NO964533L - Nye kinolon 5-(N-heterosubstituert amino) antimikrobielle forbindelser - Google Patents

Nye kinolon 5-(N-heterosubstituert amino) antimikrobielle forbindelser

Info

Publication number
NO964533L
NO964533L NO964533A NO964533A NO964533L NO 964533 L NO964533 L NO 964533L NO 964533 A NO964533 A NO 964533A NO 964533 A NO964533 A NO 964533A NO 964533 L NO964533 L NO 964533L
Authority
NO
Norway
Prior art keywords
compounds
hetero
substituted amino
quinolone
antimicrobial compounds
Prior art date
Application number
NO964533A
Other languages
English (en)
Other versions
NO964533D0 (no
Inventor
Jr Thomas Prosser Demuth
Ronald Eugene White
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of NO964533D0 publication Critical patent/NO964533D0/no
Publication of NO964533L publication Critical patent/NO964533L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Oppfinnelsen vedrører antimikrobielle 5-(N-heterosubstituert amino)kinolonforbindelser som har en struktur i samsvar med formel (I) eller (II), hvori: (1) R1, R2, R3, R9 og R10 danner hvilken eller hvilke som helst av en rekke forskjellige kinolon- og beslektede heterocykliske strukturer lignende dem som er kjent innen fagområdet til å ha antimikrobiell aktivi- tet, og (2) (a) R4 og R5 er uavhengig hydrogen, lavere alkyl, cykloalkyl, heteroalkyl, eller -C(=0)-X-R8, hvor X er en kova- lent binding. N, O eller S, og R8 er lavere alkyl, lavere alkenyl, arylalkyl, en karbocyklisk ring, eller en hetero- cyklisk ring, eller (b) R4 og R5 sammen utgjør en hetero- cyklisk ring som inkluderer det nitrogen hvortil de er bundet, og de farmasøytisk akseptable salter, biohydrolyserbare estere, biohydrolyserbare amider, og solvater derav. Oppfin- nelsen vedrører også preparater omfattende disse forbindelser, såvel som metoder for behandling av infeksiøse lidelser ved anvendelse av forbindelsene og/eller preparatene i samsvar med den foreliggende oppfinnelse.
NO964533A 1994-04-28 1996-10-25 Nye kinolon 5-(N-heterosubstituert amino) antimikrobielle forbindelser NO964533L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/235,003 US5646163A (en) 1992-10-30 1994-04-28 Quinolone 5-(N-heterosubstituted amino) antimicrobials
PCT/US1995/004495 WO1995029894A1 (en) 1994-04-28 1995-04-11 Novel quinolone 5-(n-heterosubstituted amino) antimicrobials

Publications (2)

Publication Number Publication Date
NO964533D0 NO964533D0 (no) 1996-10-25
NO964533L true NO964533L (no) 1996-12-23

Family

ID=22883653

Family Applications (1)

Application Number Title Priority Date Filing Date
NO964533A NO964533L (no) 1994-04-28 1996-10-25 Nye kinolon 5-(N-heterosubstituert amino) antimikrobielle forbindelser

Country Status (11)

Country Link
US (1) US5646163A (no)
EP (1) EP0757675A1 (no)
JP (1) JPH09512549A (no)
KR (1) KR100244992B1 (no)
CN (1) CN1157611A (no)
AU (1) AU2246695A (no)
BR (1) BR9507553A (no)
CA (1) CA2188918A1 (no)
FI (1) FI964318A7 (no)
NO (1) NO964533L (no)
WO (1) WO1995029894A1 (no)

Families Citing this family (27)

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JP4361727B2 (ja) * 2000-09-11 2009-11-11 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド チロシンキナーゼインヒビターとしてのキノリノン誘導体
AU2004267052B2 (en) * 2003-08-12 2009-02-05 Achillion Pharmaceuticals, Inc. Isothiazoloquinolones and related compounds as anti-infective agents
SG144936A1 (en) 2003-09-10 2008-08-28 Kyorin Seiyaku Kk 7-(4-substituted-3-cyclopropylaminomethyl-1- pyrrolidinyl)quinolonecarboxylic acid derivative
JP2008509909A (ja) * 2004-08-11 2008-04-03 ウィリアムスバーグ・ホールディングス・エルエルシー 心毒性のない医薬化合物
PL1776109T3 (pl) 2004-08-13 2009-06-30 Schering Plough Ltd Farmaceutyczna formulacja zawierająca antybiotyk, triazol i kortykosteroid
RU2349586C2 (ru) * 2004-09-17 2009-03-20 Сайлин Фармасьютикалз, Инк. Аналоги хинолона
US7652134B2 (en) * 2004-09-17 2010-01-26 Cylene Pharmaceuticals, Inc. Methods for converting quinolone esters into quinolone amides
EP1802306A2 (en) * 2004-09-17 2007-07-04 Cylene Pharmaceuticals, Inc. Quinolone analog as cell proliferation inhibitors
ATE445623T1 (de) * 2004-11-11 2009-10-15 Achillion Pharmaceuticals Inc 8a, 9-dihydro-4a-h-isothiazoloä5,4-bü chinolin-3, 4-dione und verwandte verbindungen als infektionsschutzmittel
WO2006074317A1 (en) * 2005-01-05 2006-07-13 Achillion Pharmaceuticals, Inc. 1-thia-2,4a-diaza-cyclopenta[b]naphthalene-3,4-diones and related compounds as anti-infective agents
WO2006084053A1 (en) 2005-02-02 2006-08-10 Achillion Pharmaceuticals, Inc. 8-n-substituted-2h-isothiazolo[5,4-b]quinolizine-3,4-diones and related compounds as antiinfective agents
EP1848723B1 (en) * 2005-02-16 2010-12-15 Achillion Pharmaceuticals, Inc. New isothiazoloquinolones and related compounds as anti-infective agents
CN101263146B (zh) * 2005-07-27 2012-12-05 艾其林医药公司 抗感染试剂8-甲氧基-9h-异噻唑并[5,4-b]喹啉-3,4-二酮及相关化合物
US7816524B2 (en) * 2005-08-05 2010-10-19 Cylene Pharmaceuticals, Inc. Methods of preparing quinolone analogs
CL2007003332A1 (es) * 2006-11-24 2008-06-20 Actelion Pharmaceuticals Ltd Compuestos derivados de heterociclos condensados; compuestos intermediarios; composicion farmaceutica; y uso en la prevencion o tratamiento de infecciones bacterianas.
US8183236B2 (en) * 2007-04-12 2012-05-22 University Of Southern California Compounds with HIV-1 integrase inhibitory activity and use thereof as anti-HIV/AIDS therapeutics
CA2688008A1 (en) * 2007-05-24 2008-11-27 Kyorin Pharmaceutical Co., Ltd. Mutilin derivative having heterocyclic aromatic ring carboxylic acid structure in substituent at 14-position
EP2145891A1 (en) * 2008-07-09 2010-01-20 Vetoquinol S.A. 9-substituted-5-carboxy-oxadiazino-quinolone derivatives, their preparation and their application as anti-bacterials
WO2010115184A2 (en) * 2009-04-03 2010-10-07 Achillion Pharmaceuticals, Inc. Hydroxythienoquinolones and related compounds as anti-infective agents
WO2011031745A1 (en) 2009-09-09 2011-03-17 Achaogen, Inc. Antibacterial fluoroquinolone analogs
BR112012008759A2 (pt) 2009-10-16 2020-08-25 Rib-X Pharmaceuticals, Inc. compostos antimicrobianos e métodos de fabricação e uso dos mesmos
WO2011047323A2 (en) 2009-10-16 2011-04-21 Rib-X Pharmaceuticals, Inc. Antimicrobial compounds and methods of making and using the same
CN105646370A (zh) * 2009-10-16 2016-06-08 梅琳塔治疗公司 抗微生物化合物和其制备和使用方法
EP3039025A4 (en) 2013-09-09 2017-05-31 Melinta Therapeutics, Inc. Antimicrobial compounds and methods of making and using the same
MX2016003046A (es) 2013-09-09 2016-09-08 Melinta Therapeutics Inc Compuestos antimicrobianos y métodos de fabricación y utilización de los mismos.
CN107922418A (zh) 2015-03-11 2018-04-17 梅琳塔治疗公司 抗微生物化合物及制备和使用所述化合物的方法
JP2019515041A (ja) 2016-05-06 2019-06-06 メリンタ セラピューティクス、 インコーポレイテッドＭｅｌｉｎｔａ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． 抗菌剤ならびにそれを作製および使用する方法

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US4665079A (en) * 1984-02-17 1987-05-12 Warner-Lambert Company Antibacterial agents
US4822801A (en) * 1984-07-20 1989-04-18 Warner-Lambert Company 4-oxo-1,4-dihydroquinoline-3-carboxylic acid derivative as antibacterial agents
IE58742B1 (en) * 1984-07-20 1993-11-05 Warner Lambert Co Substituted-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7h-pyrido[1,2,3-de] [1,4]benzoxauine-6-carboxylic acids; sibstituted-5-amino-6-6fluoro-4-oxo.1,4-dihydroquinoline-3 carboxylic acids; substituted-5-amino-6-fluoro-1,4-dihydro-4-oxo-1.8-naphthyridine-3-carboxylic acids; derivatives thereof; pharmaceutical compositions comprising the compounds; and processes for producing the compounds
US4623650A (en) * 1984-12-06 1986-11-18 Pfizer Inc. Antibiotic derivatives of 7-phenyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids
AU594983B2 (en) * 1985-10-29 1990-03-22 Dainippon Pharmaceutical Co. Ltd. Novel quinoline derivatives and processes for preparation thereof
US4954507A (en) * 1986-10-08 1990-09-04 Bristol-Myers Company 1-tertiary-alkyl-substituted naphthyridine carboxylic acid antibacterial agents
DE3711193A1 (de) * 1987-04-02 1988-10-13 Bayer Ag 5-substituierte chinolon- und naphthyridoncarbonsaeure-derivate
AU609974B2 (en) * 1988-05-18 1991-05-09 Warner-Lambert Company Improved process for the preparation of 5-amino-7- (substituted amino)-quinoline-3-carboxylic acids
JP2664950B2 (ja) * 1988-08-31 1997-10-22 日本電気株式会社 入出力処理装置
US4945160A (en) * 1988-11-22 1990-07-31 Warner-Lambert Company Preparation of certain 7-substituted quinolones
DK0525057T3 (da) * 1990-04-18 2000-07-31 Procter & Gamble Pharma Antimikrobielle quinolonyllactamer
KR100253825B1 (ko) * 1991-10-01 2000-05-01 제이코버스 코넬리스 레이서 항미 생물성 퀴놀로 닐락탐의 제조방법
EG20543A (en) * 1992-10-30 1999-07-31 Procter & Gamble Process for preparing of novel antimicrobial -5- (n-heterosubstituted amino) quinolones

Also Published As

Publication number Publication date
AU2246695A (en) 1995-11-29
CA2188918A1 (en) 1995-11-09
FI964318L (fi) 1996-12-23
EP0757675A1 (en) 1997-02-12
FI964318A0 (fi) 1996-10-25
CN1157611A (zh) 1997-08-20
WO1995029894A1 (en) 1995-11-09
NO964533D0 (no) 1996-10-25
BR9507553A (pt) 1997-08-05
KR970702849A (ko) 1997-06-10
US5646163A (en) 1997-07-08
FI964318A7 (fi) 1996-12-23
JPH09512549A (ja) 1997-12-16
KR100244992B1 (ko) 2000-03-02

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