NO970624L - In vivo mutasjoner og polymorfismer i det 17q-koblete bryst-og ovariekreft mottagelighetsgener - Google Patents

In vivo mutasjoner og polymorfismer i det 17q-koblete bryst-og ovariekreft mottagelighetsgener

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Publication number
NO970624L
NO970624L NO970624A NO970624A NO970624L NO 970624 L NO970624 L NO 970624L NO 970624 A NO970624 A NO 970624A NO 970624 A NO970624 A NO 970624A NO 970624 L NO970624 L NO 970624L
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Norway
Prior art keywords
ovarian cancer
breast
mutations
human
gene
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NO970624A
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English (en)
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NO970624D0 (no
Inventor
Donna M Shattuck-Eidens
Jacques Simard
Mitsuru Emi
Yusuke Nakamura
Francine Durocher
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Myriad Genetics Inc
Rech Du Chul Centre
Cancer Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27569596&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO970624(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/480,784 external-priority patent/US5693473A/en
Priority claimed from US08/483,553 external-priority patent/US5709999A/en
Application filed by Myriad Genetics Inc, Rech Du Chul Centre, Cancer Inst filed Critical Myriad Genetics Inc
Publication of NO970624D0 publication Critical patent/NO970624D0/no
Publication of NO970624L publication Critical patent/NO970624L/no

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Oncology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hospice & Palliative Care (AREA)
  • Public Health (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Foreliggende oppfinnelse vedrører generelt området human genetikk. Spesielt vedrøres fremgangsmåter og materialer benyttet til å isolere og detektere et human bryst- og ovariekreft predisponeringsgen (BRCA1), noen mutantalleler av hvilket forårsaker mottagelighet for kreft, særlig bryst- og ovariekreft. Mer spesielt vedrøres kjønnscelle-mutasjoner i BRCA1 genet og deres bruk i diagnose av predisponering av human bryst- og ovariekreft. Ytterligere vedrører oppfinnelsen somatiske mutasjoner i BRCA1 genet i human bryst- og ovariekreft og deres anvendelse i diagnose og prognose av human bryst- og ovariekreft. I tillegg vedrøres somatiske mutasjoner i BRCA1 genet i andre humane kreftformer og deres bruk i diagnose og prognose av humane krefttyper. Oppfinnelsen vedrører også behandling av human kreft som har mutasjoner i BRCA1 genet inkludert genterapi, proteinerstatningsterapi og proteinetterligninger. Det beskrives videre screening av legemidler for kreftbehandling. Endelig beskrives screening av BRCA1 genet for mutasjoner, som er nyttig for diagnostisering av predisponering av bryst- og ovariekreft.
NO970624A 1994-08-12 1997-02-11 In vivo mutasjoner og polymorfismer i det 17q-koblete bryst-og ovariekreft mottagelighetsgener NO970624L (no)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US28922194A 1994-08-12 1994-08-12
US30026694A 1994-09-02 1994-09-02
US30810494A 1994-09-16 1994-09-16
US34882494A 1994-11-29 1994-11-29
US40930595A 1995-03-24 1995-03-24
US08/480,784 US5693473A (en) 1994-08-12 1995-06-07 Linked breast and ovarian cancer susceptibility gene
US08/483,553 US5709999A (en) 1994-08-12 1995-06-07 Linked breast and ovarian cancer susceptibility gene
PCT/US1995/010202 WO1996005306A2 (en) 1994-08-12 1995-08-11 IN VIVO MUTATIONS AND POLYMORPHISMS IN THE 17q-LINKED BREAST AND OVARIAN CANCER SUSCEPTIBILITY GENE

Publications (2)

Publication Number Publication Date
NO970624D0 NO970624D0 (no) 1997-02-11
NO970624L true NO970624L (no) 1997-04-14

Family

ID=27569596

Family Applications (1)

Application Number Title Priority Date Filing Date
NO970624A NO970624L (no) 1994-08-12 1997-02-11 In vivo mutasjoner og polymorfismer i det 17q-koblete bryst-og ovariekreft mottagelighetsgener

Country Status (16)

Country Link
EP (1) EP0705903B2 (no)
JP (1) JP2002503943A (no)
CN (1) CN1172502A (no)
AT (1) ATE201445T1 (no)
AU (1) AU686004B2 (no)
CA (1) CA2196797C (no)
DE (1) DE69521002T3 (no)
DK (1) DK0705903T3 (no)
ES (1) ES2158048T5 (no)
FI (1) FI970513A7 (no)
GR (1) GR3036322T3 (no)
MX (1) MX9701075A (no)
NO (1) NO970624L (no)
NZ (1) NZ291621A (no)
PT (1) PT705903E (no)
WO (1) WO1996005306A2 (no)

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FI970513A0 (fi) 1997-02-07
WO1996005306A3 (en) 1996-03-14
ES2158048T3 (es) 2001-09-01
EP0705903B2 (en) 2009-08-12
AU686004B2 (en) 1998-01-29
EP0705903B1 (en) 2001-05-23
CA2196797A1 (en) 1996-02-22
CA2196797C (en) 2000-10-10
FI970513A7 (fi) 1997-04-07
WO1996005306A2 (en) 1996-02-22
NZ291621A (en) 1998-09-24
DE69521002T2 (de) 2001-11-15
CN1172502A (zh) 1998-02-04
GR3036322T3 (en) 2001-11-30
DE69521002D1 (de) 2001-06-28
MX9701075A (es) 1998-03-31
JP2002503943A (ja) 2002-02-05
AU3321295A (en) 1996-03-07
DK0705903T3 (da) 2001-08-27
PT705903E (pt) 2001-11-30
ATE201445T1 (de) 2001-06-15
NO970624D0 (no) 1997-02-11
DE69521002T3 (de) 2010-02-25
EP0705903A1 (en) 1996-04-10
ES2158048T5 (es) 2009-11-04

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