NO965394L - Nye substituerte purinylderivater med immunomodulerende aktivitet - Google Patents

Nye substituerte purinylderivater med immunomodulerende aktivitet

Info

Publication number
NO965394L
NO965394L NO965394A NO965394A NO965394L NO 965394 L NO965394 L NO 965394L NO 965394 A NO965394 A NO 965394A NO 965394 A NO965394 A NO 965394A NO 965394 L NO965394 L NO 965394L
Authority
NO
Norway
Prior art keywords
novel substituted
immunomodulatory activity
substituted purinyl
purinyl derivatives
derivatives
Prior art date
Application number
NO965394A
Other languages
English (en)
Other versions
NO965394D0 (no
NO317552B1 (no
Inventor
Christopher Penney
Boulos Zacharie
Lyne Gagnon
Giorgio Attardo
Thimothy Connolly
Yves Denis
Salam Kadhim
Guy Ely
Original Assignee
Iaf Biochem Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Iaf Biochem Int filed Critical Iaf Biochem Int
Publication of NO965394D0 publication Critical patent/NO965394D0/no
Publication of NO965394L publication Critical patent/NO965394L/no
Publication of NO317552B1 publication Critical patent/NO317552B1/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NO19965394A 1994-06-22 1996-12-13 Nye substituerte purinylderivater med immunomodulerende aktivitet NO317552B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26402894A 1994-06-22 1994-06-22
PCT/CA1995/000356 WO1995035297A1 (en) 1994-06-22 1995-06-21 Novel substituted purinyl derivatives with immunomodulating activity

Publications (3)

Publication Number Publication Date
NO965394D0 NO965394D0 (no) 1996-12-13
NO965394L true NO965394L (no) 1997-02-21
NO317552B1 NO317552B1 (no) 2004-11-15

Family

ID=23004250

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19965394A NO317552B1 (no) 1994-06-22 1996-12-13 Nye substituerte purinylderivater med immunomodulerende aktivitet

Country Status (16)

Country Link
US (2) US5994361A (no)
EP (1) EP0766683A1 (no)
JP (1) JP4151765B2 (no)
CN (1) CN1051083C (no)
AU (1) AU2666795A (no)
BR (1) BR9508115A (no)
FI (1) FI965040A7 (no)
HU (1) HUT77780A (no)
IL (1) IL114266A0 (no)
MX (1) MX9700211A (no)
NO (1) NO317552B1 (no)
NZ (1) NZ287827A (no)
PL (1) PL184342B1 (no)
RU (1) RU2191189C2 (no)
WO (1) WO1995035297A1 (no)
ZA (1) ZA955131B (no)

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WO2003037860A2 (en) * 2001-10-30 2003-05-08 Conforma Therapeutics Corporation Purine analogs having hsp90-inhibiting activity
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CA2547020C (en) 2003-11-25 2014-03-25 3M Innovative Properties Company 1h-imidazo[4,5-c]pyridine-4-amine derivatives as immune response modifier
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JPWO2007034882A1 (ja) * 2005-09-22 2009-03-26 大日本住友製薬株式会社 新規アデニン化合物
JPWO2007034817A1 (ja) * 2005-09-22 2009-03-26 大日本住友製薬株式会社 新規アデニン化合物
JPWO2007034881A1 (ja) * 2005-09-22 2009-03-26 大日本住友製薬株式会社 新規アデニン化合物
US20090105212A1 (en) * 2005-09-22 2009-04-23 Dainippon Sumitomo Pharma Co., Ltd. a corporation of Japan Novel adenine compound
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US8138172B2 (en) * 2006-07-05 2012-03-20 Astrazeneca Ab 8-oxoadenine derivatives acting as modulators of TLR7
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ES2457316T3 (es) * 2007-03-19 2014-04-25 Astrazeneca Ab Compuestos 8-oxo-adenina 9 sustituidos como moduladores del receptor similares a toll (TLR7)
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JPWO2008114819A1 (ja) * 2007-03-20 2010-07-08 大日本住友製薬株式会社 新規アデニン化合物
HRP20120895T1 (hr) * 2007-05-08 2012-11-30 Astrazeneca Ab Imidazokinolini sa imuno-modulacijskim svojstvima
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JPWO2009091031A1 (ja) * 2008-01-17 2011-05-26 大日本住友製薬株式会社 アデニン化合物の製造方法
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AU2010250923A1 (en) 2009-05-21 2011-11-17 Astrazeneca Ab Novel pyrimidine derivatives and their use in the treatment of cancer and further diseases
JP2013512859A (ja) * 2009-12-03 2013-04-18 大日本住友製薬株式会社 トール様受容体（ｔｌｒ）を介して作用するイミダゾキノリン
RU2492825C2 (ru) * 2010-10-18 2013-09-20 Федеральное государственное учреждение "Ростовский научно-исследовательский онкологический институт Федерального агентства по высокотехнологичной медицинской помощи" Способ лечения рака сигмовидной кишки у женщин по сидоренко ю.с.
CN103370317B (zh) 2010-12-16 2015-10-07 阿斯利康(瑞典)有限公司 可用于治疗的咪唑并[4,5-c]喹啉-1-基衍生物
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JP6184423B2 (ja) 2012-05-18 2017-08-23 大日本住友製薬株式会社 カルボン酸化合物
KR102685007B1 (ko) * 2015-08-31 2024-07-12 쓰리엠 이노베이티브 프로퍼티즈 컴파니 구아니딘 치환된 이미다조[4,5-c] 고리 화합물
US10118925B2 (en) * 2015-08-31 2018-11-06 3M Innovative Properties Company Imidazo[4,5-c] ring compounds containing substituted guanidine groups
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Also Published As

Publication number Publication date
NO965394D0 (no) 1996-12-13
US6110923A (en) 2000-08-29
AU2666795A (en) 1996-01-15
WO1995035297A1 (en) 1995-12-28
CN1051083C (zh) 2000-04-05
RU2191189C2 (ru) 2002-10-20
IL114266A0 (en) 1995-10-31
CN1157618A (zh) 1997-08-20
BR9508115A (pt) 1998-11-03
FI965040L (fi) 1997-02-21
FI965040A7 (fi) 1997-02-21
ZA955131B (en) 1997-03-24
NZ287827A (en) 1999-02-25
NO317552B1 (no) 2004-11-15
PL184342B1 (pl) 2002-10-31
HUT77780A (hu) 1998-08-28
JPH10501533A (ja) 1998-02-10
JP4151765B2 (ja) 2008-09-17
PL317902A1 (en) 1997-04-28
MX9700211A (es) 1998-01-31
US5994361A (en) 1999-11-30
EP0766683A1 (en) 1997-04-09
HU9603492D0 (en) 1997-02-28
FI965040A0 (fi) 1996-12-16

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