NO960713L - Substituerte azaindolylidenforbindelser og fremgangsmåte for deres fremstilling - Google Patents

Substituerte azaindolylidenforbindelser og fremgangsmåte for deres fremstilling

Info

Publication number: NO960713L
Authority: NO; Norway
Prior art keywords: choh; nch; alkyl; nch2oh; substituted
Prior art date: 1994-06-24

Application number

NO960713A

Other languages

English (en)

Norwegian (no)

Other versions

NO960713D0 (no

Inventor

Franco Buzzetti

Gabriella Maria Brasca

Antonio Longo

Dario Ballinari

Original Assignee

Pharmacia Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-06-24

Filing date

1996-02-22

Publication date

1996-02-22

1996-02-22 Application filed by Pharmacia Spa filed Critical Pharmacia Spa

1996-02-22 Publication of NO960713D0 publication Critical patent/NO960713D0/no

1996-02-22 Publication of NO960713L publication Critical patent/NO960713L/no

Links

150000001875 compounds Chemical class 0.000 title abstract 2
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
-1 amino, carboxy Chemical group 0.000 abstract 1
125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 abstract 1
125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229940121358 tyrosine kinase inhibitor Drugs 0.000 abstract 1
239000005483 tyrosine kinase inhibitor Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biochemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Molecular Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Indole Compounds (AREA)

NO960713A 1994-06-24 1996-02-22 Substituerte azaindolylidenforbindelser og fremgangsmåte for deres fremstilling NO960713L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB9412719A GB9412719D0 (en)	1994-06-24	1994-06-24	Substituted azaindolylidene compounds and process for their preparation
PCT/EP1995/002043 WO1996000226A1 (en)	1994-06-24	1995-05-30	Substituted azaindolylidene compounds and process for their preparation

Publications (2)

Publication Number	Publication Date
NO960713D0 NO960713D0 (no)	1996-02-22
NO960713L true NO960713L (no)	1996-02-22

Family

ID=10757269

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO960713A NO960713L (no)	1994-06-24	1996-02-22	Substituerte azaindolylidenforbindelser og fremgangsmåte for deres fremstilling

Country Status (21)

Country	Link
US (1)	US5663346A (da)
EP (1)	EP0715628B1 (da)
JP (1)	JP3773257B2 (da)
KR (1)	KR960703911A (da)
CN (1)	CN1129941A (da)
AT (1)	ATE225348T1 (da)
AU (1)	AU2671695A (da)
CA (1)	CA2168659C (da)
DE (1)	DE69528437T2 (da)
DK (1)	DK0715628T3 (da)
ES (1)	ES2186721T3 (da)
FI (1)	FI960751A0 (da)
GB (1)	GB9412719D0 (da)
HU (1)	HUT74609A (da)
IL (1)	IL114156A0 (da)
MX (1)	MX9600686A (da)
NO (1)	NO960713L (da)
PL (1)	PL313166A1 (da)
PT (1)	PT715628E (da)
WO (1)	WO1996000226A1 (da)
ZA (1)	ZA955223B (da)

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US6906093B2 (en)	1995-06-07	2005-06-14	Sugen, Inc.	Indolinone combinatorial libraries and related products and methods for the treatment of disease
US6696448B2 (en)	1996-06-05	2004-02-24	Sugen, Inc.	3-(piperazinylbenzylidenyl)-2-indolinone compounds and derivatives as protein tyrosine kinase inhibitors
GB9613021D0 (en) *	1996-06-21	1996-08-28	Pharmacia Spa	Bicyclic 4-aralkylaminopyrimidine derivatives as tyrosine kinase inhibitors
DE69734521T9 (de) *	1996-08-23	2006-12-07	Sugen, Inc., South San Francisco	Kombinatorische indolinonbibliotheken und verwandte produkte und verfahren zur behandlung von erkrankungen
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JP2002511852A (ja) *	1997-05-07	2002-04-16	スージェン・インコーポレーテッド	蛋白質キナーゼ活性の調節剤としての２−インドリノン誘導体
US6486185B1 (en)	1997-05-07	2002-11-26	Sugen, Inc.	3-heteroarylidene-2-indolinone protein kinase inhibitors
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US6943191B1 (en)	1998-02-27	2005-09-13	The United States Of America As Represented By The Department Of Health And Human Services	Disubstituted lavendustin A analogs and pharmaceutical composition comprising the analogs
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US6153634A (en) *	1998-12-17	2000-11-28	Hoffmann-La Roche Inc.	4,5-azolo-oxindoles
CN1136217C (zh)	1998-12-17	2004-01-28	霍夫曼-拉罗奇有限公司	作为jnk蛋白质激酶抑制剂的4-芳基羟吲哚
BR9916327A (pt)	1998-12-17	2001-09-18	Hoffmann La Roche	Oxindóis de 4-alquenila (e alquinila) como inibidores de cinases dependentes de ciclina, em particular, cdk2
KR20010108024A (ko)	1998-12-17	2001-12-07	프리돌린 클라우스너, 롤란드 비. 보레르	단백질 키나제 억제제로서의 4,5-피라진옥신돌
GB9904933D0 (en)	1999-03-04	1999-04-28	Glaxo Group Ltd	Compounds
US6492398B1 (en)	1999-03-04	2002-12-10	Smithkline Beechman Corporation	Thiazoloindolinone compounds
US6624171B1 (en)	1999-03-04	2003-09-23	Smithkline Beecham Corporation	Substituted aza-oxindole derivatives
US6689806B1 (en)	1999-03-24	2004-02-10	Sugen, Inc.	Indolinone compounds as kinase inhibitors
US6541477B2 (en)	1999-08-27	2003-04-01	Scios, Inc.	Inhibitors of p38-a kinase
US6878733B1 (en)	1999-11-24	2005-04-12	Sugen, Inc.	Formulations for pharmaceutical agents ionizable as free acids or free bases
US6313310B1 (en)	1999-12-15	2001-11-06	Hoffmann-La Roche Inc.	4-and 5-alkynyloxindoles and 4-and 5-alkenyloxindoles
JP3663382B2 (ja)	2000-02-15	2005-06-22	スージェン・インコーポレーテッド	ピロール置換２−インドリノン蛋白質キナーゼ阻害剤
US6620818B1 (en)	2000-03-01	2003-09-16	Smithkline Beecham Corporation	Method for reducing the severity of side effects of chemotherapy and/or radiation therapy
MY128450A (en)	2000-05-24	2007-02-28	Upjohn Co	1-(pyrrolidin-1-ylmethyl)-3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives
JP2003535847A (ja)	2000-06-02	2003-12-02	スージェン・インコーポレーテッド	蛋白質キナーゼ／ホスファターゼ阻害剤としてのインドリノン誘導体
US6335342B1 (en)	2000-06-19	2002-01-01	Pharmacia & Upjohn S.P.A.	Azaindole derivatives, process for their preparation, and their use as antitumor agents
AR042586A1 (es)	2001-02-15	2005-06-29	Sugen Inc	3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa
US6599902B2 (en)	2001-05-30	2003-07-29	Sugen, Inc.	5-aralkysufonyl-3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives as kinase inhibitors
US6960572B2 (en)	2001-06-21	2005-11-01	Ariad Pharmaceuticals, Inc.	Indolinones and uses thereof
US6797825B2 (en) *	2001-12-13	2004-09-28	Abbott Laboratories	Protein kinase inhibitors
CN1925855B (zh)	2003-12-19	2010-06-16	普莱希科公司	开发Ret调节剂的化合物和方法
GB0330042D0 (en) *	2003-12-24	2004-01-28	Pharmacia Italia Spa	Pyrrolo [2,3-b] pyridine derivatives active as kinase inhibitors process for their preparation and pharmaceutical compositions them
DE602005026553D1 (de) *	2004-10-12	2011-04-07	Decode Genetics Ehf	Peri-substituierte bicyclische sulfonamide gegen arterielle verschlusskrankheit
US7371862B2 (en)	2005-11-11	2008-05-13	Pfizer Italia S.R.L.	Azaindolylidene derivatives as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
WO2007059219A1 (en)	2005-11-15	2007-05-24	Vertex Pharmaceuticals Incorporated	Azaindazoles useful as inhibitors of kinases
CA2652152A1 (en) *	2006-05-16	2007-11-29	Decode Genetics Ehf	Process for preparing 7-(acryloyl)indoles
WO2008063888A2 (en)	2006-11-22	2008-05-29	Plexxikon, Inc.	Compounds modulating c-fms and/or c-kit activity and uses therefor
WO2009012283A1 (en)	2007-07-17	2009-01-22	Plexxikon Inc.	Compounds and methods for kinase modulation, and indications therefor
MY172424A (en)	2009-04-03	2019-11-25	Hoffmann La Roche	Propane- i-sulfonic acid {3- (4-chloro-phenyl)-1h-pyrrolo [2, 3-b] pyridine-3-carconyl] -2, 4-difluoro-phenyl} -amide compositions and uses thereof
IN2012DN01983A (da)	2009-08-24	2015-07-24	Ascepion Pharmaceuticals Inc
CN106220623A (zh)	2009-11-06	2016-12-14	普莱希科公司	用于激酶调节的化合物和方法及其适应症
US20130035325A1 (en)	2009-11-16	2013-02-07	The Regents Of The University Of California	Kinase inhibitors
WO2011153050A1 (en)	2010-06-02	2011-12-08	The Trustees Of The University Of Pennsylvania	Methods and use of compounds that bind to her2/neu receptor complex
WO2011153049A1 (en)	2010-06-02	2011-12-08	The Trustees Of The University Of Pennsylvania	Methods and use of compounds that bind to her2/neu receptor complex
US9624213B2 (en)	2011-02-07	2017-04-18	Plexxikon Inc.	Compounds and methods for kinase modulation, and indications therefor
AR085279A1 (es)	2011-02-21	2013-09-18	Plexxikon Inc	Formas solidas de {3-[5-(4-cloro-fenil)-1h-pirrolo[2,3-b]piridina-3-carbonil]-2,4-difluor-fenil}-amida del acido propano-1-sulfonico
US9150570B2 (en)	2012-05-31	2015-10-06	Plexxikon Inc.	Synthesis of heterocyclic compounds
WO2014018888A1 (en) *	2012-07-26	2014-01-30	Confluence Life Sciences Inc.	4-alkoxy/aralkoxy-5-substituted-pyrrolopyrimidine compounds as tak1 inhibitors in disease treatment
US9468681B2 (en)	2013-03-01	2016-10-18	California Institute Of Technology	Targeted nanoparticles
EP2837626A1 (en) *	2013-08-16	2015-02-18	Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.	Indolinone derivatives as GRK5 modulators
EP3096761A1 (en)	2014-01-24	2016-11-30	Confluence Life Sciences, Inc.	Substituted pyroolopyridines and pyrrolopyrazines for treating cancer or inflammatory diseases
AU2015233686B2 (en) *	2014-03-18	2019-07-11	Algiax Pharmaceuticals Gmbh	2-Cyano-3-cyclopropyl-3-hydroxy-N-aryl-thioacrylamide derivatives
EP3247353A4 (en)	2015-01-23	2018-07-04	Confluence Life Sciences, Inc.	Heterocyclic itk inhibitors for treating inflammation and cancer
ES2882255T3 (es)	2015-07-01	2021-12-01	California Inst Of Techn	Sistemas de administración basados en polímeros de ácido múcico catiónicos
CA3067746A1 (en)	2017-06-30	2019-01-03	The Regents Of The University Of California	Compositions and methods for modulating hair growth
WO2019241327A1 (en)	2018-06-13	2019-12-19	California Institute Of Technology	Nanoparticles for crossing the blood brain barrier and methods of treatment using the same
BR112021012829A2 (pt) *	2019-01-02	2021-11-09	Univ California	Composições e métodos para modular o crescimento capilar
WO2022006040A1 (en)	2020-06-30	2022-01-06	The Regents Of The University Of California	Compositions and methods for modulating hair growth
ES3022196A1 (es) *	2023-11-27	2025-05-28	Univ Madrid Complutense	Derivados de 2-indolinona y usos de los mismos

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GB9004483D0 (en) *	1990-02-28	1990-04-25	Erba Carlo Spa	New aryl-and heteroarylethenylene derivatives and process for their preparation
GB9115160D0 (en) *	1991-07-12	1991-08-28	Erba Carlo Spa	Methylen-oxindole derivatives and process for their preparation
GB9226855D0 (en) *	1992-12-23	1993-02-17	Erba Carlo Spa	Vinylene-azaindole derivatives and process for their preparation

1994
- 1994-06-24 GB GB9412719A patent/GB9412719D0/en active Pending
1995
- 1995-05-30 KR KR1019960700926A patent/KR960703911A/ko not_active Withdrawn
- 1995-05-30 EP EP95921777A patent/EP0715628B1/en not_active Expired - Lifetime
- 1995-05-30 ES ES95921777T patent/ES2186721T3/es not_active Expired - Lifetime
- 1995-05-30 US US08/592,297 patent/US5663346A/en not_active Expired - Fee Related
- 1995-05-30 WO PCT/EP1995/002043 patent/WO1996000226A1/en not_active Ceased
- 1995-05-30 CN CN95190567A patent/CN1129941A/zh active Pending
- 1995-05-30 CA CA002168659A patent/CA2168659C/en not_active Expired - Fee Related
- 1995-05-30 HU HU9600729A patent/HUT74609A/hu unknown
- 1995-05-30 DK DK95921777T patent/DK0715628T3/da active
- 1995-05-30 DE DE69528437T patent/DE69528437T2/de not_active Expired - Fee Related
- 1995-05-30 AU AU26716/95A patent/AU2671695A/en not_active Abandoned
- 1995-05-30 MX MX9600686A patent/MX9600686A/es unknown
- 1995-05-30 JP JP50274196A patent/JP3773257B2/ja not_active Expired - Fee Related
- 1995-05-30 AT AT95921777T patent/ATE225348T1/de not_active IP Right Cessation
- 1995-05-30 PT PT95921777T patent/PT715628E/pt unknown
- 1995-05-30 PL PL95313166A patent/PL313166A1/xx unknown
- 1995-06-15 IL IL11415695A patent/IL114156A0/xx unknown
- 1995-06-23 ZA ZA955223A patent/ZA955223B/xx unknown
1996
- 1996-02-19 FI FI960751A patent/FI960751A0/fi not_active Application Discontinuation
- 1996-02-22 NO NO960713A patent/NO960713L/no unknown

Also Published As

Publication number	Publication date
KR960703911A (ko)	1996-08-31
JPH09502457A (ja)	1997-03-11
NO960713D0 (no)	1996-02-22
ATE225348T1 (de)	2002-10-15
CN1129941A (zh)	1996-08-28
ZA955223B (en)	1996-01-31
JP3773257B2 (ja)	2006-05-10
HU9600729D0 (en)	1996-05-28
DE69528437T2 (de)	2003-06-12
HUT74609A (en)	1997-01-28
CA2168659A1 (en)	1996-01-04
DK0715628T3 (da)	2003-02-10
WO1996000226A1 (en)	1996-01-04
FI960751A7 (fi)	1996-02-19
ES2186721T3 (es)	2003-05-16
EP0715628B1 (en)	2002-10-02
MX9600686A (es)	1997-06-28
GB9412719D0 (en)	1994-08-17
FI960751A0 (fi)	1996-02-19
DE69528437D1 (de)	2002-11-07
EP0715628A1 (en)	1996-06-12
PT715628E (pt)	2003-02-28
AU2671695A (en)	1996-01-19
US5663346A (en)	1997-09-02
IL114156A0 (en)	1995-10-31
CA2168659C (en)	2006-12-19
PL313166A1 (en)	1996-06-10

Publication	Publication Date	Title
NO960713L (no)	1996-02-22	Substituerte azaindolylidenforbindelser og fremgangsmåte for deres fremstilling
DE69513383D1 (de)	1999-12-23	Substituierte 3-arylidinene-7-azaoxindol verbindungen und verfahren zu ihrer herstellung
DK0862567T3 (da)	2001-10-08	5-azabicyclo[3.1.0]hexylalkyl-2-piperidoner og-glutarimider som neurokininreceptorantagonister
NZ511739A (en)	2002-11-26	New esters derived from substituted phenyl-cyclohexyl compounds
CA2324418A1 (en)	1999-09-16	Novel opiate compounds, methods of making and methods of use
CA2206005A1 (en)	1996-06-20	Aniline derivatives possessing an inhibitory effect of nitric oxide synthase
ES8503666A1 (es)	1985-03-01	Procedimiento para la preparacion de 1-ariloxi-2,3,4,5-tetrahidro-3-benzazepinas
JO2308B1 (en)	2005-09-12	Derivatives of phenylpyrmidine
DK0526531T3 (da)	1994-08-22	Liposomer med positiv overskudsladning
ES8504205A1 (es)	1985-04-16	Un procedimiento para la preparacion de nuevos derivados de cefalosporina.
DK0759027T3 (da)	2000-03-27	Bicykliske amidinderivater som inhibitorer af nitrogenoxidsynthetase
FI812804L (fi)	1982-03-11	2-(1,4-bensodioxan-2-ylalkyl)-imidazoler anvaendbara som antidepressiva laekemedel
DK0383686T3 (da)	1993-12-20	Carboxyalkylethere af 2-amino-7-hydroxytetralin samt fremgangsmåde til fremstilling deraf
GR78456B (da)	1983-03-04
ES8504180A1 (es)	1985-04-01	Procedimiento para preparar nuevos derivados de piperidina
JPS5758660A (en)	1982-04-08	Benzophenone derivative
ES8800663A1 (es)	1987-12-01	Procedimiento para preparar compuestos arilsulfonicos.
ES8801212A1 (es)	1988-01-01	Un procedimiento para preparar 5,8,13,14-tetrahido-(9- y 12 -hidroxi)-14-metilben (5,6)-isoindolo (2,1-b)isoquinolin-8,13-diona
FI861328A7 (fi)	1986-09-28	Nya 1,2-benzioxazol-3-yl- och 1,2-benzisotiazol-3-yl-derivat.
CA2245926A1 (en)	1999-02-27	7-phenyl-1,4-diazepane compounds, process for their preparation, and pharmaceutical compositions containing them
PE56197A1 (es)	1998-01-08	Derivados de pirimidina condensados con un anillo heterociclico