NO980647L - Fremgangsmåte for diagnostisk bildeanalyse ved anvendelse av biokonjugater av metallkomplekser av nitrogeninneholdende makrocykliske ligander - Google Patents
Fremgangsmåte for diagnostisk bildeanalyse ved anvendelse av biokonjugater av metallkomplekser av nitrogeninneholdende makrocykliske liganderInfo
- Publication number
- NO980647L NO980647L NO980647A NO980647A NO980647L NO 980647 L NO980647 L NO 980647L NO 980647 A NO980647 A NO 980647A NO 980647 A NO980647 A NO 980647A NO 980647 L NO980647 L NO 980647L
- Authority
- NO
- Norway
- Prior art keywords
- bioconjugates
- nitrogen
- image analysis
- metal complexes
- diagnostic image
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Radiology & Medical Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US239495P | 1995-08-17 | 1995-08-17 | |
| PCT/US1996/013044 WO1997006830A1 (fr) | 1995-08-17 | 1996-08-16 | Methodes d'analyse d'images diagnostiques utilisant des conjugues biologiques de complexes metalliques de ligands macrocycliques renfermant de l'azote |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO980647D0 NO980647D0 (no) | 1998-02-16 |
| NO980647L true NO980647L (no) | 1998-04-03 |
Family
ID=21700561
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO980647A NO980647L (no) | 1995-08-17 | 1998-02-16 | Fremgangsmåte for diagnostisk bildeanalyse ved anvendelse av biokonjugater av metallkomplekser av nitrogeninneholdende makrocykliske ligander |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US20040057904A1 (fr) |
| EP (1) | EP0846003A1 (fr) |
| JP (1) | JPH11511168A (fr) |
| AU (1) | AU6896796A (fr) |
| BR (1) | BR9610241A (fr) |
| CA (1) | CA2229781A1 (fr) |
| NO (1) | NO980647L (fr) |
| WO (1) | WO1997006830A1 (fr) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6127356A (en) | 1993-10-15 | 2000-10-03 | Duke University | Oxidant scavengers |
| AU6896796A (en) * | 1995-08-17 | 1997-03-12 | Monsanto Company | Methods of diagnostic image analysis using bioconjugates of metal complexes of nitrogen-containing macrocyclic ligands |
| JP2001521939A (ja) | 1997-11-03 | 2001-11-13 | デューク・ユニバーシティー | 置換されたポルフィリン類 |
| EP1155019B1 (fr) | 1999-01-25 | 2005-12-07 | National Jewish Medical and Research Center | Porphyrines substituees et leur utilisation therapeutique |
| US7445641B1 (en) | 1999-05-27 | 2008-11-04 | Pharmacia Corporation | Biomaterials modified with superoxide dismutase mimics |
| US20040137638A1 (en) | 2002-03-04 | 2004-07-15 | Slomczynska Urszula J. | Chromatography of metal complexes |
| EP1405066B1 (fr) * | 2001-03-02 | 2015-06-17 | Galera Therapeutics LLC | Chromatographie de complexes metalliques |
| JP2005508864A (ja) | 2001-06-01 | 2005-04-07 | ナショナル・ジュウィッシュ・メディカル・アンド・リサーチ・センター | 糖尿病の治療、または移植術における使用、または免疫寛容の誘導のためのオキシダントスカベンジャー |
| EP1513537A4 (fr) | 2002-06-07 | 2006-09-06 | Univ Duke | Porphyrines substituees |
| CA2665984C (fr) | 2006-10-12 | 2017-02-28 | Activbiotics, Inc. | Mimetiques de superoxyde dismutase pour le traitement de la mucosite orale |
| US11382895B2 (en) | 2008-05-23 | 2022-07-12 | National Jewish Health | Methods for treating injury associated with exposure to an alkylating species |
| US20110105417A1 (en) * | 2008-06-26 | 2011-05-05 | The Curators Of The University Of Missouri | Drug Conjugates |
| CA2849456C (fr) | 2011-09-26 | 2021-12-07 | Galera Therapeutics, Llc | Methodes de traitement de maladies |
| HUE049926T2 (hu) | 2015-08-11 | 2020-11-30 | Galera Labs Llc | Makrociklusos pentaazagyûrûkomplexek orális biológiai hozzáférhetõséggel |
| CN109414454A (zh) | 2016-05-03 | 2019-03-01 | 加莱拉实验室有限责任公司 | 用于癌症治疗的组合疗法 |
| EP3506907B1 (fr) | 2016-09-01 | 2023-06-07 | Galera Labs, LLC | Polythérapie anticancéreuse avec un complexe d'un cycle macrocyclique pentaaza et un composé ascorbate |
| EA201992431A1 (ru) | 2017-10-13 | 2020-03-13 | ГАЛЕРА ЛЭБЗ, ЭлЭлСи | Комбинированная иммунотерапия рака с использованием пента-аза-макроциклического кольцевого комплекса |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4001212A (en) * | 1973-10-03 | 1977-01-04 | E. I. Du Pont De Nemours And Company | Macrocyclic polyamines |
| US3930867A (en) * | 1974-01-07 | 1976-01-06 | E. I. Du Pont De Nemours And Company | Macrocyclic polyamines as sensitizers for silver halide emulsions |
| NO149961C (no) | 1981-06-01 | 1984-07-25 | Borregaard Ind | Fremgangsmaate for fremstilling av n-(2-hydroksyetyl)-derivater av makrocykliske polyaminer, inneholdende flere nitrogenatomer i 1,4-forhold i ringen |
| US4647447A (en) * | 1981-07-24 | 1987-03-03 | Schering Aktiengesellschaft | Diagnostic media |
| US4749560A (en) * | 1984-08-13 | 1988-06-07 | Research Corporation | Metal organo phosphorous compounds for NMR analysis |
| US5316757A (en) | 1984-10-18 | 1994-05-31 | Board Of Regents, The University Of Texas System | Synthesis of polyazamacrocycles with more than one type of side-chain chelating groups |
| JPS61226751A (ja) * | 1985-03-30 | 1986-10-08 | Konishiroku Photo Ind Co Ltd | ハロゲン化銀写真感光材料用処理液及びその処理方法 |
| CA1283904C (fr) | 1987-03-06 | 1991-05-07 | Mitsuaki Maeda | Complexe de platine (ii) liposoluble, et sa preparation |
| FR2614020B1 (fr) | 1987-04-14 | 1989-07-28 | Guerbet Sa | Nouveaux ligands cycliques azotes, complexes metalliques formes par ces ligands, compositions de diagnostic contenant ces complexes et procede de preparation des ligands. |
| US4994560A (en) | 1987-06-24 | 1991-02-19 | The Dow Chemical Company | Functionalized polyamine chelants and radioactive rhodium complexes thereof for conjugation to antibodies |
| US4952289A (en) * | 1988-05-09 | 1990-08-28 | Aquanautics Corporation | Macrocyclic amine complexes for ligand extraction and generation |
| CA1340527C (fr) | 1988-05-31 | 1999-05-04 | Lidia Vallarino | Complexes macrocycliques d'ions d'yttrium, de lanthanides et d'actinides, renfermant des fonctions de couplage peripherique |
| US5096724A (en) * | 1988-06-03 | 1992-03-17 | Aquanautics Corporation | Methods, compositions, and systems for ligand extraction |
| BR8907277A (pt) | 1988-12-22 | 1991-03-26 | Dow Chemical Co | Processo para preparar poliazamacrociclos mono-n-alquilados |
| US5252720A (en) | 1989-03-06 | 1993-10-12 | Board Of Regents, The University Of Texas System | Metal complexes of water soluble texaphyrins |
| FR2644785B1 (fr) | 1989-03-24 | 1991-07-05 | Guerbet Sa | Nouveaux ligands macrocycliques azotes, procede de preparation, complexes metalliques formes par ces ligands et composition de diagnostic les contenant |
| US5914095A (en) | 1989-04-07 | 1999-06-22 | Salutar, Inc. | Polychelants containg amide bonds |
| GB9001245D0 (en) | 1990-01-19 | 1990-03-21 | Salutar Inc | Compounds |
| EP0511275A1 (fr) * | 1990-01-19 | 1992-11-04 | Nycomed Imaging As | Composes de chelation |
| GB9008724D0 (en) | 1990-04-18 | 1990-06-13 | Celltech Ltd | Chemical compounds |
| US5162109A (en) * | 1990-09-13 | 1992-11-10 | Mallinckrodt Medical, Inc. | Magnetic resonance imaging agents |
| GB9024208D0 (en) | 1990-11-07 | 1990-12-19 | Salutar Inc | Compounds |
| US5312617A (en) | 1991-05-23 | 1994-05-17 | Unger Evan C | Liposoluble compounds useful as magnetic resonance imaging agents |
| KR0145953B1 (ko) * | 1991-07-19 | 1998-08-17 | 제임스 클리프튼 보올딩 | 슈퍼옥사이드의 불균화촉매로서 효과적인 질소를 포함하는 마크로사이클 릭리간드의 망간착물 |
| CA2072934C (fr) * | 1991-07-19 | 2007-08-28 | Karl William Aston | Complexes de manganese et de ligands macrocycliques contenant de l'azote, efficaces comme catalyseurs de la dismutation de superoxydes |
| US5248498A (en) * | 1991-08-19 | 1993-09-28 | Mallinckrodt Medical, Inc. | Fullerene compositions for magnetic resonance spectroscopy and imaging |
| FR2680787B1 (fr) | 1991-08-30 | 1994-11-04 | Cis Bio Int | Complexes macrocycliques de terres rares et leur utilisation pour reduire les interferences dans un dosage par fluorescence. |
| EP0588229A3 (en) | 1992-09-12 | 1994-06-15 | Hoechst Ag | Macrocyclic chelating agents for the preparation of technetium or rhenium complexes |
| US6204259B1 (en) | 1993-01-14 | 2001-03-20 | Monsanto Company | Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide |
| WO1994026315A1 (fr) | 1993-05-06 | 1994-11-24 | The Dow Chemical Company | Complexes et conjugues de complexes d'acides bicyclopolyazamacrocyclocarboxyliques, procedes de preparation de ces derniers et d'utilisation en tant que produits radiopharmaceutiques |
| US5358704A (en) * | 1993-09-30 | 1994-10-25 | Bristol-Myers Squibb | Hepatobiliary tetraazamacrocyclic magnetic resonance contrast agents |
| US5747026A (en) * | 1993-10-15 | 1998-05-05 | University Of Alabama At Birmingham Research Foundation | Antioxidants |
| AU706642B2 (en) * | 1994-04-22 | 1999-06-17 | G.D. Searle & Co. | Diagnostic image analysis with metal complexes |
| CA2196408A1 (fr) * | 1994-08-10 | 1996-02-22 | Roderick T. Coward | Methode d'utilisation de l'acide hyaluronique pour la detection, la localisation et le diagnostic de tumeurs |
| US6525041B1 (en) * | 1995-06-06 | 2003-02-25 | Pharmacia Corporation | Manganese or iron complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide |
| CA2224088A1 (fr) | 1995-06-07 | 1996-12-19 | Monsanto Company | Procede de preparation de polyazamacrocycles substitues |
| AU6896796A (en) * | 1995-08-17 | 1997-03-12 | Monsanto Company | Methods of diagnostic image analysis using bioconjugates of metal complexes of nitrogen-containing macrocyclic ligands |
| US5976498A (en) * | 1995-08-17 | 1999-11-02 | Neumann; William L. | Methods of diagnostic image analysis using metal complexes of nitrogen-containing macrocyclic ligands |
| US6214817B1 (en) * | 1997-06-20 | 2001-04-10 | Monsanto Company | Substituted pyridino pentaazamacrocyle complexes having superoxide dismutase activity |
-
1996
- 1996-08-16 AU AU68967/96A patent/AU6896796A/en not_active Abandoned
- 1996-08-16 EP EP96929671A patent/EP0846003A1/fr not_active Withdrawn
- 1996-08-16 CA CA002229781A patent/CA2229781A1/fr not_active Abandoned
- 1996-08-16 JP JP9509397A patent/JPH11511168A/ja active Pending
- 1996-08-16 BR BR9610241A patent/BR9610241A/pt not_active Application Discontinuation
- 1996-08-16 WO PCT/US1996/013044 patent/WO1997006830A1/fr not_active Ceased
-
1998
- 1998-02-16 NO NO980647A patent/NO980647L/no unknown
-
2003
- 2003-04-01 US US10/405,044 patent/US20040057904A1/en not_active Abandoned
- 2003-12-16 US US10/737,486 patent/US7407645B2/en not_active Expired - Fee Related
-
2008
- 2008-08-04 US US12/185,433 patent/US20090098047A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US7407645B2 (en) | 2008-08-05 |
| US20090098047A1 (en) | 2009-04-16 |
| US20040057904A1 (en) | 2004-03-25 |
| JPH11511168A (ja) | 1999-09-28 |
| AU6896796A (en) | 1997-03-12 |
| BR9610241A (pt) | 1999-06-29 |
| CA2229781A1 (fr) | 1997-02-27 |
| US20040131550A1 (en) | 2004-07-08 |
| NO980647D0 (no) | 1998-02-16 |
| WO1997006830A1 (fr) | 1997-02-27 |
| EP0846003A1 (fr) | 1998-06-10 |
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