NO960747L - Benzodiazpinderivater - Google Patents
BenzodiazpinderivaterInfo
- Publication number
- NO960747L NO960747L NO960747A NO960747A NO960747L NO 960747 L NO960747 L NO 960747L NO 960747 A NO960747 A NO 960747A NO 960747 A NO960747 A NO 960747A NO 960747 L NO960747 L NO 960747L
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- benzodiazpinderivater
- nrur
- nhcho
- gastrin
- Prior art date
Links
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 229940123406 CCK B receptor antagonist Drugs 0.000 abstract 1
- 108010089448 Cholecystokinin B Receptor Proteins 0.000 abstract 1
- 102000052874 Gastrin receptors Human genes 0.000 abstract 1
- 125000003310 benzodiazepinyl group Chemical class N1N=C(C=CC2=C1C=CC=C2)* 0.000 abstract 1
- AOXOCDRNSPFDPE-UKEONUMOSA-N chembl413654 Chemical compound C([C@H](C(=O)NCC(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)CNC(=O)[C@@H](N)CCC(O)=O)C1=CC=C(O)C=C1 AOXOCDRNSPFDPE-UKEONUMOSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Nutrition Science (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Fats And Perfumes (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Lubricants (AREA)
Abstract
Benzodiazepinderivat med formel I, eller et farmasøytisk akseptabelt salt derav; (c) R2 er en aromatisk 5- eller 6-leddet, substitu- ert eller usbustituert heterocyklus innehol- dende minst to heteroatomer hvorav minst ett er nitrogen. Forbindelsene er gastrin og/eller CCK-B- reseptorantagonister. hvori: (a) R4 er en alkyl, cykloalkyl eller arylgruppe. (b) R10 er valgt fra halogen, OH, CH3, OCH3, NRUR12, N02) NHCHO, C02H og CN, og R1' og R12 uavhengig er valgt fra H og alkyl (C,-C5) eller NRUR12 sammen danner en cyklisk struktur II, (CH2). -N hvori a er 1-6; og
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9317693A GB2282595A (en) | 1993-08-25 | 1993-08-25 | Benzodiazepine derivatives |
| PCT/GB1994/001859 WO1995006040A1 (en) | 1993-08-25 | 1994-08-25 | Benzodiazepine compounds useful as antagonists of cck or of gastrine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO960747D0 NO960747D0 (no) | 1996-02-23 |
| NO960747L true NO960747L (no) | 1996-04-25 |
Family
ID=10741026
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO960747A NO960747L (no) | 1993-08-25 | 1996-02-23 | Benzodiazpinderivater |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5728829A (no) |
| EP (1) | EP0715624B1 (no) |
| JP (1) | JPH09504005A (no) |
| KR (1) | KR960703873A (no) |
| CN (1) | CN1129442A (no) |
| AT (1) | ATE164840T1 (no) |
| AU (1) | AU687433B2 (no) |
| CA (1) | CA2169089A1 (no) |
| CZ (1) | CZ53096A3 (no) |
| DE (1) | DE69409534T2 (no) |
| DK (1) | DK0715624T3 (no) |
| ES (1) | ES2117797T3 (no) |
| FI (1) | FI960836A7 (no) |
| GB (1) | GB2282595A (no) |
| HU (1) | HUT73978A (no) |
| IL (1) | IL110783A0 (no) |
| NO (1) | NO960747L (no) |
| NZ (1) | NZ271131A (no) |
| PL (1) | PL313165A1 (no) |
| WO (1) | WO1995006040A1 (no) |
| ZA (1) | ZA946474B (no) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20000057137A (ko) | 1996-11-19 | 2000-09-15 | 스티븐 엠. 오드레 | 아릴 및 헤테로아릴로 치환된 융합 피롤 항염증제 |
| PT945445E (pt) * | 1996-12-10 | 2004-01-30 | Zeria Pharm Co Ltd | Derivados de 1,5-benzodiazepina |
| FR2782997A1 (fr) * | 1998-09-08 | 2000-03-10 | Hoechst Marion Roussel Inc | Nouveaux derives de la benzodiazepinone, procede de preparation et intermediaires de ce procede, application a titre de medicaments et compositions pharmaceutiques les renfermant |
| US20040138207A1 (en) * | 2001-05-11 | 2004-07-15 | Mayumi Yamano | Antitumor agents |
| GB0221923D0 (en) * | 2002-09-20 | 2002-10-30 | Arrow Therapeutics Ltd | Chemical compounds |
| CA2529227A1 (en) * | 2003-06-26 | 2005-01-06 | Merck & Co., Inc. | Benzodiazepine cgrp receptor antagonists |
| US8053413B2 (en) * | 2005-06-06 | 2011-11-08 | The Board Of Trustees Of The University Of Illinois | Methods for treating sleep disorders by cholecystokinin (CCK) receptor B antagonists |
| WO2015077572A1 (en) | 2013-11-22 | 2015-05-28 | CL BioSciences LLC | Gastrin antagonists (eg yf476, netazepide) for treatment and prevention of osteoporosis |
| GB201414116D0 (en) | 2014-08-08 | 2014-09-24 | Trio Medicines Ltd | Benzodiazepine derivatives |
| GB201513979D0 (en) * | 2015-08-07 | 2015-09-23 | Trio Medicines Ltd | Synthesis of benzodiazepine derivatives |
| US10881667B2 (en) | 2018-10-30 | 2021-01-05 | City University Of Hong Kong | Method and composition for treating epilepsy |
| CN109553591B (zh) * | 2019-01-15 | 2020-12-15 | 山东安信制药有限公司 | 一种富马酸喹硫平中间体的制备方法 |
| US11285161B2 (en) | 2019-04-26 | 2022-03-29 | City University Of Hong Kong | Method and composition for treating mental disorder and pain associated with nerve damage |
| FR3097222B1 (fr) * | 2019-06-11 | 2021-05-28 | Michelin & Cie | Nouveaux composes 1,3-dipolaires comprenant un heterocycle aromatique et un cycle imidazole |
| US20250186634A1 (en) * | 2023-12-07 | 2025-06-12 | Evergreen Discovery, LLC | Methods of treating small cell lung cancer |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4820834A (en) * | 1984-06-26 | 1989-04-11 | Merck & Co., Inc. | Benzodiazepine analogs |
| IL96613A0 (en) * | 1989-12-18 | 1991-09-16 | Merck & Co Inc | Pharmaceutical compositions containing benzodiazepine analogs |
| WO1992011246A1 (en) * | 1990-12-25 | 1992-07-09 | Yamanouchi Pharmaceutical Co., Ltd. | Novel benzodiazepine derivative |
| GB9116113D0 (en) * | 1991-07-25 | 1991-09-11 | Merck Sharp & Dohme | Therapeutic agents |
| WO1993007131A1 (en) * | 1991-10-10 | 1993-04-15 | Merck Sharp & Dohme Limited | Benzodiazepine derivatives and their use as antagonists of cholecystokinin and/or gastrin receptors |
| FR2682381B1 (fr) * | 1991-10-10 | 1995-04-07 | Rhone Poulenc Rorer Sa | Derives de benzodiazepine, leur preparation et les medicaments les contenant. |
| WO1993008175A1 (en) * | 1991-10-24 | 1993-04-29 | Glaxo Group Limited | Benzodiazepine derivatives as antagonists of gastrin and/or cholecystokinin |
| IL104853A (en) * | 1992-02-27 | 1997-11-20 | Yamanouchi Pharma Co Ltd | Benzodiazepine derivatives, their preparation and pharmaceutical compositions containing them |
| GB2264492B (en) * | 1992-02-27 | 1996-09-25 | Yamanouchi Pharma Co Ltd | Benzodiazepine derivatives |
| HUT68208A (en) * | 1992-06-24 | 1995-06-28 | Yamanouchi Pharma Co Ltd | Novel benzodiazepine derivatives and pharmaceutical preparations containing them |
-
1993
- 1993-08-25 GB GB9317693A patent/GB2282595A/en not_active Withdrawn
-
1994
- 1994-08-25 DK DK94924368T patent/DK0715624T3/da active
- 1994-08-25 EP EP94924368A patent/EP0715624B1/en not_active Expired - Lifetime
- 1994-08-25 US US08/591,567 patent/US5728829A/en not_active Expired - Lifetime
- 1994-08-25 HU HU9600205A patent/HUT73978A/hu unknown
- 1994-08-25 AU AU74661/94A patent/AU687433B2/en not_active Ceased
- 1994-08-25 KR KR1019960700905A patent/KR960703873A/ko not_active Withdrawn
- 1994-08-25 DE DE69409534T patent/DE69409534T2/de not_active Expired - Lifetime
- 1994-08-25 WO PCT/GB1994/001859 patent/WO1995006040A1/en not_active Ceased
- 1994-08-25 IL IL11078394A patent/IL110783A0/xx unknown
- 1994-08-25 JP JP7507439A patent/JPH09504005A/ja active Pending
- 1994-08-25 NZ NZ271131A patent/NZ271131A/en not_active IP Right Cessation
- 1994-08-25 ZA ZA946474A patent/ZA946474B/xx unknown
- 1994-08-25 AT AT94924368T patent/ATE164840T1/de active
- 1994-08-25 ES ES94924368T patent/ES2117797T3/es not_active Expired - Lifetime
- 1994-08-25 CN CN94193134A patent/CN1129442A/zh active Pending
- 1994-08-25 PL PL94313165A patent/PL313165A1/xx unknown
- 1994-08-25 CA CA002169089A patent/CA2169089A1/en not_active Abandoned
- 1994-08-25 CZ CZ96530A patent/CZ53096A3/cs unknown
-
1996
- 1996-02-23 NO NO960747A patent/NO960747L/no unknown
- 1996-02-23 FI FI960836A patent/FI960836A7/fi unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR960703873A (ko) | 1996-08-31 |
| JPH09504005A (ja) | 1997-04-22 |
| DK0715624T3 (da) | 1999-01-11 |
| IL110783A0 (en) | 1994-11-11 |
| EP0715624A1 (en) | 1996-06-12 |
| EP0715624B1 (en) | 1998-04-08 |
| FI960836A0 (fi) | 1996-02-23 |
| GB2282595A (en) | 1995-04-12 |
| NZ271131A (en) | 1997-11-24 |
| AU7466194A (en) | 1995-03-21 |
| FI960836A7 (fi) | 1996-04-22 |
| HUT73978A (en) | 1996-10-28 |
| CZ53096A3 (en) | 1996-09-11 |
| AU687433B2 (en) | 1998-02-26 |
| DE69409534T2 (de) | 1998-08-06 |
| ES2117797T3 (es) | 1998-08-16 |
| WO1995006040A1 (en) | 1995-03-02 |
| GB9317693D0 (en) | 1993-10-13 |
| CA2169089A1 (en) | 1995-03-02 |
| CN1129442A (zh) | 1996-08-21 |
| US5728829A (en) | 1998-03-17 |
| HU9600205D0 (en) | 1996-04-29 |
| PL313165A1 (en) | 1996-06-10 |
| NO960747D0 (no) | 1996-02-23 |
| ZA946474B (en) | 1996-03-25 |
| DE69409534D1 (de) | 1998-05-14 |
| ATE164840T1 (de) | 1998-04-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO960747L (no) | Benzodiazpinderivater | |
| IL127296A (en) | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them | |
| TW358808B (en) | Morpholine derivatives, preparation thereof and pharmaceutical composition containing the same | |
| IL97049A0 (en) | Aryl-and heteroarylethenylene derivatives,their preparation and pharmaceutical compositions containing them | |
| RU2004109141A (ru) | Замещенные производные индено[ [1,2-с] изохинолина и способы их применения | |
| CA2129990A1 (en) | Benzodiazepin derivatives useful as cck-receptor antagonists | |
| FI832092L (fi) | 1-aryloxi-2,3,4,5-tetrahydro-3-bensazepiner, foerfarande foer framstaellning av dem och anvaendning av dem som laekemedel | |
| SE8505715D0 (sv) | Indolderivat | |
| DE69227088D1 (de) | Verwendung von 1-(aminoalkyl)-3-Quinoxalin-2-on Derivaten zur Herstellung von neuroprotektiven Mitteln | |
| GB9215844D0 (en) | Novel compounds | |
| KR950701332A (ko) | 세로토닌 5HT₂길항제로서의 4-이미도메틸-1-[2'페닐-2'옥소에틸-]피페리딘, 이의 제조방법 및 치료에서의 용도(4-Imidomethyl-1-[2'phenyl-2'oxoethyl-] piperidines as serotonin 5HT₂-antagonists, their preparation and use in therapy) | |
| IL76175A0 (en) | Tricyclic oxindole derivatives and pharmaceutical compositions containing them | |
| ES466366A1 (es) | Un procedimiento para preparar derivados de metasulfonamido-benzamida. | |
| AU1901388A (en) | N-((2-oxopyrrolidin-1-yl)acetyl)piperazine derivatives and drug for senile dementia | |
| NO952508L (no) | Purinderivater | |
| TW221429B (no) | ||
| NZ225528A (en) | Benzimidazoles substituted in the 2 position by n(4-n-guanidyl) piperidinyl radicals; preparations thereof; pharmaceutical compositions | |
| GB2264492B (en) | Benzodiazepine derivatives | |
| DE3862660D1 (de) | 2,3-dihydro-2-oxo-3-benzofuranyl-essigsaeurederivate und diese enthaltende arzneimittel. | |
| NO982549L (no) | 5-naftalen-1-yl-1,3-dioksan-derivater, fremstilling og terapeutisk anvendelse derav | |
| GR3024388T3 (en) | 2-phenyl-and 2-thienyl-(2)-piperidine derivatives having neuroprotective properties | |
| EP0739903A4 (en) | CARBAMOYL METHYL URINE DERIVATIVES | |
| DK214190A (da) | 5-aminosulfonylmethyl-indolderivater og farmaceutiske praeparater med indhold deraf |