NO972525L - Nye benzimidazolderivater med antihistaminaktivitet - Google Patents

Nye benzimidazolderivater med antihistaminaktivitet

Info

Publication number
NO972525L
NO972525L NO972525A NO972525A NO972525L NO 972525 L NO972525 L NO 972525L NO 972525 A NO972525 A NO 972525A NO 972525 A NO972525 A NO 972525A NO 972525 L NO972525 L NO 972525L
Authority
NO
Norway
Prior art keywords
benzimidazole derivatives
antihistamine activity
new benzimidazole
new
antihistamine
Prior art date
Application number
NO972525A
Other languages
English (en)
Other versions
NO972525D0 (no
NO313195B1 (no
Inventor
Aurelio Orjales
Victor Rubio
Maravillas Bordell
Original Assignee
Espanola Prod Quimicos
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Espanola Prod Quimicos filed Critical Espanola Prod Quimicos
Publication of NO972525D0 publication Critical patent/NO972525D0/no
Publication of NO972525L publication Critical patent/NO972525L/no
Publication of NO313195B1 publication Critical patent/NO313195B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO19972525A 1996-06-04 1997-06-03 Nye benzimidazolderivater med antihistaminaktivitet og farmasöytisk preparat inneholdende disse NO313195B1 (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09601236A ES2124167B1 (es) 1996-06-04 1996-06-04 Nuevos derivados del bencimidazol con actividad antihistaminica.

Publications (3)

Publication Number Publication Date
NO972525D0 NO972525D0 (no) 1997-06-03
NO972525L true NO972525L (no) 1997-12-05
NO313195B1 NO313195B1 (no) 2002-08-26

Family

ID=8295035

Family Applications (2)

Application Number Title Priority Date Filing Date
NO19972525A NO313195B1 (no) 1996-06-04 1997-06-03 Nye benzimidazolderivater med antihistaminaktivitet og farmasöytisk preparat inneholdende disse
NO2011008C NO2011008I2 (no) 1996-06-04 2011-05-24 Bilastine eller et addisjonssalt derav

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO2011008C NO2011008I2 (no) 1996-06-04 2011-05-24 Bilastine eller et addisjonssalt derav

Country Status (27)

Country Link
US (1) US5877187A (no)
EP (1) EP0818454B1 (no)
JP (1) JP4218991B2 (no)
CN (1) CN1105716C (no)
AR (1) AR008386A1 (no)
AT (1) ATE264317T1 (no)
AU (1) AU725700B2 (no)
BR (1) BR9703276A (no)
CA (1) CA2206754C (no)
CZ (1) CZ289278B6 (no)
DE (2) DE69728608T2 (no)
DK (1) DK0818454T3 (no)
ES (1) ES2124167B1 (no)
FR (1) FR11C0023I2 (no)
HR (1) HRP970307B1 (no)
HU (1) HU227598B1 (no)
IN (1) IN186319B (no)
LU (1) LU91798I2 (no)
MX (1) MXPA97004127A (no)
NO (2) NO313195B1 (no)
PL (1) PL188908B1 (no)
PT (1) PT818454E (no)
RU (1) RU2182150C2 (no)
SI (1) SI0818454T1 (no)
TR (1) TR199700464A3 (no)
TW (1) TW438794B (no)
ZA (1) ZA974893B (no)

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CA2332178A1 (en) 1998-07-01 2000-01-13 Takeda Chemical Industries, Ltd. Retinoid-associated receptor function regulating agent
USRE39608E1 (en) 1998-11-27 2007-05-01 Abbott Gmbh & Co. Kg Substituted benzimidazoles and their use as PARP inhibitors
ES2151442B1 (es) * 1999-01-11 2001-07-01 Espanola Prod Quimicos Nuevo derivado del bencenoetanol.
US6826561B2 (en) 2000-05-22 2004-11-30 Broadcom Corporation Method and apparatus for performing a binary search on an expanded tree
RU2288917C2 (ru) * 2002-04-19 2006-12-10 Фаэс Фарма, С.А. Полиморф 4-[2-[4-[1-(2-этоксиэтил)-1h-бензимидазол-2-ил]-1-пиперидинил]этил]-альфа, альфа-диметилбензолуксусной кислоты, способ его получения, фармацевтический препарат на его основе и его применение
SI1505066T1 (sl) * 2002-04-19 2007-04-30 Faes Farma Sa Polimorf 4-(2-(4-(1-(2-etoksietil)-1h-benzimidazol-2-il) -1-piperidinil)-alfa, alfa-dimetil-benzenocetne kisline
MXPA04012628A (es) * 2002-06-13 2005-03-23 Patricia Olivershaffer DERIVADOS Y COMPUESTOS RELACIONADOS DEL áCIDO 2-UREIDO-6-HETEROARIL-3H-BENZOIMIDAZOL-4-CARBOXILICO COMO INHIBIDORES DE GIRASA Y/O TOPOISOMERASA IV PARA EL TRATAMIENTO DE INFECCIONES BACTERIALES.
US20070188330A1 (en) * 2006-01-24 2007-08-16 Morhard Robert C System and method for detecting, monitoring, tracking and identifying explosive materials using ID marks
US7247623B2 (en) * 2005-08-19 2007-07-24 Inspire Pharmaceuticals, Inc. Method of treating dry eye disease with non-drying antihistamines
KR101123903B1 (ko) 2008-02-12 2012-03-23 주식회사유한양행 2-메틸-2'-페닐프로피온산 유도체의 제조 방법 및 이에 사용되는 신규한 중간체 화합물
JP2010013472A (ja) * 2009-09-09 2010-01-21 Faes Farma Sa ４−［２−［１−（２−エトキシエチル）−１Ｈ−ベンズイミダゾール−２−イル］−１−ピペリジニル］エチル］−α，α−ジメチルベンゼノ酢酸の多形体
CN102675101B (zh) * 2012-05-16 2014-01-29 王蕾 2-(4-卤乙基)苯基-2-甲基丙酸酯的制备方法及合成比拉斯汀的方法
CZ307500B6 (cs) 2012-08-15 2018-10-24 Zentiva, K.S. Způsob přípravy derivátu 2-methyl-2´-fenylpropionové kyseliny využívající nové intermediáty
JP6284616B2 (ja) * 2013-03-15 2018-02-28 ハーキュリーズ・インコーポレーテッドＨｅｒｃｕｌｅｓ Ｉｎｃｏｒｐｏｒａｔｅｄ 沈着特性が改善されたパーソナルケア組成物を生成する組成物及び方法
CN103214454A (zh) * 2013-03-30 2013-07-24 北京万全德众医药生物技术有限公司 一种比拉斯汀晶型及制备方法
CN103214455B (zh) * 2013-03-30 2018-08-31 北京万全德众医药生物技术有限公司 一种比拉斯汀的制备方法
WO2014188453A2 (en) * 2013-05-24 2014-11-27 Msn Laboratories Private Limited Novel process for the preparation of 2-[4-(2-{4-[1-(2-ethoxyethyl)-1h-benzimidazol-2-yl]-1-piperidinyl}ethyl) phenyl]-2-methylpropanoic acid
CN103351380B (zh) * 2013-06-30 2019-01-22 北京万全德众医药生物技术有限公司 一种制备比拉斯汀的方法
CN104447683A (zh) * 2013-09-12 2015-03-25 天津市汉康医药生物技术有限公司 一种稳定的比拉斯汀化合物
CN103896915A (zh) * 2014-04-01 2014-07-02 中国药科大学 苯并咪唑类衍生物、其制备方法及其在医药上的应用
EP3040334A1 (en) 2014-12-29 2016-07-06 Faes Farma, S.A. New benzimidazole derivatives as antihistamine agents
CN106349214B (zh) * 2015-07-13 2020-11-03 南京长澳医药科技有限公司 一种比拉斯汀杂质的制备方法
KR102657147B1 (ko) * 2015-07-24 2024-04-12 울퀴마, 에스. 에이. 빌라스틴의 결정형 및 그의 제조 방법
CN105272977A (zh) * 2015-09-19 2016-01-27 万全万特制药江苏有限公司 一种制备比拉斯汀中间体的方法
EP3170817A1 (en) 2015-11-20 2017-05-24 Faes Farma, S.A. Co-crystals of benzimidazole compounds
EP3170816A1 (en) 2015-11-20 2017-05-24 Faes Farma, S.A. Supersaturated compositions of benzimidazole compounds
WO2017167949A1 (en) 2016-04-01 2017-10-05 Krka, D.D., Novo Mesto Crystalline forms of bilastine
WO2017191651A1 (en) * 2016-05-05 2017-11-09 Msn Laboratories Private Limited, R & D Center Solid state forms of 2-[4-(2-{4-[1-(2-ethoxyethyl)-1h-benzimidazol-2-yl]-1-piperidinyl}ethyl)phenyl]-2-methylpropanoic acid and process for preparation thereof
CN107365298A (zh) * 2017-03-14 2017-11-21 罗欣生物科技（上海）有限公司 一种2‑甲基‑2’‑苯基丙酸衍生物的制备方法
CN109456316A (zh) * 2017-09-06 2019-03-12 万全万特制药江苏有限公司 一种比拉斯汀杂质的制备方法
EP3453384B1 (en) 2017-09-07 2020-05-27 Alfred E. Tiefenbacher (GmbH & Co. KG) Pharmaceutical tablet composition comprising bilastine
KR20200125923A (ko) 2017-10-16 2020-11-05 파에스 파마, 에스.에이. 빌라스틴 및 모메타손을 포함하는 수성 조성물
ES2835287T3 (es) 2017-12-18 2021-06-22 Tiefenbacher Alfred E Gmbh & Co Kg Composición farmacéutica de comprimido que comprende la forma polimórfica 3 de bilastina y aluminometasilicato de magnesio
EP3641735B1 (en) 2017-12-18 2021-02-24 Alfred E. Tiefenbacher (GmbH & Co. KG) Pharmaceutical tablet composition comprising bilastine form 3 and a water-soluble filler
CA3088740A1 (en) 2018-01-18 2019-07-25 Faes Farma, S.A. Ophthalmic compositions comprising bilastine, a beta-cyclodextrin and at least one gelling agent
CN109081827A (zh) * 2018-11-06 2018-12-25 北京天弘天达医药科技股份有限公司 一种比拉斯汀的制备方法及应用
EP3725298A1 (en) 2019-04-16 2020-10-21 Faes Farma, S.A. Stable and preserved pharmaceutical compositions of bilastine
PY2162539A (es) 2020-07-30 2022-02-15 Faes Farma Sa Sistema de administración de fármacos descongestivos y bilastina
CN112110893A (zh) * 2020-10-28 2020-12-22 山东齐环医药科技有限公司 一种比拉斯汀的制备方法
US20230414597A1 (en) 2020-11-18 2023-12-28 BioPharma Synergies, S. L. Orodispersible powder composition comprising an antihistamine compound
WO2022135863A1 (en) 2020-12-23 2022-06-30 Biohorm, S.L. A non-micronized bilastine composition
WO2023156559A1 (en) 2022-02-17 2023-08-24 Faes Farma, S.A. Bilastine composition for once-daily parenteral administration
WO2024224326A1 (en) * 2023-04-27 2024-10-31 Leiutis Pharmaceuticals Llp Liquid parenteral formulations of bilastine
WO2024224308A1 (en) * 2023-04-27 2024-10-31 Leiutis Pharmaceuticals Llp Liquid parenteral formulations of bilastine free of cyclodextrins

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8904174D0 (en) * 1989-02-23 1989-04-05 British Bio Technology Compounds
CA2077897A1 (en) * 1990-04-13 1991-10-14 Robert G. Franz Substituted benzimidazoles
ES2048109B1 (es) * 1992-07-20 1994-12-16 Espanola Prod Quimicos Procedimiento de preparacion de nuevos derivados piperidicos del bencimidazol.
FI950467A7 (fi) * 1992-08-03 1995-03-31 Sepracor Inc Terfenadiinin metaboliitit ja niiden optisesti puhtaat isomeerit aller gisten sairauksien hoitamiseksi
EP1953142A1 (en) * 1993-06-25 2008-08-06 Aventis Inc. Process for the preparation of antihistaminic 4-diphenylmethyl piperidine derivatives

Also Published As

Publication number Publication date
AR008386A1 (es) 2000-01-19
US5877187A (en) 1999-03-02
AU725700B2 (en) 2000-10-19
TR199700464A2 (xx) 1997-12-21
NO972525D0 (no) 1997-06-03
IN186319B (no) 2001-08-04
DE69728608T2 (de) 2005-04-21
ES2124167B1 (es) 1999-09-16
NO313195B1 (no) 2002-08-26
ATE264317T1 (de) 2004-04-15
DE122011000006I1 (de) 2011-06-16
PL188908B1 (pl) 2005-05-31
RU2182150C2 (ru) 2002-05-10
NO2011008I2 (no) 2012-05-14
LU91798I2 (fr) 2011-05-23
TW438794B (en) 2001-06-07
HU9700997D0 (en) 1997-07-28
DE69728608D1 (de) 2004-05-19
FR11C0023I2 (fr) 2012-03-16
CA2206754C (en) 2007-01-23
PT818454E (pt) 2004-08-31
MXPA97004127A (es) 2005-07-25
CN1105716C (zh) 2003-04-16
BR9703276A (pt) 2004-08-17
DK0818454T3 (da) 2004-07-12
EP0818454A1 (en) 1998-01-14
EP0818454B1 (en) 2004-04-14
ZA974893B (en) 1997-12-30
NO2011008I1 (no) 2011-06-06
HUP9700997A1 (hu) 1999-09-28
CZ172397A3 (en) 1997-12-17
JP4218991B2 (ja) 2009-02-04
JPH1059961A (ja) 1998-03-03
CA2206754A1 (en) 1997-12-04
SI0818454T1 (en) 2004-08-31
HU227598B1 (en) 2011-09-28
TR199700464A3 (tr) 1997-12-21
CN1176964A (zh) 1998-03-25
HRP970307B1 (en) 2002-02-28
HRP970307A2 (en) 1998-04-30
CZ289278B6 (cs) 2001-12-12
PL320358A1 (en) 1997-12-08
AU2467297A (en) 1997-12-11
FR11C0023I1 (no) 2011-08-19
ES2124167A1 (es) 1999-01-16

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Legal Events

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SPCF Filing of supplementary protection certificate

Free format text: PRODUCT NAME: ZILAS; NAT. REG. NO/DATE: 09-6621 20110413; FIRST REG. NO/DATE: IS/1/10/002/01 20100923

Spc suppl protection certif: 2011008

Filing date: 20110524

SPCG Granted supplementary protection certificate

Free format text: PRODUCT NAME: ZILAS; NAT. REG. NO/DATE: 09-6621 20110413; FIRST REG. NO/DATE: IS/1/10/002/01 20100923

Spc suppl protection certif: 2011008

Filing date: 20110524

Extension date: 20220603

MK1K Patent expired
SPCX Expiry of an spc

Spc suppl protection certif: 2011008