NO982960L - Radicicol derivatives - Google Patents

Radicicol derivatives

Info

Publication number
NO982960L
NO982960L NO982960A NO982960A NO982960L NO 982960 L NO982960 L NO 982960L NO 982960 A NO982960 A NO 982960A NO 982960 A NO982960 A NO 982960A NO 982960 L NO982960 L NO 982960L
Authority
NO
Norway
Prior art keywords
substituted
unsubstituted
lower alkyl
alkanoyl
tert
Prior art date
Application number
NO982960A
Other languages
Norwegian (no)
Other versions
NO982960D0 (en
Inventor
Yoji Ino
Nobuyoshi Amishiro
Mayumi Miyata
Chikara Murakata
Harumi Ogawa
Tadakazu Akiyama
Shiro Akinaga
Shiro Soga
Yukimasa Shiotsu
Original Assignee
Kyowa Hakko Kogyo Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Kk filed Critical Kyowa Hakko Kogyo Kk
Publication of NO982960D0 publication Critical patent/NO982960D0/en
Publication of NO982960L publication Critical patent/NO982960L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Furan Compounds (AREA)

Abstract

Radicicol derivatives represented by the following formula (I) having tyrosine kinase inhibition activity or pharmacologically acceptable salts thereof: <CHEM> wherein R<1> and R<2> are the same or different, and each represents hydrogen, alkanoyl, alkenoyl, tert-butyldiphenylsilyl or tert-butyldimethylsilyl; R<3> represents Y-R<5> äwherein Y represents substituted or unsubstituted alkylene; and R<5> represents CONR<6>R<7> (wherein R<6> represents hydrogen, hydroxyl, substituted or unsubstituted lower alkyl, substituted or unsubstituted higher alkyl, and the like; R<7> represents hydroxyl, substituted lower alkyl, and the like), CO2R<12> (wherein R<12> represents substituted lower alkyl, substituted or unsubstituted higher alkyl, and the like), and the likeü and the like; X represents halogen or is combined together with R<4> to represent a single bond; and R<4> is combined together with X to represent a single bond, or represents hydrogen, alkanoyl, and the like.
NO982960A 1996-10-25 1998-06-25 Radicicol derivatives NO982960L (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP28443996 1996-10-25
JP357897 1997-01-13
PCT/JP1997/003874 WO1998018780A1 (en) 1996-10-25 1997-10-24 Radicicol derivatives

Publications (2)

Publication Number Publication Date
NO982960D0 NO982960D0 (en) 1998-06-25
NO982960L true NO982960L (en) 1998-08-25

Family

ID=26337204

Family Applications (1)

Application Number Title Priority Date Filing Date
NO982960A NO982960L (en) 1996-10-25 1998-06-25 Radicicol derivatives

Country Status (12)

Country Link
US (4) US6316491B1 (en)
EP (1) EP0889042B1 (en)
KR (1) KR19990076764A (en)
CN (1) CN1211244A (en)
AT (1) ATE266017T1 (en)
AU (1) AU727722B2 (en)
CA (1) CA2241624A1 (en)
DE (1) DE69728974T2 (en)
ES (1) ES2216130T3 (en)
NO (1) NO982960L (en)
NZ (1) NZ331062A (en)
WO (1) WO1998018780A1 (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6838810B1 (en) * 1997-03-21 2005-01-04 Chunghwa Picture Tubes, Ltd. Flat-panel display mounting system for portable computer
WO1998051702A1 (en) 1997-05-14 1998-11-19 Sloan-Kettering Institute For Cancer Research Methods and compositions for destruction of selected proteins
WO1999055689A1 (en) * 1998-04-24 1999-11-04 Kyowa Hakko Kogyo Co., Ltd. Radicicol derivatives
JP2002533389A (en) 1998-12-24 2002-10-08 ノーベーション ファーマシューティカルズ インコーポレーテッド Compounds affecting mRNA stability and uses therefor
WO2000045805A2 (en) * 1999-02-08 2000-08-10 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Methods of inhibiting the hgf-met-upa-plasmin network with geldanamycin derivates
AU769235B2 (en) 1999-04-09 2004-01-22 Sloan-Kettering Institute For Cancer Research Methods and compositions for degradation and/or inhibition of her-family tyrosine kinases
US7238682B1 (en) 1999-04-09 2007-07-03 Sloan-Kettering Institute For Cancer Research Methods and compositions for degradation and/or inhibition of HER-family tyrosine kinases
US6979574B1 (en) * 1999-08-06 2005-12-27 Institut Fuer Diagnostik Forshung Gmbh Process for detecting binding reactions with use of the measurement of the relaxation of the double refraction of magnetic particles
ATE526019T1 (en) * 2000-07-28 2011-10-15 Sloan Kettering Inst Cancer METHOD FOR TREATING CELL PROLIFERATION DISORDERS AND VIRUS INFECTIONS
EP1315732B1 (en) * 2000-08-25 2006-06-07 Sloan-Kettering Institute For Cancer Research Radicicol and monocillin and their analogues and uses thereof
JP2004529188A (en) * 2001-05-23 2004-09-24 スローン − ケッタリング インスティチュート フォー キャンサー リサーチ Treatment of cancer associated with elevation
WO2003059251A2 (en) 2001-10-22 2003-07-24 The Scripps Research Institute Antibody targeting compounds
ES2384235T3 (en) * 2001-10-22 2012-07-02 The Scripps Research Institute Integrin-directed compounds
ES2432747T3 (en) 2003-06-27 2013-12-05 Kyowa Hakko Kirin Co., Ltd. HSP90 family protein inhibitors
US20080108694A1 (en) * 2003-12-19 2008-05-08 Samuel J Danishefsky Novel Macrocycles and Uses Thereof
WO2006115509A2 (en) 2004-06-24 2006-11-02 Novartis Vaccines And Diagnostics Inc. Small molecule immunopotentiators and assays for their detection
WO2007048127A2 (en) * 2005-10-20 2007-04-26 The Scripps Research Institute Fc labeling for immunostaining and immunotargeting
GB0526615D0 (en) * 2005-12-30 2006-02-08 Novartis Ag Organic compounds
EP2136799B1 (en) * 2006-08-11 2017-10-04 Universite De Strasbourg Macrocyclic compounds useful as inhibitors of kinases and hsp90
MX2010007755A (en) * 2008-01-15 2010-12-21 Univ Strasbourg Synthesis of resorcylic acid lactones useful as therapeutic agents.
US20110190237A1 (en) * 2008-01-15 2011-08-04 Nexgenix Pharmaceuticals Macrocyclic Prodrug Compounds Useful as Therapeutics
WO2009105755A2 (en) 2008-02-21 2009-08-27 Nexgenix Pharmaceuticals Macrocyclic prodrug compounds useful as therapeutics
LT5623B (en) 2008-04-30 2010-01-25 Biotechnologijos Institutas, , 5-aryl-4-(5-substituted 2,4-dihydroxyfenil)-1,2,3-thiadiazoles as inhibitors of hsp90 chaperone and the intermediates for production thereof
WO2010093706A2 (en) 2009-02-10 2010-08-19 The Scripps Research Institute Chemically programmed vaccination

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE911915A1 (en) 1990-06-06 1991-12-18 Sankyo Co Radicicol derivatives, their preparation and their¹anti-tumor activity
JP3055967B2 (en) 1990-06-06 2000-06-26 三共株式会社 Radicicol derivative
US5650430A (en) 1990-06-06 1997-07-22 Sankyo Company, Limited Radicicol derivatives, their preparation and their anti-tumor activity
JPH06279279A (en) * 1993-03-26 1994-10-04 Tsumura & Co Arterialization inhibitor
JPH06298764A (en) 1993-04-15 1994-10-25 Kyowa Hakko Kogyo Co Ltd Immunosuppressant
JPH0840893A (en) * 1993-08-31 1996-02-13 Takeda Chem Ind Ltd Interleukin-1 production inhibitor
US5731343A (en) * 1995-02-24 1998-03-24 The Scripps Research Institute Method of use of radicicol for treatment of immunopathological disorders
ES2149468T3 (en) 1995-04-26 2000-11-01 Kyowa Hakko Kogyo Kk DERIVATIVES OF RADICICOL.
JPH09202781A (en) * 1996-01-25 1997-08-05 Sankyo Co Ltd Radicicol derivative

Also Published As

Publication number Publication date
DE69728974D1 (en) 2004-06-09
NZ331062A (en) 2000-05-26
AU4723997A (en) 1998-05-22
US6635662B2 (en) 2003-10-21
ATE266017T1 (en) 2004-05-15
US20040053990A1 (en) 2004-03-18
EP0889042A4 (en) 1999-10-06
EP0889042B1 (en) 2004-05-06
US20010027208A1 (en) 2001-10-04
NO982960D0 (en) 1998-06-25
CN1211244A (en) 1999-03-17
AU727722B2 (en) 2000-12-21
US6316491B1 (en) 2001-11-13
WO1998018780A1 (en) 1998-05-07
ES2216130T3 (en) 2004-10-16
US6239168B1 (en) 2001-05-29
CA2241624A1 (en) 1998-05-07
DE69728974T2 (en) 2005-03-31
KR19990076764A (en) 1999-10-15
EP0889042A1 (en) 1999-01-07

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