NO983914L - Protonpumpe-inhibitor - Google Patents

Protonpumpe-inhibitor

Info

Publication number
NO983914L
NO983914L NO983914A NO983914A NO983914L NO 983914 L NO983914 L NO 983914L NO 983914 A NO983914 A NO 983914A NO 983914 A NO983914 A NO 983914A NO 983914 L NO983914 L NO 983914L
Authority
NO
Norway
Prior art keywords
proton pump
represent
substituted
compounds
thiadiazole
Prior art date
Application number
NO983914A
Other languages
English (en)
Other versions
NO983914D0 (no
Inventor
Khashayar Karimian
Tim F Tam
Denis Desilets
Sue Lee
Tullio Cappelletto
Wanren Li
Original Assignee
Apotex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Apotex Inc filed Critical Apotex Inc
Publication of NO983914D0 publication Critical patent/NO983914D0/no
Publication of NO983914L publication Critical patent/NO983914L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)

Abstract

Det tilveiebringes nye tiadiazolforbindelser som er effektive som protonpumpe-inhibitorer, nyttige ved behandling av peptiske sår ved inhibering av protonpumpe-enzymet H+/K+-ATPase. Forbindelsene er 3-substituerte 1.2.4- tiadiazol[4,5-a]benzimidazol og 3-substituert i svarende til den generelle formel (I), ¿? Y hvor X og Z hver representerer en eventuelt substituert benzenring kondensert til diazol-kjernen, eller representerer en rekke uavhengige kjemiske grupperinger (hydrogen, lavere alkyl, halogen, etc.) og Y er valgt fra et bredt område, f.eks. heterocykluser og karbonylgrupper.
NO983914A 1996-02-26 1998-08-26 Protonpumpe-inhibitor NO983914L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/606,987 US5677302A (en) 1996-02-26 1996-02-26 Thiadiazole compounds useful as proton pump inhibitors
PCT/CA1997/000125 WO1997031923A1 (en) 1996-02-26 1997-02-26 Proton pump inhibitor

Publications (2)

Publication Number Publication Date
NO983914D0 NO983914D0 (no) 1998-08-26
NO983914L true NO983914L (no) 1998-10-23

Family

ID=24430335

Family Applications (1)

Application Number Title Priority Date Filing Date
NO983914A NO983914L (no) 1996-02-26 1998-08-26 Protonpumpe-inhibitor

Country Status (21)

Country Link
US (2) US5677302A (no)
EP (1) EP0883622B1 (no)
JP (1) JPH11513993A (no)
KR (1) KR19990087397A (no)
CN (1) CN1216547A (no)
AT (1) ATE217627T1 (no)
AU (1) AU1762297A (no)
BR (1) BR9707757A (no)
CA (1) CA2247901A1 (no)
CZ (1) CZ271298A3 (no)
DE (1) DE69712608T2 (no)
DK (1) DK0883622T3 (no)
ES (1) ES2176675T3 (no)
HU (1) HUP9901565A2 (no)
IL (1) IL125944A0 (no)
NO (1) NO983914L (no)
PL (1) PL328863A1 (no)
PT (1) PT883622E (no)
TR (1) TR199801670T2 (no)
WO (1) WO1997031923A1 (no)
YU (1) YU42598A (no)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6852739B1 (en) * 1999-02-26 2005-02-08 Nitromed Inc. Methods using proton pump inhibitors and nitric oxide donors
US7365047B1 (en) * 1999-09-28 2008-04-29 The Regents Of The University Of California Use of pentagastrin to inhibit gastric acid secretion or as a diuretic
UA80393C2 (uk) * 2000-12-07 2007-09-25 Алтана Фарма Аг Фармацевтична композиція, яка містить інгібітор фде 4, диспергований в матриці
MY140561A (en) * 2002-02-20 2009-12-31 Nycomed Gmbh Dosage form containing pde 4 inhibitor as active ingredient
CA2379375A1 (en) * 2002-03-28 2003-09-28 Apotex Inc. Sulfonamide derivatives of 3-substituted imidazol[1,2-d]-1,2,4-thiadiazoles and 3-substituted-[1,2,4] thiadiazolo[4,5-a] benzimidazole as inhibitors of fibrin cross-linking and transglutaminases
AU2003254282A1 (en) * 2002-08-01 2004-02-23 Nitromed, Inc. Nitrosated proton pump inhibitors, compositions and methods of use
EA009985B1 (ru) 2003-03-10 2008-04-28 Никомед Гмбх Новый способ получения рофлумиласта
ES2421916T3 (es) 2005-03-16 2013-09-06 Nycomed Gmbh Forma farmacéutica de sabor enmascarado que contiene roflumilast
US7803817B2 (en) * 2005-05-11 2010-09-28 Vecta, Ltd. Composition and methods for inhibiting gastric acid secretion
US7981908B2 (en) * 2005-05-11 2011-07-19 Vecta, Ltd. Compositions and methods for inhibiting gastric acid secretion
EP2046334B1 (en) 2006-07-25 2014-05-21 Vecta Ltd. Compositions and meth0ds for inhibiting gastric acide secretion using derivatives of small dicarboxylic acids in combination with ppi
US8653082B2 (en) * 2009-02-25 2014-02-18 Urifer Ltd. 6-phenyl-2-[((piperidin-4-ylmethyl)-piperazin-1YL) or piperazin 1-ylmethyl)-piperidin-1-yl)]-imidazo[2,1-B][1,3,4]thiadiazole derivatives and their use
CN110082487A (zh) * 2019-05-13 2019-08-02 丽珠医药集团股份有限公司 检测试剂、检测系统及拉唑类药物肠吸收的试验方法
CN113880864A (zh) * 2021-11-22 2022-01-04 吉首大学 含苯并咪唑骈杂硒咪唑亚胺的化合物及其制法和应用
CN119060069B (zh) * 2024-08-26 2025-03-11 山东峰泉新材料有限公司 防老剂mb-s及其制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3864353A (en) * 1973-12-17 1975-02-04 Squibb & Sons Inc 1-(1-Imidazolyl) (1,2,4) thiadiazolo (4,5-alpha) benzimidazoles
US5106863A (en) * 1990-03-26 1992-04-21 Ortho Pharmaceutical Corporation Substituted imidazole and pyridine derivatives
DE4023215A1 (de) * 1990-07-21 1992-01-23 Hoechst Ag Substituierte azole, verfahren zu deren herstellung, sie enthaltende mittel und deren verwendung

Also Published As

Publication number Publication date
DE69712608T2 (de) 2002-08-29
CZ271298A3 (cs) 1999-02-17
AU1762297A (en) 1997-09-16
JPH11513993A (ja) 1999-11-30
WO1997031923A1 (en) 1997-09-04
PL328863A1 (en) 1999-03-01
EP0883622A1 (en) 1998-12-16
US5677302A (en) 1997-10-14
DK0883622T3 (da) 2002-09-09
CN1216547A (zh) 1999-05-12
YU42598A (sh) 2000-12-28
US6093738A (en) 2000-07-25
KR19990087397A (ko) 1999-12-27
HUP9901565A2 (hu) 1999-08-30
EP0883622B1 (en) 2002-05-15
ES2176675T3 (es) 2002-12-01
PT883622E (pt) 2002-09-30
TR199801670T2 (xx) 1998-11-23
CA2247901A1 (en) 1997-09-04
BR9707757A (pt) 2000-10-24
DE69712608D1 (de) 2002-06-20
ATE217627T1 (de) 2002-06-15
IL125944A0 (en) 1999-04-11
NO983914D0 (no) 1998-08-26

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