NZ606805A - Pharmaceutical composition of (r)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-n-(1-(2,3-dihydroxy propyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl) cyclopropanecarboxamide and administration therof - Google Patents

Pharmaceutical composition of (r)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-n-(1-(2,3-dihydroxy propyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl) cyclopropanecarboxamide and administration therof

Info

Publication number: NZ606805A
Authority: NZ; New Zealand
Prior art keywords: pharmaceutical composition; difluorobenzo; cyclopropanecarboxamide; methylpropan; dioxol
Prior art date: 2010-08-23

Application number

NZ60680511A

Other languages

English (en)

Inventor

Rossitza Gueorguieva Alargova

Craig Antony Dunbar

Irina Nikolaevna Kadiyala

Original Assignee

Vertex Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2010-08-23

Filing date

2011-08-22

Publication date

2015-03-27

2011-08-22 Application filed by Vertex Pharma filed Critical Vertex Pharma

2015-03-27 Publication of NZ606805A publication Critical patent/NZ606805A/en

Links

239000008194 pharmaceutical composition Substances 0.000 title abstract 3
MJUVRTYWUMPBTR-MRXNPFEDSA-N 1-(2,2-difluoro-1,3-benzodioxol-5-yl)-n-[1-[(2r)-2,3-dihydroxypropyl]-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)indol-5-yl]cyclopropane-1-carboxamide Chemical group FC=1C=C2N(C[C@@H](O)CO)C(C(C)(CO)C)=CC2=CC=1NC(=O)C1(C=2C=C3OC(F)(F)OC3=CC=2)CC1 MJUVRTYWUMPBTR-MRXNPFEDSA-N 0.000 title abstract 2
201000003883 Cystic fibrosis Diseases 0.000 abstract 1
239000003085 diluting agent Substances 0.000 abstract 1
239000007884 disintegrant Substances 0.000 abstract 1
239000000945 filler Substances 0.000 abstract 1

Classifications

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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
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- A61K9/1605—Excipients; Inactive ingredients
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Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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NZ60680511A 2010-08-23 2011-08-22 Pharmaceutical composition of (r)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-n-(1-(2,3-dihydroxy propyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl) cyclopropanecarboxamide and administration therof NZ606805A (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US37597610P	2010-08-23	2010-08-23
US201161506220P	2011-07-11	2011-07-11
PCT/US2011/048565 WO2012027247A2 (en)	2010-08-23	2011-08-22	Pharmaceutical composition of (r)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-n-(1-(2,3-dihydroxy propyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl) cyclopropanecarboxamide and administration therof

Publications (1)

Publication Number	Publication Date
NZ606805A true NZ606805A (en)	2015-03-27

Family

ID=45594557

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NZ60680511A NZ606805A (en)	2010-08-23	2011-08-22	Pharmaceutical composition of (r)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-n-(1-(2,3-dihydroxy propyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl) cyclopropanecarboxamide and administration therof

Country Status (13)

Country	Link
US (1)	US20120046330A1 (2)
EP (1)	EP2608779A2 (2)
JP (1)	JP2013536231A (2)
CN (1)	CN103153287A (2)
AR (1)	AR084473A1 (2)
AU (2)	AU2011293658B2 (2)
BR (1)	BR112013004443A8 (2)
CA (1)	CA2808501A1 (2)
MX (1)	MX2013002035A (2)
NZ (1)	NZ606805A (2)
RU (1)	RU2013112937A (2)
TW (2)	TWI619515B (2)
WO (1)	WO2012027247A2 (2)

Families Citing this family (77)

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US7645789B2 (en)	2006-04-07	2010-01-12	Vertex Pharmaceuticals Incorporated	Indole derivatives as CFTR modulators
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NZ571803A (en)	2006-04-07	2011-12-22	Vertex Pharma	Amide indole derivatives as modulators of ATP-binding cassette transporters
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US8563573B2 (en) *	2007-11-02	2013-10-22	Vertex Pharmaceuticals Incorporated	Azaindole derivatives as CFTR modulators
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HUE028426T2 (en)	2007-08-24	2016-12-28	Vertex Pharma	Isothiazolopyridinones for (inter alia) treating cystic fibrosis
SI2217572T1 (sl) *	2007-11-16	2014-05-30	Vertex Pharmaceuticals Incorporated	Izokinolinski modulatorji prenaĺ alcev z atp-vezavno kaseto
SI2225230T1 (sl)	2007-12-07	2017-03-31	Vertex Pharmaceuticals Incorporated	Trdne oblike 3-(6-(1-2,2-difluorobenzo(d)(1,3)dioxol-5-il)ciklopropan- karboksamido)-3-metilpiridin-2-il) benzojske kisline
US20100036130A1 (en)	2007-12-07	2010-02-11	Vertex Pharmaceuticals Incorporated	Processes for producing cycloalkylcarboxamido-pyridine benzoic acids
EP2639224B1 (en)	2007-12-07	2016-08-24	Vertex Pharmaceuticals Incorporated	Process for producing cycloalkylcarboxiamido-pyridine benzoic acids
WO2009076141A2 (en) *	2007-12-07	2009-06-18	Vertex Pharmaceuticals Incorporated	Formulations of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cycklopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid
NZ720282A (en)	2008-02-28	2017-12-22	Vertex Pharma	Heteroaryl derivatives as cftr modulators
EP2271621B1 (en)	2008-03-31	2013-11-20	Vertex Pharmaceuticals Incorporated	Pyridyl derivatives as cftr modulators
US12458635B2 (en)	2008-08-13	2025-11-04	Vertex Pharmaceuticals Incorporated	Pharmaceutical composition and administrations thereof
US20100074949A1 (en)	2008-08-13	2010-03-25	William Rowe	Pharmaceutical composition and administration thereof
JP2012504143A (ja) *	2008-09-29	2012-02-16	バーテックスファーマシューティカルズインコーポレイテッド	３−（６−（１−（２，２−ジフルオロベンゾ［ｄ］［１，３］ジオキソール−５−イル）シクロプロパンカルボキサミド）−３−メチルピリジン−２−イル）安息香酸の用量単位
NZ592685A (en) *	2008-10-23	2013-04-26	Vertex Pharma	Modulators of cystic fibrosis transmembrane conductance regulator
SI2408750T1 (sl)	2009-03-20	2015-11-30	Vertex Pharmaceuticals Incorporated	Postopek za izdelavo modulatorjev cistično-fibroznega transmembranskega regulatorja prevodnosti
US20110251253A1 (en) *	2010-03-25	2011-10-13	Vertex Pharmaceuticals Incorporated	Solid forms of (r)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-n-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl) cyclopropanecarboxamide
US8802868B2 (en)	2010-03-25	2014-08-12	Vertex Pharmaceuticals Incorporated	Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
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- 2011-08-22 MX MX2013002035A patent/MX2013002035A/es not_active Application Discontinuation
- 2011-08-22 US US13/214,419 patent/US20120046330A1/en not_active Abandoned
- 2011-08-22 JP JP2013526057A patent/JP2013536231A/ja active Pending
- 2011-08-22 EP EP11751753.2A patent/EP2608779A2/en not_active Withdrawn
- 2011-08-22 AU AU2011293658A patent/AU2011293658B2/en not_active Ceased
- 2011-08-22 WO PCT/US2011/048565 patent/WO2012027247A2/en not_active Ceased
- 2011-08-22 BR BR112013004443A patent/BR112013004443A8/pt not_active Application Discontinuation
- 2011-08-22 CN CN2011800511228A patent/CN103153287A/zh active Pending
- 2011-08-22 NZ NZ60680511A patent/NZ606805A/en not_active IP Right Cessation
- 2011-08-22 RU RU2013112937/15A patent/RU2013112937A/ru not_active Application Discontinuation
- 2011-08-23 AR ARP110103065 patent/AR084473A1/es not_active Application Discontinuation
- 2011-08-23 TW TW103137082A patent/TWI619515B/zh active
- 2011-08-23 TW TW100130218A patent/TW201238611A/zh unknown
2015
- 2015-06-03 AU AU2015202975A patent/AU2015202975B2/en not_active Ceased

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TW201503911A (zh)	2015-02-01
EP2608779A2 (en)	2013-07-03
MX2013002035A (es)	2013-03-25
BR112013004443A8 (pt)	2018-01-02
AR084473A1 (es)	2013-05-22
JP2013536231A (ja)	2013-09-19
BR112013004443A2 (pt)	2016-06-07
CN103153287A (zh)	2013-06-12
AU2011293658A1 (en)	2013-04-04
TWI619515B (zh)	2018-04-01
CA2808501A1 (en)	2012-03-01
AU2011293658B2 (en)	2015-03-05
WO2012027247A2 (en)	2012-03-01
TW201238611A (en)	2012-10-01
AU2015202975A1 (en)	2015-06-18
US20120046330A1 (en)	2012-02-23
WO2012027247A3 (en)	2012-05-24
AU2015202975B2 (en)	2016-05-12
RU2013112937A (ru)	2014-09-27

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