NO981396L - Tetrahydrokinoliner som NMDA-antagonister - Google Patents

Tetrahydrokinoliner som NMDA-antagonister

Info

Publication number: NO981396L
Authority: NO; Norway
Prior art keywords: tetrahydroquinolines; nmda antagonists; nmda; antagonists
Prior art date: 1995-09-29

Application number

NO981396A

Other languages

English (en)

Other versions

NO981396D0 (no

NO310355B1 (no

Inventor

Romano Di Fabio

Simone Giacobbe

Barbara Bertani

Fabrizio Micheli

Original Assignee

Glaxo Wellcome Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-09-29

Filing date

1998-03-27

Publication date

1998-05-27

1995-09-29 Priority claimed from GBGB9519893.3A external-priority patent/GB9519893D0/en

1996-08-17 Priority claimed from GBGB9617306.7A external-priority patent/GB9617306D0/en

1998-03-27 Application filed by Glaxo Wellcome Spa filed Critical Glaxo Wellcome Spa

1998-03-27 Publication of NO981396D0 publication Critical patent/NO981396D0/no

1998-05-27 Publication of NO981396L publication Critical patent/NO981396L/no

2001-06-25 Publication of NO310355B1 publication Critical patent/NO310355B1/no

Links

HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 title 1
239000005557 antagonist Substances 0.000 title 1
150000003530 tetrahydroquinolines Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Virology (AREA)
Molecular Biology (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Addiction (AREA)
Communicable Diseases (AREA)
Heart & Thoracic Surgery (AREA)
Oncology (AREA)
Otolaryngology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

NO19981396A 1995-09-29 1998-03-27 Tetrahydrokinoliner som NMDA-antagonister, anvendelse derav, fremgangsmåte for fremstilling derav og farmasöytisk preparat NO310355B1 (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB9519893.3A GB9519893D0 (en)	1995-09-29	1995-09-29	Heterocyclic compounds
GBGB9617306.7A GB9617306D0 (en)	1996-08-17	1996-08-17	Heterocyclic compounds
PCT/EP1996/004206 WO1997012870A1 (en)	1995-09-29	1996-09-26	Tetrahydroquinolines as nmda antagonists

Publications (3)

Publication Number	Publication Date
NO981396D0 NO981396D0 (no)	1998-03-27
NO981396L true NO981396L (no)	1998-05-27
NO310355B1 NO310355B1 (no)	2001-06-25

Family

ID=26307841

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19981396A NO310355B1 (no)	1995-09-29	1998-03-27	Tetrahydrokinoliner som NMDA-antagonister, anvendelse derav, fremgangsmåte for fremstilling derav og farmasöytisk preparat

Country Status (28)

Country	Link
US (1)	US5977136A (no)
EP (1)	EP0854867B1 (no)
JP (1)	JP4108123B2 (no)
KR (1)	KR100464895B1 (no)
CN (1)	CN1130346C (no)
AP (1)	AP876A (no)
AR (1)	AR005233A1 (no)
AT (1)	ATE221520T1 (no)
AU (1)	AU708148B2 (no)
BR (1)	BR9610733A (no)
CA (1)	CA2232509A1 (no)
CZ (1)	CZ292379B6 (no)
DE (1)	DE69622731T2 (no)
DK (1)	DK0854867T3 (no)
EA (1)	EA000875B1 (no)
ES (1)	ES2180799T3 (no)
HU (1)	HUP9900040A3 (no)
IL (1)	IL123322A0 (no)
IS (1)	IS4677A (no)
MX (1)	MX9801967A (no)
NO (1)	NO310355B1 (no)
NZ (1)	NZ319596A (no)
PL (1)	PL186781B1 (no)
PT (1)	PT854867E (no)
SI (1)	SI0854867T1 (no)
TR (1)	TR199800531T1 (no)
TW (1)	TW460465B (no)
WO (1)	WO1997012870A1 (no)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9617305D0 (en)	1996-08-17	1996-09-25	Glaxo Wellcome Spa	Heterocyclic compounds
GB9706294D0 (en) *	1997-03-26	1997-05-14	Glaxo Wellcome Spa	Heterocyclic compound
MY125037A (en)	1998-06-10	2006-07-31	Glaxo Wellcome Spa	1,2,3,4 tetrahydroquinoline derivatives
TW555757B (en) *	1998-07-31	2003-10-01	Akzo Nobel Nv	Aminomethylcarboxylic acid derivatives
EP1103552A4 (en) *	1998-08-07	2003-01-15	Takeda Chemical Industries Ltd	BENZOTHIEPINE DERIVATIVES, METHOD FOR THEIR PRODUCTION AND THEIR USE
GB9929037D0 (en) *	1999-12-08	2000-02-02	Glaxo Wellcome Spa	Heterocyclic derivatives
NZ533566A (en) *	2001-12-28	2007-03-30	Acadia Pharm Inc	Tetrahydroquinoline analogues as muscarinic agonists
DE10236910A1 (de) *	2002-08-12	2004-03-11	Grünenthal GmbH	Substituierte 1,2,3,4-Tetrahydrochinolinderivate
RU2451014C2 (ru) *	2005-07-22	2012-05-20	Мотида Фармасьютикал Ко., Лтд.	Новое производное гетероциклиден ацетамида
JP4754566B2 (ja)	2005-07-22	2011-08-24	持田製薬株式会社	新規なヘテロシクリデンアセトアミド誘導体
DK2268644T3 (da) *	2008-03-05	2011-10-10	Boehringer Ingelheim Int	Tricycliske pyridinderivater, medikamenter indeholdende sådanne forbindelser, deres anvendelse og fremgangsmåde til deres fremstilling
EP2286808A1 (en) *	2009-08-18	2011-02-23	Rheinische Friedrich-Wilhelms Universität	Cytohesin inhibitors
MX2012008721A (es)	2010-02-16	2012-08-17	Pfizer	(r)-4-((4-((4-(tetrahidrofuran-3-iloxi)benzo[d]isoxazol-3-iloxi)m etil) tetrahidro-2h-piran-4-ol, un agonista pacial de receptores 5-ht4.
EA201201160A1 (ru)	2010-02-19	2013-04-30	Бёрингер Ингельхайм Интернациональ Гмбх	Трициклические производные пиридина, лекарственные средства, содержащие такие соединения, их применение и способ их получения
JP5947382B2 (ja)	2011-08-17	2016-07-06	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	フロ［３，４−ｃ］キノリン誘導体、このような化合物を含む薬物、それらの使用及びそれらの調製方法
WO2016114655A1 (en) *	2015-01-12	2016-07-21	Ry Pharma B.V.	Treating neuromuscular or neurologic disease through reducing gabaergic and/or glycinergic inhibitory neurotransmitter overstimulation
WO2017065602A1 (en) *	2015-10-13	2017-04-20	Ry Pharma B.V.	Treating neuromuscular or neurologic disease through reducing gabaergic and/or glycinergic inhibitory neurotransmitter overstimulation

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0386839B1 (en) *	1989-03-08	1997-01-15	Merck Sharp & Dohme Ltd.	Tetrahydroquinoline derivatives useful for neurodegenerative disorders

1996
- 1996-09-26 AT AT96933399T patent/ATE221520T1/de not_active IP Right Cessation
- 1996-09-26 AU AU72148/96A patent/AU708148B2/en not_active Ceased
- 1996-09-26 DK DK96933399T patent/DK0854867T3/da active
- 1996-09-26 AP APAP/P/1998/001212A patent/AP876A/en active
- 1996-09-26 DE DE69622731T patent/DE69622731T2/de not_active Expired - Lifetime
- 1996-09-26 US US09/029,860 patent/US5977136A/en not_active Expired - Fee Related
- 1996-09-26 NZ NZ319596A patent/NZ319596A/en not_active IP Right Cessation
- 1996-09-26 PT PT96933399T patent/PT854867E/pt unknown
- 1996-09-26 HU HU9900040A patent/HUP9900040A3/hu unknown
- 1996-09-26 JP JP51394797A patent/JP4108123B2/ja not_active Expired - Fee Related
- 1996-09-26 CN CN96198560A patent/CN1130346C/zh not_active Expired - Fee Related
- 1996-09-26 CA CA002232509A patent/CA2232509A1/en not_active Abandoned
- 1996-09-26 TR TR1998/00531T patent/TR199800531T1/xx unknown
- 1996-09-26 PL PL96325966A patent/PL186781B1/pl not_active IP Right Cessation
- 1996-09-26 SI SI9630523T patent/SI0854867T1/xx unknown
- 1996-09-26 IL IL12332296A patent/IL123322A0/xx not_active IP Right Cessation
- 1996-09-26 WO PCT/EP1996/004206 patent/WO1997012870A1/en not_active Ceased
- 1996-09-26 EA EA199800230A patent/EA000875B1/ru not_active IP Right Cessation
- 1996-09-26 ES ES96933399T patent/ES2180799T3/es not_active Expired - Lifetime
- 1996-09-26 EP EP96933399A patent/EP0854867B1/en not_active Expired - Lifetime
- 1996-09-26 KR KR10-1998-0702321A patent/KR100464895B1/ko not_active Expired - Fee Related
- 1996-09-26 CZ CZ1998940A patent/CZ292379B6/cs not_active IP Right Cessation
- 1996-09-26 BR BR9610733A patent/BR9610733A/pt not_active IP Right Cessation
- 1996-09-30 AR ARP960104543A patent/AR005233A1/es active IP Right Grant
- 1996-10-04 TW TW085112168A patent/TW460465B/zh not_active IP Right Cessation
1998
- 1998-02-27 IS IS4677A patent/IS4677A/is unknown
- 1998-03-12 MX MX9801967A patent/MX9801967A/es not_active IP Right Cessation
- 1998-03-27 NO NO19981396A patent/NO310355B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
JPH11512728A (ja)	1999-11-02
DK0854867T3 (da)	2002-12-02
DE69622731D1 (de)	2002-09-05
US5977136A (en)	1999-11-02
TR199800531T1 (xx)	1998-06-22
PT854867E (pt)	2002-12-31
HK1009133A1 (en)	1999-05-28
AP876A (en)	2000-09-27
MX9801967A (es)	1998-08-30
DE69622731T2 (de)	2003-02-20
WO1997012870A1 (en)	1997-04-10
NZ319596A (en)	1999-09-29
CZ94098A3 (cs)	1998-07-15
PL325966A1 (en)	1998-08-17
KR100464895B1 (ko)	2005-05-16
AR005233A1 (es)	1999-04-28
EP0854867A1 (en)	1998-07-29
TW460465B (en)	2001-10-21
EA000875B1 (ru)	2000-06-26
CN1130346C (zh)	2003-12-10
EA199800230A1 (ru)	1998-10-29
HUP9900040A2 (hu)	1999-04-28
PL186781B1 (pl)	2004-02-27
AU708148B2 (en)	1999-07-29
CZ292379B6 (cs)	2003-09-17
KR19990063850A (ko)	1999-07-26
EP0854867B1 (en)	2002-07-31
CA2232509A1 (en)	1997-04-10
ES2180799T3 (es)	2003-02-16
AP9801212A0 (en)	1998-03-31
NO981396D0 (no)	1998-03-27
IS4677A (is)	1998-02-27
SI0854867T1 (en)	2003-02-28
CN1202887A (zh)	1998-12-23
ATE221520T1 (de)	2002-08-15
JP4108123B2 (ja)	2008-06-25
AU7214896A (en)	1997-04-28
HUP9900040A3 (en)	2001-01-29
NO310355B1 (no)	2001-06-25
IL123322A0 (en)	1998-09-24
BR9610733A (pt)	1999-07-13

Legal Events

Date	Code	Title	Description
2011-05-09	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
DK0802910T3 (da)	2002-05-21	Estrogenagonister/antagonister
DK1009732T3 (da)	2003-09-22	1-Amino-alkylcyclohexan NMDA receptor antagonister
NO974463L (no)	1997-09-26	Anordninger for tele-arbeid
FI960516L (fi)	1996-08-07	Substituoituja bifenyylisulfonamidiendoteliiniantagonisteja
FI961628A0 (fi)	1996-04-12	Indolijohdannaisia NMDA-antagonisteina
NO961887D0 (no)	1996-05-09	-adrenergiske agonister
DK0854867T3 (da)	2002-12-02	Tetrahydroquinoliner som NMDA-antagonister
DK0922034T3 (da)	2002-11-18	Tetrahydroquinolinderivater som EAA-antagonister
DK1068202T3 (da)	2009-03-16	1-(-heteroarylpropyl- eller -prop-2-enyl)-4benzylpipderidiner som NMDA-receptor-antagonister
NO974043L (no)	1997-11-03	Indolderivater som EAA-antagonister
ATE309215T1 (de)	2005-11-15	Nmda (n-methyl-d-aspartate) antagonists
FI972862A7 (fi)	1997-09-03	Uudet stafylokinaasijohdannaiset
ATA46395A (de)	1999-03-15	Hängebahn
DK0770603T3 (da)	1999-06-14	Alkynylphenylaminosulfonylurinstoffer som herbicider
KR970702876A (ko)	1997-06-10	뉴로키닌 길항제(Neurokinine (tachykinine) antagonists)
FI970143A0 (fi)	1997-01-14	Kinoliinijohdannaiset leukotrieeniantagonisteina
KR950027351U (ko)	1995-10-18	반목 항타장치
SE9502290D0 (sv)	1995-06-26	New Preparation
FI960434A0 (fi)	1996-01-30	Slaganordning som arbetar med hydrauliskt tryck
FI940181A0 (fi)	1994-01-14	Foerfarande foer aostadkommande av en masspektrometer som fungerar under lufttryck
FIU950183U0 (fi)	1995-04-10	Faerdiggraeddad matsporation avsedd att foertaeras som engaongsportion
SK1155U (sk)	1996-05-08	Rameno