NO993948L - Anvendelse av aryl-cykloheksylamin-derivater mot CNS- forstyrrelser - Google Patents

Anvendelse av aryl-cykloheksylamin-derivater mot CNS- forstyrrelser

Info

Publication number: NO993948L
Authority: NO; Norway
Prior art keywords: lower alkyl; aryl; cns disorders; ch2oh; tetrahydronaphthyl
Prior art date: 1998-08-18

Application number

NO993948A

Other languages

English (en)

Norwegian (no)

Other versions

NO993948D0 (no

Inventor

Alexander Alanine

Bernd Buettelmann

Emmanuel Pinard

Rene Wyler

Marie-Paule Heitz Neidhart

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-08-18

Filing date

1999-08-17

Publication date

2000-02-21

1999-08-17 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1999-08-17 Publication of NO993948D0 publication Critical patent/NO993948D0/no

2000-02-21 Publication of NO993948L publication Critical patent/NO993948L/no

Links

208000015114 central nervous system disease Diseases 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 4
150000002431 hydrogen Chemical class 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 2
125000001624 naphthyl group Chemical group 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 abstract 2
102000004868 N-Methyl-D-Aspartate Receptors Human genes 0.000 abstract 1
108090001041 N-Methyl-D-Aspartate Receptors Proteins 0.000 abstract 1
125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
HNQIVZYLYMDVSB-UHFFFAOYSA-N methanesulfonimidic acid Chemical compound CS(N)(=O)=O HNQIVZYLYMDVSB-UHFFFAOYSA-N 0.000 abstract 1
-1 nitro, amino Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Emergency Medicine (AREA)
Psychology (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)

NO993948A 1998-08-18 1999-08-17 Anvendelse av aryl-cykloheksylamin-derivater mot CNS- forstyrrelser NO993948L (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP98115484		1998-08-18

Publications (2)

Publication Number	Publication Date
NO993948D0 NO993948D0 (no)	1999-08-17
NO993948L true NO993948L (no)	2000-02-21

Family

ID=8232474

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO993948A NO993948L (no)	1998-08-18	1999-08-17	Anvendelse av aryl-cykloheksylamin-derivater mot CNS- forstyrrelser

Country Status (24)

Country	Link
US (1)	US6184236B1 (de)
JP (1)	JP3455142B2 (de)
KR (1)	KR100341194B1 (de)
CN (1)	CN1141936C (de)
AR (1)	AR021770A1 (de)
AT (1)	ATE326219T1 (de)
AU (1)	AU756408B2 (de)
BR (1)	BR9903779A (de)
CA (1)	CA2280455A1 (de)
DE (1)	DE69931316D1 (de)
HR (1)	HRP990256A2 (de)
HU (1)	HUP9902737A3 (de)
ID (1)	ID23107A (de)
IL (1)	IL131399A0 (de)
MA (1)	MA26677A1 (de)
MY (1)	MY133133A (de)
NO (1)	NO993948L (de)
NZ (1)	NZ337243A (de)
PE (1)	PE20000955A1 (de)
PL (1)	PL334949A1 (de)
SG (1)	SG82014A1 (de)
TR (1)	TR199902015A3 (de)
YU (1)	YU38699A (de)
ZA (1)	ZA995212B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BR0111267A (pt) *	2000-06-06	2003-12-16	Warner Lambert Co	Cicloexilaminas bicìclicas e seu uso como antagonistas do receptor de nmda
WO2002072542A2 (en) *	2001-03-08	2002-09-19	Emory University	Ph-dependent nmda receptor antagonists
DE10153345A1 (de) *	2001-10-29	2003-05-08	Gruenenthal Gmbh	Substituierte 1H-Chinoxalin-2-on-Verbindungen und substituierte 4-Aryl- und 4-Heteroarylcyclohexan-Verbindungen
US20070004805A1 (en) *	2005-07-01	2007-01-04	Navinta Llc	Process for preparation of liquid dosage form containing sodium 4-phenylbutyrate
CN103058957A (zh)	2007-06-29	2013-04-24	埃莫里大学	用于神经保护的nmda受体拮抗剂

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4032766A1 (de)	1990-10-16	1992-04-30	Basf Ag	Phenylpiperidinoylamine und diese enthaltende arzneimittel
DE4117904A1 (de)	1991-05-31	1992-12-03	Basf Ag	Substituierte n-phenylpiperidine
ATE130851T1 (de)	1991-03-14	1995-12-15	Basf Ag	Substituierte n-phenylpiperidine und arzneimittel daraus.
US6069176A (en)	1995-10-26	2000-05-30	Mitsubishi-Tokyo Pharmaceuticals, Inc.	Phenylethanolamine compounds useful as β 3 agonists, process for producing the same, and intermediates in the production of the same

1999
- 1999-08-09 AT AT99115114T patent/ATE326219T1/de not_active IP Right Cessation
- 1999-08-09 DE DE69931316T patent/DE69931316D1/de not_active Expired - Lifetime
- 1999-08-09 US US09/370,602 patent/US6184236B1/en not_active Expired - Fee Related
- 1999-08-13 AR ARP990104079A patent/AR021770A1/es not_active Application Discontinuation
- 1999-08-13 PE PE1999000826A patent/PE20000955A1/es not_active Application Discontinuation
- 1999-08-13 CA CA002280455A patent/CA2280455A1/en not_active Abandoned
- 1999-08-13 NZ NZ337243A patent/NZ337243A/xx unknown
- 1999-08-13 IL IL13139999A patent/IL131399A0/xx unknown
- 1999-08-16 ZA ZA9905212A patent/ZA995212B/xx unknown
- 1999-08-16 HU HU9902737A patent/HUP9902737A3/hu unknown
- 1999-08-16 YU YU38699A patent/YU38699A/sh unknown
- 1999-08-16 JP JP22965899A patent/JP3455142B2/ja not_active Expired - Fee Related
- 1999-08-16 MY MYPI99003508A patent/MY133133A/en unknown
- 1999-08-16 SG SG9903973A patent/SG82014A1/en unknown
- 1999-08-16 ID IDP990791A patent/ID23107A/id unknown
- 1999-08-17 CN CNB991179110A patent/CN1141936C/zh not_active Expired - Fee Related
- 1999-08-17 MA MA25736A patent/MA26677A1/fr unknown
- 1999-08-17 NO NO993948A patent/NO993948L/no unknown
- 1999-08-17 AU AU44537/99A patent/AU756408B2/en not_active Ceased
- 1999-08-17 PL PL99334949A patent/PL334949A1/xx not_active Application Discontinuation
- 1999-08-17 BR BR9903779-3A patent/BR9903779A/pt not_active IP Right Cessation
- 1999-08-17 KR KR1019990033814A patent/KR100341194B1/ko not_active Expired - Fee Related
- 1999-08-18 TR TR1999/02015A patent/TR199902015A3/tr unknown
- 1999-08-18 HR HR98115484.2A patent/HRP990256A2/hr not_active Application Discontinuation

Also Published As

Publication number	Publication date
CA2280455A1 (en)	2000-02-18
KR20000017343A (ko)	2000-03-25
JP2000109429A (ja)	2000-04-18
JP3455142B2 (ja)	2003-10-14
MA26677A1 (fr)	2004-12-20
YU38699A (sh)	2002-03-18
SG82014A1 (en)	2001-07-24
PE20000955A1 (es)	2000-09-28
DE69931316D1 (de)	2006-06-22
AU756408B2 (en)	2003-01-09
NZ337243A (en)	2000-12-22
KR100341194B1 (ko)	2002-06-20
ATE326219T1 (de)	2006-06-15
MY133133A (en)	2007-10-31
HRP990256A2 (en)	2000-04-30
TR199902015A2 (xx)	2000-03-21
ZA995212B (en)	2000-02-18
PL334949A1 (en)	2000-02-28
NO993948D0 (no)	1999-08-17
AU4453799A (en)	2000-05-04
IL131399A0 (en)	2001-01-28
US6184236B1 (en)	2001-02-06
HUP9902737A2 (hu)	2000-06-28
ID23107A (id)	2000-02-24
CN1141936C (zh)	2004-03-17
AR021770A1 (es)	2002-08-07
TR199902015A3 (tr)	2000-03-21
HUP9902737A3 (en)	2001-01-29
CN1248439A (zh)	2000-03-29
BR9903779A (pt)	2000-09-19
HU9902737D0 (en)	1999-10-28

Publication	Publication Date	Title
BR9812046A (pt)	2000-09-26	Compostos, processos para a preperação do composto e para tratar um paciente humano ou animal, composição farmacêutica, e, uso de um composto
DK624687A (da)	1988-05-29	Farmaceutisk praeparat indeholdende imidazolderivater
EA200200446A1 (ru)	2002-12-26	НОВЫЕ α-АМИНОКИСЛОТНЫЕ СОЕДИНЕНИЯ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ, ИХ СОДЕРЖАЩИЕ
GB2188234A (en)	1987-09-30	Obesity treating agents
SE0104334D0 (sv)	2001-12-19	Therapeutic agents
ATE315022T1 (de)	2006-02-15	Prostaglandinanaloga als ep4-rezeptoragonisten
ATE512961T1 (de)	2011-07-15	Amorphes nebivolol hydrochlorid und seine herstellung
IT1250049B (it)	1995-03-30	Composti triciclici.
RU99101081A (ru)	2001-01-27	Режим введения ингибиторов н+, к+-атфазы
NO20052730L (no)	2005-08-23	Aminoalkosyindoler som 5-HT6-reseptorligander for behandling av CNS-lidelser
DK160686A (da)	1986-04-09	Tri- og tetracycliske forbindelser
EP0982026A3 (de)	2001-06-13	Verwendung von Aryl-Cyclohexylamine Derivaten zur Herstellung von NMDA-Rezeptorblockern
DK0871626T3 (da)	2002-02-25	Triazoloner som apolipoprotein-B syntheseinhibitorer
NZ337243A (en)	2000-12-22	Use of aryl-cyclohexylamine derivatives as NMDA (N-methyl-D-aspartate) receptor subtype selective blockers against CNS disorders
KR940009179A (ko)	1994-05-20	벤조푸란 유도체, 그의 제조 방법, 그를 함유한 제약조성물 및 그의 의약으로서의 용도
DK0516350T3 (da)	1995-12-04	2-hydroxy-2-phenylethylamin-derivater som beta-3-adrenoceptoragonister
TR199801774T2 (xx)	1998-12-21	4-fenil-3, 6-dihidro-2H- piridil t�revlerinin, NMDA resept�r alttip blokerleri olarak kullan�m�.
DE3470883D1 (en)	1988-06-09	Tetrahydroisoxazolo(4,5-c)pyridine derivatives and preparation thereof
ES343818A1 (es)	1968-12-01	Procedimiento para la obtencion de nuevas 3-amino - sidno- minas sustituidas.
IL87174A (en)	1993-02-21	Benzimidazole derivatives, their preparation and pharmaceutical compositions containing them
CZ30097A3 (en)	1997-05-14	Novel streptogramin derivatives, process of their preparation and pharmaceutical composition containing thereof
ECSP993105A (es)	2000-03-22	El uso de los derivados de aril- ciclohexilamina contra transtornos del sistema nervioso central
AR030410A1 (es)	2003-08-20	Derivados de 2-fenilpiran-4-ona, proceso para obtener dichos derivados, composiciones farmaceuticas que comprenden los derivados mencionados y el uso de los mismos en la manufactura de medicamentos
KR830000903A (ko)	1983-04-28	고혈압과 장장애를 억제하는 방법과 조성물
JPH0456009B2 (de)	1992-09-07