OA09483A - "Nouveaux dérivés d'aminométhylpipéridine, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent". - Google Patents
"Nouveaux dérivés d'aminométhylpipéridine, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent".Info
- Publication number
- OA09483A OA09483A OA59958A OA59958A OA09483A OA 09483 A OA09483 A OA 09483A OA 59958 A OA59958 A OA 59958A OA 59958 A OA59958 A OA 59958A OA 09483 A OA09483 A OA 09483A
- Authority
- OA
- OAPI
- Prior art keywords
- contain
- new
- pharmaceutical compositions
- preparation process
- derivatives
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- DBMHTLOVZSDLFD-UHFFFAOYSA-N piperidin-1-ylmethanamine Chemical class NCN1CCCCC1 DBMHTLOVZSDLFD-UHFFFAOYSA-N 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 238000002483 medication Methods 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 125000004193 piperazinyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9002394A FR2658823B1 (fr) | 1990-02-27 | 1990-02-27 | Nouveaux derives d'aminomethylpiperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent . |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| OA09483A true OA09483A (fr) | 1992-11-15 |
Family
ID=9394161
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| OA59958A OA09483A (fr) | 1990-02-27 | 1991-02-27 | "Nouveaux dérivés d'aminométhylpipéridine, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent". |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US5192775A (de) |
| EP (1) | EP0445026B1 (de) |
| JP (1) | JPH0786099B2 (de) |
| AT (1) | ATE100808T1 (de) |
| AU (1) | AU633696B2 (de) |
| CA (1) | CA2036978A1 (de) |
| DE (1) | DE69101067T2 (de) |
| DK (1) | DK0445026T3 (de) |
| ES (1) | ES2062706T3 (de) |
| FR (1) | FR2658823B1 (de) |
| IE (1) | IE66020B1 (de) |
| NZ (1) | NZ237225A (de) |
| OA (1) | OA09483A (de) |
| PT (1) | PT96891A (de) |
| ZA (1) | ZA911402B (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ232396A (en) * | 1989-02-10 | 1991-07-26 | Merrell Dow Pharma | 2-(diphenylalkylamino) -1,3 nn heterocyclic compounds and pharmaceutical compositions |
| FR2674524B1 (fr) * | 1991-03-25 | 1993-05-21 | Adir | Nouveaux amides alkyl heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| FR2674853B1 (fr) * | 1991-04-03 | 1995-01-20 | Synthelabo | Derives de piperidinylguanidine, leur preparation et leur application en therapeutique. |
| FR2674855B1 (fr) * | 1991-04-03 | 1994-01-14 | Synthelabo | Derives de piperidine, leur preparation et leur application en therapeutique. |
| FR2681325B1 (fr) * | 1991-09-16 | 1993-12-17 | Fabre Medicament Pierre | Derives de l'aminomethyl-4 piperidine, leur preparation et leur application en therapeutique. |
| US5309629A (en) * | 1992-09-01 | 1994-05-10 | Rogers Corporation | Method of manufacturing a multilayer circuit board |
| FR2696176B1 (fr) * | 1992-09-28 | 1994-11-10 | Synthelabo | Dérivés de pipéridine, leur préparation et leur application en thérapeutique. |
| FR2701479B1 (fr) * | 1993-02-11 | 1995-05-12 | Pf Medicament | Nouveaux dérivés hétérocycliques de l'aminométhyl-4 pipéridine, leur préparation et leur application en thérapeutique. |
| FR2702211B1 (fr) * | 1993-03-04 | 1995-06-02 | Pf Medicament | Nouveaux dérivés de la phénoxy-2 éthylamine, leur préparation et leur application en thérapeutique. |
| GB9318431D0 (en) * | 1993-09-06 | 1993-10-20 | Boots Co Plc | Therapeutic agents |
| US6096763A (en) * | 1995-02-23 | 2000-08-01 | Merck & Co., Inc. | α1a adrenergic receptor antagonists |
| US6284759B1 (en) | 1998-09-30 | 2001-09-04 | Neurogen Corporation | 2-piperazinoalkylaminobenzo-azole derivatives: dopamine receptor subtype specific ligands |
| WO2000035878A1 (en) * | 1998-12-17 | 2000-06-22 | American Home Products Corporation | 1,4-piperazine derivatives having 5ht1a receptor activity |
| US6255302B1 (en) | 1998-12-17 | 2001-07-03 | American Home Products Corporation | 1,4-piperazine derivatives |
| US6660858B2 (en) * | 2001-03-28 | 2003-12-09 | Lion Bioscience Ag | 2-aminobenzoxazole derivatives and combinatorial libraries thereof |
| US20040117031A1 (en) * | 2001-08-27 | 2004-06-17 | Stack Richard S. | Satiation devices and methods |
| AU2003238046A1 (en) * | 2002-06-27 | 2004-01-19 | Actelion Pharmaceuticals Ltd | Substituted 3- and 4- aminomethylpiperidines for use as beta-secretase in the treatment of alzheimer's disease |
| AR047759A1 (es) * | 2003-09-26 | 2006-02-22 | Vertex Pharma | Derivados de fenil - piperazina como moduladores de receptores muscarnicos |
| DE102004006808A1 (de) * | 2004-02-11 | 2005-09-01 | Grünenthal GmbH | Substituierte 4,5,6,7-Tetrahydro-benzothiazol-2-ylamin-Verbindungen |
| CN103965186B (zh) * | 2013-01-25 | 2016-05-18 | 江苏恩华药业股份有限公司 | 苯并二噁烷-苯并噁(噻)唑哌啶衍生物及其应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2886572A (en) * | 1959-05-12 | Z-aminobenzoxazoles | ||
| BE494102A (de) * | 1949-03-02 | |||
| GB1077173A (en) * | 1965-03-19 | 1967-07-26 | American Cyanamid Co | Substituted alkylene piperidines and methods of preparation thereof |
| DE2314239A1 (de) * | 1973-03-22 | 1974-09-26 | Henkel & Cie Gmbh | Neue n-benzoxazol-2-yl-substituierte 2-cyan-1,2-dihydro-pyridinderivate, deren herstellung, sowie verwendung als entzuendungshemmer in kosmetischen praeparationen |
| US4200641A (en) * | 1976-12-21 | 1980-04-29 | Janssen Pharmaceutica, N.V. | 1-[(Heterocyclyl)-alkyl]-4-diarylmethoxy piperidine derivatives |
| US4291042A (en) * | 1979-01-26 | 1981-09-22 | John Wyeth & Brother Limited | Antidepressant piperidine derivatives |
| US4359468A (en) * | 1981-02-25 | 1982-11-16 | Boehringer Ingelheim Ltd. | Antiallergic N-[4-(indolyl)-piperidino-alkyl]-benzimidazolones |
| US5010198A (en) * | 1984-12-03 | 1991-04-23 | Janssen Pharmaceutica N.V. | Intermediates for the synthesis of benzoxazol- and benzothiazolamine derivatives, useful as anti-anoxic agents |
| US4689330A (en) * | 1985-04-15 | 1987-08-25 | Janssen Pharmaceutica N.V. | Antidepressive substituted N-[(4-piperidinyl)alkyl] bicyclic condensed oxazol- and thiazolamines |
| FR2587029B1 (fr) * | 1985-09-11 | 1987-10-30 | Synthelabo | Derives de benzimidazole, leur preparation et leur application en therapeutique |
| FR2618435B1 (fr) * | 1987-07-23 | 1989-10-27 | Synthelabo | Derives de benzimidazole, leur preparation et leur application en therapeutique |
| FR2618437B1 (fr) * | 1987-07-23 | 1989-11-17 | Rhone Poulenc Sante | Nouveaux derives du benzopyranne, leur preparation et les medicaments qui les contiennent |
| FR2621588B1 (fr) * | 1987-10-08 | 1991-05-24 | Roussel Uclaf | Nouveaux derives de la 1,1-dioxo 1,2-benzoisothiazol 3-one, leur procede de preparation et leur application comme medicaments |
| NZ233525A (en) * | 1989-05-15 | 1991-09-25 | Janssen Pharmaceutica Nv | Piperidinyl, pyrrolidinyl and piperazinyl alkylphenol ethers and pharmaceutical compositions |
| US5147881A (en) * | 1990-11-14 | 1992-09-15 | Pfizer Inc | 4-(1,2-benzisoxazolyl)piperidine antipsychotic agents |
-
1990
- 1990-02-27 FR FR9002394A patent/FR2658823B1/fr not_active Expired - Lifetime
-
1991
- 1991-02-25 CA CA002036978A patent/CA2036978A1/fr not_active Abandoned
- 1991-02-26 NZ NZ237225A patent/NZ237225A/en unknown
- 1991-02-26 IE IE64291A patent/IE66020B1/en not_active IP Right Cessation
- 1991-02-26 ZA ZA911402A patent/ZA911402B/xx unknown
- 1991-02-26 PT PT96891A patent/PT96891A/pt not_active Application Discontinuation
- 1991-02-26 US US07/661,494 patent/US5192775A/en not_active Expired - Fee Related
- 1991-02-26 AU AU71374/91A patent/AU633696B2/en not_active Ceased
- 1991-02-26 JP JP3030934A patent/JPH0786099B2/ja not_active Expired - Lifetime
- 1991-02-27 DE DE69101067T patent/DE69101067T2/de not_active Expired - Fee Related
- 1991-02-27 EP EP91400527A patent/EP0445026B1/de not_active Expired - Lifetime
- 1991-02-27 OA OA59958A patent/OA09483A/xx unknown
- 1991-02-27 AT AT91400527T patent/ATE100808T1/de not_active IP Right Cessation
- 1991-02-27 ES ES91400527T patent/ES2062706T3/es not_active Expired - Lifetime
- 1991-02-27 DK DK91400527.7T patent/DK0445026T3/da active
-
1992
- 1992-10-21 US US07/964,423 patent/US5229399A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| FR2658823B1 (fr) | 1992-04-30 |
| IE66020B1 (en) | 1995-11-29 |
| US5229399A (en) | 1993-07-20 |
| JPH04211681A (ja) | 1992-08-03 |
| ES2062706T3 (es) | 1994-12-16 |
| EP0445026A1 (de) | 1991-09-04 |
| IE910642A1 (en) | 1991-08-28 |
| US5192775A (en) | 1993-03-09 |
| CA2036978A1 (fr) | 1991-08-28 |
| ZA911402B (en) | 1991-11-27 |
| JPH0786099B2 (ja) | 1995-09-20 |
| NZ237225A (en) | 1992-07-28 |
| ATE100808T1 (de) | 1994-02-15 |
| DE69101067T2 (de) | 1994-08-04 |
| DE69101067D1 (de) | 1994-03-10 |
| DK0445026T3 (da) | 1994-05-02 |
| PT96891A (pt) | 1991-10-31 |
| AU633696B2 (en) | 1993-02-04 |
| EP0445026B1 (de) | 1994-01-26 |
| AU7137491A (en) | 1991-08-29 |
| FR2658823A1 (fr) | 1991-08-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| OA09483A (fr) | "Nouveaux dérivés d'aminométhylpipéridine, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent". | |
| MX9200344A (es) | Derivados de benzamida, proceso para su preparacion y composicion farmaceutica que los contiene. | |
| OA09373A (fr) | "Nouveaux composés de l'acide 4-amino butyrique, leur procédé de préparation et les préparations pharmaceutiques qui les contiennent". | |
| OA09504A (fr) | "Nouvelles chalcones, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent". | |
| DE3069813D1 (en) | Pharmaceutical composition containing a diphenylhydantoin derivative, derivatives used and their preparation | |
| OA08825A (fr) | Nouveaux dérivés de l'amino tétrahydro-5,6,7,8 naphto (2,3b) furanne, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent. | |
| FR2695387B1 (fr) | Nouveaux composés benzopyraniques, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. | |
| DE68928644D1 (de) | Heterocyclische Derivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen | |
| FR2711139B1 (fr) | Nouveaux dérivés de 1,2,3,4-tétrahydronaphtalène, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. | |
| OA09349A (fr) | "Nouveaux dérivés du 3-aminochromane, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent". | |
| ES2103440T3 (es) | Nuevas amidas y sulfonamidas naftalenicas, procedimiento de preparacion y composiciones farmaceuticas que las contienen. | |
| FR2707085B1 (fr) | Nouveaux dérivés d'alpha amino acides, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. | |
| OA08715A (fr) | Nouveaux dérivés peptidiques à structure polyclique azotée, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. | |
| FR2696465B1 (fr) | Nouveaux dérivés d'ellipticine, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. | |
| ATE48276T1 (de) | 1,6-naphthyridin-derivate, verfahren zu deren herstellung und diese enthaltende arzneimittel. | |
| FR2379551A1 (fr) | Nouveaux derives 4''-amines d'oleandomycine et medicament les contenant | |
| DE69015787D1 (de) | Thiophenderivate, Verfahren zu deren Herstellung und sie enthaltende pharmazeutische Zusammensetzungen. | |
| OA08881A (fr) | Nouveaux tripeptides à structure polycyclique azotée, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. | |
| DE69625795D1 (de) | Thiazolidinedionderivate mit antidiabetischen, hypolipidämischen und antihypertensiven Eigenschaften, Verfahren zu deren Herstellung und pharmazeutischen Zusammenstellungen, die sie enthalten | |
| FR2701952B1 (fr) | Nouveaux dérivés cyclopeptidiques de l'angiopeptine, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. | |
| ATE86993T1 (de) | Heterotetracyclische laktamderivate, verfahren zu ihrer herstellung und pharmazeutische zubereitungen, die sie enthalten. | |
| SE8001425L (sv) | Cytostatiskt verkande lekemedel resp farmaceutiska beredningar | |
| ATE43594T1 (de) | 3-alkoxy-2-(n-pyrrolidino)-n-pyridyl-n-furyl(od r thienyl)-methyl-propylamine, ihre herstellung und diese enthaltende pharmazeutische mittel. | |
| DE69116423D1 (de) | 3'-Deamino-4'-deoxy-4'-amino-8-fluoranthracycline und Verfahren zu ihrer Herstellung | |
| OA09147A (fr) | Nouveaux dérivés de l'indole, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. |