NO971811L - Bicykliske tetrahydropyrazolopyridiner og deres anvendelse som legemidler - Google Patents

Bicykliske tetrahydropyrazolopyridiner og deres anvendelse som legemidler

Info

Publication number
NO971811L
NO971811L NO971811A NO971811A NO971811L NO 971811 L NO971811 L NO 971811L NO 971811 A NO971811 A NO 971811A NO 971811 A NO971811 A NO 971811A NO 971811 L NO971811 L NO 971811L
Authority
NO
Norway
Prior art keywords
tnf
compounds
formula
tetrahydropyrazolopyridines
bicyclic
Prior art date
Application number
NO971811A
Other languages
English (en)
Other versions
NO971811D0 (no
Inventor
Allen Jacob Duplantier
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of NO971811D0 publication Critical patent/NO971811D0/no
Publication of NO971811L publication Critical patent/NO971811L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Forbindelser med formelen. hvor R, R, R.og X er som definert. Forbindelsene med formel I og farmasøytisk godtagbare salter derav er nyttig for å hemme fosfodiesterase (PDE) type IV og produksjon av tumor-nekrose-faktor(TNF) og for behandling av astma, artritt, bronkitt, kronisk obstruktiv luftveissykdom, psoriasis, allergisk rhinitt, dermatitt og andre inflammatoriske sykdommer, AIDS, septisk sjokk og andre sykdommer som involverer produksjon av TNF.
NO971811A 1994-10-20 1997-04-18 Bicykliske tetrahydropyrazolopyridiner og deres anvendelse som legemidler NO971811L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32643494A 1994-10-20 1994-10-20
PCT/IB1995/000847 WO1996012720A1 (en) 1994-10-20 1995-10-06 Bicyclic tetrahydro pyrazolopyridines and their use as medicaments

Publications (2)

Publication Number Publication Date
NO971811D0 NO971811D0 (no) 1997-04-18
NO971811L true NO971811L (no) 1997-06-18

Family

ID=23272184

Family Applications (1)

Application Number Title Priority Date Filing Date
NO971811A NO971811L (no) 1994-10-20 1997-04-18 Bicykliske tetrahydropyrazolopyridiner og deres anvendelse som legemidler

Country Status (16)

Country Link
EP (1) EP0787132A1 (no)
JP (1) JPH09511758A (no)
KR (1) KR970707124A (no)
CN (1) CN1050129C (no)
AU (1) AU702105B2 (no)
BR (1) BR9504491A (no)
CZ (1) CZ120097A3 (no)
FI (1) FI954991A7 (no)
HU (1) HUT77517A (no)
IL (1) IL115667A0 (no)
MX (1) MX9504422A (no)
NO (1) NO971811L (no)
NZ (1) NZ292991A (no)
PL (1) PL319758A1 (no)
WO (1) WO1996012720A1 (no)
ZA (1) ZA958839B (no)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP2001002304A0 (en) * 1996-05-03 2001-12-31 Pfizer Substituted indazole derivatives and related compounds
CA2258728C (en) * 1996-06-19 2011-09-27 Rhone Poulenc Rorer Limited Substituted azabicylic compounds and their use as inhibitors of the production of tnf and cyclic amp phosphodiesterase
CN1080260C (zh) * 1996-06-25 2002-03-06 美国辉瑞有限公司 取代的吲哚衍生物以及它们作为iv型磷酸二酯酶(pde)和肿瘤坏死因子(tnf)抑制剂的用途
PT983249E (pt) 1997-05-08 2002-08-30 Pfizer Prod Inc Procesos e intermediarios para a preparacao de derivados de indazole substituidos
IL126745A (en) * 1997-11-04 2003-09-17 Pfizer Prod Inc Methods of preparing 4-cyano-4- (substituted indazole) cyclohexanecarboxylic acids useful as pde4 inhibitors
DE69921358T2 (de) 1998-12-23 2006-03-09 Bristol-Myers Squibb Pharma Co. Stickstoffhaltige heterobicyclen als faktor-xa-hemmer
US6858616B2 (en) 1998-12-23 2005-02-22 Bristol-Myers Squibb Pharma Company Nitrogen containing heterobicycles as factor Xa inhibitors
US6326495B2 (en) 1999-04-30 2001-12-04 Pfizer Inc. Process for preparing 8-cyclopentyl-6-ethyl-3-[substituted]-5,8-dihydro-4H-1,2,3a,7,8-pentaaza-as-indacenes and intermediates useful therein
EP1212089B1 (en) 1999-08-21 2006-03-22 ALTANA Pharma AG Synergistic combination of roflumilast and salmeterol
ES2349762T3 (es) * 2000-08-10 2011-01-11 Pfizer Italia S.R.L. Biciclo-pirazoles activos como inhibidores de quinasas, procedimientos para su preparación y composiciones farmacéuticas que los comprenden.
US6998408B2 (en) 2001-03-23 2006-02-14 Bristol-Myers Squibb Pharma Company 6-5, 6-6, or 6-7 Heterobicycles as factor Xa inhibitors
CA2441772A1 (en) 2001-04-18 2002-10-31 Bristol-Myers Squibb Company 1,4,5,6-tetrahydropyrazolo-¬3,4-c|-pyridin-7-ones as factor xa inhibitors
CA2444571A1 (en) 2001-04-18 2002-10-31 Bristol-Myers Squibb Company 1, 4, 5, 6-tetrahydropyrazolo-¬3, 4-c|-pyridin-7-ones as factor xa inhi bitors
US7902179B2 (en) 2001-04-26 2011-03-08 Ajinomoto Co., Inc. Heterocyclic compounds
TWI331526B (en) 2001-09-21 2010-10-11 Bristol Myers Squibb Pharma Co Lactam-containing compounds and derivatives thereof as factor xa inhibitors
CA2461202C (en) 2001-09-21 2011-07-12 Donald Pinto Lactam-containing compounds and derivatives thereof as factor xa inhibitors
CA2493625A1 (en) * 2002-07-25 2004-02-19 Pharmacia Italia S.P.A. Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
MXPA05010373A (es) 2003-04-01 2005-12-05 Applied Research Systems Inhibidores de fosfodiesterasas en infertilidad.
AR045037A1 (es) 2003-07-10 2005-10-12 Aventis Pharma Sa Tetrahidro-1h-pirazolo [3,4-c] piridinas sustituidas, composiciones que las contienen y su utilizacion.
FR2857363B1 (fr) * 2003-07-10 2007-09-07 Aventis Pharma Sa 4,5,6,7-tetrahydro-1h-pyrazolo[3,4-c] pyridines substituees compositions les contenant et utilisation
AR057959A1 (es) * 2005-12-01 2007-12-26 Elan Pharm Inc 5-pirazolpiperidinas-(sustituidas)
WO2009134203A1 (en) * 2008-04-30 2009-11-05 Fredrik Almqvist New peptidomimetic compounds
US7741350B1 (en) 2009-01-28 2010-06-22 Cara Therapeutics, Inc. Bicyclic pyrazolo-heterocycles
KR101787116B1 (ko) 2009-01-28 2017-10-18 케러 테라퓨틱스, 인코포레이티드 바이시클릭 피라졸로-헤테로사이클
TW201613917A (en) * 2014-06-06 2016-04-16 Biogen Ma Inc ATX modulating agents
CN115043768A (zh) * 2022-06-20 2022-09-13 新乡市润宇新材料科技有限公司 一种酸促进环丙基开环合成n-芳基吡咯烷-2-酮的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3340269A (en) * 1964-09-08 1967-09-05 Ciba Geigy Corp 1-substituted 4-acyl-2, 3-dioxo-piperidine
US3365459A (en) * 1964-09-08 1968-01-23 Ciba Geigy Corp Certain tetrahydro pyrazolo-pyridine and pyrazolo-piperidine derivatives
FR1463883A (fr) * 1964-09-08 1966-07-22 Ciba Geigy Procédé de préparation de triaza-composés bicycliques
RU2131876C1 (ru) * 1993-07-06 1999-06-20 Пфайзер Инк. Бициклические тетрагидропиразолпиридины или их фармацевтически приемлемые соли, фармацевтическая композиция, способ ингибирования фосфодиэстеразы, способ лечения

Also Published As

Publication number Publication date
CZ120097A3 (cs) 1998-01-14
CN1161040A (zh) 1997-10-01
EP0787132A1 (en) 1997-08-06
MX9504422A (es) 1997-04-30
JPH09511758A (ja) 1997-11-25
BR9504491A (pt) 1997-05-20
AU702105B2 (en) 1999-02-11
ZA958839B (en) 1997-04-21
FI954991L (fi) 1996-04-21
WO1996012720A1 (en) 1996-05-02
HUT77517A (hu) 1998-05-28
AU3531795A (en) 1996-05-15
NZ292991A (en) 1999-02-25
FI954991A0 (fi) 1995-10-19
FI954991A7 (fi) 1996-04-21
KR970707124A (ko) 1997-12-01
NO971811D0 (no) 1997-04-18
CN1050129C (zh) 2000-03-08
IL115667A0 (en) 1996-01-19
PL319758A1 (en) 1997-08-18

Similar Documents

Publication Publication Date Title
NO971811L (no) Bicykliske tetrahydropyrazolopyridiner og deres anvendelse som legemidler
CA2166721A1 (en) Bicyclic tetrahydro pyrazolopyridines
FI945555A0 (fi) Substituoituja oksindoleja
CA2150812A1 (en) Catechol diethers as selective pde iv inhibitors
DE60004655T2 (de) Pyridin- und pyrimidinderivate und deren verwendung als inhibitor von cytokinbedingten krankheiten
ATE370138T1 (de) Neue imidazopyridine und ihre verwendung
WO2004024728A3 (en) Pyrazolo[3,4-b]pyridine compounds, and their use as phosphodiesterase inhibitors
TR200100433T2 (tr) Fosfodiesteraz 4 önleyicileri olarak ikame edilmiş 1,8-naftiridin-4(1H)-onlar
NO962386L (no) Heterocykliske ring-kondenserte pyrimidin-derivater
MY116527A (en) Tricyclic 5, 6-dihydro-9h-pyrazolo [3,4,-c]-1,2,4- triazolo [4,3-a] pyridines
DE60305514D1 (de) Neue verwendung von benzothiazolderivaten
DK0869945T3 (da) Catecholdiethere derivater nyttige som farmaceutisk middel
RU2738837C2 (ru) Некоторые ингибиторы протеинкиназы
AU580050B2 (en) Triazolopyrimidine derivatives
MY135776A (en) PYRAZOLO [3,4-b] PYRIDINE COMPOUNDS, AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS
MXPA01009502A (en) Pyridine and pyrimidine derivatives and their use as inhibitors of cytokine mediated disease