NO981633L - Farmas÷ytisk blanding for administrering av en aktiv forbindelse til eller gjennom hud eller en mukosaoverflate - Google Patents

Farmas÷ytisk blanding for administrering av en aktiv forbindelse til eller gjennom hud eller en mukosaoverflate

Info

Publication number
NO981633L
NO981633L NO981633A NO981633A NO981633L NO 981633 L NO981633 L NO 981633L NO 981633 A NO981633 A NO 981633A NO 981633 A NO981633 A NO 981633A NO 981633 L NO981633 L NO 981633L
Authority
NO
Norway
Prior art keywords
analogs
composition
active substance
prodrugs
solubility
Prior art date
Application number
NO981633A
Other languages
English (en)
Other versions
NO981633D0 (no
Inventor
Lise Sylvest Nielsen
Jens Hansen
Original Assignee
Gs Dev Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gs Dev Ab filed Critical Gs Dev Ab
Publication of NO981633D0 publication Critical patent/NO981633D0/no
Publication of NO981633L publication Critical patent/NO981633L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1274—Non-vesicle bilayer structures, e.g. liquid crystals, tubules, cubic phases or cochleates; Sponge phases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Farmasøytiske sammensetninger for administrering av en aktiv substans til eller gjennom en skadet eller uskadet hud eller mukosaoverflate eller til det orale hulrommet inkludert tennene til et dyr slikt som et menneske. Blandingen har fordelaktige egenskaper med hensyn på frigjøring av den aktive substansen fra blandingen og, videre, er blandingen bioadhesiv. Blandingen innbefatter den aktive substansen og en effektiv mengde av en fettsyreester som, sammen med en flytende fase, kan generere en flytende krystallinsk fase der bestanddelene av blandingen er innesluttet, der den aktive substansen har en løselighet i den flytende krystallinske fasen på det meste 20 mg/g ved 20 °C, og en løselighet i vann på det meste 10 mg/ml ved 20 °C, vannet, der det er passende, er bufret til en pH som er vesentlig lik den pH som er rådende i den flytende krystallinske fasen (pH ca. 3,6-9). Blandingen er spesielt egnet for administrering av substanser som har en veldig lav vannløselighet og som skal bli gitt i en effektiv mengde til en lokalisert region over en tidsperiode. Aktive substanser med spesiell viktighet er anti-herpesvirusagenser inkludert antivirale legemidler og prodroger derav, slik som nukleosider, nukleosid- analoger, fosforylerte nukleosider (nukleotider), nukleotidanaloger og salter, komplekser og prodroger derav; f.eks. guanosinanaloger, deoksyguanosinanaloger, guanin, guaninanaloger, tymidinanaloger, uracilanaloger og adeninanaloger. Spesielt interessante anti-herpesvirusagenser til bruk enten alene eller i kombinasjon i en blanding i henhold til den foreliggende oppfinnelsen er valgt fra acyklovir, famciklovir, deciklovir, penciklovir, zidovudin, ganciklovir, didanosin, zalcitabin, valaciklovir, sorivudin, lobukavir, brivudin, cidofovir, n-dokosanol, ISIS-2922, og prodroger og analoger derav.
NO981633A 1995-10-12 1998-04-08 Farmas÷ytisk blanding for administrering av en aktiv forbindelse til eller gjennom hud eller en mukosaoverflate NO981633L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK115095 1995-10-12
PCT/DK1996/000437 WO1997013528A1 (en) 1995-10-12 1996-10-11 A pharmaceutical composition for administration of an active substance to or through a skin or mucosal surface

Publications (2)

Publication Number Publication Date
NO981633D0 NO981633D0 (no) 1998-04-08
NO981633L true NO981633L (no) 1998-06-04

Family

ID=8101575

Family Applications (1)

Application Number Title Priority Date Filing Date
NO981633A NO981633L (no) 1995-10-12 1998-04-08 Farmas÷ytisk blanding for administrering av en aktiv forbindelse til eller gjennom hud eller en mukosaoverflate

Country Status (7)

Country Link
EP (1) EP0871489A1 (no)
JP (1) JPH11513393A (no)
AU (1) AU702030B2 (no)
CA (1) CA2231273A1 (no)
FI (1) FI980822A0 (no)
NO (1) NO981633L (no)
WO (1) WO1997013528A1 (no)

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CN111821254B (zh) * 2019-04-18 2021-10-15 华东师范大学 一种抗病毒水凝胶及其制备方法和应用
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CN112791047A (zh) * 2021-01-15 2021-05-14 中国人民解放军总医院第三医学中心 一种白藜芦醇层状液晶及其制备方法
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Also Published As

Publication number Publication date
WO1997013528A1 (en) 1997-04-17
EP0871489A1 (en) 1998-10-21
FI980822A7 (fi) 1998-04-09
JPH11513393A (ja) 1999-11-16
AU7279296A (en) 1997-04-30
FI980822A0 (fi) 1998-04-09
CA2231273A1 (en) 1997-04-17
AU702030B2 (en) 1999-02-11
NO981633D0 (no) 1998-04-08

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