NO982155L - FremgangsmÕte for fremstilling av korrekt foldet, biologisk aktivt rekombinant protein - Google Patents

FremgangsmÕte for fremstilling av korrekt foldet, biologisk aktivt rekombinant protein

Info

Publication number
NO982155L
NO982155L NO982155A NO982155A NO982155L NO 982155 L NO982155 L NO 982155L NO 982155 A NO982155 A NO 982155A NO 982155 A NO982155 A NO 982155A NO 982155 L NO982155 L NO 982155L
Authority
NO
Norway
Prior art keywords
recombinant protein
cells
correctly folded
active recombinant
biologically active
Prior art date
Application number
NO982155A
Other languages
English (en)
Other versions
NO982155D0 (no
NO320175B1 (no
Inventor
Jan-Gunnar Gustafsson
Johan Ihman
Original Assignee
Pharmacia & Upjohn Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Ab filed Critical Pharmacia & Upjohn Ab
Publication of NO982155D0 publication Critical patent/NO982155D0/no
Publication of NO982155L publication Critical patent/NO982155L/no
Publication of NO320175B1 publication Critical patent/NO320175B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
NO19982155A 1995-11-13 1998-05-12 Fremgangsmate for fremstilling av korrekt foldet, biologisk aktivt rekombinant protein eller polypeptid. NO320175B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9504019A SE9504019D0 (sv) 1995-11-13 1995-11-13 Method for production of proteins
PCT/SE1996/001456 WO1997018233A1 (en) 1995-11-13 1996-11-12 Method for producing a correctly folded, biological active recombinant protein

Publications (3)

Publication Number Publication Date
NO982155D0 NO982155D0 (no) 1998-05-12
NO982155L true NO982155L (no) 1998-05-12
NO320175B1 NO320175B1 (no) 2005-11-07

Family

ID=20400188

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19982155A NO320175B1 (no) 1995-11-13 1998-05-12 Fremgangsmate for fremstilling av korrekt foldet, biologisk aktivt rekombinant protein eller polypeptid.

Country Status (10)

Country Link
US (1) US6605706B1 (no)
EP (1) EP0952981B1 (no)
JP (1) JP3930051B2 (no)
AT (1) ATE261985T1 (no)
AU (1) AU705192B2 (no)
CA (1) CA2236751C (no)
DE (1) DE69631906T2 (no)
NO (1) NO320175B1 (no)
SE (1) SE9504019D0 (no)
WO (1) WO1997018233A1 (no)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6653098B1 (en) 1998-02-23 2003-11-25 G. D. Searle & Co. Method of producing mouse and human endostatin
DK1066328T3 (da) 1998-03-31 2009-02-09 Tonghua Gantech Biotechnology Kimært protein, der indeholder en intramolekylær chaperon-lignende sekvens, og dets anvendelse til insulinproduktion
GB9913437D0 (en) * 1999-06-09 1999-08-11 Medical Res Council Fusion proteins
FR2820424B1 (fr) * 2001-02-05 2004-01-02 Merieux Oravax Procede de purification de alpa
AU2007272412B2 (en) 2006-07-14 2013-11-07 Genentech, Inc. Refolding of recombinant proteins
US9119832B2 (en) 2014-02-05 2015-09-01 The Regents Of The University Of California Methods of treating mild brain injury
WO2017075535A1 (en) 2015-10-28 2017-05-04 Oxeia Biopharmaceuticals, Inc. Methods of treating neurodegenerative conditions
CN116368149A (zh) * 2020-11-05 2023-06-30 希米科控股有限公司 重组胰岛素样生长因子i的制造方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8505922D0 (sv) * 1985-12-13 1985-12-13 Kabigen Ab Construction of an igg binding protein to facilitate downstream processing using protein engineering
US5231178A (en) 1991-01-16 1993-07-27 The Salk Institute Biotechnology/Industrial Associates, Inc. Method for the purification of intact, correctly-folded insulin-like growth factor-1
US5288931A (en) * 1991-12-06 1994-02-22 Genentech, Inc. Method for refolding insoluble, misfolded insulin-like growth factor-I into an active conformation
EP0600372B1 (de) * 1992-12-02 1997-02-05 Hoechst Aktiengesellschaft Verfahren zur Gewinnung von Proinsulin mit korrekt verbundenen Cystinbrücken
US5407810A (en) * 1993-08-20 1995-04-18 Genentech, Inc. Aqueous multiple-phase isolation of polypeptide
US5663304A (en) * 1993-08-20 1997-09-02 Genentech, Inc. Refolding of misfolded insulin-like growth factor-I

Also Published As

Publication number Publication date
AU7659696A (en) 1997-06-05
CA2236751A1 (en) 1997-05-22
EP0952981A1 (en) 1999-11-03
NO982155D0 (no) 1998-05-12
AU705192B2 (en) 1999-05-20
US6605706B1 (en) 2003-08-12
DE69631906T2 (de) 2005-01-20
SE9504019D0 (sv) 1995-11-13
ATE261985T1 (de) 2004-04-15
WO1997018233A1 (en) 1997-05-22
JP2000500023A (ja) 2000-01-11
CA2236751C (en) 2007-01-09
NO320175B1 (no) 2005-11-07
HK1023781A1 (en) 2000-09-22
EP0952981B1 (en) 2004-03-17
DE69631906D1 (de) 2004-04-22
JP3930051B2 (ja) 2007-06-13

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