NO971836L - Rekombinante Alternaria alternata allergener - Google Patents
Rekombinante Alternaria alternata allergenerInfo
- Publication number
- NO971836L NO971836L NO971836A NO971836A NO971836L NO 971836 L NO971836 L NO 971836L NO 971836 A NO971836 A NO 971836A NO 971836 A NO971836 A NO 971836A NO 971836 L NO971836 L NO 971836L
- Authority
- NO
- Norway
- Prior art keywords
- protein
- allergens
- alt
- allergen
- recombinant
- Prior art date
Links
- 239000013566 allergen Substances 0.000 title abstract 6
- 241000223602 Alternaria alternata Species 0.000 title abstract 3
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 3
- 206010020751 Hypersensitivity Diseases 0.000 abstract 2
- 102000002278 Ribosomal Proteins Human genes 0.000 abstract 2
- 108010000605 Ribosomal Proteins Proteins 0.000 abstract 2
- 208000026935 allergic disease Diseases 0.000 abstract 2
- 230000007815 allergy Effects 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 241000233866 Fungi Species 0.000 abstract 1
- 102000006010 Protein Disulfide-Isomerase Human genes 0.000 abstract 1
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 abstract 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 abstract 1
- 210000003719 b-lymphocyte Anatomy 0.000 abstract 1
- 230000000903 blocking effect Effects 0.000 abstract 1
- 239000002299 complementary DNA Substances 0.000 abstract 1
- 230000016396 cytokine production Effects 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 206010025135 lupus erythematosus Diseases 0.000 abstract 1
- 230000004492 positive regulation of T cell proliferation Effects 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 108020003519 protein disulfide isomerase Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Mycology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
Denne oppfinnelsen vedrører den fullstendige cDNA-sekvens av Alternaria alternata-allergenene Alt a 45 og Alt a 12. Det er blitt mulig innenfor rammen av den molekylærbiologiske analyse av allergenene å identifisere Alt a 45 som en proteindisulfidisomerase. Dette protein er et 45 kD stort protein som 47% av pasientene reagerer på, og er således et viktig primært allergen. Alt a 12 som 8% av pasientene reagerer på ble identifisert som et ribosomalt protein som er av interesse fordi autoantistoffer mot ribosomale proteiner blir funnet i pasienter som lider av lupus. Det gjenstår å se hvorvidt det er en eventuell forbindelse mellom allergi mot muggsopp og autcimmuniske sykdommer. Ved anvendelse av denne rekombinante sekvens og datamaskinanalyse er det blitt mulig å identifisere svært potente B- og T- celieepitoper og å anvende peptidene avledet fra de rekombinante proteiner for diagnosen av allergi mot alternaria alternata muggsopper. Peptidene har også vist seg egnet både for in vitro og in vivo allergenspesifik stimulering av T-celler proliterasjon, interleukinfremstiiling, og for blokkering av T-cellcne som resulterer i en toleranse av de allergenspesifikke T-lymfocytter.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT0203894A AT401181B (de) | 1994-11-02 | 1994-11-02 | Rekombinante dna moleküle |
| PCT/AT1995/000212 WO1996014407A1 (de) | 1994-11-02 | 1995-10-31 | Rekombinante alternaria alternata allergene |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO971836D0 NO971836D0 (no) | 1997-04-21 |
| NO971836L true NO971836L (no) | 1997-06-25 |
Family
ID=3526463
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO971836A NO971836L (no) | 1994-11-02 | 1997-04-21 | Rekombinante Alternaria alternata allergener |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0787184A1 (no) |
| JP (1) | JPH10508474A (no) |
| AT (1) | AT401181B (no) |
| AU (1) | AU3736795A (no) |
| CA (1) | CA2204362A1 (no) |
| FI (1) | FI971894A0 (no) |
| NO (1) | NO971836L (no) |
| WO (1) | WO1996014407A1 (no) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201209862D0 (en) | 2012-06-01 | 2012-07-18 | Circassia Ltd | Cladosporium peptides |
| CN116098124B (zh) * | 2022-12-16 | 2025-02-11 | 中国医学科学院北京协和医院 | 利用Alt a 1对链格孢霉过敏性哮喘小鼠行皮下特异性免疫治疗模型的建立方法 |
-
1994
- 1994-11-02 AT AT0203894A patent/AT401181B/de active
-
1995
- 1995-10-31 AU AU37367/95A patent/AU3736795A/en not_active Abandoned
- 1995-10-31 WO PCT/AT1995/000212 patent/WO1996014407A1/de not_active Ceased
- 1995-10-31 CA CA002204362A patent/CA2204362A1/en not_active Abandoned
- 1995-10-31 EP EP95935287A patent/EP0787184A1/de not_active Withdrawn
- 1995-10-31 FI FI971894A patent/FI971894A0/fi not_active Application Discontinuation
- 1995-10-31 JP JP8514890A patent/JPH10508474A/ja active Pending
-
1997
- 1997-04-21 NO NO971836A patent/NO971836L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATA203894A (de) | 1995-11-15 |
| FI971894L (fi) | 1997-05-02 |
| JPH10508474A (ja) | 1998-08-25 |
| FI971894A7 (fi) | 1997-05-02 |
| EP0787184A1 (de) | 1997-08-06 |
| NO971836D0 (no) | 1997-04-21 |
| AU3736795A (en) | 1996-05-31 |
| WO1996014407A1 (de) | 1996-05-17 |
| FI971894A0 (fi) | 1997-05-02 |
| CA2204362A1 (en) | 1996-05-17 |
| AT401181B (de) | 1996-07-25 |
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