NO993758L - Nye forbindelser og mikroorganismer med ökt produksjon av klavulansyre - Google Patents

Nye forbindelser og mikroorganismer med ökt produksjon av klavulansyre

Info

Publication number
NO993758L
NO993758L NO993758A NO993758A NO993758L NO 993758 L NO993758 L NO 993758L NO 993758 A NO993758 A NO 993758A NO 993758 A NO993758 A NO 993758A NO 993758 L NO993758 L NO 993758L
Authority
NO
Norway
Prior art keywords
microorganisms
new compounds
increased production
clavulanic acid
clavulanic
Prior art date
Application number
NO993758A
Other languages
English (en)
Norwegian (no)
Other versions
NO993758D0 (no
Inventor
Barry Barton
John Patrick Griffin
Cecilia Anders
Susan Jensen
Roy Henry Mosher
Ashis Sudhakar Paradkar
Original Assignee
Smithkline Beecham Plc
Univ Alberta
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc, Univ Alberta filed Critical Smithkline Beecham Plc
Publication of NO993758D0 publication Critical patent/NO993758D0/no
Publication of NO993758L publication Critical patent/NO993758L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/36—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinomyces; from Streptomyces (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/76—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Actinomyces; for Streptomyces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Public Health (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NO993758A 1997-02-04 1999-08-03 Nye forbindelser og mikroorganismer med ökt produksjon av klavulansyre NO993758L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9702218.0A GB9702218D0 (en) 1997-02-04 1997-02-04 Novel product
PCT/EP1998/000644 WO1998033896A2 (en) 1997-02-04 1998-02-02 Microorganisms with increased production of clavulanic acid

Publications (2)

Publication Number Publication Date
NO993758D0 NO993758D0 (no) 1999-08-03
NO993758L true NO993758L (no) 1999-08-03

Family

ID=10807030

Family Applications (1)

Application Number Title Priority Date Filing Date
NO993758A NO993758L (no) 1997-02-04 1999-08-03 Nye forbindelser og mikroorganismer med ökt produksjon av klavulansyre

Country Status (32)

Country Link
US (5) US6936458B1 (de)
EP (2) EP1405913A3 (de)
JP (2) JP4227199B2 (de)
KR (2) KR100514964B1 (de)
CN (2) CN1192107C (de)
AP (1) AP1320A (de)
AR (2) AR011100A1 (de)
AT (1) ATE312926T1 (de)
AU (1) AU735782B2 (de)
BG (1) BG103704A (de)
BR (1) BR9807144A (de)
CA (1) CA2279207A1 (de)
DE (1) DE69832783T2 (de)
DZ (1) DZ2413A1 (de)
EA (1) EA003773B1 (de)
ES (1) ES2255149T3 (de)
GB (1) GB9702218D0 (de)
HU (1) HUP0001048A3 (de)
ID (1) ID22144A (de)
IL (1) IL131043A0 (de)
MA (1) MA24464A1 (de)
MY (1) MY140928A (de)
NO (1) NO993758L (de)
NZ (1) NZ336894A (de)
OA (1) OA11082A (de)
PL (1) PL334961A1 (de)
SK (1) SK105499A3 (de)
TR (1) TR199901862T2 (de)
TW (2) TW589377B (de)
UY (2) UY24874A1 (de)
WO (1) WO1998033896A2 (de)
ZA (1) ZA98868B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HK1047957A1 (zh) * 1999-09-16 2003-03-14 The Johns-Hopkins University 克拉伏拉尼克酸产量的提高
AU1385701A (en) * 1999-10-22 2001-05-08 Smithkline Beecham Plc Novel compounds
GB0308696D0 (en) * 2003-04-15 2003-05-21 Glaxo Group Ltd New process
EP2589663A1 (de) 2011-11-04 2013-05-08 LEK Pharmaceuticals d.d. Verfahren zur Herstellung von Clavulansäure
CN107964522B (zh) * 2018-01-04 2020-12-08 上海交通大学 海洋链霉菌dut11及其抗补体活性应用
EP3994154A1 (de) 2019-07-05 2022-05-11 GlaxoSmithKline Intellectual Property (No.2) Limited Streptomyces clavuligerus

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4110165A (en) * 1974-04-20 1978-08-29 Beecham Group Limited Process for the production of clavulanic acid
YU40452B (en) * 1975-02-07 1986-02-28 Beecham Group Plc Process for the elimination of contaminating impurities from clavulinic acid
GB1585661A (en) 1976-06-08 1981-03-11 Glaxo Lab Ltd Clavam derivatives
JPS589679B2 (ja) 1977-02-24 1983-02-22 武田薬品工業株式会社 抗生物質の製造法
US4202819A (en) 1979-05-04 1980-05-13 Hoffman-La Roche Inc. 2-(3-Alanyl)clavam antibiotic
GB8521516D0 (en) * 1985-08-29 1985-10-02 Beecham Group Plc Compounds
GB9020683D0 (en) 1990-09-22 1990-11-07 Univ Strathclyde Isolation of dna
CA2108113C (en) * 1993-10-08 2006-12-05 Susan E. Jensen Dna sequence encoding enzymes of clavulanic acid biosynthesis

Also Published As

Publication number Publication date
DE69832783D1 (de) 2006-01-19
ID22144A (id) 1999-09-09
EP0970198A2 (de) 2000-01-12
US20030022321A1 (en) 2003-01-30
EA199900718A1 (ru) 2000-02-28
JP2001511001A (ja) 2001-08-07
CN1696301A (zh) 2005-11-16
UY25197A1 (es) 1998-11-27
JP2009022298A (ja) 2009-02-05
US20030124690A1 (en) 2003-07-03
ZA98868B (en) 1999-08-03
ATE312926T1 (de) 2005-12-15
BG103704A (en) 2000-05-31
HUP0001048A2 (hu) 2000-08-28
BR9807144A (pt) 2000-01-25
EP1405913A2 (de) 2004-04-07
TW200307041A (en) 2003-12-01
US6936458B1 (en) 2005-08-30
JP4227199B2 (ja) 2009-02-18
US20070298470A1 (en) 2007-12-27
CN1251612A (zh) 2000-04-26
US7344869B2 (en) 2008-03-18
UY24874A1 (es) 2001-07-31
WO1998033896A2 (en) 1998-08-06
AU735782B2 (en) 2001-07-12
CA2279207A1 (en) 1998-08-06
CN1192107C (zh) 2005-03-09
MA24464A1 (fr) 1998-10-01
KR20050053794A (ko) 2005-06-08
NZ336894A (en) 2001-08-31
DZ2413A1 (fr) 2003-01-04
EA003773B1 (ru) 2003-08-28
AP1320A (en) 2004-10-29
WO1998033896A3 (en) 1998-11-19
KR100514964B1 (ko) 2005-09-15
AP9901614A0 (en) 1999-09-30
AU6295398A (en) 1998-08-25
AR011100A1 (es) 2000-08-02
AR018304A2 (es) 2001-11-14
EP1405913A3 (de) 2004-08-04
JP5042186B2 (ja) 2012-10-03
NO993758D0 (no) 1999-08-03
OA11082A (en) 2003-03-13
ES2255149T3 (es) 2006-06-16
GB9702218D0 (en) 1997-03-26
US20030166175A1 (en) 2003-09-04
SK105499A3 (en) 2000-05-16
TW589377B (en) 2004-06-01
KR20000070723A (ko) 2000-11-25
EP0970198B1 (de) 2005-12-14
HUP0001048A3 (en) 2001-09-28
MY140928A (en) 2010-02-12
DE69832783T2 (de) 2006-07-20
TR199901862T2 (xx) 2000-12-21
IL131043A0 (en) 2001-01-28
PL334961A1 (en) 2000-03-27

Similar Documents

Publication Publication Date Title
NO307828B1 (no) FremgangsmÕte for fremstilling av Astaxantin og nye mellomprodukter derav
FI941730L (fi) Uusia biologisia menetelmiä 7-ACA:n ja 7-ADAC:n valmistamiseksi
DE69629670D1 (de) Lactam-enthaltende hydroxamsäure-derivate, deren herstellung und deren verwendung als inhibitoren von matrix-metalloproteasen
NO20015547L (no) Fremgangsmåte for hemisyntese av forbindelser og nye forbindelser
HUP0202705A3 (en) Methods and microorganisms or production of panto-compounds
PL332720A1 (en) Novel derivatives of piperydinketone carboxylic acids, their production and application
FI940509A0 (fi) Menetelmä normaalin ja ultrahienon sementin valmistamiseksi
FI951046A7 (fi) Parannettuja entsyymejä 2-keto-L-gulonihapon tuotantoon
DE69737044D1 (de) Herstellung von fugizides Chinazolinonen und nützliche Zwischenprodukte
NO902628D0 (no) Produksjon av pyrrolopyrimidiner og mellomprodukter derav.
PL329241A1 (en) Novel derivatives of alpha-hydroxycarboxylic acids, their production and application
DE59606486D1 (de) Herstellung von Poly-o-hydroxyamiden und Poly-o-mercaptoamiden
PL329240A1 (en) Novel derivatives of carboxylic acid, their production and application
PL329238A1 (en) Novel derivatives of alpha-hydroxycarboxylic acids, their production and application
DE69816274D1 (de) Herstellung von carbonsäureverbindungen und deren derivaten
NO993758D0 (no) Nye forbindelser og mikroorganismer med ökt produksjon av klavulansyre
EP1443104A4 (de) Mikroorganismus und produktion von carotinoidverbindungen mit diesem mikroorganismus
SI0811689T1 (en) Process for the production of clavulanic acid and/or salts thereof
EE9700186A (et) Klavulaanhappe soolad
FI941380A7 (fi) Heterosyklisesti substituoitujen fenyylietikkahappojohdannnaisten fenyyliglysiiniamidit
NO992225D0 (no) FremgangsmÕte for fremstilling av salter og estere av klavulansyre
FI953457L (fi) Intsyymiä sisältävä granulaatti, sen valmistusmenetelmä ja sen käyttö
PL325398A1 (en) Novel derivatives of carboxylic acids, their production and application
NO942598D0 (no) Miniatyr bioreaktor med kontinuerlig fornyelse av næringsmedium
NO970428D0 (no) Fremgangsmåte for fremstilling av antimikrobielle kinolonyllaktamforbindelser og nye mellomprodukter

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application