NO961274L - Azolderivat og farmasöytiske preparat derav - Google Patents

Azolderivat og farmasöytiske preparat derav

Info

Publication number
NO961274L
NO961274L NO961274A NO961274A NO961274L NO 961274 L NO961274 L NO 961274L NO 961274 A NO961274 A NO 961274A NO 961274 A NO961274 A NO 961274A NO 961274 L NO961274 L NO 961274L
Authority
NO
Norway
Prior art keywords
different
same
pharmaceutical preparations
lower alkyl
azole derivatives
Prior art date
Application number
NO961274A
Other languages
English (en)
Other versions
NO961274D0 (no
Inventor
Minoru Okada
Toru Yoden
Eiji Kawaminami
Yoshiaki Shimada
Tsukasa Ishihara
Masafumi Kudou
Original Assignee
Yamanouchi Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharma Co Ltd filed Critical Yamanouchi Pharma Co Ltd
Publication of NO961274D0 publication Critical patent/NO961274D0/no
Publication of NO961274L publication Critical patent/NO961274L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Azolderivat representert ved generell formel (I) (D et salt derav, et hydrat derav eller et solvat derav, hvori R1 og R2 kan være like eller forskjellige, og hver beteg- ner hydrogen, lavere alkyl, eller even- tuelt halogenert fenyl; A, B og D kan være like eller forskjellige, og hver betegner =CR3- eller nitrogen; X og Y kan være like eller forskjellige, og hver betegner enkeltbinding, metylen, oksygen, S(0)n, eller -NR4-; R3 og R4 kan være like eller forskjellige, og hver betegner hydrogen eller lavere alkyl; og n betegner O, l eller 2. Det har en steroid 17-20-lyaseinhibitorak- tivitet og er anvendbart som et middel for forhindring eller behandling av prostatisk cancer, prostatisk hypertro- fi, maskulinitet, brystkreft, masto- pati, uterusmyom og endometriose.
NO961274A 1993-09-30 1996-03-29 Azolderivat og farmasöytiske preparat derav NO961274L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP24494493 1993-09-30
PCT/JP1994/001593 WO1995009157A1 (en) 1993-09-30 1994-09-28 Azole derivative and pharmaceutical composition thereof

Publications (2)

Publication Number Publication Date
NO961274D0 NO961274D0 (no) 1996-03-29
NO961274L true NO961274L (no) 1996-03-29

Family

ID=17126291

Family Applications (1)

Application Number Title Priority Date Filing Date
NO961274A NO961274L (no) 1993-09-30 1996-03-29 Azolderivat og farmasöytiske preparat derav

Country Status (12)

Country Link
US (1) US5807880A (no)
EP (1) EP0721943A4 (no)
KR (1) KR960704852A (no)
CN (1) CN1131944A (no)
AU (1) AU679119B2 (no)
CA (1) CA2170874A1 (no)
FI (1) FI961418A7 (no)
HU (1) HUT75871A (no)
NO (1) NO961274L (no)
NZ (1) NZ273681A (no)
PL (1) PL313769A1 (no)
WO (1) WO1995009157A1 (no)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6518423B1 (en) 1996-08-09 2003-02-11 Eisai Co., Ltd. Benzopiperidine derivatives
WO1998037070A1 (en) * 1997-02-21 1998-08-27 Takeda Chemical Industries, Ltd. Fused ring compounds, process for producing the same and use thereof
US6559157B2 (en) 1997-10-02 2003-05-06 Daiichi Pharmaceutical Co., Ltd. Dihydronaphthalene compounds
DE69823222T2 (de) * 1997-10-02 2005-04-14 Daiichi Pharmaceutical Co., Ltd. Dihydronaphthalinderivate und verfahren zur herstellung derselben
EP1073640B1 (en) 1998-04-23 2005-04-13 Takeda Pharmaceutical Company Limited Naphthalene derivatives, their production and use
JP4546589B2 (ja) * 1998-04-23 2010-09-15 武田薬品工業株式会社 ナフタレン誘導体
AU7950100A (en) * 1999-10-22 2001-05-08 Takeda Chemical Industries Ltd. 1-substituted phenyl-1-(1h-imidazol-4-yl) alcohols, process for producing the same and use thereof
JP4520012B2 (ja) * 1999-10-22 2010-08-04 武田薬品工業株式会社 １−置換−１−（１ｈ−イミダゾール−４−イル）メタノール類
PE20010781A1 (es) 1999-10-22 2001-08-08 Takeda Chemical Industries Ltd Compuestos 1-(1h-imidazol-4-il)-1-(naftil-2-sustituido)etanol, su produccion y utilizacion
PE20020596A1 (es) 2000-11-17 2002-08-13 Takeda Chemical Industries Ltd Derivados de imidazol, metodos de produccion e intermediarios del mismo
ATE502030T1 (de) 2000-11-20 2011-04-15 Takeda Pharmaceutical Imidazolderivate, verfahren zu deren herstellung und deren verwendung
CA2431171A1 (en) 2000-12-08 2002-06-13 Takeda Chemical Industries, Ltd. Substituted thiazole derivatives bearing 3-pyridyl groups, process for preparing the same and use thereof
EP1607092A4 (en) * 2003-03-17 2010-12-15 Takeda Pharmaceutical COMPOSITIONS WITH CONTROLLED RELEASE
WO2008021250A2 (en) * 2006-08-10 2008-02-21 Fred Hutchinson Cancer Research Center Compositions and methods for modulating apoptosis in cells over-expressing bcl-2 family member proteins
WO2010149755A1 (en) 2009-06-26 2010-12-29 Novartis Ag 1, 3-disubstituted imidazolidin-2-one derivatives as inhibitors of cyp 17
WO2011041731A2 (en) 2009-10-02 2011-04-07 Fred Hutchinson Cancer Research Center Method of inhibiting bcl-2-related survival proteins
WO2011041737A2 (en) 2009-10-02 2011-04-07 Fred Hutchinson Cancer Research Center Gain-of-function bcl-2 inhibitors
KR101926320B1 (ko) 2010-08-04 2018-12-06 펠피큐어 파마슈티걸즈 아이엔씨 전립선 암종의 치료를 위한 병용 요법
JP2013537210A (ja) 2010-09-16 2013-09-30 ノバルティス アーゲー １７α−ヒドロキシラーゼ／Ｃ１７，２０−リアーゼ阻害剤
CN103328452A (zh) * 2010-12-13 2013-09-25 威尔金制药有限公司 金属酶抑制剂化合物
US9029399B2 (en) 2011-04-28 2015-05-12 Novartis Ag 17α-hydroxylase/C17,20-lyase inhibitors
JP5990059B2 (ja) * 2012-08-03 2016-09-07 花王株式会社 ＳｔＡＲ発現抑制剤
JP6275378B2 (ja) * 2012-12-26 2018-02-07 エヌ・イーケムキャット株式会社 カルバゾール類の製造方法およびこの方法により製造されたカルバゾール類。
CA2902335C (en) 2013-03-14 2021-09-14 Pellficure Pharmaceuticals, Inc. Novel therapy for prostate carcinoma
WO2016040896A1 (en) 2014-09-12 2016-03-17 Pellficure Pharmaceuticals, Inc. Compositions and methods for treatment of prostate carcinoma
AU2017350690A1 (en) 2016-10-24 2019-06-13 Pellficure Pharmaceuticals Inc. Pharmaceutical compositions of 5-hydroxy-2-methylnaphthalene-1, 4-dione
EP3786156B1 (en) * 2018-04-27 2024-06-05 Chengdu Henghao Investment Co. Limited 10h-phenothiazine ferroptosis inhibitor and preparation method therefor and application thereof
CN109748884B (zh) * 2019-02-19 2022-06-24 成都恒昊创新科技有限公司 一种铁死亡抑制剂及其制备方法与应用
US12448376B2 (en) 2019-11-21 2025-10-21 Chengdu Henghao Innovative Science And Technology Co., Ltd. Phenothiazine ferroptosis inhibitor, preparation method therefor and application thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ221729A (en) * 1986-09-15 1989-07-27 Janssen Pharmaceutica Nv Imidazolyl methyl-substituted benzimidazole derivatives and pharmaceutical compositions
DE3942227A1 (de) * 1989-12-21 1991-06-27 Bayer Ag Triarylmethan-farbbildner
GB9310635D0 (en) * 1993-05-21 1993-07-07 Glaxo Group Ltd Chemical compounds
AU7275894A (en) * 1993-08-04 1995-02-28 Yamanouchi Pharmaceutical Co., Ltd. Imidazolylalkylamine derivative and pharmaceutical composition thereof

Also Published As

Publication number Publication date
EP0721943A4 (en) 1996-09-04
FI961418A0 (fi) 1996-03-29
NO961274D0 (no) 1996-03-29
WO1995009157A1 (en) 1995-04-06
HUT75871A (en) 1997-05-28
NZ273681A (en) 1996-09-25
HU9600813D0 (en) 1996-05-28
KR960704852A (ko) 1996-10-09
FI961418L (fi) 1996-03-29
AU7707194A (en) 1995-04-18
CN1131944A (zh) 1996-09-25
PL313769A1 (en) 1996-07-22
FI961418A7 (fi) 1996-03-29
EP0721943A1 (en) 1996-07-17
US5807880A (en) 1998-09-15
AU679119B2 (en) 1997-06-19
CA2170874A1 (en) 1995-04-06

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