NO970356L - PTH eller PTHrP antagonister - Google Patents

PTH eller PTHrP antagonister

Info

Publication number
NO970356L
NO970356L NO970356A NO970356A NO970356L NO 970356 L NO970356 L NO 970356L NO 970356 A NO970356 A NO 970356A NO 970356 A NO970356 A NO 970356A NO 970356 L NO970356 L NO 970356L
Authority
NO
Norway
Prior art keywords
pth
amino acid
pthrp
tryptophan
aromatic
Prior art date
Application number
NO970356A
Other languages
English (en)
Other versions
NO970356D0 (no
Inventor
Francois Cardinaux
Jean Honore M Feyen
Rainer Gamse
Frank Otto Gombert
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9415254A external-priority patent/GB9415254D0/en
Priority claimed from GB9415255A external-priority patent/GB9415255D0/en
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of NO970356D0 publication Critical patent/NO970356D0/no
Publication of NO970356L publication Critical patent/NO970356L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)

Abstract

PTH eller PTHrP forbindelser som har kraftig antagonistisk aktivitet ved PTH/PTHrP reseptoren hvori minst en av amino- syrerestene som naturlig forekommer i stillinger 2 og 10 er erstattet med tryptofan eller en annen aminosyrerest som bærer en aromatisk eller heteroaromatisk gruppe på sin sidekjede, og eventuelt er minst en av aminosyrerestene som naturlig forekommer i stillinger 3 og 6 videre erstattet med tryptofan eller en annen aminosyrerest som bærer en aromatisk eller heteroaromatisk gruppe på sin sidekjede, som har far- makologisk aktivitet, f.eks. forebygging eller behandling av tilstander som er assosiert med okt plasmakalsium forårsaket av overdreven frigivelse av PTH eller PTHrp.
NO970356A 1994-07-28 1997-01-28 PTH eller PTHrP antagonister NO970356L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9415254A GB9415254D0 (en) 1994-07-28 1994-07-28 Organic compounds
GB9415255A GB9415255D0 (en) 1994-07-28 1994-07-28 Organic compounds
PCT/EP1995/002993 WO1996003437A1 (en) 1994-07-28 1995-07-27 PTH OR PTHrP ANTAGONISTS

Publications (2)

Publication Number Publication Date
NO970356D0 NO970356D0 (no) 1997-01-28
NO970356L true NO970356L (no) 1997-01-28

Family

ID=26305357

Family Applications (1)

Application Number Title Priority Date Filing Date
NO970356A NO970356L (no) 1994-07-28 1997-01-28 PTH eller PTHrP antagonister

Country Status (15)

Country Link
EP (1) EP0773958A1 (no)
JP (1) JPH10502091A (no)
AU (1) AU3167095A (no)
BR (1) BR9508433A (no)
CA (1) CA2192787A1 (no)
CO (1) CO4410206A1 (no)
CZ (1) CZ23397A3 (no)
FI (1) FI970168A0 (no)
HU (1) HUT77979A (no)
IL (1) IL114736A0 (no)
NO (1) NO970356L (no)
PL (1) PL318017A1 (no)
SK (1) SK12097A3 (no)
TR (1) TR199500915A2 (no)
WO (1) WO1996003437A1 (no)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW505654B (en) 1996-07-30 2002-10-11 Hoffmann La Roche Synthesis of analogs of PTH and PTHrP
AU3819497A (en) 1996-07-31 1998-02-20 General Hospital Corporation, The Novel parathyroid hormone-related peptide analogs
CZ106299A3 (cs) 1996-09-26 1999-08-11 Chugai Seiyaku Kabushiki Kaisha Protilátky proti proteinu příbuznému s lidským parathyroidálním hormonem
SK151599A3 (en) 1997-05-14 2000-09-12 Rhone Poulenc Rorer Pharma Peptide parathyroid hormone analogs
TR199902800T2 (xx) 1997-05-15 2000-04-21 Chugai Seiyaku Kabushiki Kaisha Ka�eksiyi tedavi edici madde.
WO2001002011A1 (fr) * 1999-07-02 2001-01-11 Chugai Seiyaku Kabushiki Kaisha REMEDES CONTRE LES MALADIES CAUSEES PAR PTH OU PTHrP
TWI255718B (en) 1999-07-02 2006-06-01 Chugai Pharmaceutical Co Ltd Ameliorative agent for low vasopressin concentration
RU2002102916A (ru) * 1999-07-06 2003-11-10 Чугаи Сейяку Кабусики Кайся (Jp) Терапевтический агент для лечения устойчивой к лекраственным препаратам гиперкальциемии
EP1221966B1 (en) * 1999-09-20 2005-11-16 Eli Lilly And Company Use of a parathyroid hormone for reducing the risk of cancer
WO2001054725A1 (en) * 2000-01-25 2001-08-02 Chugai Seiyaku Kabushiki Kaisha Remedies and preventives for dental diseases
WO2001064249A1 (fr) * 2000-02-28 2001-09-07 Chugai Seiyaku Kabushiki Kaisha Inhibiteur de decomposition de tissu
ATE420661T1 (de) 2000-04-28 2009-01-15 Chugai Pharmaceutical Co Ltd Zellproliferation-inhibitoren
EP1312378A4 (en) * 2000-08-16 2004-03-17 Chugai Pharmaceutical Co Ltd SUBSTANCES FOR IMPROVING SYMPTOMS IN JOINT DISEASES
CN101784281B (zh) 2007-08-01 2014-07-02 总医院有限公司 确定g蛋白偶联受体激动剂的方法
US9492508B2 (en) 2010-05-13 2016-11-15 The General Hospital Corporation Parathyroid hormone analogs and uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2040264A1 (en) * 1990-04-12 1991-10-13 Tatsuhiko Kanmera Parathyroid hormone antagonists
JPH05509098A (ja) * 1990-07-13 1993-12-16 ザ リージェンツ オブ ザ ユニバーシティー オブ カリフォルニア ３，６または９位において変性されている副甲状腺ホルモン類似体
AU672790B2 (en) * 1992-07-15 1996-10-17 Novartis Ag Variants of parathyroid hormone and its fragments

Also Published As

Publication number Publication date
IL114736A0 (en) 1995-11-27
AU3167095A (en) 1996-02-22
FI970168A7 (fi) 1997-01-15
CO4410206A1 (es) 1997-01-09
SK12097A3 (en) 1997-08-06
PL318017A1 (en) 1997-05-12
CA2192787A1 (en) 1996-02-08
MX9700446A (es) 1998-06-28
BR9508433A (pt) 1998-07-14
CZ23397A3 (en) 1997-07-16
JPH10502091A (ja) 1998-02-24
TR199500915A2 (tr) 1996-06-21
EP0773958A1 (en) 1997-05-21
NO970356D0 (no) 1997-01-28
WO1996003437A1 (en) 1996-02-08
FI970168L (fi) 1997-01-15
HUT77979A (hu) 1999-01-28
FI970168A0 (fi) 1997-01-15

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