NO965247L - Anvendelse av kryssbundet hemoglobin ved behandling av subarakuoidalblödning - Google Patents
Anvendelse av kryssbundet hemoglobin ved behandling av subarakuoidalblödningInfo
- Publication number
- NO965247L NO965247L NO965247A NO965247A NO965247L NO 965247 L NO965247 L NO 965247L NO 965247 A NO965247 A NO 965247A NO 965247 A NO965247 A NO 965247A NO 965247 L NO965247 L NO 965247L
- Authority
- NO
- Norway
- Prior art keywords
- cross
- hemorrhage
- subarakuoid
- treatment
- linked hemoglobin
- Prior art date
Links
- 102000001554 Hemoglobins Human genes 0.000 title abstract 2
- 108010054147 Hemoglobins Proteins 0.000 title abstract 2
- 208000032843 Hemorrhage Diseases 0.000 title abstract 2
- 206010058558 Hypoperfusion Diseases 0.000 abstract 2
- 208000032851 Subarachnoid Hemorrhage Diseases 0.000 abstract 1
- 230000000740 bleeding effect Effects 0.000 abstract 1
- 230000037396 body weight Effects 0.000 abstract 1
- 238000001802 infusion Methods 0.000 abstract 1
- 230000003961 neuronal insult Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/41—Porphyrin- or corrin-ring-containing peptides
- A61K38/42—Haemoglobins; Myoglobins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Infusjon av kryssbundet hemo- globin etter subaraknoidalblødning reduserer dramatisk vevsområdet med hypoperfusjon og reduserer omfanget av neuronskade i området med hypoperfu- sjon. En terapeutisk effektiv dose varierer fra ca. l 000 til 5 500 mg kroppsvekt og kan administreres opp til 72 timer etter inntreden av blødning.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41920995A | 1995-04-10 | 1995-04-10 | |
| PCT/US1996/004776 WO1996032130A1 (en) | 1995-04-10 | 1996-04-08 | The use of cross-linked hemoglobin in treating subarachnoid hemorrhage |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO965247L true NO965247L (no) | 1996-12-09 |
| NO965247D0 NO965247D0 (no) | 1996-12-09 |
Family
ID=23661264
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO965247A NO965247D0 (no) | 1995-04-10 | 1996-12-09 | Anvendelse av kryssbundet hemoglobin ved behandling av subarakuoidalblödning |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5854210A (no) |
| EP (1) | EP0767675A4 (no) |
| JP (1) | JPH10501823A (no) |
| AU (1) | AU693354B2 (no) |
| NO (1) | NO965247D0 (no) |
| TW (1) | TW370461B (no) |
| WO (1) | WO1996032130A1 (no) |
| ZA (1) | ZA962843B (no) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001502351A (ja) * | 1996-10-21 | 2001-02-20 | バクスター インターナショナル インコーポレイテッド | 頭部損傷を処置するためのヘモグロビンの治療的使用 |
| KR100281083B1 (ko) * | 1998-01-23 | 2001-02-01 | 서평원 | 이동데이터단말기간무선데이터통신방법 |
| DE10220992A1 (de) * | 2002-05-11 | 2003-12-04 | Sanguibiotech Ag | Verwendung eines oder mehrerer Sauerstoffträger, ausgewählt aus Hämoglobin, Myoglobin und Derivaten hiervon zur Behandlung einer Organfunktionsstörung infolge eines akuten Versorgungsmangels und zur Behandlung/Vermeidung einer Gewebeschädigung infolge einer solchen Störung |
| AU2003234944A1 (en) * | 2002-08-27 | 2004-03-18 | Bayer Healthcare, Llc | Methods of Determining Glucose Concentration in Whole Blood Samples |
| AU2010254117A1 (en) * | 2009-05-26 | 2012-01-19 | Duke University | Method of providing neuroprotection using substituted porphyrins |
| WO2013019290A2 (en) * | 2011-04-21 | 2013-02-07 | Streck, Inc. | Immature reticulocyte fraction reference control and related methods |
| CA2856382C (en) * | 2011-11-22 | 2020-07-14 | Siemens Healthcare Diagnostics Inc. | Devices containing dried reagents for reconstitution as calibration and/or quality control solutions, and methods of production and use thereof |
| WO2019018403A1 (en) | 2017-07-18 | 2019-01-24 | Virtech Bio, Llc | BLOOD SUBSTITUTES COMPRISING HEMOGLOBIN AND METHODS OF MAKING |
| CN113975378A (zh) * | 2021-11-19 | 2022-01-28 | 润方(北京)生物医药研究院有限公司 | 一种聚合血红蛋白在制备治疗缺血性脑卒中药物的应用 |
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| US2464284A (en) * | 1943-10-18 | 1949-03-15 | Smith Kline French Lab | Vasoconstrictor composition |
| DE1121054B (de) * | 1960-11-23 | 1962-01-04 | Merck Ag E | Verfahren zur Herstellung eines neuen Imidazolinderivates und dessen Saeureadditionssalzen |
| US3681459A (en) * | 1970-10-01 | 1972-08-01 | Armour Pharma | Guanidine compounds and use of same |
| US3925344A (en) * | 1973-04-11 | 1975-12-09 | Community Blood Council | Plasma protein substitute |
| US4001401A (en) * | 1975-02-02 | 1977-01-04 | Alza Corporation | Blood substitute and blood plasma expander comprising polyhemoglobin |
| US4053590A (en) * | 1975-02-27 | 1977-10-11 | Alza Corporation | Compositions of matter comprising macromolecular hemoglobin |
| JPS52128205A (en) * | 1976-04-16 | 1977-10-27 | Green Cross Corp:The | Prophylactic and therapeutic drugs for cerebro-vascular contraction |
| DE2617493C3 (de) * | 1976-04-22 | 1979-03-01 | The Green Cross Corp., Osaka (Japan) | Verwendung von Haptoglobin oder Hämoglobin-Haptoglobin-Komplexen bei der Prophylaxe und Therapie von zerebralen Vasospasmen |
| US4757052A (en) * | 1982-09-03 | 1988-07-12 | Markov Angel K | Method of preserving blood |
| US4529719A (en) * | 1983-05-04 | 1985-07-16 | Tye Ross W | Modified crosslinked stroma-free tetrameric hemoglobin |
| GB8328917D0 (en) * | 1983-10-28 | 1983-11-30 | Fisons Plc | Blood substitute |
| US4598064A (en) * | 1984-06-27 | 1986-07-01 | University Of Iowa Research Foundation | Alpha-alpha cross-linked hemoglobins |
| USRE34271E (en) * | 1984-06-27 | 1993-06-01 | University Of Iowa Research Foundation | Production of alpha-alpha cross-linked hemoglobins in high yield |
| US4600531A (en) * | 1984-06-27 | 1986-07-15 | University Of Iowa Research Foundation | Production of alpha-alpha cross-linked hemoglobins in high yield |
| US4826811A (en) * | 1986-06-20 | 1989-05-02 | Northfield Laboratories, Inc. | Acellular red blood cell substitute |
| US5464814A (en) * | 1986-06-20 | 1995-11-07 | Northfield Laboratories, Inc. | Acellular red blood cell substitute |
| US5194590A (en) * | 1986-06-20 | 1993-03-16 | Northfield Laboratories, Inc. | Acellular red blood cell substitute |
| FR2600894B1 (fr) * | 1986-07-02 | 1989-01-13 | Centre Nat Rech Scient | Conjugues macromoleculaires d'hemoglobine, leur procede de preparation et leurs applications |
| JP2531661B2 (ja) * | 1987-02-25 | 1996-09-04 | 味の素株式会社 | 酸素運搬剤 |
| US5449759A (en) * | 1987-05-16 | 1995-09-12 | Somatogen, Inc. | Hemoglobins with intersubunit desulfide bonds |
| US5268500A (en) * | 1987-06-15 | 1993-12-07 | Montefiore Medical Center | Compound, composition and method for the reduction of lipids the modification of the affinity of hemoblogin for oxygen and the prevention of platelet aggregation |
| US4994444A (en) * | 1987-07-31 | 1991-02-19 | The Trustees Of Columbia In The City Of New York | Macromolecules for sealing capillary endothelial junctions |
| US4988515A (en) * | 1988-01-28 | 1991-01-29 | The Regents Of The Univ. Of Calif. | Cardioplegic solution |
| FR2630329B1 (fr) * | 1988-04-20 | 1991-07-05 | Merieux Inst | Conjugues macromoleculaires d'hemoglobine, leur procede de preparation et leurs applications |
| IL87707A (en) * | 1988-09-08 | 1994-06-24 | Technion Inst For Research And | Hemoglobin-based blood substitute substantially similar to human blood and method for preparation thereof |
| IL87708A (en) * | 1988-09-08 | 1994-04-12 | Technion Inst For Research And | Hemoglobin-based blood substitute possessing a colloid oncotic pressure substantially similar to human blood and method for the preparation thereof |
| US5128452A (en) * | 1989-04-19 | 1992-07-07 | Baxter International Inc. | Process for the production of crosslinked hemoglobin in the presence of sodium tripolyphosphate |
| JP3297433B2 (ja) * | 1989-06-15 | 2002-07-02 | ローヌ−プーラン ローラー インターナショナル (ホウルディングス) インコーポレイテッド | ウイルスで汚染された薬理組成物中のウイルスの不活性化方法 |
| US5059712A (en) * | 1989-09-13 | 1991-10-22 | Cornell Research Foundation, Inc. | Isolating aminoarginine and use to block nitric oxide formation in body |
| US5173426A (en) * | 1989-10-06 | 1992-12-22 | Yale University | DNAs encoding genetically engineered low oxygen affinity mutants of human hemoglobin |
| US5370870A (en) * | 1989-10-06 | 1994-12-06 | Genentech, Inc. | Method for protection against reactive oxygen species |
| US5386014A (en) * | 1989-11-22 | 1995-01-31 | Enzon, Inc. | Chemically modified hemoglobin as an effective, stable, non-immunogenic red blood cell substitute |
| US5478806A (en) * | 1989-11-22 | 1995-12-26 | Enzon, Inc. | Enhancement of antitumor therapy with hemoglobin-based conjugates |
| WO1992013875A1 (en) * | 1991-02-12 | 1992-08-20 | Texas Tech University | Improved blood substitute |
| WO1991009615A1 (en) * | 1989-12-29 | 1991-07-11 | Texas Tech University | Polyhemoglobin stabilized by purine derivatives and glutathione |
| US5439882A (en) * | 1989-12-29 | 1995-08-08 | Texas Tech University Health Sciences Center | Blood substitute |
| US5248785A (en) * | 1990-02-12 | 1993-09-28 | Virginia Commonwealth University | Using allosteric hemoglobin modifiers to decrease oxygen affinity in blood |
| US5049695A (en) * | 1990-02-12 | 1991-09-17 | Center For Innovative Technology | Allosteric hemoglobin modifiers |
| US5382680A (en) * | 1990-12-07 | 1995-01-17 | The Center For Innovative Technology | Allosteric hemoglobin modifier compounds |
| US5122539A (en) * | 1990-02-12 | 1992-06-16 | Center For Innovative Technology | Allosteric hemoglobin modifiers useful for decreasing oxygen affinity and preserving oxygen carrying capability of stored blood |
| US5432191A (en) * | 1990-02-12 | 1995-07-11 | The Center For Innovative Technology | Allosteric hemoglobin modifiers to decrease oxygen affinity in blood |
| US5290803A (en) * | 1990-02-12 | 1994-03-01 | The Center Of Innovative Technology | Using allosteric hemoglobin modifiers to decrease oxygen affinity in blood |
| AU636713B2 (en) * | 1990-02-26 | 1993-05-06 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of nitric oxide biosynthesis |
| US5248766A (en) * | 1990-08-17 | 1993-09-28 | Baxter International Inc. | Oxirane-modified hemoglobin based composition |
| ZW1992A1 (en) * | 1991-02-25 | 1993-09-22 | Janssen Pharmaceutica Nv | 4-/(2-benzotiazolyl)methylamino/-b-/(3,4-difluorephenoxy)methyl/-1-piperidine ethanol |
| US5295944A (en) * | 1991-05-14 | 1994-03-22 | Dana-Farber Cancer Institute | Method for treating a tumor with ionizing radiation |
| WO1992020369A1 (en) * | 1991-05-14 | 1992-11-26 | Dana Farber Cancer Institute | Use of hemoglobin in a method for the treatment of tumors with chemotherapeutic agents |
| US5334706A (en) * | 1992-01-30 | 1994-08-02 | Baxter International | Administration of low dose hemoglobin to increase perfusion |
| US5296466A (en) * | 1992-02-19 | 1994-03-22 | Board Of Regents, The University Of Texas System | Inhibition of nitric oxide-mediated hypotension and septic shock with iron-containing hemoprotein |
| WO1993016720A1 (en) * | 1992-02-20 | 1993-09-02 | The Regents Of The University Of California | Inhibition of bacterial endotoxin |
| CA2101361A1 (en) * | 1992-08-27 | 1994-02-28 | Robert A. Snow | Low diol polyalkylene oxide biologically active proteinaceous substances |
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| WO1994022482A1 (en) * | 1993-03-26 | 1994-10-13 | Biorelease Technologies, Inc. | Compositions including heme-containing proteins and methods relating thereto |
| TW381022B (en) * | 1993-08-16 | 2000-02-01 | Hsia Jen Chang | Compositions and methods utilizing nitroxides to avoid oxygen toxicity, particularly in stabilized, polymerized, conjugated, or encapsulated hemoglobin used as a red cell substitute |
| DE4338812A1 (de) * | 1993-11-15 | 1995-05-18 | Braun Melsungen Ag | Verwendung von Lösungen von vernetztem Hämoglobin zur Bekämpfung des septischen und hämorrhagischen Schocks bei Säugetieren |
| CA2163743A1 (en) * | 1994-03-28 | 1995-10-05 | Jack E. Mckenzie | Therapeutic use of hemoglobin in the treatment of blood vessel blockage |
| ATE222926T1 (de) * | 1995-03-23 | 2002-09-15 | Biopure Corp | Stabiles polymerisiertes hämoglobin- blutersatzmittel |
-
1996
- 1996-04-08 JP JP8531079A patent/JPH10501823A/ja active Pending
- 1996-04-08 WO PCT/US1996/004776 patent/WO1996032130A1/en not_active Ceased
- 1996-04-08 AU AU55372/96A patent/AU693354B2/en not_active Ceased
- 1996-04-08 EP EP96912607A patent/EP0767675A4/en not_active Withdrawn
- 1996-04-10 ZA ZA962843A patent/ZA962843B/xx unknown
- 1996-06-24 TW TW085107552A patent/TW370461B/zh active
- 1996-11-12 US US08/747,941 patent/US5854210A/en not_active Expired - Fee Related
- 1996-12-09 NO NO965247A patent/NO965247D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO1996032130A1 (en) | 1996-10-17 |
| ZA962843B (en) | 1996-10-11 |
| JPH10501823A (ja) | 1998-02-17 |
| EP0767675A1 (en) | 1997-04-16 |
| AU5537296A (en) | 1996-10-30 |
| NO965247D0 (no) | 1996-12-09 |
| EP0767675A4 (en) | 1998-08-05 |
| AU693354B2 (en) | 1998-06-25 |
| US5854210A (en) | 1998-12-29 |
| TW370461B (en) | 1999-09-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |