NO963854D0 - Okulart spenningsnedsettende middel - Google Patents

Okulart spenningsnedsettende middel

Info

Publication number: NO963854D0
Authority: NO; Norway
Prior art keywords: group; alkyl; formula; alkenyl; carboxyl
Prior art date: 1994-03-16

Application number

NO963854A

Other languages

English (en)

Other versions

NO311068B1 (no

NO963854L (no

Inventor

Tomihisa Yokoyama

Tsunemichi Hosokawa

Hiroaki Yanagisawa

Original Assignee

Sankyo Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-03-16

Filing date

1996-09-13

Publication date

1996-09-13

1996-09-13 Application filed by Sankyo Co filed Critical Sankyo Co

1996-09-13 Publication of NO963854D0 publication Critical patent/NO963854D0/no

1996-11-14 Publication of NO963854L publication Critical patent/NO963854L/no

2001-10-08 Publication of NO311068B1 publication Critical patent/NO311068B1/no

Links

239000003638 chemical reducing agent Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 5
125000001424 substituent group Chemical group 0.000 abstract 5
125000003342 alkenyl group Chemical group 0.000 abstract 3
125000003118 aryl group Chemical group 0.000 abstract 3
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000000753 cycloalkyl group Chemical group 0.000 abstract 2
150000002431 hydrogen Chemical class 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
208000010412 Glaucoma Diseases 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
206010030043 Ocular hypertension Diseases 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
125000001931 aliphatic group Chemical group 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
239000002876 beta blocker Substances 0.000 abstract 1
229940097320 beta blocking agent Drugs 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
125000003431 oxalo group Chemical group 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
229910052717 sulfur Chemical group 0.000 abstract 1
239000011593 sulfur Chemical group 0.000 abstract 1
125000004299 tetrazol-5-yl group Chemical group [H]N1N=NC(*)=N1 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Ophthalmology & Optometry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Steroid Compounds (AREA)
Materials For Medical Uses (AREA)

NO19963854A 1994-03-16 1996-09-13 Anvendelse av imidazolforbindelser for fremstilling av et medikament for behandling av okular hypertensjon og/eller glaukom NO311068B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP4540494		1994-03-16
PCT/JP1995/000444 WO1995024902A1 (en)	1994-03-16	1995-03-16	Ocular tension depressant

Publications (3)

Publication Number	Publication Date
NO963854D0 true NO963854D0 (no)	1996-09-13
NO963854L NO963854L (no)	1996-11-14
NO311068B1 NO311068B1 (no)	2001-10-08

Family

ID=12718322

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19963854A NO311068B1 (no)	1994-03-16	1996-09-13	Anvendelse av imidazolforbindelser for fremstilling av et medikament for behandling av okular hypertensjon og/eller glaukom

Country Status (19)

Country	Link
US (1)	US5925664A (no)
EP (2)	EP0795326B1 (no)
KR (1)	KR100211446B1 (no)
CN (2)	CN1104898C (no)
AT (2)	ATE266402T1 (no)
AU (1)	AU684916B2 (no)
CZ (1)	CZ284395B6 (no)
DE (2)	DE69522955T2 (no)
DK (2)	DK0795326T3 (no)
ES (2)	ES2163501T3 (no)
FI (2)	FI114897B (no)
GR (1)	GR3036989T3 (no)
HU (1)	HUT74734A (no)
MX (1)	MX9604109A (no)
NO (1)	NO311068B1 (no)
NZ (1)	NZ282485A (no)
PT (2)	PT1110551E (no)
RU (1)	RU2123847C1 (no)
WO (1)	WO1995024902A1 (no)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2242619T3 (es)	1999-06-11	2005-11-16	Sankyo Company, Limited	Composicion para disminuir la tension ocular para la administracion topica.
JP4000505B2 (ja) *	1999-12-01	2007-10-31	第一三共株式会社	緑内障を治療するための併用剤
GR20000100281A (el) *	2000-08-17	2002-05-24	Ιωαννης Ματσουκας	Ανταγωνιστες του υποδοχεα της αγγεοτενσινης ιι και συνθετικες μεθοδοι για την θεραπεια της υπερτασης και καρδιοαγγειακων ασθενειων
WO2002045748A1 (en) *	2000-12-05	2002-06-13	Sankyo Company, Limited	Ocular tension-lowering compositions for topical administration
ES2535291T3 (es) *	2003-04-15	2015-05-08	Daiichi Sankyo Company, Limited	Medoxomilo de olmesartán para prevención o tratamiento de enfermedades oculares angiogénicas

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2549049B1 (fr) *	1983-07-13	1986-06-20	Chauvin Blache Lab	Nouvelles amidines, leur procede de preparation et leur application therapeutique
US5138069A (en) *	1986-07-11	1992-08-11	E. I. Du Pont De Nemours And Company	Angiotensin II receptor blocking imidazoles
CA1334092C (en) *	1986-07-11	1995-01-24	David John Carini	Angiotensin ii receptor blocking imidazoles
ZA875052B (en) *	1986-07-11	1989-03-29	Du Pont	Angiotensin ii receptor blocking imidazoles
US4820843A (en) *	1987-05-22	1989-04-11	E. I. Du Pont De Nemours And Company	Tetrazole intermediates to antihypertensive compounds
CA1338238C (en) *	1988-01-07	1996-04-09	David John Carini	Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids
US4880804A (en) *	1988-01-07	1989-11-14	E. I. Du Pont De Nemours And Company	Angiotensin II receptor blocking benzimidazoles
US4916129A (en) *	1989-01-19	1990-04-10	E. I. Du Pont De Nemours And Company	Combination β-blocking/angiotensin II blocking antihypertensives
HU217958B (hu) *	1989-06-30	2000-05-28	E. I. Du Pont De Nemours And Co.	Helyettesített imidazolszármazékok, ezeket tartalmazó gyógyszerkészítmények és eljárás előállításukra
WO1991015206A1 (en) *	1990-04-05	1991-10-17	E.I. Du Pont De Nemours And Company	Treatment of glaucoma and ocular hypertension with imidazole angiotensin-ii receptor antagonists
US5196444A (en) *	1990-04-27	1993-03-23	Takeda Chemical Industries, Ltd.	1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof
US5126342A (en) *	1990-10-01	1992-06-30	Merck & Co., Inc.	Imidazole angiotensin ii antagonists incorporating acidic functional groups
CA2229000C (en) *	1991-02-21	2002-04-09	Sankyo Company, Limited	1-biphenylimidazole derivatives, their preparation and their therapeutic use
US5616599A (en) *	1991-02-21	1997-04-01	Sankyo Company, Limited	Angiotensin II antagosist 1-biphenylmethylimidazole compounds and their therapeutic use
DE4132631A1 (de) *	1991-10-01	1993-04-08	Bayer Ag	Imidazolyl-propensaeurederivate
US5219856A (en) *	1992-04-06	1993-06-15	E. I. Du Pont De Nemours And Company	Angiotensin-II receptor blocking, heterocycle substituted imidazoles
EP0573218B1 (en) *	1992-06-02	2001-03-07	Sankyo Company Limited	4-Carboxyimidazoles as angiotensin II antagonists and their thrapeutic use
US5310929A (en) *	1992-08-06	1994-05-10	E. I. Du Pont De Nemours And Company	Prodrugs of imidazole carboxylic acids as angiotensin II receptor antagonists
JP3501484B2 (ja) *	1992-12-17	2004-03-02	三共株式会社	ビフェニル誘導体
CZ154994A3 (en) *	1993-07-02	1995-09-13	Senju Pharma Co	Visual hypotensive agent
ATE300287T1 (de) *	1994-02-08	2005-08-15	Novartis Pharma Gmbh	Behandlung von normaldruckglaukom mit valsartan

1995
- 1995-03-16 WO PCT/JP1995/000444 patent/WO1995024902A1/ja not_active Ceased
- 1995-03-16 DE DE69522955T patent/DE69522955T2/de not_active Expired - Fee Related
- 1995-03-16 PT PT01102527T patent/PT1110551E/pt unknown
- 1995-03-16 ES ES95912428T patent/ES2163501T3/es not_active Expired - Lifetime
- 1995-03-16 DK DK95912428T patent/DK0795326T3/da active
- 1995-03-16 HU HU9602534A patent/HUT74734A/hu unknown
- 1995-03-16 DE DE69533045T patent/DE69533045T2/de not_active Expired - Fee Related
- 1995-03-16 MX MX9604109A patent/MX9604109A/es not_active IP Right Cessation
- 1995-03-16 EP EP95912428A patent/EP0795326B1/en not_active Expired - Lifetime
- 1995-03-16 PT PT95912428T patent/PT795326E/pt unknown
- 1995-03-16 CN CN95193132A patent/CN1104898C/zh not_active Expired - Fee Related
- 1995-03-16 NZ NZ282485A patent/NZ282485A/en not_active IP Right Cessation
- 1995-03-16 AU AU19602/95A patent/AU684916B2/en not_active Ceased
- 1995-03-16 AT AT01102527T patent/ATE266402T1/de not_active IP Right Cessation
- 1995-03-16 RU RU96121253A patent/RU2123847C1/ru active
- 1995-03-16 CZ CZ962694A patent/CZ284395B6/cs not_active IP Right Cessation
- 1995-03-16 EP EP01102527A patent/EP1110551B1/en not_active Expired - Lifetime
- 1995-03-16 ES ES01102527T patent/ES2221872T3/es not_active Expired - Lifetime
- 1995-03-16 AT AT95912428T patent/ATE206050T1/de not_active IP Right Cessation
- 1995-03-16 KR KR1019960705082A patent/KR100211446B1/ko not_active Expired - Fee Related
- 1995-03-16 DK DK01102527T patent/DK1110551T3/da active
1996
- 1996-09-13 NO NO19963854A patent/NO311068B1/no not_active IP Right Cessation
- 1996-09-16 FI FI963645A patent/FI114897B/fi active IP Right Grant
- 1996-09-16 US US08/725,197 patent/US5925664A/en not_active Expired - Fee Related
2001
- 2001-10-24 GR GR20010401862T patent/GR3036989T3/el not_active IP Right Cessation
2002
- 2002-05-11 CN CNB021199396A patent/CN1202819C/zh not_active Expired - Fee Related
2004
- 2004-09-24 FI FI20041236A patent/FI115197B/fi active IP Right Grant

Also Published As

Publication number	Publication date
FI115197B (fi)	2005-03-31
ES2163501T3 (es)	2002-02-01
GR3036989T3 (en)	2002-01-31
KR970701542A (ko)	1997-04-12
HU9602534D0 (en)	1996-11-28
PT1110551E (pt)	2004-07-30
ATE206050T1 (de)	2001-10-15
FI963645A7 (fi)	1996-11-14
FI114897B (fi)	2005-01-31
DK0795326T3 (da)	2001-11-26
PT795326E (pt)	2002-01-30
HUT74734A (en)	1997-02-28
EP0795326A1 (en)	1997-09-17
AU684916B2 (en)	1998-01-08
CZ284395B6 (cs)	1998-11-11
CZ269496A3 (en)	1996-12-11
DE69533045T2 (de)	2005-01-27
CN1148809A (zh)	1997-04-30
US5925664A (en)	1999-07-20
KR100211446B1 (ko)	1999-08-02
DE69522955D1 (de)	2001-10-31
NZ282485A (en)	1997-06-24
AU1960295A (en)	1995-10-03
HK1000551A1 (en)	2002-04-12
CN1202819C (zh)	2005-05-25
ATE266402T1 (de)	2004-05-15
FI963645A0 (fi)	1996-09-16
ES2221872T3 (es)	2005-01-16
WO1995024902A1 (en)	1995-09-21
EP1110551A2 (en)	2001-06-27
RU2123847C1 (ru)	1998-12-27
DE69533045D1 (de)	2004-06-17
NO311068B1 (no)	2001-10-08
EP0795326B1 (en)	2001-09-26
CN1104898C (zh)	2003-04-09
DK1110551T3 (da)	2004-06-07
FI20041236L (fi)	2004-09-24
CN1387846A (zh)	2003-01-01
MX9604109A (es)	1997-09-30
EP1110551A3 (en)	2001-08-16
EP0795326A4 (no)	1997-09-17
EP1110551B1 (en)	2004-05-12
DE69522955T2 (de)	2002-05-29
NO963854L (no)	1996-11-14

Legal Events

Date	Code	Title	Description
2010-11-01	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
DE69116909D1 (de)	1996-03-21	3,5-Di-tertiärbutyl-4-hydroxyphenylmethylenderivate von 2-substituierten Thiazolidinonen, Oxazolidinonen und Imidazolidinonen als antientzündlich wirkende Mittel
ATE216584T1 (de)	2002-05-15	Xanthine-derivate als antidepressiva
ATE194335T1 (de)	2000-07-15	4,5-diaryloxazol-derivate
ES2070186T3 (es)	1995-06-01	Nuevos derivados de 2,4-diamino-pirimidina-3-oxido y su utilizacion en la prevencion de la caida de los cabellos.
ATE173249T1 (de)	1998-11-15	N,n'-di(aralkyl)-n,n'-di(2- azaaralkyl)alkylendiamin-derivate und ihre verwendung in pharmazeutischen und kosmetischen zusammensetzungen
ATE421524T1 (de)	2009-02-15	5-ring-heterocyclen, ihre herstellung, ihre verwendung als inhibitoren der leukozytenadhäsion und sie enthaltende pharmazeutische präparate
DK0678090T3 (da)	1999-06-23	Piperazinderivater
NO963854L (no)	1996-11-14	Okulart spenningsnedsettende middel
KR920701240A (ko)	1992-08-11	글루타티온 유도체
NO872874D0 (no)	1987-07-10	Amid-derivater.
NO893039L (no)	1990-01-29	Bruk av imidazopyrazol-derivater som analgesiske og antiinflammatoriske midler.
ATE144900T1 (de)	1996-11-15	Verwendung von xanthinderivaten gegen magengeschwüre