NO990697L - FremgangsmÕte for fremstilling av N-[(1-n-butyl-4-piperidyl)metyl]-3,4-dihydro-2H-[1,3]oksazino[3,2-a]indol-10-karboksamid og salter og mellomprodukter i fremgangsmÕten - Google Patents

FremgangsmÕte for fremstilling av N-[(1-n-butyl-4-piperidyl)metyl]-3,4-dihydro-2H-[1,3]oksazino[3,2-a]indol-10-karboksamid og salter og mellomprodukter i fremgangsmÕten

Info

Publication number
NO990697L
NO990697L NO990697A NO990697A NO990697L NO 990697 L NO990697 L NO 990697L NO 990697 A NO990697 A NO 990697A NO 990697 A NO990697 A NO 990697A NO 990697 L NO990697 L NO 990697L
Authority
NO
Norway
Prior art keywords
oxazino
piperidyl
carboxamide
indole
dihydro
Prior art date
Application number
NO990697A
Other languages
English (en)
Other versions
NO311574B1 (no
NO990697D0 (no
Inventor
Michael Fedouloff
David William Guest
Gillian Elizabeth Smith
John Bryce Strachan
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9617188.9A external-priority patent/GB9617188D0/en
Priority claimed from GBGB9618968.3A external-priority patent/GB9618968D0/en
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of NO990697L publication Critical patent/NO990697L/no
Publication of NO990697D0 publication Critical patent/NO990697D0/no
Publication of NO311574B1 publication Critical patent/NO311574B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Indole Compounds (AREA)
NO19990697A 1996-08-16 1999-02-15 Fremgangsmåte for fremstilling av N-[(1-n-butyl-4- piperidinyl)metyl]-3,4-dihydro-2H-[1,3]oksazino[3,2-a]indol-10-karboksamid og salter derav, og mellomprodukter som anvendes ifremgangsmåten NO311574B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9617188.9A GB9617188D0 (en) 1996-08-16 1996-08-16 Pharmaceuticals
GBGB9618968.3A GB9618968D0 (en) 1996-09-11 1996-09-11 Pharmaceuticals
PCT/EP1997/004413 WO1998007728A1 (en) 1996-08-16 1997-08-11 PROCESS FOR THE PREPARATION OF N-[(1-nBUTYL-4-PIPERIDYL)METHYL] -3,4-DIHYDRO -2H-[1,3] OXAZINO[3,2-a] INDOLE-10-CARBOXAMIDE AND SALTS AND INTERMEDIATES IN THE PROCESS

Publications (3)

Publication Number Publication Date
NO990697L true NO990697L (no) 1999-02-15
NO990697D0 NO990697D0 (no) 1999-02-15
NO311574B1 NO311574B1 (no) 2001-12-10

Family

ID=26309880

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19990697A NO311574B1 (no) 1996-08-16 1999-02-15 Fremgangsmåte for fremstilling av N-[(1-n-butyl-4- piperidinyl)metyl]-3,4-dihydro-2H-[1,3]oksazino[3,2-a]indol-10-karboksamid og salter derav, og mellomprodukter som anvendes ifremgangsmåten

Country Status (24)

Country Link
EP (1) EP0922048B1 (no)
JP (1) JP3911297B2 (no)
KR (1) KR100494278B1 (no)
CN (1) CN1104435C (no)
AR (1) AR008297A1 (no)
AT (1) ATE197588T1 (no)
AU (1) AU717177B2 (no)
BR (1) BR9711189A (no)
CA (1) CA2263480C (no)
CZ (1) CZ290517B6 (no)
DE (1) DE69703554T2 (no)
DK (1) DK0922048T3 (no)
ES (1) ES2151743T3 (no)
GR (1) GR3034895T3 (no)
IL (1) IL128499A (no)
NO (1) NO311574B1 (no)
NZ (1) NZ334064A (no)
PL (1) PL185815B1 (no)
PT (1) PT922048E (no)
SA (1) SA97180430B1 (no)
SI (1) SI0922048T1 (no)
TR (1) TR199900321T2 (no)
TW (1) TW427990B (no)
WO (1) WO1998007728A1 (no)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020091271A1 (en) 1998-07-16 2002-07-11 Smithkline Beecham Plc Process for the preparation of an indole derivative
GB9815483D0 (en) * 1998-07-16 1998-09-16 Smithkline Beecham Plc Pharmaceuticals
GB9815481D0 (en) * 1998-07-16 1998-09-16 Smithkline Beecham Plc Pharmaceuticals
US6277456B1 (en) * 1999-09-24 2001-08-21 Brady Worldwide, Inc. Labeling media and method of making
AU782863C (en) * 2000-08-07 2006-08-31 Glaxo Group Limited The use of 5HT4 receptor antagonists in the prophylaxis or treatment of certain cardiovascular conditions
AU782870C (en) * 2000-08-07 2007-03-15 Glaxo Group Limited The use of 5HT4 receptor antagonists in the prophylaxis or treatment of certain cardiovascular conditions
MXPA03001210A (es) * 2000-08-07 2004-08-12 Smithkline Beecham Corp Uso de antagonista del receptor 5-ht4 en la fabricacion de un medicamento para la profilaxis o tratamiento de fibrilacion atrial.
BR0307666A (pt) * 2002-02-14 2005-01-11 Glaxo Group Ltd Composição farmacêutica compreendendo n-[(1-n-butil-4-piperidinil)metil]-3,4-diidro-2h[1-3]oxazi no(3,2-a) indol-10-carboxamida ou sal e processo para esta compreendendo granulação seca
GB0211230D0 (en) 2002-05-16 2002-06-26 Medinnova Sf Treatment of heart failure
ITMI20030287A1 (it) 2003-02-18 2004-08-19 Acraf Indazolammidi dotate di attivita' analgesica metodo, per
ITMI20030972A1 (it) 2003-05-15 2004-11-16 Acraf Indazolo dotato di attivita' analgesica, metodo per prepararlo e composizione farmaceutica che lo comprende.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2104279C1 (ru) * 1992-03-12 1998-02-10 Смитклайн Бичам Плс Конденсированное индольное производное или его фармацевтически приемлемая соль, фармацевтическая композиция, проявляющая активность антагониста 5-нт*004-рецептора

Also Published As

Publication number Publication date
PL185815B1 (pl) 2003-08-29
HK1020731A1 (en) 2000-06-09
ES2151743T3 (es) 2001-01-01
PL331647A1 (en) 1999-08-02
PT922048E (pt) 2001-03-30
CN1104435C (zh) 2003-04-02
JP2000516240A (ja) 2000-12-05
CA2263480A1 (en) 1998-02-26
CZ51699A3 (cs) 1999-07-14
CZ290517B6 (cs) 2002-08-14
WO1998007728A1 (en) 1998-02-26
KR20000068174A (ko) 2000-11-25
TR199900321T2 (xx) 1999-04-21
DE69703554D1 (de) 2000-12-21
EP0922048A1 (en) 1999-06-16
TW427990B (en) 2001-04-01
BR9711189A (pt) 1999-08-17
NZ334064A (en) 2000-08-25
DE69703554T2 (de) 2001-07-05
SA97180430B1 (ar) 2006-10-29
AU717177B2 (en) 2000-03-16
NO311574B1 (no) 2001-12-10
AR008297A1 (es) 1999-12-29
JP3911297B2 (ja) 2007-05-09
CA2263480C (en) 2007-03-06
IL128499A (en) 2002-11-10
IL128499A0 (en) 2000-01-31
EP0922048B1 (en) 2000-11-15
CN1233250A (zh) 1999-10-27
DK0922048T3 (da) 2001-01-08
AU4204897A (en) 1998-03-06
ATE197588T1 (de) 2000-12-15
GR3034895T3 (en) 2001-02-28
NO990697D0 (no) 1999-02-15
KR100494278B1 (ko) 2005-06-13
SI0922048T1 (en) 2001-02-28

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