NO971811L - Bicykliske tetrahydropyrazolopyridiner og deres anvendelse som legemidler - Google Patents

Bicykliske tetrahydropyrazolopyridiner og deres anvendelse som legemidler

Info

Publication number
NO971811L
NO971811L NO971811A NO971811A NO971811L NO 971811 L NO971811 L NO 971811L NO 971811 A NO971811 A NO 971811A NO 971811 A NO971811 A NO 971811A NO 971811 L NO971811 L NO 971811L
Authority
NO
Norway
Prior art keywords
tnf
compounds
formula
tetrahydropyrazolopyridines
bicyclic
Prior art date
Application number
NO971811A
Other languages
English (en)
Other versions
NO971811D0 (no
Inventor
Allen Jacob Duplantier
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of NO971811D0 publication Critical patent/NO971811D0/no
Publication of NO971811L publication Critical patent/NO971811L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Forbindelser med formelen. hvor R, R, R.og X er som definert. Forbindelsene med formel I og farmasøytisk godtagbare salter derav er nyttig for å hemme fosfodiesterase (PDE) type IV og produksjon av tumor-nekrose-faktor(TNF) og for behandling av astma, artritt, bronkitt, kronisk obstruktiv luftveissykdom, psoriasis, allergisk rhinitt, dermatitt og andre inflammatoriske sykdommer, AIDS, septisk sjokk og andre sykdommer som involverer produksjon av TNF.
NO971811A 1994-10-20 1997-04-18 Bicykliske tetrahydropyrazolopyridiner og deres anvendelse som legemidler NO971811L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32643494A 1994-10-20 1994-10-20
PCT/IB1995/000847 WO1996012720A1 (en) 1994-10-20 1995-10-06 Bicyclic tetrahydro pyrazolopyridines and their use as medicaments

Publications (2)

Publication Number Publication Date
NO971811D0 NO971811D0 (no) 1997-04-18
NO971811L true NO971811L (no) 1997-06-18

Family

ID=23272184

Family Applications (1)

Application Number Title Priority Date Filing Date
NO971811A NO971811L (no) 1994-10-20 1997-04-18 Bicykliske tetrahydropyrazolopyridiner og deres anvendelse som legemidler

Country Status (16)

Country Link
EP (1) EP0787132A1 (no)
JP (1) JPH09511758A (no)
KR (1) KR970707124A (no)
CN (1) CN1050129C (no)
AU (1) AU702105B2 (no)
BR (1) BR9504491A (no)
CZ (1) CZ120097A3 (no)
FI (1) FI954991A7 (no)
HU (1) HUT77517A (no)
IL (1) IL115667A0 (no)
MX (1) MX9504422A (no)
NO (1) NO971811L (no)
NZ (1) NZ292991A (no)
PL (1) PL319758A1 (no)
WO (1) WO1996012720A1 (no)
ZA (1) ZA958839B (no)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP2001002304A0 (en) * 1996-05-03 2001-12-31 Pfizer Substituted indazole derivatives and related compounds
JP4373497B2 (ja) 1996-06-19 2009-11-25 ローン−プーラン・ロレ・リミテツド 置換されたアザビシクロ化合物、ならびにｔｎｆおよびサイクリックａｍｐホスホジエステラーゼ産生の阻害剤としてのそれらの使用
EA002274B1 (ru) * 1996-06-25 2002-02-28 Пфайзер Инк. Призводные замещенного индазола и их применение в качестве ингибиторов фосфодиэстеразы (фдэ) типа iv и фактора некроза опухоли (фно)
US6011159A (en) 1997-05-08 2000-01-04 Pfizer Inc Processes and intermediates for preparing substituted indazole derivatives
IL126745A (en) * 1997-11-04 2003-09-17 Pfizer Prod Inc Methods of preparing 4-cyano-4- (substituted indazole) cyclohexanecarboxylic acids useful as pde4 inhibitors
US6858616B2 (en) 1998-12-23 2005-02-22 Bristol-Myers Squibb Pharma Company Nitrogen containing heterobicycles as factor Xa inhibitors
CN100340559C (zh) 1998-12-23 2007-10-03 布里斯托尔-迈尔斯斯奎布药品公司 作为凝血因子xa抑制剂的含氮杂双环
US6326495B2 (en) 1999-04-30 2001-12-04 Pfizer Inc. Process for preparing 8-cyclopentyl-6-ethyl-3-[substituted]-5,8-dihydro-4H-1,2,3a,7,8-pentaaza-as-indacenes and intermediates useful therein
CA2715683A1 (en) 1999-08-21 2001-03-01 Nycomed Gmbh Synergistic combination
JP4555547B2 (ja) * 2000-08-10 2010-10-06 ファイザー イタリア ソシエタ ア レスポンサビリタ リミタータ キナーゼ阻害剤としての二環式ピラゾール、それらを製造するための方法およびそれらを含む医薬組成物
US6998408B2 (en) 2001-03-23 2006-02-14 Bristol-Myers Squibb Pharma Company 6-5, 6-6, or 6-7 Heterobicycles as factor Xa inhibitors
US6750225B2 (en) 2001-04-18 2004-06-15 Bristol-Myers Squibb Pharms Company 1,4,5,6-tetrahydropyrazolo-[3,4,-c]-pyridin-7-ones useful as factor Xa inhibitors
CA2441772A1 (en) 2001-04-18 2002-10-31 Bristol-Myers Squibb Company 1,4,5,6-tetrahydropyrazolo-¬3,4-c|-pyridin-7-ones as factor xa inhibitors
JP4196678B2 (ja) 2001-04-26 2008-12-17 味の素株式会社 複素環化合物
EP1427415B1 (en) 2001-09-21 2009-08-12 Brystol-Myers Squibb Company Lactam-containing compounds and derivatives thereof as factor xa inhibitors
TWI331526B (en) 2001-09-21 2010-10-11 Bristol Myers Squibb Pharma Co Lactam-containing compounds and derivatives thereof as factor xa inhibitors
CA2493625A1 (en) * 2002-07-25 2004-02-19 Pharmacia Italia S.P.A. Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
EA200501548A1 (ru) 2003-04-01 2006-02-24 Апплайд Резеч Системз Арс Холдинг Н.В. Ингибиторы фосфодиэстераз при бесплодии
FR2857363B1 (fr) * 2003-07-10 2007-09-07 Aventis Pharma Sa 4,5,6,7-tetrahydro-1h-pyrazolo[3,4-c] pyridines substituees compositions les contenant et utilisation
AR045037A1 (es) * 2003-07-10 2005-10-12 Aventis Pharma Sa Tetrahidro-1h-pirazolo [3,4-c] piridinas sustituidas, composiciones que las contienen y su utilizacion.
CA2632227A1 (en) * 2005-12-01 2007-06-07 Elan Pharmaceuticals, Inc. 5-(arylsulfonyl)-pyrazolopiperidines
WO2009134203A1 (en) * 2008-04-30 2009-11-05 Fredrik Almqvist New peptidomimetic compounds
US7741350B1 (en) 2009-01-28 2010-06-22 Cara Therapeutics, Inc. Bicyclic pyrazolo-heterocycles
WO2010088050A2 (en) 2009-01-28 2010-08-05 Cara Therapeutics, Inc. Bicyclic pyrazolo-heterocycles
TW201613917A (en) * 2014-06-06 2016-04-16 Biogen Ma Inc ATX modulating agents
CN115043768A (zh) * 2022-06-20 2022-09-13 新乡市润宇新材料科技有限公司 一种酸促进环丙基开环合成n-芳基吡咯烷-2-酮的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1463883A (fr) * 1964-09-08 1966-07-22 Ciba Geigy Procédé de préparation de triaza-composés bicycliques
US3365459A (en) * 1964-09-08 1968-01-23 Ciba Geigy Corp Certain tetrahydro pyrazolo-pyridine and pyrazolo-piperidine derivatives
US3340269A (en) * 1964-09-08 1967-09-05 Ciba Geigy Corp 1-substituted 4-acyl-2, 3-dioxo-piperidine
AU695301B2 (en) * 1993-07-06 1998-08-13 Pfizer Inc. Bicyclic tetrahydro pyrazolopyridines

Also Published As

Publication number Publication date
KR970707124A (ko) 1997-12-01
IL115667A0 (en) 1996-01-19
FI954991A0 (fi) 1995-10-19
CN1161040A (zh) 1997-10-01
EP0787132A1 (en) 1997-08-06
JPH09511758A (ja) 1997-11-25
NO971811D0 (no) 1997-04-18
MX9504422A (es) 1997-04-30
HUT77517A (hu) 1998-05-28
CN1050129C (zh) 2000-03-08
PL319758A1 (en) 1997-08-18
FI954991L (fi) 1996-04-21
CZ120097A3 (cs) 1998-01-14
NZ292991A (en) 1999-02-25
BR9504491A (pt) 1997-05-20
WO1996012720A1 (en) 1996-05-02
AU3531795A (en) 1996-05-15
FI954991A7 (fi) 1996-04-21
AU702105B2 (en) 1999-02-11
ZA958839B (en) 1997-04-21

Similar Documents

Publication Publication Date Title
CA2166721A1 (en) Bicyclic tetrahydro pyrazolopyridines
FI945555A0 (fi) Substituoituja oksindoleja
CA2150812A1 (en) Catechol diethers as selective pde iv inhibitors
DE60315674D1 (de) Neue imidazopyridine und ihre verwendung
MX9504422A (es) Tetrahidropirazolopiridinas biciclicas.
WO2004024728A3 (en) Pyrazolo[3,4-b]pyridine compounds, and their use as phosphodiesterase inhibitors
TR200100433T2 (tr) Fosfodiesteraz 4 önleyicileri olarak ikame edilmiş 1,8-naftiridin-4(1H)-onlar
NO962386L (no) Heterocykliske ring-kondenserte pyrimidin-derivater
NO980313L (no) N-(aroyl)glysin-hydroksaminsyre-derivater og beslektete forbindelser
MY116527A (en) Tricyclic 5, 6-dihydro-9h-pyrazolo [3,4,-c]-1,2,4- triazolo [4,3-a] pyridines
ATE284860T1 (de) Neue verwendung von phenylheteroalkylamin- derivaten
DE60305514D1 (de) Neue verwendung von benzothiazolderivaten
MXPA04010055A (es) Derivados de tioxantina como inhibidores de mieloperoxidasa.
DK0869945T3 (da) Catecholdiethere derivater nyttige som farmaceutisk middel
RU2738837C2 (ru) Некоторые ингибиторы протеинкиназы
ATE265428T1 (de) Neue verwendung von phenylheteroalkylamin- derivaten
ATE49765T1 (de) Triazolopyrimidinderivate.
MY135776A (en) PYRAZOLO [3,4-b] PYRIDINE COMPOUNDS, AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS
MXPA01009502A (en) Pyridine and pyrimidine derivatives and their use as inhibitors of cytokine mediated disease