NO955172L - Delesjonsvarianter av protein S med manglende C4BP-bindingsaktivitet, men med APC-kofaktoraktivitet, samt materiale og terapeutiske metoder - Google Patents

Delesjonsvarianter av protein S med manglende C4BP-bindingsaktivitet, men med APC-kofaktoraktivitet, samt materiale og terapeutiske metoder

Info

Publication number
NO955172L
NO955172L NO955172A NO955172A NO955172L NO 955172 L NO955172 L NO 955172L NO 955172 A NO955172 A NO 955172A NO 955172 A NO955172 A NO 955172A NO 955172 L NO955172 L NO 955172L
Authority
NO
Norway
Prior art keywords
protein
lack
well
activity
c4bp
Prior art date
Application number
NO955172A
Other languages
English (en)
Other versions
NO955172D0 (no
Inventor
Rogier Maria Bertina
Bonno Nammen Bouma
Original Assignee
Univ Leiden
Bonno Nammen Bouma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Leiden, Bonno Nammen Bouma filed Critical Univ Leiden
Publication of NO955172D0 publication Critical patent/NO955172D0/no
Publication of NO955172L publication Critical patent/NO955172L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Den foreliggende oppfinnelse vedrører forskjellige '; funksjonelle varianter av rekombinant protein S (PS) som '¿ ikke signifikant binder C4b-bindende protein (C4BP), samt - anvendelser 'av variantene som terapeutiske reagenser. Nærmere bestemt vedrører oppfinnelsen delesjonsmutanter av i protein S som har kofaktor-aktivitet mot APC og som mangler minst de to postulerte C4BP-bindende domener av det SHBG-lignende domene av det korresponderende modne ,villtypeprotein S. Nærmere bestemt mangler slike dele- sjonsmutanter minst aminosyrene 401-457 og 583-635 av det korresponderende humane modne villtypeprotein S.
NO955172A 1993-06-30 1995-12-20 Delesjonsvarianter av protein S med manglende C4BP-bindingsaktivitet, men med APC-kofaktoraktivitet, samt materiale og terapeutiske metoder NO955172L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP93201906 1993-06-30
PCT/NL1994/000149 WO1995001433A1 (en) 1993-06-30 1994-06-28 Protein s deletion variants deficient in c4bp binding activity, but having apc cofactor activity, compositions and therapeutic methods

Publications (2)

Publication Number Publication Date
NO955172D0 NO955172D0 (no) 1995-12-20
NO955172L true NO955172L (no) 1996-02-16

Family

ID=8213942

Family Applications (1)

Application Number Title Priority Date Filing Date
NO955172A NO955172L (no) 1993-06-30 1995-12-20 Delesjonsvarianter av protein S med manglende C4BP-bindingsaktivitet, men med APC-kofaktoraktivitet, samt materiale og terapeutiske metoder

Country Status (7)

Country Link
US (2) US5663142A (no)
EP (1) EP0706564A1 (no)
JP (1) JPH08511948A (no)
AU (1) AU6985594A (no)
FI (1) FI956352A7 (no)
NO (1) NO955172L (no)
WO (1) WO1995001433A1 (no)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5863896A (en) * 1995-11-09 1999-01-26 Immuno Ag Evaluation of substances for altering and for increasing APC response
SE9604378D0 (sv) * 1996-11-27 1996-11-27 Tac Ab Methods and reagents for determining protein S
SE9701228D0 (sv) * 1997-04-03 1997-04-03 Bjoern Dahlbaeck Rekombinanta protein-C-och protein-S-varianter
WO2004030619A2 (en) * 2002-09-30 2004-04-15 Socratech L.L.C. Protein s protects the nervous system from injury
US20070142272A1 (en) * 2003-01-24 2007-06-21 Zlokovic Berislav V Neuroprotective activity of activated protein c independent of its anticoagulant activity
CA2522984A1 (en) * 2003-04-18 2004-10-28 Novartis Ag Methods and compositions targeting tyrosine kinases for the diagnosis and treatment of osteoarthritis
JP2008507561A (ja) * 2004-07-23 2008-03-13 ザ ユニバーシティ オブ ロチェスター 活性化プロテインｃによる、脳内のプラスミノゲン活性化因子の不都合な作用の阻害
PT3524617T (pt) * 2013-03-15 2023-07-12 Gladiator Biosciences Inc Domínios gla como agentes terapêuticos
SG11202001535RA (en) 2017-09-05 2020-03-30 Gladiator Biosciences Inc Method of targeting exosomes

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5321123A (en) * 1991-07-02 1994-06-14 The Scripps Research Institute Protein S polypeptides and anti-peptide antibodies that inhibit protein S binding to C4B binding protein, diagnostic systems and therapeutic methods
US5405946A (en) * 1992-12-02 1995-04-11 The Scripps Research Institute Recombinant protein S variants deficient in C4BP binding activity, compositions and therapeutic methods

Also Published As

Publication number Publication date
AU6985594A (en) 1995-01-24
JPH08511948A (ja) 1996-12-17
FI956352L (fi) 1996-02-28
US5663142A (en) 1997-09-02
EP0706564A1 (en) 1996-04-17
FI956352A7 (fi) 1996-02-28
NO955172D0 (no) 1995-12-20
US5656484A (en) 1997-08-12
WO1995001433A1 (en) 1995-01-12
FI956352A0 (fi) 1995-12-29

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