NO970054L - Implantert anordning inneholdende tumorceller for behandling av cancer - Google Patents

Implantert anordning inneholdende tumorceller for behandling av cancer

Info

Publication number: NO970054L
Authority: NO; Norway
Prior art keywords: cells; tumor; tumor cells; chamber; patient
Prior art date: 1994-07-08

Application number

NO970054A

Other languages

English (en)

Norwegian (no)

Other versions

NO970054D0 (no

Inventor

Robin Lee Geller

James H Brauker

William D Johnston

Steven A Levon

David A Maryanov

Original Assignee

Baxter Int

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-07-08

Filing date

1997-01-07

Publication date

1997-03-10

1997-01-07 Application filed by Baxter Int filed Critical Baxter Int

1997-01-07 Publication of NO970054D0 publication Critical patent/NO970054D0/no

1997-03-10 Publication of NO970054L publication Critical patent/NO970054L/no

Links

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Classifications

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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/13—Tumour cells, irrespective of tissue of origin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5152—Tumor cells

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Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Biomedical Technology (AREA)
Zoology (AREA)
Cell Biology (AREA)
Virology (AREA)
Microbiology (AREA)
Mycology (AREA)
Oncology (AREA)
Biotechnology (AREA)
Neurosurgery (AREA)
Dermatology (AREA)
Developmental Biology & Embryology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Prostheses (AREA)
Medicinal Preparation (AREA)

NO970054A 1994-07-08 1997-01-07 Implantert anordning inneholdende tumorceller for behandling av cancer NO970054L (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US27218994A	1994-07-08	1994-07-08
US46224995A	1995-06-05	1995-06-05
PCT/US1995/008151 WO1996001611A1 (en)	1994-07-08	1995-06-29	Implanted device containing tumor cells for the treatment of cancer

Publications (2)

Publication Number	Publication Date
NO970054D0 NO970054D0 (no)	1997-01-07
NO970054L true NO970054L (no)	1997-03-10

Family

ID=26955354

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO970054A NO970054L (no)	1994-07-08	1997-01-07	Implantert anordning inneholdende tumorceller for behandling av cancer

Country Status (13)

Country	Link
EP (1)	EP0769932B1 (de)
JP (1)	JPH10502638A (de)
KR (1)	KR970704410A (de)
CN (1)	CN1157560A (de)
AT (1)	ATE172099T1 (de)
AU (1)	AU699405B2 (de)
CA (1)	CA2194555C (de)
DE (1)	DE69505391T2 (de)
DK (1)	DK0769932T3 (de)
ES (1)	ES2125630T3 (de)
IL (1)	IL114482A0 (de)
NO (1)	NO970054L (de)
WO (1)	WO1996001611A1 (de)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6224912B1 (en)	1996-04-03	2001-05-01	The Rogo Institute	Cancer-cell proliferation-suppressing material produced by cancer cells restricted by entrapment
US7297331B2 (en)	1996-04-03	2007-11-20	The Rogosin Institute	Beads containing restricted cancer cells producing material suppressing cancer cell proliferation
US5888497A (en) *	1996-04-03	1999-03-30	The Rogosin Institute	Agarose coated agarose beads containing cancer cells that produce material which suppresses cancer cell proliferation
US5964261A (en)	1996-05-29	1999-10-12	Baxter International Inc.	Implantation assembly
US6001067A (en)	1997-03-04	1999-12-14	Shults; Mark C.	Device and method for determining analyte levels
US6862465B2 (en)	1997-03-04	2005-03-01	Dexcom, Inc.	Device and method for determining analyte levels
US6558321B1 (en)	1997-03-04	2003-05-06	Dexcom, Inc.	Systems and methods for remote monitoring and modulation of medical devices
US7192450B2 (en)	2003-05-21	2007-03-20	Dexcom, Inc.	Porous membranes for use with implantable devices
US6741877B1 (en)	1997-03-04	2004-05-25	Dexcom, Inc.	Device and method for determining analyte levels
US8527026B2 (en)	1997-03-04	2013-09-03	Dexcom, Inc.	Device and method for determining analyte levels
ES2355483T3 (es) *	1998-02-20	2011-03-28	University Of Miami	Complejo de proteina de choque térmico modificada-péptido antigénico.
US8974386B2 (en)	1998-04-30	2015-03-10	Abbott Diabetes Care Inc.	Analyte monitoring device and methods of use
US6175752B1 (en)	1998-04-30	2001-01-16	Therasense, Inc.	Analyte monitoring device and methods of use
US8688188B2 (en)	1998-04-30	2014-04-01	Abbott Diabetes Care Inc.	Analyte monitoring device and methods of use
US8346337B2 (en)	1998-04-30	2013-01-01	Abbott Diabetes Care Inc.	Analyte monitoring device and methods of use
US8465425B2 (en)	1998-04-30	2013-06-18	Abbott Diabetes Care Inc.	Analyte monitoring device and methods of use
US9066695B2 (en)	1998-04-30	2015-06-30	Abbott Diabetes Care Inc.	Analyte monitoring device and methods of use
US8480580B2 (en)	1998-04-30	2013-07-09	Abbott Diabetes Care Inc.	Analyte monitoring device and methods of use
NO983911D0 (no)	1998-08-26	1998-08-26	Norsk Hydro As	Alginatkapsler til bruk ved behandling av hjernesvulst
ATE407695T1 (de)	1999-02-09	2008-09-15	Riken	Tumorimpfstoff
US6560471B1 (en)	2001-01-02	2003-05-06	Therasense, Inc.	Analyte monitoring device and methods of use
US20030032874A1 (en)	2001-07-27	2003-02-13	Dexcom, Inc.	Sensor head for use with implantable devices
US6702857B2 (en)	2001-07-27	2004-03-09	Dexcom, Inc.	Membrane for use with implantable devices
US7613491B2 (en)	2002-05-22	2009-11-03	Dexcom, Inc.	Silicone based membranes for use in implantable glucose sensors
US10022078B2 (en)	2004-07-13	2018-07-17	Dexcom, Inc.	Analyte sensor
US8260393B2 (en)	2003-07-25	2012-09-04	Dexcom, Inc.	Systems and methods for replacing signal data artifacts in a glucose sensor data stream
US8364229B2 (en)	2003-07-25	2013-01-29	Dexcom, Inc.	Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise
US8010174B2 (en)	2003-08-22	2011-08-30	Dexcom, Inc.	Systems and methods for replacing signal artifacts in a glucose sensor data stream
US9247901B2 (en)	2003-08-22	2016-02-02	Dexcom, Inc.	Systems and methods for replacing signal artifacts in a glucose sensor data stream
US7226978B2 (en)	2002-05-22	2007-06-05	Dexcom, Inc.	Techniques to improve polyurethane membranes for implantable glucose sensors
US7134999B2 (en)	2003-04-04	2006-11-14	Dexcom, Inc.	Optimized sensor geometry for an implantable glucose sensor
EP1648298A4 (de)	2003-07-25	2010-01-13	Dexcom Inc	Sauerstoffverbessernde membransysteme für implantierbare vorrichtungen
US9763609B2 (en)	2003-07-25	2017-09-19	Dexcom, Inc.	Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise
US7774145B2 (en)	2003-08-01	2010-08-10	Dexcom, Inc.	Transcutaneous analyte sensor
US7591801B2 (en)	2004-02-26	2009-09-22	Dexcom, Inc.	Integrated delivery device for continuous glucose sensor
US8275437B2 (en)	2003-08-01	2012-09-25	Dexcom, Inc.	Transcutaneous analyte sensor
US20140121989A1 (en)	2003-08-22	2014-05-01	Dexcom, Inc.	Systems and methods for processing analyte sensor data
US7920906B2 (en)	2005-03-10	2011-04-05	Dexcom, Inc.	System and methods for processing analyte sensor data for sensor calibration
US8615282B2 (en)	2004-07-13	2013-12-24	Dexcom, Inc.	Analyte sensor
US9247900B2 (en)	2004-07-13	2016-02-02	Dexcom, Inc.	Analyte sensor
US8423114B2 (en)	2006-10-04	2013-04-16	Dexcom, Inc.	Dual electrode system for a continuous analyte sensor
DE602004029092D1 (de)	2003-12-05	2010-10-21	Dexcom Inc	Kalibrationsmethoden für einen kontinuierlich arbeitenden analytsensor
US11633133B2 (en)	2003-12-05	2023-04-25	Dexcom, Inc.	Dual electrode system for a continuous analyte sensor
WO2005079257A2 (en)	2004-02-12	2005-09-01	Dexcom, Inc.	Biointerface with macro- and micro- architecture
US8808228B2 (en)	2004-02-26	2014-08-19	Dexcom, Inc.	Integrated medicament delivery device for use with continuous analyte sensor
US8565848B2 (en)	2004-07-13	2013-10-22	Dexcom, Inc.	Transcutaneous analyte sensor
US7905833B2 (en)	2004-07-13	2011-03-15	Dexcom, Inc.	Transcutaneous analyte sensor
US8452368B2 (en)	2004-07-13	2013-05-28	Dexcom, Inc.	Transcutaneous analyte sensor
US7946984B2 (en)	2004-07-13	2011-05-24	Dexcom, Inc.	Transcutaneous analyte sensor
US20200037874A1 (en)	2007-05-18	2020-02-06	Dexcom, Inc.	Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise
US8562558B2 (en)	2007-06-08	2013-10-22	Dexcom, Inc.	Integrated medicament delivery device for use with continuous analyte sensor
EP4159114B1 (de)	2007-10-09	2024-04-10	DexCom, Inc.	Integriertes insulin-abgabesystem mit kontinuierlichem glucosesensor
WO2009114085A2 (en)	2008-03-03	2009-09-17	The University Of Miami	Allogeneic cancer cell-based immunotherapy
AU2009226077B2 (en)	2008-03-20	2012-04-19	University Of Miami	Heat shock protein gp96 vaccination and methods of using same
US8583204B2 (en)	2008-03-28	2013-11-12	Dexcom, Inc.	Polymer membranes for continuous analyte sensors
US11730407B2 (en)	2008-03-28	2023-08-22	Dexcom, Inc.	Polymer membranes for continuous analyte sensors
US8682408B2 (en)	2008-03-28	2014-03-25	Dexcom, Inc.	Polymer membranes for continuous analyte sensors
WO2011041463A2 (en)	2009-09-30	2011-04-07	Dexcom, Inc.	Transcutaneous analyte sensor
US10046047B2 (en)	2015-02-06	2018-08-14	Heat Biologics, Inc.	Vector co-expressing vaccine and costimulatory molecules
US11666649B2 (en)	2016-10-11	2023-06-06	University Of Miami	Vectors and vaccine cells for immunity against Zika virus
EP4595951A3 (de)	2016-11-10	2025-08-27	ViaCyte, Inc.	Pdx1-pankreatische endodermzellen in zellfreisetzungsvorrichtungen und verfahren dafür
WO2018187260A1 (en)	2017-04-04	2018-10-11	Heat Biologics, Inc.	Intratumoral vaccination
CN111246797B (zh)	2017-10-24	2025-09-09	德克斯康公司	预连接分析物传感器
US11331022B2 (en)	2017-10-24	2022-05-17	Dexcom, Inc.	Pre-connected analyte sensors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2117647B (en) *	1982-04-06	1985-06-19	James Victor Watson	Medical treatment and apparatus therefor

1995
- 1995-06-29 EP EP95924737A patent/EP0769932B1/de not_active Expired - Lifetime
- 1995-06-29 JP JP8504331A patent/JPH10502638A/ja not_active Ceased
- 1995-06-29 WO PCT/US1995/008151 patent/WO1996001611A1/en not_active Ceased
- 1995-06-29 AU AU29128/95A patent/AU699405B2/en not_active Ceased
- 1995-06-29 CA CA002194555A patent/CA2194555C/en not_active Expired - Fee Related
- 1995-06-29 AT AT95924737T patent/ATE172099T1/de not_active IP Right Cessation
- 1995-06-29 DE DE69505391T patent/DE69505391T2/de not_active Expired - Fee Related
- 1995-06-29 CN CN95194968A patent/CN1157560A/zh active Pending
- 1995-06-29 ES ES95924737T patent/ES2125630T3/es not_active Expired - Lifetime
- 1995-06-29 DK DK95924737T patent/DK0769932T3/da active
- 1995-07-06 IL IL11448295A patent/IL114482A0/xx unknown
1997
- 1997-01-07 NO NO970054A patent/NO970054L/no not_active Application Discontinuation
- 1997-01-08 KR KR1019970700082A patent/KR970704410A/ko not_active Withdrawn

Also Published As

Publication number	Publication date
DE69505391T2 (de)	1999-06-17
KR970704410A (ko)	1997-09-06
AU2912895A (en)	1996-02-09
EP0769932B1 (de)	1998-10-14
ATE172099T1 (de)	1998-10-15
CA2194555C (en)	2002-01-29
WO1996001611A1 (en)	1996-01-25
IL114482A0 (en)	1995-11-27
DK0769932T3 (da)	1999-06-23
CN1157560A (zh)	1997-08-20
JPH10502638A (ja)	1998-03-10
CA2194555A1 (en)	1996-01-25
AU699405B2 (en)	1998-12-03
ES2125630T3 (es)	1999-03-01
NO970054D0 (no)	1997-01-07
EP0769932A1 (de)	1997-05-02
DE69505391D1 (de)	1998-11-19

Legal Events

Date	Code	Title	Description
2001-03-12	FC2A	Withdrawal, rejection or dismissal of laid open patent application

Publication	Publication Date	Title
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