NO985891L - Substituerte benzamid-derivater og deres anvendelse som antikonvulsjonsmidler - Google Patents

Substituerte benzamid-derivater og deres anvendelse som antikonvulsjonsmidler

Info

Publication number
NO985891L
NO985891L NO985891A NO985891A NO985891L NO 985891 L NO985891 L NO 985891L NO 985891 A NO985891 A NO 985891A NO 985891 A NO985891 A NO 985891A NO 985891 L NO985891 L NO 985891L
Authority
NO
Norway
Prior art keywords
anticonvulsants
benzamide derivatives
substituted benzamide
relates
compounds
Prior art date
Application number
NO985891A
Other languages
English (en)
Other versions
NO985891D0 (no
Inventor
John David Harling
Barry Sidney Orlek
Mervyn Thompson
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9612608.1A external-priority patent/GB9612608D0/en
Priority claimed from GBGB9615352.3A external-priority patent/GB9615352D0/en
Priority claimed from GBGB9711013.4A external-priority patent/GB9711013D0/en
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of NO985891D0 publication Critical patent/NO985891D0/no
Publication of NO985891L publication Critical patent/NO985891L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Oppfinnelsen angår substituerte benzamido-heterocykliske forbindelser med den generelle formel (I). som har en alkoksysubstituent i C2-stillingen på benzamidogruppen og forskjellige substituenter i stillingene C4 og C5, idet den eventuelt er substituert på N-atomet i det heterocykliske system, og hvor den umettede ring i det heterocykliske system er en 5-, 6-, 7- eller 8-leddet ring. Oppfinnelsen angår også anvendelse av disse forbindelser som anti-konvulsjonsmidler ved visse medisinsk tilstander, og frem-gangsmåter for fremstilling av dem.P
NO985891A 1996-06-17 1998-12-16 Substituerte benzamid-derivater og deres anvendelse som antikonvulsjonsmidler NO985891L (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9612608.1A GB9612608D0 (en) 1996-06-17 1996-06-17 Novel compounds
GBGB9615352.3A GB9615352D0 (en) 1996-07-22 1996-07-22 Novel compounds
GBGB9711013.4A GB9711013D0 (en) 1997-05-28 1997-05-28 Novel compounds
PCT/EP1997/003131 WO1997048683A1 (en) 1996-06-17 1997-06-13 Substituted benzamide derivatives and their use as anticonvulsants

Publications (2)

Publication Number Publication Date
NO985891D0 NO985891D0 (no) 1998-12-16
NO985891L true NO985891L (no) 1998-12-16

Family

ID=27268330

Family Applications (1)

Application Number Title Priority Date Filing Date
NO985891A NO985891L (no) 1996-06-17 1998-12-16 Substituerte benzamid-derivater og deres anvendelse som antikonvulsjonsmidler

Country Status (14)

Country Link
US (1) US6110934A (no)
EP (1) EP0906283A1 (no)
AR (1) AR008234A1 (no)
AU (1) AU729124B2 (no)
BR (1) BR9709906A (no)
CA (1) CA2258238A1 (no)
CZ (1) CZ416498A3 (no)
HU (1) HUP9902166A3 (no)
IL (1) IL127068A0 (no)
NO (1) NO985891L (no)
NZ (1) NZ332757A (no)
PL (1) PL330465A1 (no)
TR (1) TR199802745T2 (no)
WO (1) WO1997048683A1 (no)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DZ2446A1 (fr) * 1997-03-18 2003-01-11 Smithkline Beecham Plc Nouveaux composés
CA2284218A1 (en) * 1997-03-18 1998-09-24 Smithkline Beecham P.L.C. Substituted isoquinoline derivatives and their use as anticonvulsants
US20010016657A1 (en) 1997-03-18 2001-08-23 Smithkline Beecham P.L.C. Substituted isoquinoline derivatives and their use as anticonvulsants
GB9726695D0 (en) * 1997-12-17 1998-02-18 Smithkline Beecham Plc Novel compounds
GB9711257D0 (en) * 1997-05-30 1997-07-30 Smithkline Beecham Plc Novel compounds
GB9812683D0 (en) 1998-06-12 1998-08-12 Smithkline Beecham Plc Novel compounds
GB9816984D0 (en) * 1998-08-05 1998-09-30 Smithkline Beecham Plc Novel compounds
GB9817424D0 (en) * 1998-08-11 1998-10-07 Smithkline Beecham Plc Novel compounds
GB9915589D0 (en) 1999-07-02 1999-09-01 Smithkline Beecham Plc Novel compounds
AR038420A1 (es) * 2002-02-15 2005-01-12 Glaxo Group Ltd Compuesto de amida, procedimiento para la preparacion del mismo, su uso para la fabricacion de un medicamento y composicion farmaceutica que lo comprende
GB0210762D0 (en) * 2002-05-10 2002-06-19 Glaxo Group Ltd Compounds
EP1632477B1 (en) 2003-06-12 2017-03-01 Astellas Pharma Inc. Benzamide derivative or salt thereof
WO2005072681A2 (en) * 2004-01-23 2005-08-11 Amgen Inc. Vanilloid receptor ligands and their use in treatments of inflammatory and neurotic pain.
CA2645551C (en) * 2006-03-16 2016-06-28 Renovis, Inc. Bicycloheteroaryl compounds as p2x7 modulators and uses thereof
PT2046787E (pt) 2006-08-01 2011-06-15 Glaxo Group Ltd Compostos de pirazolo[3,4-b]piridina e sua utilização como inibidores de pde4
CN115397412B (zh) 2020-04-17 2025-03-25 伊赛恩特制药公司 Mas相关g蛋白受体x4的调节剂及相关产物和方法
CN117285463A (zh) * 2023-09-04 2023-12-26 南通敏言生物医药科技有限公司 一种5-氨基-8-溴-2-叔丁氧羰基-1,2,3,4-四氢异喹啉的合成方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE634851A (no) * 1963-05-15 1900-01-01
US4022900A (en) * 1970-09-09 1977-05-10 Marion Laboratories, Inc. Compositions containing 1,2,3,4-tetrahydroisoquinolines used as hypotensive agents
GB9112721D0 (en) * 1991-06-13 1991-07-31 Smithkline Beecham Plc Novel treatment

Also Published As

Publication number Publication date
US6110934A (en) 2000-08-29
AU729124B2 (en) 2001-01-25
WO1997048683A1 (en) 1997-12-24
HUP9902166A2 (hu) 1999-10-28
AR008234A1 (es) 1999-12-29
NO985891D0 (no) 1998-12-16
TR199802745T2 (xx) 1999-04-21
AU3259597A (en) 1998-01-07
CA2258238A1 (en) 1997-12-24
IL127068A0 (en) 1999-09-22
BR9709906A (pt) 1999-08-10
EP0906283A1 (en) 1999-04-07
NZ332757A (en) 1999-06-29
HUP9902166A3 (en) 2001-01-29
CZ416498A3 (cs) 1999-06-16
PL330465A1 (en) 1999-05-24

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Legal Events

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FC2A Withdrawal, rejection or dismissal of laid open patent application