NO972887L - Piperidinedacetic acid derivatives useful as fibrinogen antagonist agent - Google Patents

Piperidinedacetic acid derivatives useful as fibrinogen antagonist agent

Info

Publication number
NO972887L
NO972887L NO972887A NO972887A NO972887L NO 972887 L NO972887 L NO 972887L NO 972887 A NO972887 A NO 972887A NO 972887 A NO972887 A NO 972887A NO 972887 L NO972887 L NO 972887L
Authority
NO
Norway
Prior art keywords
piperidinedacetic
acid derivatives
derivatives useful
antagonist agent
fibrinogen antagonist
Prior art date
Application number
NO972887A
Other languages
Norwegian (no)
Other versions
NO972887D0 (en
Inventor
David George Allen
Colin David Eldred
William Leonard Mitchell
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9426231.8A external-priority patent/GB9426231D0/en
Priority claimed from GBGB9503133.2A external-priority patent/GB9503133D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of NO972887D0 publication Critical patent/NO972887D0/en
Publication of NO972887L publication Critical patent/NO972887L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Denne oppfinnelse tilveiebringer forbindelsene med formel (1) 0) COjH og farmasøytisk akseptable derivater derav, hvori: X representerer enten CHj-CHj eller CH=CH; og Y "representerer et hydrogenatom eller en fenylmetylgruppe, hvori fenylgruppen eventuelt er substituert med ett eller flere halogenatomer. Forbindelser med formel (1) inhiberer blodplateaggregering.This invention provides the compounds of formula (1) O) CO 2 H and pharmaceutically acceptable derivatives thereof, wherein: X represents either CH 2 -CH 2 or CH = CH; and Y "represents a hydrogen atom or a phenylmethyl group, wherein the phenyl group is optionally substituted by one or more halogen atoms. Compounds of formula (1) inhibit platelet aggregation.

NO972887A 1994-12-23 1997-06-20 Piperidinedacetic acid derivatives useful as fibrinogen antagonist agent NO972887L (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9426231.8A GB9426231D0 (en) 1994-12-23 1994-12-23 Chemical compounds
GBGB9503133.2A GB9503133D0 (en) 1995-02-17 1995-02-17 Chemical compounds
PCT/EP1995/005043 WO1996020192A1 (en) 1994-12-23 1995-12-21 Piperidineacetic acid derivatives useful as fibrinogen antagonist agent

Publications (2)

Publication Number Publication Date
NO972887D0 NO972887D0 (en) 1997-06-20
NO972887L true NO972887L (en) 1997-08-20

Family

ID=26306268

Family Applications (1)

Application Number Title Priority Date Filing Date
NO972887A NO972887L (en) 1994-12-23 1997-06-20 Piperidinedacetic acid derivatives useful as fibrinogen antagonist agent

Country Status (21)

Country Link
US (1) US5861414A (en)
EP (1) EP0799223B1 (en)
JP (1) JPH10511375A (en)
CN (1) CN1175254A (en)
AP (1) AP9701010A0 (en)
AR (1) AR002260A1 (en)
AT (1) ATE181071T1 (en)
AU (1) AU704496B2 (en)
CO (1) CO4700291A1 (en)
DE (1) DE69510228T2 (en)
DK (1) DK0799223T3 (en)
ES (1) ES2132761T3 (en)
FI (1) FI972684A7 (en)
GR (1) GR3031027T3 (en)
IL (1) IL116480A0 (en)
NO (1) NO972887L (en)
NZ (1) NZ298400A (en)
PE (1) PE63696A1 (en)
SI (1) SI0799223T1 (en)
WO (1) WO1996020192A1 (en)
ZA (1) ZA951822B (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5760028A (en) * 1995-12-22 1998-06-02 The Dupont Merck Pharmaceutical Company Integrin receptor antagonists
GB9613096D0 (en) * 1996-06-21 1996-08-28 Glaxo Group Ltd Medicaments
DE59713007D1 (en) 1996-10-14 2009-06-25 Bayer Healthcare Ag NEW HETEROCYCLYLMETHYL-SUBSTITUTED PYRAZOLE DERIVATIVES AND THEIR USE IN THE TREATMENT OF HEART CIRCULATION DISEASES
WO1998043962A1 (en) * 1997-03-28 1998-10-08 Du Pont Pharmaceuticals Company Heterocyclic integrin inhibitor prodrugs
US7141581B2 (en) * 1999-07-02 2006-11-28 Agouron Pharmaceuticals, Inc. Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use
TWI262914B (en) * 1999-07-02 2006-10-01 Agouron Pharma Compounds and pharmaceutical compositions for inhibiting protein kinases
PE20010306A1 (en) * 1999-07-02 2001-03-29 Agouron Pharma INDAZOLE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM USEFUL FOR THE INHIBITION OF PROTEIN KINASE
YU54202A (en) 2000-01-18 2006-01-16 Agouron Pharmaceuticals Inc. Indazole compounds,pharmaceutical compositions,and methods for mediating or inhibiting cell proliferation
BR0116323A (en) * 2000-12-22 2003-10-14 Wyeth Corp Heterocyclylazole and -azaindazole compounds as 5-hydroxytryptamine-6 ligands
US7008953B2 (en) 2003-07-30 2006-03-07 Agouron Pharmaceuticals, Inc. 3, 5 Disubstituted indazole compounds, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation
GB0400895D0 (en) * 2004-01-15 2004-02-18 Smithkline Beecham Corp Chemical compounds
AR050253A1 (en) * 2004-06-24 2006-10-11 Smithkline Beecham Corp COMPOSITE DERIVED FROM INDAZOL CARBOXAMIDE, COMPOSITION THAT INCLUDES IT AND ITS USE FOR THE PREPARATION OF A MEDICINAL PRODUCT
US8063071B2 (en) 2007-10-31 2011-11-22 GlaxoSmithKline, LLC Chemical compounds
PE20081889A1 (en) 2007-03-23 2009-03-05 Smithkline Beecham Corp INDOL CARBOXAMIDES AS INHIBITORS OF IKK2
GB201511382D0 (en) 2015-06-29 2015-08-12 Imp Innovations Ltd Novel compounds and their use in therapy
WO2024052684A1 (en) 2022-09-09 2024-03-14 MyricX Pharma Limited Antibody drug conjugate comprising nmt inhibitor and its use

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3681382A (en) * 1969-02-07 1972-08-01 Ciba Geigy Corp 3-aminoindazoles
AU2915892A (en) * 1991-11-14 1993-06-15 Glaxo Group Limited Piperidine acetic acid derivatives as inhibitors of fibrinogen-dependent blood platelet aggregation
US5219867A (en) * 1991-12-16 1993-06-15 Research Corporation Technologies, Inc. Platelet aggregation inhibitory agents
JPH05255308A (en) * 1992-03-11 1993-10-05 Ajinomoto Co Inc Piperidine derivative
JP3194777B2 (en) * 1992-03-13 2001-08-06 学校法人東京薬科大学 Stereoselective D-ribofuranosylation method
JPH06234633A (en) * 1993-02-10 1994-08-23 Ajinomoto Co Inc Amine derivative and antiplatelet agent containing the derivative

Also Published As

Publication number Publication date
NO972887D0 (en) 1997-06-20
JPH10511375A (en) 1998-11-04
WO1996020192A1 (en) 1996-07-04
ZA951822B (en) 1996-09-26
ATE181071T1 (en) 1999-06-15
DK0799223T3 (en) 1999-12-27
PE63696A1 (en) 1997-01-11
FI972684A0 (en) 1997-06-19
AP9701010A0 (en) 1997-07-31
CN1175254A (en) 1998-03-04
IL116480A0 (en) 1996-03-31
AR002260A1 (en) 1998-03-11
DE69510228T2 (en) 1999-11-04
ES2132761T3 (en) 1999-08-16
EP0799223A1 (en) 1997-10-08
AU4387896A (en) 1996-07-19
US5861414A (en) 1999-01-19
NZ298400A (en) 1999-10-28
GR3031027T3 (en) 1999-12-31
CO4700291A1 (en) 1998-12-29
DE69510228D1 (en) 1999-07-15
FI972684L (en) 1997-06-19
FI972684A7 (en) 1997-06-19
EP0799223B1 (en) 1999-06-09
AU704496B2 (en) 1999-04-22
SI0799223T1 (en) 1999-10-31

Similar Documents

Publication Publication Date Title
DE68924681D1 (en) Heterocyclic bisphosphonic acid derivatives.
NO944911L (en) Non-peptide takykininreseptorantagonister
WO1993010091A3 (en) Piperidine acetic acid derivatives as inhibitors of fibrinogen-dependent blood platelet aggregation
ZA95639B (en) Substituted aromatic compounds
NO934536L (en) Phenoxy and phenoxyalkylpepiridines as antivirals
AP9701010A0 (en) Piperidineacetic acid derivatives useful as fibrinogen.
PL309874A1 (en) Novel derivatives of pyrrolocarbasol, method of obtaining them and pharmaceutical composition containing such derivatives
NO944930L (en) Inhibition of dysfunctional uterine bleeding
NZ214156A (en) Quindone derivatives and pharmaceutical compositions
DE69828284D1 (en) NAPHTHYRIDINE DERIVATIVES OR SALTS THEREOF
DK0420121T3 (en) Antitumor agent
MY125037A (en) 1,2,3,4 tetrahydroquinoline derivatives
CA2014521A1 (en) 2-Substituted N,N'-Ditrimethoxybenzoyl Piperazines, a Preparation Process of the Same and Therapeutic Compositions Containing Them
NO20023041L (en) Process for the preparation of pyrazolopyridazine derivatives
SE8303913L (en) Heterocyclic Associations
DK0556813T3 (en) Amphoteric tricyclic compounds such as antihistamine and antiallergic agents
GB8701494D0 (en) Chemical compounds
DK0420224T3 (en) Anthihepatopathic remedy
DK23089D0 (en) THIOFORMAMIDE DERIVATIVES AND THEIR USE
NO944577L (en) Inhibition of the effect of amyloidogenic proteins
ATE53022T1 (en) ALPHA,ALPHA-DIARYL-4-ARYL-4-HYDROXY-1-PIPERIDINE BUTANAMIDE-N-OXIDE.
ES556048A0 (en) A PROCEDURE FOR THE PREPARATION OF A THIAZOLIDINE DERIVATIVE.
TW355184B (en) Substituted thiophenylsulfonylureas and -thioureas, process for their preparation, their use as a medicament or diagnostic, and medicament containing them
DE60239324D1 (en) Phenyl- and pyridyl-piperidines with TNF-effect
ATE189813T1 (en) PROSTAGLANDIN-I ANALOGUE