-18 1985-02-20 Smith Kline French Lab Chemical compounds
US5086052A (en) * 1987-07-17 1992-02-04 Abbott Laboratories Substituted 1,4,5,6-tetrahydro-2H-pyridazin-3-one and -3-thione compounds having lipoxygenase inhibitory activity
US4992441A (en) * 1987-10-14 1991-02-12 Mcneilab, Inc. 1-[[5-[[4-substituted-1-piperazinyl]methyl]-pyrrol-2-yl or furan-2-yl]methyl-2-piperidinones useful in treating schizophrenia
IE913866A1 (en) * 1990-11-28 1992-06-03 Ici Plc Aryl derivatives
NZ256776A (en) * 1992-09-22 1997-10-24 Univ Rochester Transgenic mammalian cells containing a dna sequence expressing pghs-2
US5543297A (en) * 1992-12-22 1996-08-06 Merck Frosst Canada, Inc. Human cyclooxygenase-2 cDNA and assays for evaluating cyclooxygenase-2 activity
US5332736A (en) * 1993-11-01 1994-07-26 Ortho Pharmaceutical Corporation Anti-convulsant aroyl aminoacylpyrroles
US5622948A (en) * 1994-12-01 1997-04-22 Syntex (U.S.A.) Inc. Pyrrole pyridazine and pyridazinone anti-inflammatory agents
KR102081455B1 (ko) * 2017-06-09 2020-04-28 선상규 다중브러시를 이용한 직류발전장치

Also Published As

Publication number Publication date
CN1132206A (zh) 1996-10-02
PL311536A1 (en) 1996-06-10
EP0714895A1 (en) 1996-06-05
AR001771A1 (es) 1997-12-10
ZA9510027B (en) 1996-06-03
CO4650183A1 (es) 1998-09-03
JPH08208639A (ja) 1996-08-13
MA23735A1 (fr) 1996-07-01
CZ316995A3 (en) 1996-06-12
FI955783A0 (fi) 1995-12-01
BR9505610A (pt) 1997-09-16
IL116139A0 (en) 1996-01-31
NO954878D0 (no) 1995-11-30
HU9503384D0 (en) 1996-01-29
CN1066726C (zh) 2001-06-06
FI955783L (fi) 1996-06-02
AU3906295A (en) 1996-06-06
KR960022506A (ko) 1996-07-18
FI955783A7 (fi) 1996-06-02
US5622948A (en) 1997-04-22
CA2163490A1 (en) 1996-06-02
TR199501528A1 (tr) 1996-11-21
HUT75117A (en) 1997-04-28

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