NO975558L - Oligonucleotides with phosphorothioate bonds with high chiral purity - Google Patents

Oligonucleotides with phosphorothioate bonds with high chiral purity

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Publication number
NO975558L
NO975558L NO975558A NO975558A NO975558L NO 975558 L NO975558 L NO 975558L NO 975558 A NO975558 A NO 975558A NO 975558 A NO975558 A NO 975558A NO 975558 L NO975558 L NO 975558L
Authority
NO
Norway
Prior art keywords
oligonucleotides
chiral purity
phosphorothioate bonds
high chiral
sequence
Prior art date
Application number
NO975558A
Other languages
Norwegian (no)
Other versions
NO975558D0 (en
Inventor
Phillip Dan Cook
Glenn Hoke
Original Assignee
Isis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/469,851 external-priority patent/US5587361A/en
Priority claimed from US08/468,447 external-priority patent/US5576302A/en
Priority claimed from US08/467,597 external-priority patent/US5607923A/en
Priority claimed from US08/471,966 external-priority patent/US5661134A/en
Priority claimed from US08/466,692 external-priority patent/US5654284A/en
Priority claimed from US08/471,967 external-priority patent/US5599797A/en
Priority claimed from US08/470,129 external-priority patent/US5635488A/en
Priority claimed from US08/468,569 external-priority patent/US5620963A/en
Application filed by Isis Pharmaceuticals Inc filed Critical Isis Pharmaceuticals Inc
Publication of NO975558D0 publication Critical patent/NO975558D0/en
Publication of NO975558L publication Critical patent/NO975558L/en

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    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates

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Abstract

Det blir fremskaffet sekvens-spesifikke fosfortioatoligonukleotider omfattende nukleo- sidenheter som er forbundet sammen ved enten hovedsakelig kun Sp- eller hovedsakelig kun Rp-fosfortioatintersukkerbindinger. Slike sekvensspesifikke fosfortioatoligonukleo- tider som har hovedsakelig chiralt rene intersukkerbindinger, blir fremstilt ved enzyma- tisk eller kjemisk syntese.Sequence-specific phosphorothioate oligonucleotides are obtained comprising nucleoside moieties which are joined together by either essentially only Sp- or substantially only Rp-phosphorothioate interconnection. Such sequence-specific phosphorothioate oligonucleotides, which have substantially chirally pure inter-sugar bonds, are prepared by enzymatic or chemical synthesis.

NO975558A 1995-06-06 1997-12-02 Oligonucleotides with phosphorothioate bonds with high chiral purity NO975558L (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US08/469,851 US5587361A (en) 1991-10-15 1995-06-06 Oligonucleotides having phosphorothioate linkages of high chiral purity
US08/468,447 US5576302A (en) 1991-10-15 1995-06-06 Oligonucleotides for modulating hepatitis C virus having phosphorothioate linkages of high chiral purity
US08/467,597 US5607923A (en) 1991-10-15 1995-06-06 Oligonucleotides for modulating cytomegalovirus having phosphorothioate linkages of high chiral purity
US08/471,966 US5661134A (en) 1991-10-15 1995-06-06 Oligonucleotides for modulating Ha-ras or Ki-ras having phosphorothioate linkages of high chiral purity
US08/466,692 US5654284A (en) 1991-10-15 1995-06-06 Oligonucleotides for modulating RAF kinase having phosphorothioate linkages of high chiral purity
US08/471,967 US5599797A (en) 1991-10-15 1995-06-06 Oligonucleotides having phosphorothioate linkages of high chiral purity
US08/470,129 US5635488A (en) 1991-10-15 1995-06-06 Compounds having phosphorodithioate linkages of high chiral purity
US08/468,569 US5620963A (en) 1991-10-15 1995-06-06 Oligonucleotides for modulating protein kinase C having phosphorothioate linkages of high chiral purity
PCT/US1996/008757 WO1996039154A1 (en) 1995-06-06 1996-06-05 Oligonucleotides having phosphorothioate linkages of high chiral purity

Publications (2)

Publication Number Publication Date
NO975558D0 NO975558D0 (en) 1997-12-02
NO975558L true NO975558L (en) 1998-01-26

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Family Applications (1)

Application Number Title Priority Date Filing Date
NO975558A NO975558L (en) 1995-06-06 1997-12-02 Oligonucleotides with phosphorothioate bonds with high chiral purity

Country Status (6)

Country Link
EP (1) EP0831854A4 (en)
JP (3) JPH10510433A (en)
AU (1) AU698739B2 (en)
CA (1) CA2223103A1 (en)
NO (1) NO975558L (en)
WO (1) WO1996039154A1 (en)

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