NO970356L - PTH eller PTHrP antagonister - Google Patents

PTH eller PTHrP antagonister

Info

Publication number
NO970356L
NO970356L NO970356A NO970356A NO970356L NO 970356 L NO970356 L NO 970356L NO 970356 A NO970356 A NO 970356A NO 970356 A NO970356 A NO 970356A NO 970356 L NO970356 L NO 970356L
Authority
NO
Norway
Prior art keywords
pth
amino acid
pthrp
tryptophan
aromatic
Prior art date
Application number
NO970356A
Other languages
English (en)
Other versions
NO970356D0 (no
Inventor
Francois Cardinaux
Jean Honore M Feyen
Rainer Gamse
Frank Otto Gombert
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9415254A external-priority patent/GB9415254D0/en
Priority claimed from GB9415255A external-priority patent/GB9415255D0/en
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of NO970356L publication Critical patent/NO970356L/no
Publication of NO970356D0 publication Critical patent/NO970356D0/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PTH eller PTHrP forbindelser som har kraftig antagonistisk aktivitet ved PTH/PTHrP reseptoren hvori minst en av amino- syrerestene som naturlig forekommer i stillinger 2 og 10 er erstattet med tryptofan eller en annen aminosyrerest som bærer en aromatisk eller heteroaromatisk gruppe på sin sidekjede, og eventuelt er minst en av aminosyrerestene som naturlig forekommer i stillinger 3 og 6 videre erstattet med tryptofan eller en annen aminosyrerest som bærer en aromatisk eller heteroaromatisk gruppe på sin sidekjede, som har far- makologisk aktivitet, f.eks. forebygging eller behandling av tilstander som er assosiert med okt plasmakalsium forårsaket av overdreven frigivelse av PTH eller PTHrp.
NO970356A 1994-07-28 1997-01-28 PTH eller PTHrP antagonister NO970356D0 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9415254A GB9415254D0 (en) 1994-07-28 1994-07-28 Organic compounds
GB9415255A GB9415255D0 (en) 1994-07-28 1994-07-28 Organic compounds
PCT/EP1995/002993 WO1996003437A1 (en) 1994-07-28 1995-07-27 PTH OR PTHrP ANTAGONISTS

Publications (2)

Publication Number Publication Date
NO970356L true NO970356L (no) 1997-01-28
NO970356D0 NO970356D0 (no) 1997-01-28

Family

ID=26305357

Family Applications (1)

Application Number Title Priority Date Filing Date
NO970356A NO970356D0 (no) 1994-07-28 1997-01-28 PTH eller PTHrP antagonister

Country Status (15)

Country Link
EP (1) EP0773958A1 (no)
JP (1) JPH10502091A (no)
AU (1) AU3167095A (no)
BR (1) BR9508433A (no)
CA (1) CA2192787A1 (no)
CO (1) CO4410206A1 (no)
CZ (1) CZ23397A3 (no)
FI (1) FI970168L (no)
HU (1) HUT77979A (no)
IL (1) IL114736A0 (no)
NO (1) NO970356D0 (no)
PL (1) PL318017A1 (no)
SK (1) SK12097A3 (no)
TR (1) TR199500915A2 (no)
WO (1) WO1996003437A1 (no)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW505654B (en) * 1996-07-30 2002-10-11 Hoffmann La Roche Synthesis of analogs of PTH and PTHrP
AU3819497A (en) 1996-07-31 1998-02-20 General Hospital Corporation, The Novel parathyroid hormone-related peptide analogs
CZ106299A3 (cs) 1996-09-26 1999-08-11 Chugai Seiyaku Kabushiki Kaisha Protilátky proti proteinu příbuznému s lidským parathyroidálním hormonem
EA002819B1 (ru) 1997-05-14 2002-10-31 Авентис Фармасьютикалз Продактс Инк. Циклическое пептидное соединение и его применение, бициклопептидное соединение, пептидное соединение и его применение, фармацевтическая композиция
WO1998051329A1 (en) 1997-05-15 1998-11-19 Chugai Seiyaku Kabushiki Kaisha Cachexia remedy
TWI255718B (en) 1999-07-02 2006-06-01 Chugai Pharmaceutical Co Ltd Ameliorative agent for low vasopressin concentration
WO2001002011A1 (fr) * 1999-07-02 2001-01-11 Chugai Seiyaku Kabushiki Kaisha REMEDES CONTRE LES MALADIES CAUSEES PAR PTH OU PTHrP
WO2001002012A1 (fr) * 1999-07-06 2001-01-11 Chugai Seiyaku Kabushiki Kaisha Remedes contre l'hypercalcemie chimio-resistante
AU7363000A (en) * 1999-09-20 2001-04-24 Eli Lilly And Company Method for reducing the risk of cancer
WO2001054725A1 (en) * 2000-01-25 2001-08-02 Chugai Seiyaku Kabushiki Kaisha Remedies and preventives for dental diseases
CA2401357A1 (en) * 2000-02-28 2001-09-07 Chugai Seiyaku Kabushiki Kaisha Tissue degradation inhibitor agent
WO2001082968A1 (fr) 2000-04-28 2001-11-08 Chugai Seiyaku Kabushiki Kaisha Inhibiteurs de proliferation cellulaire
AU2001278742A1 (en) * 2000-08-16 2002-02-25 Chugai Seiyaku Kabushiki Kaisha Agents for ameliorating symptoms caused by joint diseases
BRPI0814962B8 (pt) 2007-08-01 2021-05-25 Chugai Pharmaceutical Co Ltd métodos in vitro para determinar se um composto candidato é um agonista de longa duração ou de curta duração de um receptor acoplado à proteína g, polipeptídeo, seu uso e composição farmacêutica
CN103002906B (zh) 2010-05-13 2017-12-29 总医院有限公司 甲状旁腺激素类似物及其应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2040264A1 (en) * 1990-04-12 1991-10-13 Tatsuhiko Kanmera Parathyroid hormone antagonists
WO1992000753A1 (en) * 1990-07-13 1992-01-23 The Regents Of The University Of California PARATHYROID HORMONE ANALOGUES MODIFIED AT POSITIONS 3, 6 or 9
AU672790B2 (en) * 1992-07-15 1996-10-17 Novartis Ag Variants of parathyroid hormone and its fragments

Also Published As

Publication number Publication date
WO1996003437A1 (en) 1996-02-08
TR199500915A2 (tr) 1996-06-21
PL318017A1 (en) 1997-05-12
MX9700446A (es) 1998-06-28
FI970168A0 (fi) 1997-01-15
NO970356D0 (no) 1997-01-28
AU3167095A (en) 1996-02-22
CO4410206A1 (es) 1997-01-09
SK12097A3 (en) 1997-08-06
IL114736A0 (en) 1995-11-27
JPH10502091A (ja) 1998-02-24
HUT77979A (hu) 1999-01-28
FI970168A7 (fi) 1997-01-15
CA2192787A1 (en) 1996-02-08
BR9508433A (pt) 1998-07-14
FI970168L (fi) 1997-01-15
EP0773958A1 (en) 1997-05-21
CZ23397A3 (en) 1997-07-16

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