NO991384L - Substituerte heterocykler som anti-tumormidler - Google Patents

Substituerte heterocykler som anti-tumormidler

Info

Publication number
NO991384L
NO991384L NO991384A NO991384A NO991384L NO 991384 L NO991384 L NO 991384L NO 991384 A NO991384 A NO 991384A NO 991384 A NO991384 A NO 991384A NO 991384 L NO991384 L NO 991384L
Authority
NO
Norway
Prior art keywords
compounds
formula
tumor agents
substituted heterocycles
useful
Prior art date
Application number
NO991384A
Other languages
English (en)
Other versions
NO991384D0 (no
Inventor
Edmond J Lavoie
Leroy Fong Liu
Darshan B Makhey
Original Assignee
Univ Rutgers
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Rutgers filed Critical Univ Rutgers
Publication of NO991384D0 publication Critical patent/NO991384D0/no
Publication of NO991384L publication Critical patent/NO991384L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/18—Ring systems of four or more rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Den foreliggende oppfinnelse tilveiebringer forbindelsene fra formel (I) hvori Ri-R?, W, X, Y og Z har enhver av verdiene definert i beskrivelsen, og farmasøytisk akseptable salt derav, som er nyttige som anti-cancermidler. Også beskrevet er farmasøytiske sammensetninger som omfatter en eller flere forbindelser fra formel (I), metoder for fremstilling av forbindelsene fra formel (I) og intermediater nyttige for fremstilling av forbindelser fra formel (I).
NO991384A 1996-09-23 1999-03-22 Substituerte heterocykler som anti-tumormidler NO991384L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2651196P 1996-09-23 1996-09-23
PCT/US1997/017012 WO1998012181A1 (en) 1996-09-23 1997-09-23 Substituted heterocycles as anti-tumor agents

Publications (2)

Publication Number Publication Date
NO991384D0 NO991384D0 (no) 1999-03-22
NO991384L true NO991384L (no) 1999-05-20

Family

ID=21832257

Family Applications (1)

Application Number Title Priority Date Filing Date
NO991384A NO991384L (no) 1996-09-23 1999-03-22 Substituerte heterocykler som anti-tumormidler

Country Status (14)

Country Link
US (1) US5981541A (no)
EP (1) EP0950054A1 (no)
JP (1) JP2001501197A (no)
KR (1) KR20000048537A (no)
AU (1) AU725938B2 (no)
BR (1) BR9711296A (no)
CA (1) CA2266321A1 (no)
CZ (1) CZ102499A3 (no)
IL (1) IL129096A0 (no)
NO (1) NO991384L (no)
NZ (1) NZ334954A (no)
PL (1) PL332416A1 (no)
TR (1) TR199900636T2 (no)
WO (1) WO1998012181A1 (no)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL137351A0 (en) 1998-02-12 2001-07-24 Univ Rutgers Heterocyclic topoisomerase poisons
US6858598B1 (en) 1998-12-23 2005-02-22 G. D. Searle & Co. Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US8133421B2 (en) * 1999-02-23 2012-03-13 Warsaw Orthopedic, Inc. Methods of making shaped load-bearing osteoimplant
US20070233272A1 (en) * 1999-02-23 2007-10-04 Boyce Todd M Shaped load-bearing osteoimplant and methods of making same
US6740650B2 (en) 1999-10-29 2004-05-25 Rutgers, The State University Of New Jersey Heterocyclic cytotoxic agents
US20030139409A1 (en) 1999-12-02 2003-07-24 John Milton Benzo[A] [phenazin-11-carboxamide derivatives and their use as joint inhibitors of topomerase I and II
GB9928542D0 (en) * 1999-12-02 2000-02-02 Xenova Ltd Pharmaceutical compounds
JP2003528858A (ja) * 2000-03-27 2003-09-30 アクゾ・ノベル・エヌ・ベー エストロゲン関連治療用のノンステロイド系四環式化合物
KR100381716B1 (ko) * 2000-10-09 2003-04-26 한국화학연구원 항암활성을 가지는 아크리딘 유도체
WO2003041660A2 (en) * 2001-11-14 2003-05-22 Rutgers, The State University Solubilized topoisomerase poisons
ATE390923T1 (de) 2001-11-14 2008-04-15 Univ Rutgers Topoisomerase-giftmittel
ES2311639T3 (es) * 2001-11-14 2009-02-16 Rutgers, The State University Agentes citotoxicos.
JP4789414B2 (ja) 2001-11-14 2011-10-12 ラトガーズ，ザ ステイト ユニバーシティ 可溶化トポイソメラーゼ毒性剤
WO2004014862A1 (en) * 2002-08-09 2004-02-19 Rutgers, The State University Nitro and amino substituted heterocycles as topoisomerase i targeting agents
WO2004014918A1 (en) * 2002-08-09 2004-02-19 Rutgers, The State University Nitro and amino substituted topoisomerase agents
US6992089B2 (en) 2002-08-09 2006-01-31 Rutgers, The University Of New Jersey Nitro and amino substituted topoisomerase agents
AU2003290818A1 (en) * 2002-11-12 2004-06-03 Edmond J. Lavoie Topoisomerase-targeting agents
DK2403856T3 (da) 2009-03-06 2013-04-08 Univ Rutgers Methylendioxybenzo[i]phenanthridinderivater anvendt til behandling af cancer
WO2010127363A1 (en) 2009-05-01 2010-11-04 Rutgers, The State University Of New Jersey Toposiomerase inhibitors
US20110288086A1 (en) * 2010-05-21 2011-11-24 Jianqi Li Polycyclic quinazolines, preparation thereof, and use thereof
CN102351870B (zh) * 2011-08-25 2014-03-12 中山大学 一种苯并吖啶衍生物的制备方法及其作为抗癌药物的用途
CN105669551B (zh) * 2015-12-02 2018-04-17 广西中医药大学 7‑苯并(c)吖啶对氟苯甲酰胺基硫脲及其制备方法和用途
JP2019515025A (ja) 2016-04-04 2019-06-06 ラトガース ザ ステイト ユニバーシティー オブ ニュージャージー トポイソメラーゼ毒

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US26065A (en) * 1859-11-08 Improvement in cotton-gins
USRE26065E (en) 1966-07-19 Folybenzimidazoles and their preparation
US2981731A (en) * 1961-04-25 Acridine derivatives
US2985661A (en) * 1956-02-06 1961-05-23 American Cyanamid Co Preparation of 2(omicron-aminophenyl)-benzimidazole
US2915523A (en) * 1956-12-03 1959-12-01 Parke Davis & Co Benzacridine compounds
US3272707A (en) * 1964-07-17 1966-09-13 Smith Kline French Lab Pharmaceutical compositions and methods for their use
CH420044A (de) * 1964-09-01 1967-03-15 Ciba Geigy Verwendung von neuen Azol-Derivaten als optische Aufheller für textile organische Materialien
US3267107A (en) * 1964-09-17 1966-08-16 American Home Prod 3-(4'-5'-methylenedioxy-phenyl)-7, 8-dimethoxy-1, 2, 3, 4,-tetrahydroisoquinolines
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DE1670684A1 (de) * 1966-04-01 1970-12-03 Hoechst Ag Verfahren zur Herstellung von basisch substituierten Bis-benzimidazol-derivaten
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Also Published As

Publication number Publication date
CA2266321A1 (en) 1998-03-26
WO1998012181A1 (en) 1998-03-26
BR9711296A (pt) 1999-08-17
JP2001501197A (ja) 2001-01-30
CZ102499A3 (cs) 1999-09-15
NO991384D0 (no) 1999-03-22
AU4589797A (en) 1998-04-14
KR20000048537A (ko) 2000-07-25
EP0950054A1 (en) 1999-10-20
NZ334954A (en) 2000-08-25
US5981541A (en) 1999-11-09
TR199900636T2 (xx) 1999-10-21
PL332416A1 (en) 1999-09-13
AU725938B2 (en) 2000-10-26
IL129096A0 (en) 2000-02-17

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