NO961138L - Protein kinase C aktivatorer og anvendelse derav for å redusere ekspresjon av celleantigener - Google Patents

Protein kinase C aktivatorer og anvendelse derav for å redusere ekspresjon av celleantigener

Info

Publication number
NO961138L
NO961138L NO961138A NO961138A NO961138L NO 961138 L NO961138 L NO 961138L NO 961138 A NO961138 A NO 961138A NO 961138 A NO961138 A NO 961138A NO 961138 L NO961138 L NO 961138L
Authority
NO
Norway
Prior art keywords
protein kinase
activators
cell antigen
antigen expression
tumor cells
Prior art date
Application number
NO961138A
Other languages
English (en)
Other versions
NO961138D0 (no
Inventor
Paul B Fisher
Jorge A Leon
Original Assignee
Univ Columbia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Columbia filed Critical Univ Columbia
Publication of NO961138D0 publication Critical patent/NO961138D0/no
Publication of NO961138L publication Critical patent/NO961138L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/42—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/43—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Sammensetning for oppregulering av ekspresjonen til celleantigener uten å indusere avgivelse som omfatter en proteinkinase C aktivator, en fremgangsmåte for detektering og behandling av tumorceller som omfatter kontakting av tumorccllene med en effektiv mengde av en proteinkinase C aktivator for oppregulering av ekspresjonen av antigenene til tumorceller, uten å indusere antigenavgivelse, og detektering av tilstedeværelse av nevnte antigen eller deretter videre kontakting av nevnte tumorceller med en effektiv mengde av et antistoff rettet mot nevnte antigen, er beskrevet.
NO961138A 1993-09-21 1996-03-20 Protein kinase C aktivatorer og anvendelse derav for å redusere ekspresjon av celleantigener NO961138L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/124,716 US5681860A (en) 1993-09-21 1993-09-21 Method of increasing expression of HLA, cell surface and TAA antigens of cells using 3-(N-acetylamino)-5-(N-decyl-N-methylamino)-benzyl alcohol
PCT/US1994/010755 WO1995008326A1 (en) 1993-09-21 1994-09-21 Protein kinase c activators and their use in decreasing expression of cell antigens

Publications (2)

Publication Number Publication Date
NO961138D0 NO961138D0 (no) 1996-03-20
NO961138L true NO961138L (no) 1996-05-14

Family

ID=22416439

Family Applications (1)

Application Number Title Priority Date Filing Date
NO961138A NO961138L (no) 1993-09-21 1996-03-20 Protein kinase C aktivatorer og anvendelse derav for å redusere ekspresjon av celleantigener

Country Status (8)

Country Link
US (4) US5681860A (no)
EP (1) EP0730446A4 (no)
JP (1) JP2001525787A (no)
KR (1) KR960704539A (no)
AU (1) AU7841094A (no)
CA (1) CA2172383A1 (no)
NO (1) NO961138L (no)
WO (1) WO1995008326A1 (no)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5681860A (en) * 1993-09-21 1997-10-28 The Trustees Of Columbia University In The City Of New York Method of increasing expression of HLA, cell surface and TAA antigens of cells using 3-(N-acetylamino)-5-(N-decyl-N-methylamino)-benzyl alcohol
CA2397207C (en) * 2000-01-13 2013-12-03 Genentech, Inc. Novel stra6 polypeptides
US6984522B2 (en) 2000-08-03 2006-01-10 Regents Of The University Of Michigan Isolation and use of solid tumor stem cells
AU2003238287A1 (en) * 2002-06-21 2004-01-06 California Institute Of Technology Identification of a receptor controlling migration and metastasis of skin cancer cells
US6981767B2 (en) * 2003-01-15 2006-01-03 Ssgii, Inc. Printed item having an image with a high durability and/or resolution
JP5429772B2 (ja) * 2008-06-30 2014-02-26 株式会社アルバック 電源装置
US10617161B2 (en) * 2012-02-09 2020-04-14 Medline Industries, Inc. Garments for healthcare workers
US11771869B2 (en) * 2018-03-14 2023-10-03 Philips Image Guided Therapy Corporation Electromagnetic control for intraluminal sensing devices and associated devices, systems, and methods

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4925649A (en) * 1987-06-12 1990-05-15 The University Of Michigan Radioiodinated diacylglycerol analogues and methods of use
ES2061963T3 (es) * 1988-01-13 1994-12-16 Univ Arizona State Briostatinas inmunomoduladoras.
WO1990005731A1 (en) * 1988-11-24 1990-05-31 University Of Queensland Cytotoxic macromolecules
US5681860A (en) * 1993-09-21 1997-10-28 The Trustees Of Columbia University In The City Of New York Method of increasing expression of HLA, cell surface and TAA antigens of cells using 3-(N-acetylamino)-5-(N-decyl-N-methylamino)-benzyl alcohol

Also Published As

Publication number Publication date
NO961138D0 (no) 1996-03-20
US6187819B1 (en) 2001-02-13
EP0730446A4 (en) 1999-01-20
EP0730446A1 (en) 1996-09-11
KR960704539A (ko) 1996-10-09
US6069174A (en) 2000-05-30
US5681860A (en) 1997-10-28
JP2001525787A (ja) 2001-12-11
AU7841094A (en) 1995-04-10
US20020040062A1 (en) 2002-04-04
CA2172383A1 (en) 1995-03-30
WO1995008326A1 (en) 1995-03-30

Similar Documents

Publication Publication Date Title
ES2045216T3 (es) Inmunoensayo y derivados polimeros de igg para la compensacion de factores de perturbacion en el inmunoensayo.
NO985150L (no) Antigenbindingsfragmenter som spesifikt detekterer cancerceller, nukleotider som koder fragmentene samt anvendelse derav for profylakse og deteksjon av cancere
EP0344940A3 (en) Antibodies to human papillomavirus latent proteins, diagnostic systems and methods
Grahame Different isozymes of methylcobalamin: 2-mercaptoethanesulfonate methyltransferase predominate in methanol-versus acetate-grown Methanosarcina barkeri
FI873398L (fi) Bestaemning av kliniska parametrar med hjaelp av en enzymatisk immunoprocess.
DE3584035D1 (de) Nachweis von menschlichem cytomegalovirus-spezifischem igm.
OA08485A (fr) Monoclonal antibodies and antigen for human non-small cell lung carcinoma and certain other human carcinomas.
DK0673390T3 (da) Deltalignende gen, som udtrykkes i neuroendokrine tumorer
KR890015714A (ko) 폐암의 조기 검출 방법
NO961138L (no) Protein kinase C aktivatorer og anvendelse derav for å redusere ekspresjon av celleantigener
EP0352722A3 (en) Adenocarcinoma antigen binding methods and reagents
NO973875L (no) Fremgangsmåte for stimulering av en immunrespons
WO1999002545A3 (en) Antigen binding fragments, designated 4b5, that specifically detect cancer cells, nucleotides encoding the fragments, and use thereof for the prophylaxis and detection of cancers
DK314586A (da) Monoklonale antistoffer og antigener for humane lungecarcinomer, der ikke er af typen med smaa celler
JPS5516290A (en) Purified antigen for testing against neisseria gonorrhoeae antibody
AU6828387A (en) Assay for human breast cancer
SE8004542L (sv) Diagnostiskt test
NO942660L (no) Fremgangsmåte til bestemmelse av cytolytiske T-celle-forstadier
DK0547059T3 (da) Pankreas-elastase-1-specifikt antistof, fremgangsmåde til udvinding deraf og testkit indeholdende så danne antistoffer
DE3674933D1 (de) Spezifisch hemmender speichel-alpha-amylase monoklonaler antikoerper und dessen verwendung zur bestimmung von pankreas-alpha-amylase.
NO168311C (no) Monoklonale antistoffer for humane ikke-smaacelle lungekarsinomer, cellelinjer som produserer disse samt diagnostisksett
ATE164681T1 (de) Immunoassay-verfahren mit verwendung von zeta potential
EP0248147A3 (en) Method of determining the presence of cancer cells
ES552074A0 (es) Un metodo en emparedado de doble anticuerpo para detectar o ensayar un antigeno seleccionado de urocinasa humana y un precursor de la misma
DE68926813D1 (de) Von gemeinsamen sequenzen von antigenen und antiidiotypischen antikörpern oder von antikörpern mit spezifizität für die zellulären rezeptoren der antigene abgeleitete immunogene und biologisch aktive peptide