NO981946L - Imidazoquinasolin derivater - Google Patents
Imidazoquinasolin derivaterInfo
- Publication number
- NO981946L NO981946L NO981946A NO981946A NO981946L NO 981946 L NO981946 L NO 981946L NO 981946 A NO981946 A NO 981946A NO 981946 A NO981946 A NO 981946A NO 981946 L NO981946 L NO 981946L
- Authority
- NO
- Norway
- Prior art keywords
- substituted
- unsubstituted
- tricycloalkyl
- bicycloalkyl
- lower alkyl
- Prior art date
Links
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 150000001602 bicycloalkyls Chemical group 0.000 abstract 3
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 3
- 102000004861 Phosphoric Diester Hydrolases Human genes 0.000 abstract 2
- 108090001050 Phosphoric Diester Hydrolases Proteins 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 206010002383 Angina Pectoris Diseases 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 208000011775 arteriosclerosis disease Diseases 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 201000001881 impotence Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 150000004712 monophosphates Chemical class 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP23080796 | 1996-08-30 | ||
| PCT/JP1997/003023 WO1998008848A1 (en) | 1996-08-30 | 1997-08-29 | Imidazoquinazoline derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO981946D0 NO981946D0 (no) | 1998-04-29 |
| NO981946L true NO981946L (no) | 1998-06-29 |
Family
ID=16913591
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO981946A NO981946L (no) | 1996-08-30 | 1998-04-29 | Imidazoquinasolin derivater |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6127541A (de) |
| EP (1) | EP0863144A4 (de) |
| KR (1) | KR19990067248A (de) |
| AU (1) | AU724809B2 (de) |
| CA (1) | CA2236012A1 (de) |
| HU (1) | HUP9900790A3 (de) |
| NO (1) | NO981946L (de) |
| NZ (1) | NZ330292A (de) |
| WO (1) | WO1998008848A1 (de) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6410584B1 (en) | 1998-01-14 | 2002-06-25 | Cell Pathways, Inc. | Method for inhibiting neoplastic cells with indole derivatives |
| WO1999043674A1 (en) * | 1998-02-27 | 1999-09-02 | Kyowa Hakko Kogyo Co., Ltd. | Remedies for erectile dysfunction |
| US6087368A (en) * | 1998-06-08 | 2000-07-11 | Bristol-Myers Squibb Company | Quinazolinone inhibitors of cGMP phosphodiesterase |
| US6326379B1 (en) | 1998-09-16 | 2001-12-04 | Bristol-Myers Squibb Co. | Fused pyridine inhibitors of cGMP phosphodiesterase |
| US6200771B1 (en) | 1998-10-15 | 2001-03-13 | Cell Pathways, Inc. | Method of using a novel phosphodiesterase in pharmaceutical screeing to identify compounds for treatment of neoplasia |
| US6133271A (en) * | 1998-11-19 | 2000-10-17 | Cell Pathways, Inc. | Method for inhibiting neoplastic cells and related conditions by exposure thienopyrimidine derivatives |
| US6187779B1 (en) | 1998-11-20 | 2001-02-13 | Cell Pathways, Inc. | Method for inhibiting neoplastic cells and related conditions by exposure to 2,8-disubstituted quinazoline derivatives |
| US6369092B1 (en) | 1998-11-23 | 2002-04-09 | Cell Pathways, Inc. | Method for treating neoplasia by exposure to substituted benzimidazole derivatives |
| US6077842A (en) * | 1998-11-24 | 2000-06-20 | Cell Pathways, Inc. | Method of inhibiting neoplastic cells with pyrazolopyridylpyridazinone derivatives |
| US6486155B1 (en) | 1998-11-24 | 2002-11-26 | Cell Pathways Inc | Method of inhibiting neoplastic cells with isoquinoline derivatives |
| US6034099A (en) * | 1998-11-24 | 2000-03-07 | Cell Pathways, Inc. | Method for inhibiting neoplastic lesions by administering 4-(arylmethylene)- 2, 3- dihydro-pyrazol-3-ones |
| US6875575B1 (en) | 1998-11-25 | 2005-04-05 | Osi Pharmaceuticals, Inc. | Diagnostic methods for neoplasia |
| US6020379A (en) * | 1999-02-19 | 2000-02-01 | Cell Pathways, Inc. | Position 7 substituted indenyl-3-acetic acid derivatives and amides thereof for the treatment of neoplasia |
| US6358954B1 (en) * | 1999-11-09 | 2002-03-19 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | PDGF receptor kinase inhibitory compounds, their preparation, purification and pharmaceutical compositions including same |
| US6576644B2 (en) | 2000-09-06 | 2003-06-10 | Bristol-Myers Squibb Co. | Quinoline inhibitors of cGMP phosphodiesterase |
| US6821978B2 (en) | 2000-09-19 | 2004-11-23 | Schering Corporation | Xanthine phosphodiesterase V inhibitors |
| CA2465893A1 (en) | 2001-11-09 | 2003-05-22 | Schering Corporation | Polycyclic guanine derivative phosphodiesterase v inhibitors |
| US20050107394A1 (en) * | 2001-12-17 | 2005-05-19 | Ardeschir Ghofrani | Novel use of selective pde5 inhibitors |
| US7208516B2 (en) | 2002-03-20 | 2007-04-24 | Celgene Corporation | Methods of the treatment of psoriatic arthritis using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione |
| US7276529B2 (en) | 2002-03-20 | 2007-10-02 | Celgene Corporation | Methods of the treatment or prevention of exercise-induced asthma using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione |
| US6962940B2 (en) | 2002-03-20 | 2005-11-08 | Celgene Corporation | (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof |
| US7893101B2 (en) | 2002-03-20 | 2011-02-22 | Celgene Corporation | Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof |
| EP1699436A2 (de) * | 2003-12-12 | 2006-09-13 | Myogen, Inc. | Enoximon-formulierungen und ihre verwendung bei der behandlung von herzhypertrophy und herzinsuffizienz |
| EP2650286A1 (de) * | 2004-02-19 | 2013-10-16 | Rexahn Pharmaceuticals, Inc. | Chinazolinderivate und therapeutische Verwendung davon |
| CA2560528A1 (en) * | 2004-03-22 | 2005-10-06 | Myogen, Inc. | (s) - enoximone sulfoxide and its use in the treatment of pde-iii mediated diseases |
| JP2007530566A (ja) * | 2004-03-22 | 2007-11-01 | ミオゲン インコーポレイティッド | (r)−エノキシモンスルホキシドおよびpde−iii媒介疾患の治療におけるその使用 |
| EP1776108A1 (de) * | 2004-06-23 | 2007-04-25 | Myogen, Inc. | Enoximon-formulierungen und ihre verwendung bei der behandlung von pde-iii-vermittelten erkrankungen |
| KR20080015594A (ko) * | 2006-08-16 | 2008-02-20 | 주식회사종근당 | 포스포디에스테라제 저해제로서 유용한 퀴나졸린 유도체 및그 제조방법 |
| US9006252B2 (en) * | 2008-09-26 | 2015-04-14 | National Health Research Institutes | Fused multicyclic compounds as protein kinase inhibitors |
| MX2016014384A (es) | 2014-06-23 | 2017-01-20 | Celgene Corp | Apremilast para el tratamiento de una enfermedad del higado o una anormalidad en la funcion del higado. |
| AU2023319145A1 (en) * | 2022-08-05 | 2025-02-13 | Macquarie University | Inhibitors and uses therefor |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9314884D0 (en) * | 1993-07-19 | 1993-09-01 | Zeneca Ltd | Tricyclic derivatives |
| WO1995006648A1 (fr) * | 1993-09-03 | 1995-03-09 | Kyowa Hakko Kogyo Co., Ltd. | Derive d'imidazoquinazoline |
| IL112248A0 (en) * | 1994-01-25 | 1995-03-30 | Warner Lambert Co | Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them |
| US5654307A (en) * | 1994-01-25 | 1997-08-05 | Warner-Lambert Company | Bicyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family |
| AU4844396A (en) * | 1995-03-01 | 1996-09-18 | Kyowa Hakko Kogyo Co. Ltd. | Imidazoquinazoline derivatives |
-
1997
- 1997-08-29 EP EP97937841A patent/EP0863144A4/de not_active Withdrawn
- 1997-08-29 CA CA002236012A patent/CA2236012A1/en not_active Abandoned
- 1997-08-29 NZ NZ330292A patent/NZ330292A/xx unknown
- 1997-08-29 WO PCT/JP1997/003023 patent/WO1998008848A1/ja not_active Ceased
- 1997-08-29 AU AU40323/97A patent/AU724809B2/en not_active Ceased
- 1997-08-29 KR KR1019980703207A patent/KR19990067248A/ko not_active Withdrawn
- 1997-08-29 US US09/065,061 patent/US6127541A/en not_active Expired - Fee Related
- 1997-08-29 HU HU9900790A patent/HUP9900790A3/hu unknown
-
1998
- 1998-04-29 NO NO981946A patent/NO981946L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| US6127541A (en) | 2000-10-03 |
| CA2236012A1 (en) | 1998-03-05 |
| EP0863144A4 (de) | 2001-04-11 |
| NZ330292A (en) | 2000-01-28 |
| AU724809B2 (en) | 2000-09-28 |
| EP0863144A1 (de) | 1998-09-09 |
| AU4032397A (en) | 1998-03-19 |
| NO981946D0 (no) | 1998-04-29 |
| HUP9900790A2 (hu) | 1999-06-28 |
| KR19990067248A (ko) | 1999-08-16 |
| HUP9900790A3 (en) | 2001-11-28 |
| WO1998008848A1 (en) | 1998-03-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO981946L (no) | Imidazoquinasolin derivater | |
| US5223504A (en) | Xanthine compounds and compositions, and methods of using them | |
| US6153630A (en) | Phenylpyridyl compounds for inhibiting phosphodiesterase IV and methods of using same | |
| CA2318349A1 (en) | Estrone sulfamate inhibitors of estrone sulfatase, and associated pharmaceutical compositions and methods of use | |
| HUP0102851A2 (hu) | Parazitaellenes artemizinin-származékok (endoperoxidok), eljárás előállításukra és a vegyületeket tartalmazó gyógyászati készítmények | |
| NO972091L (no) | Bestemte substituerte benzylaminderivater; en ny klasse nouropeptid-yl-spesifikke ligander | |
| MA26861A1 (fr) | Inhibiteurs non peptidiques de la liaison cellulaire sous la dependance de vla-4 utiles dans le traitement des maladies inflammatoires, auto-immunes et respiratoires | |
| HU194171B (en) | Process for preparing asymmetric diesters of 1,4-dihydro-2,6-dimethyl-pyridine-3,5-dicarboxylic acid and pharmaceuticals comprising such compounds | |
| NO20052038L (no) | Ny adeninforbindelse og anvendelse derav | |
| NO20054224L (no) | Nye 2-pyridinkarboksamidderivater | |
| NO20041531L (no) | Alkyleterderivater eller salter derav | |
| DE69717867D1 (de) | Pyrazolopyridylpyrazinon-derivate und ein verfahren zu ihrer herstellung | |
| EP1020434A4 (de) | 3-amidinoanilin-derivate, inhibitoren des aktivierten blutgerinnungsfaktors x und zwischenpodukte zur herstellung beider | |
| NO974890D0 (no) | Radicicolderivater | |
| MX2024012320A (es) | Derivado de uracilo que tiene actividad inhibidora del crecimiento viral y composicion farmaceutica que lo contiene | |
| WO1995024392A1 (en) | 2-chloro and 2-bromo derivatives of 1,5-iminosugars | |
| CA2238875A1 (en) | Tri-aryl ethane derivatives as pde iv inhibitors | |
| HUP0400362A2 (hu) | Antiaritmiás hatású helyettesített benzopiránszármazékok | |
| NO952289L (no) | Substituerte benzazepinoner | |
| ATE121385T1 (de) | Harnstoffderivate, ihre herstellung und ihre verwendung bei der therapie. | |
| NO963655L (no) | Nye aminosyrederivater, fremgangsmåte for fremstilling av dem og farmasöytiske blandinger som inneholder dem | |
| US5744473A (en) | PDE IV inhibitors: "bis-compounds" | |
| EP1419771A4 (de) | Mittel zur prävention und/oder behandlung von krankheiten, die auf arteriosklerotische wirkung zurückzuführen sind | |
| FI64149C (fi) | Foerfarande foer framstaellning av nya antihypertensiva pyridazinylhydrazoner | |
| JPH0578554B2 (de) |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |