NZ334992A - Meningococcus vaccine comprising the valence of BZ83 strain - Google Patents

Meningococcus vaccine comprising the valence of BZ83 strain

Info

Publication number: NZ334992A
Authority: NZ; New Zealand
Prior art keywords: gly; ala; lys; ser; thr
Prior art date: 1997-08-07

Application number

NZ334992A

Other languages

English (en)

Inventor

Marie-Jose Quentin-Millet

Bachra Rokbi

Original Assignee

Pasteur Merieux Serums Vacc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-08-07

Filing date

1998-08-03

Publication date

2001-09-28

1998-08-03 Application filed by Pasteur Merieux Serums Vacc filed Critical Pasteur Merieux Serums Vacc

2001-09-28 Publication of NZ334992A publication Critical patent/NZ334992A/en

Links

229960005486 vaccine Drugs 0.000 title description 9
108010031127 Transferrin-Binding Protein B Proteins 0.000 claims abstract description 151
239000008194 pharmaceutical composition Substances 0.000 claims abstract description 29
108091028043 Nucleic acid sequence Proteins 0.000 claims abstract description 22
101000766306 Homo sapiens Serotransferrin Proteins 0.000 claims abstract description 13
XNSAINXGIQZQOO-SRVKXCTJSA-N protirelin Chemical compound NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H]1NC(=O)CC1)CC1=CN=CN1 XNSAINXGIQZQOO-SRVKXCTJSA-N 0.000 claims abstract description 13
102000007238 Transferrin Receptors Human genes 0.000 claims abstract description 9
239000012634 fragment Substances 0.000 claims description 58
108020004414 DNA Proteins 0.000 claims description 57
241000588650 Neisseria meningitidis Species 0.000 claims description 50
239000002773 nucleotide Substances 0.000 claims description 26
125000003729 nucleotide group Chemical group 0.000 claims description 26
238000003752 polymerase chain reaction Methods 0.000 claims description 23
102000053602 DNA Human genes 0.000 claims description 20
125000003275 alpha amino acid group Chemical group 0.000 claims description 16
102000040430 polynucleotide Human genes 0.000 claims description 14
108091033319 polynucleotide Proteins 0.000 claims description 14
239000002157 polynucleotide Substances 0.000 claims description 14
201000009906 Meningitis Diseases 0.000 abstract description 9
241000588653 Neisseria Species 0.000 abstract 1
BYXHQQCXAJARLQ-ZLUOBGJFSA-N Ala-Ala-Ala Chemical compound C[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(O)=O BYXHQQCXAJARLQ-ZLUOBGJFSA-N 0.000 description 250
RLMISHABBKUNFO-WHFBIAKZSA-N Ala-Ala-Gly Chemical compound C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(O)=O RLMISHABBKUNFO-WHFBIAKZSA-N 0.000 description 108
VPZXBVLAVMBEQI-UHFFFAOYSA-N glycyl-DL-alpha-alanine Natural products OC(=O)C(C)NC(=O)CN VPZXBVLAVMBEQI-UHFFFAOYSA-N 0.000 description 23
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239000000203 mixture Substances 0.000 description 20
JBCLFWXMTIKCCB-UHFFFAOYSA-N H-Gly-Phe-OH Natural products NCC(=O)NC(C(O)=O)CC1=CC=CC=C1 JBCLFWXMTIKCCB-UHFFFAOYSA-N 0.000 description 19
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YYSWCHMLFJLLBJ-ZLUOBGJFSA-N Ala-Ala-Ser Chemical compound C[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(O)=O YYSWCHMLFJLLBJ-ZLUOBGJFSA-N 0.000 description 17
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OAGVHWYIBZMWLA-YFKPBYRVSA-N Glu-Gly-Gly Chemical compound OC(=O)CC[C@H](N)C(=O)NCC(=O)NCC(O)=O OAGVHWYIBZMWLA-YFKPBYRVSA-N 0.000 description 11
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CXZFXHGJJPVUJE-CIUDSAMLSA-N Ala-Cys-Leu Chemical compound C[C@@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(C)C)C(=O)O)N CXZFXHGJJPVUJE-CIUDSAMLSA-N 0.000 description 10
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101100245206 Dictyostelium discoideum psmC4 gene Proteins 0.000 description 10
DHDOADIPGZTAHT-YUMQZZPRSA-N Gly-Glu-Arg Chemical compound NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@H](C(O)=O)CCCN=C(N)N DHDOADIPGZTAHT-YUMQZZPRSA-N 0.000 description 10
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RIYZXJVARWJLKS-KKUMJFAQSA-N Phe-Asp-Leu Chemical compound CC(C)C[C@@H](C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](N)CC1=CC=CC=C1 RIYZXJVARWJLKS-KKUMJFAQSA-N 0.000 description 10
XQPHBAKJJJZOBX-SRVKXCTJSA-N Pro-Lys-Glu Chemical compound [H]N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(O)=O XQPHBAKJJJZOBX-SRVKXCTJSA-N 0.000 description 10
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108010082286 glycyl-seryl-alanine Proteins 0.000 description 10
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108010047926 leucyl-lysyl-tyrosine Proteins 0.000 description 10
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CSSYQJWUGATIHM-IKGCZBKSSA-N l-phenylalanyl-l-lysyl-l-cysteinyl-l-arginyl-l-arginyl-l-tryptophyl-l-glutaminyl-l-tryptophyl-l-arginyl-l-methionyl-l-lysyl-l-lysyl-l-leucylglycyl-l-alanyl-l-prolyl-l-seryl-l-isoleucyl-l-threonyl-l-cysteinyl-l-valyl-l-arginyl-l-arginyl-l-alanyl-l-phenylal Chemical compound C([C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 CSSYQJWUGATIHM-IKGCZBKSSA-N 0.000 description 1
229940078795 lactoferrin Drugs 0.000 description 1
235000021242 lactoferrin Nutrition 0.000 description 1
IZWSFJTYBVKZNK-UHFFFAOYSA-N lauryl sulfobetaine Chemical compound CCCCCCCCCCCC[N+](C)(C)CCCS([O-])(=O)=O IZWSFJTYBVKZNK-UHFFFAOYSA-N 0.000 description 1
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102000006240 membrane receptors Human genes 0.000 description 1
108020004084 membrane receptors Proteins 0.000 description 1
230000002503 metabolic effect Effects 0.000 description 1
229910052751 metal Inorganic materials 0.000 description 1
239000002184 metal Substances 0.000 description 1
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230000005012 migration Effects 0.000 description 1
238000013508 migration Methods 0.000 description 1
238000002156 mixing Methods 0.000 description 1
229940101270 nicotinamide adenine dinucleotide (nad) Drugs 0.000 description 1
230000003287 optical effect Effects 0.000 description 1
230000008520 organization Effects 0.000 description 1
244000052769 pathogen Species 0.000 description 1
230000035699 permeability Effects 0.000 description 1
108010024607 phenylalanylalanine Proteins 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
150000008104 phosphatidylethanolamines Chemical class 0.000 description 1
239000013600 plasmid vector Substances 0.000 description 1
238000002264 polyacrylamide gel electrophoresis Methods 0.000 description 1
229920000768 polyamine Polymers 0.000 description 1
229920000656 polylysine Polymers 0.000 description 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
230000000069 prophylactic effect Effects 0.000 description 1
230000001681 protective effect Effects 0.000 description 1
230000005180 public health Effects 0.000 description 1
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239000011780 sodium chloride Substances 0.000 description 1
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PFNFFQXMRSDOHW-UHFFFAOYSA-N spermine Chemical class NCCCNCCCCNCCCN PFNFFQXMRSDOHW-UHFFFAOYSA-N 0.000 description 1
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210000001519 tissue Anatomy 0.000 description 1
230000032258 transport Effects 0.000 description 1
STCOOQWBFONSKY-UHFFFAOYSA-N tributyl phosphate Chemical compound CCCCOP(=O)(OCCCC)OCCCC STCOOQWBFONSKY-UHFFFAOYSA-N 0.000 description 1
WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 1
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230000003612 virological effect Effects 0.000 description 1
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Epidemiology (AREA)
Communicable Diseases (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Gastroenterology & Hepatology (AREA)
Oncology (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

NZ334992A 1997-08-07 1998-08-03 Meningococcus vaccine comprising the valence of BZ83 strain NZ334992A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9710301A FR2767060B1 (fr)	1997-08-07	1997-08-07	Vaccin meningocoque comportant la valence de souche bz83

Publications (1)

Publication Number	Publication Date
NZ334992A true NZ334992A (en)	2001-09-28

Family

ID=9510254

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NZ334992A NZ334992A (en)	1997-08-07	1998-08-03	Meningococcus vaccine comprising the valence of BZ83 strain

Country Status (10)

Country	Link
EP (1)	EP0948534A1 (fr)
JP (1)	JP2001503068A (fr)
CN (1)	CN1241193A (fr)
AU (1)	AU8987598A (fr)
CA (1)	CA2267066A1 (fr)
FR (1)	FR2767060B1 (fr)
HU (1)	HUP0001451A3 (fr)
NO (1)	NO991558L (fr)
NZ (1)	NZ334992A (fr)
WO (1)	WO1999007741A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0107219D0 (en) *	2001-03-22	2001-05-16	Microbiological Res Authority	Immunogenic commensal neisseria sequences
ES2912751T3 (es) *	2013-12-02	2022-05-27	Eng Antigens Inc	Composiciones inmunogénicas y vacunas derivadas de proteínas receptoras de superficie bacteriana
WO2016091902A1 (fr) *	2014-12-09	2016-06-16	Sanofi Pasteur	Compositions comprenant des protéines de n. meningitidis

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5292869A (en) *	1989-04-27	1994-03-08	The Board Of Governors Of The University	Method for isolating and purifying transferrin and lactoferrin receptor proteins from bacteria and the preparation of vaccines containing the same
FR2682041B1 (fr) *	1991-10-03	1994-01-14	Pasteur Merieux Serums Vaccins	Vaccin contre les infections a neisseria meningitidis.
FR2692592B1 (fr) *	1992-06-19	1995-03-31	Pasteur Merieux Serums Vacc	Fragments d'ADN codant pour les sous-unités du récepteur de la transferrine de Neisseria meningitidis et procédés les exprimant.
FR2720408B1 (fr) *	1994-05-31	1996-08-14	Pasteur Merieux Serums Vacc	Fragments Tbp2 de Neisseria meningitidis.
FR2739624B1 (fr) *	1995-10-10	1997-12-05	Pasteur Merieux Serums Vacc	Nouvelle sous-unite tbp2 de neisseria meningitidis

1997
- 1997-08-07 FR FR9710301A patent/FR2767060B1/fr not_active Expired - Fee Related
1998
- 1998-08-03 EP EP98941530A patent/EP0948534A1/fr not_active Withdrawn
- 1998-08-03 HU HU0001451A patent/HUP0001451A3/hu unknown
- 1998-08-03 CN CN98801479A patent/CN1241193A/zh active Pending
- 1998-08-03 JP JP11511756A patent/JP2001503068A/ja active Pending
- 1998-08-03 NZ NZ334992A patent/NZ334992A/en unknown
- 1998-08-03 AU AU89875/98A patent/AU8987598A/en not_active Abandoned
- 1998-08-03 CA CA002267066A patent/CA2267066A1/fr not_active Abandoned
- 1998-08-03 WO PCT/FR1998/001730 patent/WO1999007741A1/fr not_active Ceased
1999
- 1999-03-30 NO NO991558A patent/NO991558L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
WO1999007741A1 (fr)	1999-02-18
HUP0001451A2 (hu)	2001-04-28
CA2267066A1 (fr)	1999-02-18
CN1241193A (zh)	2000-01-12
EP0948534A1 (fr)	1999-10-13
HUP0001451A3 (en)	2001-09-28
JP2001503068A (ja)	2001-03-06
FR2767060B1 (fr)	2000-02-11
FR2767060A1 (fr)	1999-02-12
NO991558D0 (no)	1999-03-30
NO991558L (no)	1999-03-30
AU8987598A (en)	1999-03-01

Legal Events

Date	Code	Title	Description
2002-02-01	PSEA	Patent sealed

Publication	Publication Date	Title
Maciver et al.	1996	Identification of an outer membrane protein involved in utilization of hemoglobin-haptoglobin complexes by nontypeable Haemophilus influenzae
EP0749322A1 (fr)	1996-12-27	H. pilori n'exprimant pas une toxine vacuolisante et procedes associes
US20100143412A1 (en)	2010-06-10	Basb027 proteins and genes from moraxella catarrhalis, antigens, antibodies, and uses
WO1999055871A1 (fr)	1999-11-04	Polypeptides isoles a partir de moraxella (branhamella) catarrhalis
US6617128B2 (en)	2003-09-09	Nucleic acid molecules encoding proteins which impart the adhesion of neisseria cells to human cells
NZ334992A (en)	2001-09-28	Meningococcus vaccine comprising the valence of BZ83 strain
US7592158B2 (en)	2009-09-22	BASB019 proteins and genes from Moraxella catarrhalis, antigens, antibodies, and uses
JP4503175B2 (ja)	2010-07-14	モラクセラ・カタラーリス（Ｍｏｒａｘｅｌｌａｃａｔａｒｒｈａｌｉｓ）由来の化合物
US7432366B2 (en)	2008-10-07	Moraxella catarrhalis BASB034 polypeptides and used thereof
EP1082436B1 (fr)	2004-11-03	Proteines pilq de moraxella catarrhalis
JP2003506027A (ja)	2003-02-18	モラクセラ・カタラーリス（Ｍｏｒａｘｅｌｌａｃａｔａｒｒｈａｌｉｓ）のＢＡＳＢ１１４抗原およびその使用
ZA200007108B (en)	2002-02-01	BASB027 proteins and genes from moraxella catarrhalis, antigens, antibodies, and uses.