NO993868L - 3-piperidyl-4-oksokinazolinderivater og farmasöytiske preparater omfattende samme - Google Patents

3-piperidyl-4-oksokinazolinderivater og farmasöytiske preparater omfattende samme

Info

Publication number: NO993868L
Authority: NO; Norway
Prior art keywords: compounds; piperidyl; group; ldl; substituted
Prior art date: 1997-12-12

Application number

NO993868A

Other languages

English (en)

Norwegian (no)

Other versions

NO993868D0 (no

Inventor

Motohide Sato

Takeo Katsushima

Hajime Kinoshita

Original Assignee

Japan Tobacco Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-12-12

Filing date

1999-08-11

Publication date

1999-10-12

1999-08-11 Application filed by Japan Tobacco Inc filed Critical Japan Tobacco Inc

1999-08-11 Publication of NO993868D0 publication Critical patent/NO993868D0/no

1999-10-12 Publication of NO993868L publication Critical patent/NO993868L/no

Links

YVXDOICWRFTZHG-UHFFFAOYSA-N 2-piperidin-3-yl-1h-quinazolin-4-one Chemical class N1C2=CC=CC=C2C(=O)N=C1C1CCCNC1 YVXDOICWRFTZHG-UHFFFAOYSA-N 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
125000003277 amino group Chemical group 0.000 abstract 2
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
201000010099 disease Diseases 0.000 abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
208000035150 Hypercholesterolemia Diseases 0.000 abstract 1
-1 LDL in the blood Chemical compound 0.000 abstract 1
102000004895 Lipoproteins Human genes 0.000 abstract 1
108090001030 Lipoproteins Proteins 0.000 abstract 1
208000008589 Obesity Diseases 0.000 abstract 1
206010033645 Pancreatitis Diseases 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
239000008280 blood Substances 0.000 abstract 1
210000004369 blood Anatomy 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
235000012000 cholesterol Nutrition 0.000 abstract 1
125000004122 cyclic group Chemical group 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
201000005577 familial hyperlipidemia Diseases 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
150000002632 lipids Chemical class 0.000 abstract 1
XJGVXQDUIWGIRW-UHFFFAOYSA-N loxapine Chemical compound C1CN(C)CCN1C1=NC2=CC=CC=C2OC2=CC=C(Cl)C=C12 XJGVXQDUIWGIRW-UHFFFAOYSA-N 0.000 abstract 1
235000020824 obesity Nutrition 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229940124597 therapeutic agent Drugs 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

NO993868A 1997-12-12 1999-08-11 3-piperidyl-4-oksokinazolinderivater og farmasöytiske preparater omfattende samme NO993868L (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP36281997		1997-12-12
JP10288979A JP2959765B2 (ja)	1997-12-12	1998-10-12	３−ピペリジル−４−オキソキナゾリン誘導体及びそれを含有してなる医薬組成物
PCT/JP1998/005628 WO1999031085A1 (fr)	1997-12-12	1998-12-11	Derives du 3-piperidyl-4-oxoquinazoline et compositions medicinales les contenant

Publications (2)

Publication Number	Publication Date
NO993868D0 NO993868D0 (no)	1999-08-11
NO993868L true NO993868L (no)	1999-10-12

Family

ID=26557408

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO993868A NO993868L (no)	1997-12-12	1999-08-11	3-piperidyl-4-oksokinazolinderivater og farmasöytiske preparater omfattende samme

Country Status (18)

Country	Link
US (1)	US6235730B1 (fr)
EP (1)	EP0970954A4 (fr)
JP (1)	JP2959765B2 (fr)
KR (1)	KR20000070983A (fr)
CN (1)	CN1252068A (fr)
AR (1)	AR009212A1 (fr)
AU (1)	AU717963B2 (fr)
BR (1)	BR9807339A (fr)
CA (1)	CA2280705A1 (fr)
HU (1)	HUP0001154A3 (fr)
ID (1)	ID23439A (fr)
IL (1)	IL131319A0 (fr)
NO (1)	NO993868L (fr)
NZ (1)	NZ337118A (fr)
PE (1)	PE20000054A1 (fr)
SK (1)	SK109399A3 (fr)
TR (1)	TR199901933T1 (fr)
WO (1)	WO1999031085A1 (fr)

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US6258819B1 (en) *	1999-08-05	2001-07-10	Syntex (U.S.A.) Llc	Substituted 2(4-piperidyl)-4(3H)-quinazolinones and 2-(4-piperidyl)-4(3H)-azaquinazolinones
JP2003104971A (ja) *	1999-08-12	2003-04-09	Wakunaga Pharmaceut Co Ltd	新規アニリド誘導体又はその塩及びこれを含有する医薬
EP1255735A2 (fr) *	2000-02-03	2002-11-13	Eli Lilly And Company	Agents de potentialisation de recepteurs de glutamate
US7718644B2 (en) *	2004-01-22	2010-05-18	The Trustees Of Columbia University In The City Of New York	Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof
US20060293266A1 (en) *	2000-05-10	2006-12-28	The Trustees Of Columbia	Phosphodiesterase 4D in the ryanodine receptor complex protects against heart failure
US7879840B2 (en) *	2005-08-25	2011-02-01	The Trustees Of Columbia University In The City Of New York	Agents for preventing and treating disorders involving modulation of the RyR receptors
US7312044B2 (en)	2003-03-07	2007-12-25	The Trustees Of Columbia University In The City Of New York	Type 1 ryanodine receptor-based methods
US6489125B1 (en) *	2000-05-10	2002-12-03	The Trustees Of Columbia University In The City Of New York	Methods for identifying chemical compounds that inhibit dissociation of FKBP12.6 binding protein from type 2 ryanodine receptor
US8022058B2 (en)	2000-05-10	2011-09-20	The Trustees Of Columbia University In The City Of New York	Agents for preventing and treating disorders involving modulation of the RyR receptors
US7393652B2 (en) *	2000-05-10	2008-07-01	The Trustees Of Columbia University In The City Of New York	Methods for identifying a chemical compound that directly enhances binding of FKBP12.6 to PKA-phosphorylated type 2 ryanodine receptor (RyR2)
US20040048780A1 (en) *	2000-05-10	2004-03-11	The Trustees Of Columbia University In The City Of New York	Method for treating and preventing cardiac arrhythmia
US20040229781A1 (en) *	2000-05-10	2004-11-18	Marks Andrew Robert	Compounds and methods for treating and preventing exercise-induced cardiac arrhythmias
IL158516A0 (en) *	2001-06-28	2004-05-12	Pfizer Prod Inc	Triamide-substituted indoles, benzofuranes and benzothiophenes as inhibitors of microsomal triglyceride transfer protein (mtp) and/or apolipoprotein b (apo b) secretion
CN1943786A (zh)	2002-02-28	2007-04-11	日本烟草产业株式会社	酯化合物及其医药用途
US7544678B2 (en) *	2002-11-05	2009-06-09	The Trustees Of Columbia University In The City Of New York	Anti-arrythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2)
EP1669345A4 (fr)	2003-08-29	2008-02-20	Japan Tobacco Inc	Derive d'ester et utilisation medicale de celui-ci
ES2332051T3 (es) *	2003-10-08	2010-01-25	Eli Lilly And Company	Compuestos y procedimientos para tratar dislipidemia.
US8710045B2 (en) *	2004-01-22	2014-04-29	The Trustees Of Columbia University In The City Of New York	Agents for preventing and treating disorders involving modulation of the ryanodine receptors
US7378426B2 (en) *	2004-03-01	2008-05-27	Bristol-Myers Squibb Company	Fused heterotricyclic compounds as inhibitors of 17β-hydroxysteroid dehydrogenase 3
US7417040B2 (en) *	2004-03-01	2008-08-26	Bristol-Myers Squibb Company	Fused tricyclic compounds as inhibitors of 17β-hydroxysteroid dehydrogenase 3
US20060030623A1 (en) *	2004-07-16	2006-02-09	Noboru Furukawa	Agent for the treatment or prevention of diabetes, obesity or arteriosclerosis
US8101774B2 (en)	2004-10-18	2012-01-24	Japan Tobacco Inc.	Ester derivatives and medicinal use thereof
WO2006046623A1 (fr) *	2004-10-25	2006-05-04	Japan Tobacco Inc.	Préparation médicinale solide améliorée en termes de solubilité et de stabilité et procédé servant à produire celle-ci
EP1890767A2 (fr) *	2005-05-27	2008-02-27	Pfizer Products Inc.	Combinaison d'un antagoniste des recepteurs cannabinoides-1 et d'un inhibiteur des proteines microsomales de transfert de triglycerides pour traiter l'obesite ou maintenir une perte de poids
US7704990B2 (en) *	2005-08-25	2010-04-27	The Trustees Of Columbia University In The City Of New York	Agents for preventing and treating disorders involving modulation of the RyR receptors
WO2007056388A2 (fr) *	2005-11-07	2007-05-18	The General Hospital Corporation	Compositions et procédés de modulation de l’activité de la poly(adp-ribose) polymérase
EP2727585A1 (fr)	2006-05-16	2014-05-07	Takeda Pharmaceutical Company Limited	Méthode de dépistage in-vivo
WO2007141029A1 (fr) *	2006-06-08	2007-12-13	Helmholtz Zentrum München Deutsches Forschungszentrum Für Gesundheit Und Umwelt (Gmbh)	Inhibiteurs spécifiques de protéase et leur utilisation pour le traitement du cancer
MX2009003673A (es) *	2006-10-04	2009-04-22	Pfizer Prod Inc	Derivados de piridido[4,3-d]pirimidin-4(3h)-ona como antagonistas de los receptores de calcio.
US8735391B2 (en) *	2008-09-26	2014-05-27	University Of Kansas	Synthesis of functionalized octahydro-isoquinolin-1-one-8-carboxamides, octahydro-isoquinolin-1-one-8-carboxylic esters and analogs, and therapeutic methods
WO2014102592A2 (fr)	2012-12-27	2014-07-03	Purdue Pharma L.P.	Composés de pipéridine de type quinoxaline substituée par oxime et leurs utilisations
AU2017311691B2 (en) *	2016-08-18	2021-12-02	Vidac Pharma Ltd.	Piperazine derivatives, pharmaceutical compositions and methods of use thereof

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US4292321A (en)	1979-05-24	1981-09-29	Warner-Lambert Company	1,3,8-Triazaspirodecane-4-ones, pharmaceutical compositions thereof and method of use thereof
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1998
- 1998-10-12 JP JP10288979A patent/JP2959765B2/ja not_active Expired - Lifetime
- 1998-12-11 AU AU15068/99A patent/AU717963B2/en not_active Ceased
- 1998-12-11 US US09/367,242 patent/US6235730B1/en not_active Expired - Fee Related
- 1998-12-11 CA CA002280705A patent/CA2280705A1/fr not_active Abandoned
- 1998-12-11 CN CN98803899A patent/CN1252068A/zh active Pending
- 1998-12-11 EP EP98959187A patent/EP0970954A4/fr not_active Withdrawn
- 1998-12-11 AR ARP980106296A patent/AR009212A1/es unknown
- 1998-12-11 BR BR9807339A patent/BR9807339A/pt not_active IP Right Cessation
- 1998-12-11 NZ NZ337118A patent/NZ337118A/xx unknown
- 1998-12-11 TR TR1999/01933T patent/TR199901933T1/xx unknown
- 1998-12-11 HU HU0001154A patent/HUP0001154A3/hu unknown
- 1998-12-11 WO PCT/JP1998/005628 patent/WO1999031085A1/fr not_active Ceased
- 1998-12-11 ID IDW991010A patent/ID23439A/id unknown
- 1998-12-11 KR KR1019997007249A patent/KR20000070983A/ko not_active Ceased
- 1998-12-11 IL IL13131998A patent/IL131319A0/xx unknown
- 1998-12-11 SK SK1093-99A patent/SK109399A3/sk unknown
- 1998-12-14 PE PE1998001218A patent/PE20000054A1/es not_active Application Discontinuation
1999
- 1999-08-11 NO NO993868A patent/NO993868L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
HUP0001154A2 (hu)	2001-04-28
WO1999031085A1 (fr)	1999-06-24
KR20000070983A (ko)	2000-11-25
US6235730B1 (en)	2001-05-22
CN1252068A (zh)	2000-05-03
IL131319A0 (en)	2001-01-28
JPH11228569A (ja)	1999-08-24
PE20000054A1 (es)	2000-02-09
AU1506899A (en)	1999-07-05
SK109399A3 (en)	2000-01-18
EP0970954A1 (fr)	2000-01-12
AR009212A1 (es)	2000-04-12
ID23439A (id)	2000-04-20
NZ337118A (en)	2000-03-27
JP2959765B2 (ja)	1999-10-06
HUP0001154A3 (en)	2001-06-28
CA2280705A1 (fr)	1999-06-24
NO993868D0 (no)	1999-08-11
EP0970954A4 (fr)	2001-01-10
TR199901933T1 (xx)	2000-03-21
AU717963B2 (en)	2000-04-06
BR9807339A (pt)	2000-03-21

Legal Events

Date	Code	Title	Description
2002-09-23	FC2A	Withdrawal, rejection or dismissal of laid open patent application

Publication	Publication Date	Title
NO993868L (no)	1999-10-12	3-piperidyl-4-oksokinazolinderivater og farmasöytiske preparater omfattende samme
TR200202200T2 (tr)	2002-12-23	Glükopiranosiloksibenzilbenzen türevleri, bu türevleri ihtiva eden tıbbi bileşimler ve türevlerin hazırlanması için ara-maddeler.
NO20014225L (no)	2001-10-17	Nye sykliske tetrapeptid-derivater og anvendelse av dem som legemidler
TW200800988A (en)	2008-01-01	Polycyclic carbamoylpyridone derivative having HIV integrase inhibitory activity
NO20074657L (no)	2003-06-19	Nitrogenholdige aromatiske ringforbindelser
NO20074310L (no)	2007-10-29	Spiroketalderivat og anvendelse derav som diabetesmedisin
EP1258252A4 (fr)	2005-11-02	Inhibiteurs de l'expression de l'integrine
NO20051411L (no)	2005-04-26	Pyrazolderivater, medisinske sammensetninger inneholdende slike, medisinsk bruk derav samt intermediater til fremstilling derav
NO20065573L (no)	2007-01-18	Orto-substituerte aryl eller heteroarylamidforbindelser
DK0870765T3 (da)	2004-02-23	Aminothiazolderivat, lægemiddel indeholdende samme og mellemprodukt til fremstilling af forbindelsen
NO20052802L (no)	2005-07-19	Pyrrolopyrimidinderivativer
EP1736467A4 (fr)	2009-07-01	Nouveau derive sulfonamide
DK0874812T3 (da)	2000-09-11	Hidtil ukendte 2,3,5-trimethyl-4-hydroxyanilidderivater, fremstilling deraf og terapeutisk anvendelse deraf
NO973635L (no)	1997-09-29	Fremgangsmåte for hemming av celle-celle adhesjon
UA66864C2 (uk)	2004-06-15	Похідні сечовини, фармацевтична композиція і спосіб лікування або профілактики запальних, аутоімунних або респіраторних захворювань
NO20054330L (no)	2005-12-21	8-substituerte-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-on-derivater
NO20054331L (no)	2005-12-21	Substituerte-8-perfluoralkyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-on-derivater
CA2336412A1 (fr)	2000-01-13	Medicament pour le traitement du diabete
Rubino et al.	2011	Biphenyl sulfonylamino methyl bisphosphonic acids as inhibitors of matrix metalloproteinases and bone resorption
NO20055921L (no)	2006-01-24	Heterocykliske metylsulfonderivater
MXPA06001094A (es)	2006-04-11	Compuestos quimicos.
TR199902350T2 (xx)	2000-04-21	Yeni piridin t�revleri ve onlardan olu�an farmakotik bile�imler.
ES2011427A4 (es)	1990-01-16	Derivados de oxina de octahidronaftaleno para inhibicion de la sintesis del colesterol, procesos para su preparacion y composiciones que los contienen.
EP0921122A4 (fr)	2001-06-13	Nouveaux derives d'epoxysuccinamide et sels associes
NO20023251L (no)	2002-09-06	Nye tetrahydropyridiner, fremgangsmåte for deres fremstilling og farmasöytiske preparater inneholdende de samme