NO993738L - 2-amino-substituted pyridines which can be used in the treatment of arteriosclerosis and hyper-lipoproteinemia - Google Patents

2-amino-substituted pyridines which can be used in the treatment of arteriosclerosis and hyper-lipoproteinemia

Info

Publication number
NO993738L
NO993738L NO993738A NO993738A NO993738L NO 993738 L NO993738 L NO 993738L NO 993738 A NO993738 A NO 993738A NO 993738 A NO993738 A NO 993738A NO 993738 L NO993738 L NO 993738L
Authority
NO
Norway
Prior art keywords
amino
substituted pyridines
arteriosclerosis
treatment
lipoproteinemia
Prior art date
Application number
NO993738A
Other languages
Norwegian (no)
Other versions
NO993738D0 (en
Inventor
Carsten Schmeck
Arndt Brandes
Michael Loegers
Gunter Schmidt
Klaus-Dieter Bremm
Hilmar Bischoff
Delf Schmidt
Joachim Schuhmacher
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of NO993738D0 publication Critical patent/NO993738D0/en
Publication of NO993738L publication Critical patent/NO993738L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Det beskrives nye 2-amino-substituerte pyridiner med formel (I). Disse fremstilles ved først å omdanne tilsvarende pyridinaldehyder til tilsvarende hydroksyder ved hjelp av metallorganiske forbindelser som Grignard-forbindelser og så å redusere hydroksydene til en deshydroksyforbindelse. De nye 2-amino-substituerte pyridiner er egnet for anvendelse som aktive bestanddeler i medikamenter og særlig slike som benyttes ved behandling av arteriosklerose.New 2-amino-substituted pyridines of formula (I) are disclosed. These are prepared by first converting corresponding pyridinal aldehydes to corresponding hydroxides by means of metallic organic compounds such as Grignard compounds and then reducing the hydroxides to a dehydroxy compound. The new 2-amino-substituted pyridines are suitable for use as active ingredients in drugs and especially those used in the treatment of arteriosclerosis.

NO993738A 1997-02-05 1999-08-02 2-amino-substituted pyridines which can be used in the treatment of arteriosclerosis and hyper-lipoproteinemia NO993738L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19704243A DE19704243A1 (en) 1997-02-05 1997-02-05 New 2-amino-substituted pyridines
PCT/EP1998/000362 WO1998034920A1 (en) 1997-02-05 1998-01-23 2-amino substituted pyridines for use in the treatment of arteriosclerosis and hyperlipoproteinaemia

Publications (2)

Publication Number Publication Date
NO993738D0 NO993738D0 (en) 1999-08-02
NO993738L true NO993738L (en) 1999-09-17

Family

ID=7819326

Family Applications (1)

Application Number Title Priority Date Filing Date
NO993738A NO993738L (en) 1997-02-05 1999-08-02 2-amino-substituted pyridines which can be used in the treatment of arteriosclerosis and hyper-lipoproteinemia

Country Status (19)

Country Link
EP (1) EP0973744A1 (en)
JP (1) JP2001510478A (en)
KR (1) KR20000070756A (en)
CN (1) CN1252057A (en)
AU (1) AU730109B2 (en)
BG (1) BG103631A (en)
BR (1) BR9807181A (en)
CA (1) CA2279636A1 (en)
CZ (1) CZ279299A3 (en)
DE (1) DE19704243A1 (en)
HU (1) HUP0001022A2 (en)
ID (1) ID24208A (en)
IL (1) IL131127A0 (en)
NO (1) NO993738L (en)
NZ (1) NZ337011A (en)
PL (1) PL334899A1 (en)
SK (1) SK104099A3 (en)
TR (1) TR199901857T2 (en)
WO (1) WO1998034920A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19845402B4 (en) * 1998-10-02 2005-04-07 Aventis Pharma Deutschland Gmbh Heterocyclic substituted propanolamine derivatives, process for their preparation, pharmaceutical compositions containing them and their use
JP4547148B2 (en) 2001-06-22 2010-09-22 ベンド・リサーチ・インコーポレーテッド Pharmaceutical composition of adsorbate of amorphous drug
MXPA03011784A (en) 2001-06-22 2004-04-02 Pfizer Prod Inc Pharmaceutical compositions of dispersions of drugs and neutral polymers.
WO2003063833A1 (en) 2002-02-01 2003-08-07 Pfizer Products Inc. Pharmaceutical compositions of amorphous dispersions of drugs and lipophilic microphase-forming materials
AU2004222436A1 (en) 2003-03-17 2004-09-30 Japan Tobacco Inc. Method for increasing the oral bioavailability of S-(2-(((1- (2-ethylbutyl) cyclohexyl)carbonyl) amino) phenyl)-2-methylpropanethioate
CL2004001884A1 (en) 2003-08-04 2005-06-03 Pfizer Prod Inc DRYING PROCEDURE FOR SPRAYING FOR THE FORMATION OF SOLID DISPERSIONS AMORPHES OF A PHARMACO AND POLYMERS.
MXPA06001417A (en) 2003-08-04 2006-05-15 Pfizer Prod Inc Pharmaceutical compositions of adsorbates of amorphous drugs and lipophilic microphase-forming materials.
RU2330682C2 (en) 2003-09-26 2008-08-10 Джапан Тобакко Инк. Method of residual lipoproteins producing inhibition
DOP2005000123A (en) * 2004-07-02 2011-07-15 Merck Sharp & Dohme CETP INHIBITORS
WO2006032987A1 (en) * 2004-09-23 2006-03-30 Pfizer Products Inc. Indoline compounds and their use in the treatment of arteriosclerosis
EP2548894A1 (en) 2005-02-03 2013-01-23 Bend Research, Inc. Pharmaceutical compositions with enhanced performance
US20100113473A1 (en) 2008-10-30 2010-05-06 Player Mark R Aryl amide compound as an acetyl coenzyme a carboxylase inhibitor

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5169857A (en) * 1988-01-20 1992-12-08 Bayer Aktiengesellschaft 7-(polysubstituted pyridyl)-hept-6-endates useful for treating hyperproteinaemia, lipoproteinaemia or arteriosclerosis

Also Published As

Publication number Publication date
TR199901857T2 (en) 1999-10-21
JP2001510478A (en) 2001-07-31
KR20000070756A (en) 2000-11-25
NO993738D0 (en) 1999-08-02
ID24208A (en) 2000-07-13
AU730109B2 (en) 2001-02-22
NZ337011A (en) 2001-04-27
AU6212398A (en) 1998-08-26
CN1252057A (en) 2000-05-03
EP0973744A1 (en) 2000-01-26
WO1998034920A1 (en) 1998-08-13
CA2279636A1 (en) 1998-08-13
DE19704243A1 (en) 1998-08-06
PL334899A1 (en) 2000-03-27
HUP0001022A2 (en) 2000-09-28
SK104099A3 (en) 2000-01-18
BR9807181A (en) 2000-01-25
CZ279299A3 (en) 1999-11-17
IL131127A0 (en) 2001-01-28
BG103631A (en) 2000-11-30

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