NO982987L - Amidinoproteasehemmere - Google Patents
AmidinoproteasehemmereInfo
- Publication number
- NO982987L NO982987L NO982987A NO982987A NO982987L NO 982987 L NO982987 L NO 982987L NO 982987 A NO982987 A NO 982987A NO 982987 A NO982987 A NO 982987A NO 982987 L NO982987 L NO 982987L
- Authority
- NO
- Norway
- Prior art keywords
- amidinoproteasehemmere
- compounds
- formula
- benzamidino
- amidino
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/195—Radicals derived from nitrogen analogues of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Cephalosporin Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Detergent Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US943195P | 1995-12-29 | 1995-12-29 | |
| PCT/US1996/020087 WO1997024135A1 (en) | 1995-12-29 | 1996-12-20 | Amidino protease inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO982987D0 NO982987D0 (no) | 1998-06-26 |
| NO982987L true NO982987L (no) | 1998-08-28 |
Family
ID=21737595
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO982987A NO982987L (no) | 1995-12-29 | 1998-06-26 | Amidinoproteasehemmere |
Country Status (19)
| Country | Link |
|---|---|
| US (5) | US6034127A (de) |
| EP (1) | EP0883405B1 (de) |
| JP (1) | JP2000503010A (de) |
| KR (1) | KR19990076817A (de) |
| AT (1) | ATE260112T1 (de) |
| BR (1) | BR9612360A (de) |
| CA (1) | CA2256309C (de) |
| CZ (1) | CZ206698A3 (de) |
| DE (1) | DE69631692T2 (de) |
| DK (1) | DK0883405T3 (de) |
| ES (1) | ES2213786T3 (de) |
| HU (1) | HUP9902256A3 (de) |
| IL (1) | IL124883A0 (de) |
| MX (1) | MX9805152A (de) |
| NO (1) | NO982987L (de) |
| NZ (1) | NZ326076A (de) |
| PL (1) | PL327986A1 (de) |
| PT (1) | PT883405E (de) |
| WO (1) | WO1997024135A1 (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ206698A3 (cs) | 1995-12-29 | 1998-11-11 | 3- Dimensional Pharmaceuticals, Inc. | Amidinové inhibitory proteas |
| SE9602646D0 (sv) | 1996-07-04 | 1996-07-04 | Astra Ab | Pharmaceutically-useful compounds |
| TW499412B (en) | 1996-11-26 | 2002-08-21 | Dimensional Pharm Inc | Aminoguanidines and alkoxyguanidines as protease inhibitors |
| EP1007037A4 (de) | 1997-06-26 | 2004-10-06 | Lilly Co Eli | Antithrombose mittel |
| US6740682B2 (en) | 1997-08-29 | 2004-05-25 | Tularik Limited | Meta-benzamidine derivatives as serine protease inhibitors |
| US6262069B1 (en) * | 1997-08-29 | 2001-07-17 | Protherics Molecular Design Limited | 1-amino-7-isoquinoline derivatives as serine protease inhibitors |
| AU771666B2 (en) | 1998-11-20 | 2004-04-01 | Fuso Pharmaceutical Industries, Ltd. | Novel serine protease BSSP5 |
| AR023510A1 (es) | 1999-04-21 | 2002-09-04 | Astrazeneca Ab | Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina. |
| US6586617B1 (en) * | 1999-04-28 | 2003-07-01 | Sumitomo Chemical Takeda Agro Company, Limited | Sulfonamide derivatives |
| JP2001026506A (ja) * | 1999-04-28 | 2001-01-30 | Takeda Chem Ind Ltd | スルホンアミド誘導体 |
| US6635637B2 (en) | 2000-08-04 | 2003-10-21 | Dimensional Pharmaceuticals, Inc. | Cyclic oxyguanidine protease inhibitors |
| JP4399160B2 (ja) * | 2000-11-03 | 2010-01-13 | ザ ジェイ. デビッド グラッドストーン インスティテューツ | apoEに関連する疾患を治療する方法 |
| US8394813B2 (en) | 2000-11-14 | 2013-03-12 | Shire Llc | Active agent delivery systems and methods for protecting and administering active agents |
| ATE388143T1 (de) * | 2001-04-24 | 2008-03-15 | Aryx Therapeutics | Cumarin derivate und ihre verwendung als anticoagulantien |
| EP1569912B1 (de) | 2002-12-03 | 2015-04-29 | Pharmacyclics, Inc. | 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidinderivate als faktor vii-a hemmer |
| MXPA06010899A (es) * | 2004-03-25 | 2006-12-15 | Elan Pharm Inc | 1,3-diaminopropanos substituidos con 2-amino y 2-tio. |
| GB0815781D0 (en) * | 2008-08-29 | 2008-10-08 | Xention Ltd | Novel potassium channel blockers |
| GB0815784D0 (en) * | 2008-08-29 | 2008-10-08 | Xention Ltd | Novel potassium channel blockers |
| GB0815782D0 (en) | 2008-08-29 | 2008-10-08 | Xention Ltd | Novel potassium channel blockers |
| CN103402549A (zh) | 2010-12-31 | 2013-11-20 | 考瑞多制药公司 | 精氨酸酶抑制剂及其使用方法 |
| EP2989080A1 (de) * | 2013-04-22 | 2016-03-02 | Reuter Chemische Apparatebau KG | Verfahren zur herstellung von enantiomer angereichertem 3-hydroxymethylpiperidin |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3577432A (en) * | 1968-12-23 | 1971-05-04 | Robins Co Inc A H | 1-substituted-3-phenoxypyrrolidines |
| CH526535A (de) | 1970-02-05 | 1972-08-15 | Sandoz Ag | Verfahren zur Herstellung neuer Pyrrolidin-1-carboxamidinderivate |
| JPS537436B2 (de) * | 1974-04-16 | 1978-03-17 | ||
| JPS5175042A (ja) * | 1974-12-26 | 1976-06-29 | Ono Pharmaceutical Co | Guanijinoshibosanamidojudotaino seizohoho |
| HU177098B (en) * | 1979-01-04 | 1981-07-28 | Gyogyszerkutato Intezet | Process for producing new peptidyl-n-carboxy-l-arginin-a |
| US4316899A (en) | 1979-08-24 | 1982-02-23 | Beecham Group Limited | Chromanone derivatives, a process for their preparation and compositions containing them |
| US4433152A (en) * | 1981-05-25 | 1984-02-21 | Nippon Chemiphar Co., Ltd. | Amidinopiperidine derivatives |
| JPS58194861A (ja) * | 1982-05-10 | 1983-11-12 | Nippon Chemiphar Co Ltd | 新規ピペリジン誘導体およびその製造法 |
| JPS62145060A (ja) | 1985-12-17 | 1987-06-29 | Tanabe Seiyaku Co Ltd | ピペラジン誘導体及びその製法 |
| US5039805A (en) * | 1988-12-08 | 1991-08-13 | Hoffmann-La Roche Inc. | Novel benzoic and phenylacetic acid derivatives |
| DE3913597A1 (de) | 1989-04-25 | 1990-11-08 | Heumann Pharma Gmbh & Co | Diazinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| TW201303B (de) * | 1990-07-05 | 1993-03-01 | Hoffmann La Roche | |
| DE4127404A1 (de) | 1991-08-19 | 1993-02-25 | Thomae Gmbh Dr K | Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| CA2129526A1 (en) | 1992-02-05 | 1993-08-06 | Franz Birke | Novel amidine derivatives, their preparation and their use as medicaments with ltb4 antagonistic effect |
| TW223629B (de) * | 1992-03-06 | 1994-05-11 | Hoffmann La Roche | |
| TW257757B (de) * | 1993-03-03 | 1995-09-21 | Boehringer Mannheim Gmbh | |
| US5466811A (en) * | 1994-07-18 | 1995-11-14 | Merck & Co., Inc. | Dioxolenylmethyl carbamates pro moieties for amine drugs |
| DE4430757A1 (de) * | 1994-08-30 | 1996-03-07 | Boehringer Mannheim Gmbh | Neue 4-Aminopyridazine, Verfahren zu ihrer Herstellung sowie diese Verbindungen enthaltende Arzneimittel |
| DE4430755A1 (de) * | 1994-08-30 | 1996-03-07 | Boehringer Mannheim Gmbh | Neue Phosphanoxide, Verfahren zu ihrer Herstellung sowie diese Verbindungen enthaltende Arzneimittel |
| CZ92298A3 (cs) * | 1995-09-29 | 1998-07-15 | 3-Dimensional Pharmaceuticals, Inc. | Inhibitory guanidin proteasy |
| CZ206698A3 (cs) | 1995-12-29 | 1998-11-11 | 3- Dimensional Pharmaceuticals, Inc. | Amidinové inhibitory proteas |
-
1996
- 1996-12-20 CZ CZ982066A patent/CZ206698A3/cs unknown
- 1996-12-20 AT AT96944847T patent/ATE260112T1/de not_active IP Right Cessation
- 1996-12-20 IL IL12488396A patent/IL124883A0/xx unknown
- 1996-12-20 PT PT96944847T patent/PT883405E/pt unknown
- 1996-12-20 DE DE69631692T patent/DE69631692T2/de not_active Expired - Fee Related
- 1996-12-20 DK DK96944847T patent/DK0883405T3/da active
- 1996-12-20 KR KR1019980704943A patent/KR19990076817A/ko not_active Ceased
- 1996-12-20 EP EP96944847A patent/EP0883405B1/de not_active Expired - Lifetime
- 1996-12-20 JP JP09524371A patent/JP2000503010A/ja not_active Ceased
- 1996-12-20 HU HU9902256A patent/HUP9902256A3/hu unknown
- 1996-12-20 WO PCT/US1996/020087 patent/WO1997024135A1/en not_active Ceased
- 1996-12-20 ES ES96944847T patent/ES2213786T3/es not_active Expired - Lifetime
- 1996-12-20 PL PL96327986A patent/PL327986A1/xx unknown
- 1996-12-20 CA CA002256309A patent/CA2256309C/en not_active Expired - Fee Related
- 1996-12-20 NZ NZ326076A patent/NZ326076A/en unknown
- 1996-12-20 BR BR9612360A patent/BR9612360A/pt unknown
- 1996-12-27 US US08/782,894 patent/US6034127A/en not_active Expired - Lifetime
-
1998
- 1998-06-24 MX MX9805152A patent/MX9805152A/es unknown
- 1998-06-26 NO NO982987A patent/NO982987L/no not_active Application Discontinuation
-
1999
- 1999-03-16 US US09/270,734 patent/US6133315A/en not_active Expired - Lifetime
-
2000
- 2000-02-11 US US09/502,005 patent/US6281206B1/en not_active Expired - Lifetime
- 2000-08-01 US US09/631,107 patent/US6225302B1/en not_active Expired - Lifetime
-
2001
- 2001-05-09 US US09/851,123 patent/US6414020B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| HUP9902256A3 (en) | 2000-01-28 |
| US6281206B1 (en) | 2001-08-28 |
| EP0883405A4 (de) | 1999-04-28 |
| US6414020B2 (en) | 2002-07-02 |
| NZ326076A (en) | 1999-02-25 |
| DE69631692T2 (de) | 2004-12-02 |
| AU706145B2 (en) | 1999-06-10 |
| BR9612360A (pt) | 1999-07-13 |
| CA2256309C (en) | 2006-08-15 |
| EP0883405B1 (de) | 2004-02-25 |
| PT883405E (pt) | 2004-06-30 |
| US6225302B1 (en) | 2001-05-01 |
| KR19990076817A (ko) | 1999-10-15 |
| US6034127A (en) | 2000-03-07 |
| AU1432397A (en) | 1997-07-28 |
| EP0883405A1 (de) | 1998-12-16 |
| WO1997024135A1 (en) | 1997-07-10 |
| HUP9902256A1 (hu) | 1999-10-28 |
| ATE260112T1 (de) | 2004-03-15 |
| US20010025041A1 (en) | 2001-09-27 |
| NO982987D0 (no) | 1998-06-26 |
| DK0883405T3 (da) | 2004-06-28 |
| MX9805152A (es) | 1998-10-31 |
| CA2256309A1 (en) | 1997-07-10 |
| PL327986A1 (en) | 1999-01-04 |
| CZ206698A3 (cs) | 1998-11-11 |
| JP2000503010A (ja) | 2000-03-14 |
| DE69631692D1 (de) | 2004-04-01 |
| IL124883A0 (en) | 1999-01-26 |
| US6133315A (en) | 2000-10-17 |
| ES2213786T3 (es) | 2004-09-01 |
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