NO984076L - Kovalent modifisering av overflater med polymerer for Õ °ke biokompatibiliteten - Google Patents
Kovalent modifisering av overflater med polymerer for Õ °ke biokompatibilitetenInfo
- Publication number
- NO984076L NO984076L NO984076A NO984076A NO984076L NO 984076 L NO984076 L NO 984076L NO 984076 A NO984076 A NO 984076A NO 984076 A NO984076 A NO 984076A NO 984076 L NO984076 L NO 984076L
- Authority
- NO
- Norway
- Prior art keywords
- tissue
- cell surfaces
- reducing
- covalent modification
- cell
- Prior art date
Links
- 230000004048 modification Effects 0.000 title abstract 3
- 238000012986 modification Methods 0.000 title abstract 3
- 229920000642 polymer Polymers 0.000 title abstract 3
- 210000004027 cell Anatomy 0.000 abstract 6
- 238000000034 method Methods 0.000 abstract 6
- 238000007631 vascular surgery Methods 0.000 abstract 2
- KKJUPNGICOCCDW-UHFFFAOYSA-N 7-N,N-Dimethylamino-1,2,3,4,5-pentathiocyclooctane Chemical compound CN(C)C1CSSSSSC1 KKJUPNGICOCCDW-UHFFFAOYSA-N 0.000 abstract 1
- 102000018697 Membrane Proteins Human genes 0.000 abstract 1
- 108010052285 Membrane Proteins Proteins 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 229920000249 biocompatible polymer Polymers 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004204 blood vessel Anatomy 0.000 abstract 1
- 230000021164 cell adhesion Effects 0.000 abstract 1
- 230000008021 deposition Effects 0.000 abstract 1
- 125000005442 diisocyanate group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000005847 immunogenicity Effects 0.000 abstract 1
- 238000002650 immunosuppressive therapy Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 210000000265 leukocyte Anatomy 0.000 abstract 1
- 230000000873 masking effect Effects 0.000 abstract 1
- 208000037803 restenosis Diseases 0.000 abstract 1
- 230000002792 vascular Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/0076—Chemical modification of the substrate
- A61L33/0088—Chemical modification of the substrate by grafting of a monomer onto the substrate
Landscapes
- Health & Medical Sciences (AREA)
- Hematology (AREA)
- Surgery (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Materials For Medical Uses (AREA)
- Treatments Of Macromolecular Shaped Articles (AREA)
- Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
Abstract
Kovalent modifisering av vevs- og celleoverflater som hindrer celleadhesjon. Fremgangsmåten utføres under akseptable in vivo-betingelser og anvender en biokompatibel polymer som har en reaktiv gruppe bundet til minst en ende som reagerer med grupper til stede eller på vevs- og celleoverflater under vandig og milde betingelser, og som dermed bindes kovalent til polymeren på vevs- eller celleoverflaten. Fortrinnsvis reagerer den reaktive gruppe bundet til polymeren med aminer og hydroksyler til stede på vevs- og celleoverflater. I en foretrukken utførelsesform frembringer fremgangsmåten ifølge oppfinnelsen kovalent modifisering av vevs- og celleoverflater ved hjelp av PEG- diisocyanatløsning. Fremgangsmåten er spesielt nyttig for å svekke blodplate- og leukocyttavsetning i blodkar og dermed motvirke tromboser og restenoser, en alminnelig komplikasjon ved vaskulære prosedyrer inkludert PTCA og vaskulær kirurgi. Videre er fremgangsmåtene ifølge oppfinnelsen nyttige ved å redusere trombogenisitet av transplantater og redusere komplikasjonene ved vaskulær kirurgi ved å maskere vevesoverflateproteiner fra blodelementer. Fremgangsmåten reduserer immunogenisiteten av transplanterte vev og celler og reduserer dermed nødvendigheten av immunsuppressiv terapi.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/612,270 US5977252A (en) | 1996-03-07 | 1996-03-07 | Covalent modification of surfaces with polymers to increase biocompatibility |
| PCT/US1997/003591 WO1997032617A1 (en) | 1996-03-07 | 1997-03-07 | Covalent modification of surfaces with polymers to increase biocompatibility |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO984076D0 NO984076D0 (no) | 1998-09-04 |
| NO984076L true NO984076L (no) | 1998-11-06 |
Family
ID=24452457
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO984076A NO984076L (no) | 1996-03-07 | 1998-09-04 | Kovalent modifisering av overflater med polymerer for Õ °ke biokompatibiliteten |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5977252A (no) |
| EP (1) | EP0885023A1 (no) |
| JP (1) | JP2000507849A (no) |
| CN (1) | CN1217664A (no) |
| AU (1) | AU711031B2 (no) |
| CA (1) | CA2248124A1 (no) |
| CZ (1) | CZ278498A3 (no) |
| HU (1) | HUP9903953A3 (no) |
| IL (1) | IL126085A0 (no) |
| NO (1) | NO984076L (no) |
| PL (1) | PL328720A1 (no) |
| SK (1) | SK122998A3 (no) |
| WO (1) | WO1997032617A1 (no) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002000685A1 (en) * | 2000-06-28 | 2002-01-03 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Localized delivery to a target surface |
| DE10136722A1 (de) * | 2001-07-27 | 2003-02-13 | Evotec Ag | Verfahren zur Verhinderung der Adhäsion von Partikeln |
| US7198945B2 (en) | 2001-08-09 | 2007-04-03 | Teruyuki Nagamune | Cell having modified cell membrane |
| WO2003037400A2 (en) * | 2001-10-31 | 2003-05-08 | Ventrigraft Inc | Methods and device compositions for the recruitment of cells to blood contacting surfaces in vivo |
| DE10162435A1 (de) * | 2001-12-19 | 2003-07-17 | Joerg Lahann | Verfahren zur Erzeugung von Oberflächenbeschichtungen, die die Adsorption von Proteinen bzw. die Adhäsion von Bakterien und/oder Zellen vermindern |
| US7767220B2 (en) * | 2004-04-23 | 2010-08-03 | Boston Scientific Scimed, Inc. | Implantable or insertable medical articles having covalently modified, biocompatible surfaces |
| US20050281866A1 (en) * | 2004-05-24 | 2005-12-22 | Genzyme Corporation | Adherent polymeric compositions |
| EP1796693A2 (en) * | 2004-08-26 | 2007-06-20 | Chandrashekhar P. Pathak | Implantable tissue compositions and method |
| EP1799278A2 (en) | 2004-09-28 | 2007-06-27 | Baylor University | Spatially-defined modification of fresh tissue using covalent chemistry |
| WO2018034097A1 (ja) * | 2016-08-17 | 2018-02-22 | 国立研究開発法人物質・材料研究機構 | 細胞の内包化方法および内包化細胞 |
| US10814036B2 (en) | 2016-11-07 | 2020-10-27 | Baylor University | Drug-eluting live tissue for transplantation |
| JP7286078B2 (ja) * | 2018-09-26 | 2023-06-05 | 国立研究開発法人物質・材料研究機構 | 細胞凝集抑制剤、細胞凝集抑制方法、細胞分散方法、及び、細胞分析方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1541435A (en) * | 1975-02-04 | 1979-02-28 | Searle & Co | Immunological materials |
| US4373009A (en) * | 1981-05-18 | 1983-02-08 | International Silicone Corporation | Method of forming a hydrophilic coating on a substrate |
| JPS60227763A (ja) * | 1984-04-27 | 1985-11-13 | 筏 義人 | 抗血栓性医用材料 |
| US5462990A (en) * | 1990-10-15 | 1995-10-31 | Board Of Regents, The University Of Texas System | Multifunctional organic polymers |
| US5580923A (en) * | 1995-03-14 | 1996-12-03 | Collagen Corporation | Anti-adhesion films and compositions for medical use |
-
1996
- 1996-03-07 US US08/612,270 patent/US5977252A/en not_active Expired - Lifetime
-
1997
- 1997-03-07 HU HU9903953A patent/HUP9903953A3/hu unknown
- 1997-03-07 CZ CZ982784A patent/CZ278498A3/cs unknown
- 1997-03-07 SK SK1229-98A patent/SK122998A3/sk unknown
- 1997-03-07 WO PCT/US1997/003591 patent/WO1997032617A1/en not_active Ceased
- 1997-03-07 CA CA002248124A patent/CA2248124A1/en not_active Abandoned
- 1997-03-07 PL PL97328720A patent/PL328720A1/xx unknown
- 1997-03-07 AU AU21988/97A patent/AU711031B2/en not_active Ceased
- 1997-03-07 JP JP9531964A patent/JP2000507849A/ja active Pending
- 1997-03-07 EP EP97914905A patent/EP0885023A1/en not_active Withdrawn
- 1997-03-07 CN CN97192849A patent/CN1217664A/zh not_active Withdrawn
- 1997-03-07 IL IL12608597A patent/IL126085A0/xx unknown
-
1998
- 1998-09-04 NO NO984076A patent/NO984076L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SK122998A3 (en) | 1999-03-12 |
| AU711031B2 (en) | 1999-10-07 |
| AU2198897A (en) | 1997-09-22 |
| US5977252A (en) | 1999-11-02 |
| CA2248124A1 (en) | 1997-09-12 |
| HUP9903953A2 (hu) | 2000-03-28 |
| CN1217664A (zh) | 1999-05-26 |
| IL126085A0 (en) | 1999-05-09 |
| EP0885023A1 (en) | 1998-12-23 |
| WO1997032617A1 (en) | 1997-09-12 |
| JP2000507849A (ja) | 2000-06-27 |
| HUP9903953A3 (en) | 2000-09-28 |
| PL328720A1 (en) | 1999-02-15 |
| CZ278498A3 (cs) | 1999-01-13 |
| NO984076D0 (no) | 1998-09-04 |
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