OA10395A - Utilisation du triacétate de glycéryle pour le traitement d'onychomycoses - Google Patents

Utilisation du triacétate de glycéryle pour le traitement d'onychomycoses Download PDF

Info

Publication number: OA10395A
Authority: OA; OAPI
Prior art keywords: nail polish; formula; nail; hydroxy; pyridone
Prior art date: 1995-05-18

Application number

OA60953A

Other languages

English (en)

French (fr)

Inventor

Manfred Bohn

Karl Kraemer

Astrid Markus

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-05-18

Filing date

1997-01-17

Publication date

2001-12-04

1997-01-17 Application filed by Hoechst Ag filed Critical Hoechst Ag

2001-12-04 Publication of OA10395A publication Critical patent/OA10395A/fr

Links

URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 title claims abstract description 52
235000013773 glyceryl triacetate Nutrition 0.000 title claims abstract description 26
229960002622 triacetin Drugs 0.000 title claims abstract description 26
239000001087 glyceryl triacetate Substances 0.000 title claims abstract description 24
208000010195 Onychomycosis Diseases 0.000 title claims abstract description 10
238000011282 treatment Methods 0.000 title claims description 20
201000005882 tinea unguium Diseases 0.000 title claims description 8
239000003795 chemical substances by application Substances 0.000 claims abstract description 14
150000001875 compounds Chemical class 0.000 claims abstract description 13
239000002966 varnish Substances 0.000 claims abstract description 7
SNUSZUYTMHKCPM-UHFFFAOYSA-N 1-hydroxypyridin-2-one Chemical class ON1C=CC=CC1=O SNUSZUYTMHKCPM-UHFFFAOYSA-N 0.000 claims abstract 2
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125000004432 carbon atom Chemical group C* 0.000 claims description 12
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239000003814 drug Substances 0.000 claims description 8
125000000217 alkyl group Chemical group 0.000 claims description 7
238000004519 manufacturing process Methods 0.000 claims description 6
238000011321 prophylaxis Methods 0.000 claims description 6
229910052717 sulfur Inorganic materials 0.000 claims description 6
UTOVMEACOLCUCK-PLNGDYQASA-N butyl maleate Chemical compound CCCCOC(=O)\C=C/C(O)=O UTOVMEACOLCUCK-PLNGDYQASA-N 0.000 claims description 5
XJRBAMWJDBPFIM-UHFFFAOYSA-N methyl vinyl ether Chemical compound COC=C XJRBAMWJDBPFIM-UHFFFAOYSA-N 0.000 claims description 5
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 4
239000000460 chlorine Substances 0.000 claims description 4
229910052801 chlorine Inorganic materials 0.000 claims description 4
ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims description 4
125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 4
229910052760 oxygen Inorganic materials 0.000 claims description 4
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 3
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 3
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 3
229910052794 bromium Inorganic materials 0.000 claims description 3
USIUVYZYUHIAEV-UHFFFAOYSA-N diphenyl ether Chemical compound C=1C=CC=CC=1OC1=CC=CC=C1 USIUVYZYUHIAEV-UHFFFAOYSA-N 0.000 claims description 3
125000004430 oxygen atom Chemical group O* 0.000 claims description 3
229920006395 saturated elastomer Polymers 0.000 claims description 3
239000011593 sulfur Substances 0.000 claims description 3
UDYUIWXQUBNDHC-UHFFFAOYSA-N 6-[[4-(4-chlorophenoxy)phenoxy]methyl]-1-hydroxy-4-methylpyridin-2-one Chemical compound ON1C(=O)C=C(C)C=C1COC(C=C1)=CC=C1OC1=CC=C(Cl)C=C1 UDYUIWXQUBNDHC-UHFFFAOYSA-N 0.000 claims description 2
YUDRVAHLXDBKSR-UHFFFAOYSA-N [CH]1CCCCC1 Chemical compound [CH]1CCCCC1 YUDRVAHLXDBKSR-UHFFFAOYSA-N 0.000 claims description 2
125000003118 aryl group Chemical group 0.000 claims description 2
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 2
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239000004305 biphenyl Substances 0.000 claims description 2
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125000005843 halogen group Chemical group 0.000 claims description 2
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 2
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125000001424 substituent group Chemical group 0.000 claims description 2
125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims description 2
229910052727 yttrium Inorganic materials 0.000 claims description 2
OXGWNVOZSZXLDA-UHFFFAOYSA-N 1-hydroxy-4-methyl-3-(2,4,4-trimethylpentyl)pyridin-2-one Chemical compound CC(Cc1c(C)ccn(O)c1=O)CC(C)(C)C OXGWNVOZSZXLDA-UHFFFAOYSA-N 0.000 claims 1
125000002947 alkylene group Chemical group 0.000 claims 1
125000002619 bicyclic group Chemical group 0.000 claims 1
125000001153 fluoro group Chemical group F* 0.000 claims 1
229910052740 iodine Inorganic materials 0.000 claims 1
238000000034 method Methods 0.000 claims 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
210000000282 nail Anatomy 0.000 description 30
239000000203 mixture Substances 0.000 description 18
239000002904 solvent Substances 0.000 description 12
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 11
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Natural products CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 10
238000002360 preparation method Methods 0.000 description 8
239000000126 substance Substances 0.000 description 6
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SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 4
NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 4
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238000009835 boiling Methods 0.000 description 4
235000019439 ethyl acetate Nutrition 0.000 description 4
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CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 3
YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
150000001298 alcohols Chemical class 0.000 description 3
230000037304 dermatophytes Effects 0.000 description 3
230000000694 effects Effects 0.000 description 3
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 3
210000004904 fingernail bed Anatomy 0.000 description 3
208000015181 infectious disease Diseases 0.000 description 3
HRDXJKGNWSUIBT-UHFFFAOYSA-N methoxybenzene Chemical group [CH2]OC1=CC=CC=C1 HRDXJKGNWSUIBT-UHFFFAOYSA-N 0.000 description 3
239000000049 pigment Substances 0.000 description 3
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
239000000020 Nitrocellulose Substances 0.000 description 2
FJWGYAHXMCUOOM-QHOUIDNNSA-N [(2s,3r,4s,5r,6r)-2-[(2r,3r,4s,5r,6s)-4,5-dinitrooxy-2-(nitrooxymethyl)-6-[(2r,3r,4s,5r,6s)-4,5,6-trinitrooxy-2-(nitrooxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-3,5-dinitrooxy-6-(nitrooxymethyl)oxan-4-yl] nitrate Chemical compound O([C@@H]1O[C@@H]([C@H]([C@H](O[N+]([O-])=O)[C@H]1O[N+]([O-])=O)O[C@H]1[C@@H]([C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@@H](CO[N+]([O-])=O)O1)O[N+]([O-])=O)CO[N+](=O)[O-])[C@@H]1[C@@H](CO[N+]([O-])=O)O[C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@H]1O[N+]([O-])=O FJWGYAHXMCUOOM-QHOUIDNNSA-N 0.000 description 2
239000013543 active substance Substances 0.000 description 2
SCKYRAXSEDYPSA-UHFFFAOYSA-N ciclopirox Chemical compound ON1C(=O)C=C(C)C=C1C1CCCCC1 SCKYRAXSEDYPSA-UHFFFAOYSA-N 0.000 description 2
239000002537 cosmetic Substances 0.000 description 2
LDHQCZJRKDOVOX-NSCUHMNNSA-N crotonic acid Chemical compound C\C=C\C(O)=O LDHQCZJRKDOVOX-NSCUHMNNSA-N 0.000 description 2
238000009792 diffusion process Methods 0.000 description 2
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238000011081 inoculation Methods 0.000 description 2
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 2
229920001220 nitrocellulos Polymers 0.000 description 2
230000035515 penetration Effects 0.000 description 2
229920000642 polymer Polymers 0.000 description 2
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239000011118 polyvinyl acetate Substances 0.000 description 2
UBQKCCHYAOITMY-UHFFFAOYSA-N pyridin-2-ol Chemical group OC1=CC=CC=N1 UBQKCCHYAOITMY-UHFFFAOYSA-N 0.000 description 2
YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 2
LDHQCZJRKDOVOX-UHFFFAOYSA-N trans-crotonic acid Natural products CC=CC(O)=O LDHQCZJRKDOVOX-UHFFFAOYSA-N 0.000 description 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 description 1
DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 1
KMZHZAAOEWVPSE-UHFFFAOYSA-N 2,3-dihydroxypropyl acetate Chemical compound CC(=O)OCC(O)CO KMZHZAAOEWVPSE-UHFFFAOYSA-N 0.000 description 1
XVBOGEUUVJVJTD-UHFFFAOYSA-M 2-chloroethyl(trimethyl)azanium;2-methylprop-2-enoate Chemical compound CC(=C)C([O-])=O.C[N+](C)(C)CCCl XVBOGEUUVJVJTD-UHFFFAOYSA-M 0.000 description 1
WBXDEEFCGDIKFC-UHFFFAOYSA-N 6-(3-bicyclo[2.2.1]heptanyl)-1-hydroxy-4-methylpyridin-2-one Chemical compound ON1C(=O)C=C(C)C=C1C1C(C2)CCC2C1 WBXDEEFCGDIKFC-UHFFFAOYSA-N 0.000 description 1
NOMIBIVUURZCPM-UHFFFAOYSA-N 6-[[4-(4-chlorophenoxy)phenoxy]methyl]-1-hydroxy-3,4-dimethylpyridin-2-one Chemical compound ON1C(=O)C(C)=C(C)C=C1COC(C=C1)=CC=C1OC1=CC=C(Cl)C=C1 NOMIBIVUURZCPM-UHFFFAOYSA-N 0.000 description 1
WQRDQQATCFVLNN-UHFFFAOYSA-N 6-[[4-[(2,4-dichlorophenyl)methoxy]phenoxy]methyl]-1-hydroxy-4-methylpyridin-2-one Chemical compound ON1C(=O)C=C(C)C=C1COC(C=C1)=CC=C1OCC1=CC=C(Cl)C=C1Cl WQRDQQATCFVLNN-UHFFFAOYSA-N 0.000 description 1
NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 1
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235000001674 Agaricus brunnescens Nutrition 0.000 description 1
241000283690 Bos taurus Species 0.000 description 1
DKPFZGUDAPQIHT-UHFFFAOYSA-N Butyl acetate Natural products CCCCOC(C)=O DKPFZGUDAPQIHT-UHFFFAOYSA-N 0.000 description 1
JGKNAYUWDPRDCK-UHFFFAOYSA-N CC(=O)OC(C)=O.CC(=O)OC(C)=O.CC(=O)OC(C)=O Chemical compound CC(=O)OC(C)=O.CC(=O)OC(C)=O.CC(=O)OC(C)=O JGKNAYUWDPRDCK-UHFFFAOYSA-N 0.000 description 1
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PQUCIEFHOVEZAU-UHFFFAOYSA-N Diammonium sulfite Chemical class [NH4+].[NH4+].[O-]S([O-])=O PQUCIEFHOVEZAU-UHFFFAOYSA-N 0.000 description 1
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239000002253 acid Substances 0.000 description 1
239000008272 agar Substances 0.000 description 1
125000001931 aliphatic group Chemical group 0.000 description 1
125000005250 alkyl acrylate group Chemical group 0.000 description 1
125000005907 alkyl ester group Chemical group 0.000 description 1
QGZKDVFQNNGYKY-UHFFFAOYSA-O ammonium group Chemical group [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
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125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
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125000001246 bromo group Chemical group Br* 0.000 description 1
229960000846 camphor Drugs 0.000 description 1
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BFPSDSIWYFKGBC-UHFFFAOYSA-N chlorotrianisene Chemical compound C1=CC(OC)=CC=C1C(Cl)=C(C=1C=CC(OC)=CC=1)C1=CC=C(OC)C=C1 BFPSDSIWYFKGBC-UHFFFAOYSA-N 0.000 description 1
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125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 1
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YHAIUSTWZPMYGG-UHFFFAOYSA-L disodium;2,2-dioctyl-3-sulfobutanedioate Chemical compound [Na+].[Na+].CCCCCCCCC(C([O-])=O)(C(C([O-])=O)S(O)(=O)=O)CCCCCCCC YHAIUSTWZPMYGG-UHFFFAOYSA-L 0.000 description 1
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150000004665 fatty acids Chemical class 0.000 description 1
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229910052731 fluorine Inorganic materials 0.000 description 1
239000011737 fluorine Substances 0.000 description 1
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125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 description 1
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FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 description 1
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FJQXCDYVZAHXNS-UHFFFAOYSA-N methadone hydrochloride Chemical compound Cl.C=1C=CC=CC=1C(CC(C)N(C)C)(C(=O)CC)C1=CC=CC=C1 FJQXCDYVZAHXNS-UHFFFAOYSA-N 0.000 description 1
WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical compound [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 description 1
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q3/00—Manicure or pedicure preparations
- A61Q3/02—Nail coatings

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Epidemiology (AREA)
Birds (AREA)
Medicinal Chemistry (AREA)
Chemical & Material Sciences (AREA)
Emergency Medicine (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
Communicable Diseases (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Cosmetics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pyridine Compounds (AREA)

OA60953A 1995-05-18 1997-01-17 Utilisation du triacétate de glycéryle pour le traitement d'onychomycoses OA10395A (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19518262A DE19518262A1 (de)	1995-05-18	1995-05-18	Die Verwendung von Glyceryltriacetat zur Behandlung von Onychomykosen

Publications (1)

Publication Number	Publication Date
OA10395A true OA10395A (fr)	2001-12-04

Family

ID=7762250

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
OA60953A OA10395A (fr)	1995-05-18	1997-01-17	Utilisation du triacétate de glycéryle pour le traitement d'onychomycoses

Country Status (31)

Country	Link
US (1)	US6162420A (pl)
EP (1)	EP0777457B1 (pl)
JP (1)	JP3653098B2 (pl)
KR (1)	KR100442161B1 (pl)
CN (1)	CN1193730C (pl)
AR (1)	AR002743A1 (pl)
AT (1)	ATE221763T1 (pl)
AU (1)	AU699323B2 (pl)
BG (1)	BG63589B1 (pl)
BR (1)	BR9606662B1 (pl)
CA (1)	CA2195455A1 (pl)
CY (1)	CY2386B1 (pl)
CZ (1)	CZ290526B6 (pl)
DE (2)	DE19518262A1 (pl)
DK (1)	DK0777457T3 (pl)
ES (1)	ES2180774T3 (pl)
HU (1)	HU226246B1 (pl)
IL (1)	IL118289A (pl)
MA (1)	MA23870A1 (pl)
MX (1)	MX9700470A (pl)
MY (1)	MY124480A (pl)
NO (1)	NO312395B1 (pl)
NZ (1)	NZ307555A (pl)
OA (1)	OA10395A (pl)
PL (1)	PL184648B1 (pl)
PT (1)	PT777457E (pl)
RO (1)	RO120039B1 (pl)
TW (1)	TW496738B (pl)
UA (1)	UA44280C2 (pl)
WO (1)	WO1996036311A1 (pl)
ZA (1)	ZA963935B (pl)

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19643831A1 (de)	1996-10-30	1998-05-07	Hoechst Ag	Verwendung von 1-Hydroxy-2-pyridonen zur Behandlung von schwer therapierbaren Schleimhauterkrankungen
US20040039030A1 (en) *	1996-09-27	2004-02-26	Hoechst Akeengesellschaft	Use of 1-hydroxy-2-pyridones for the treatment of seborrheic dermatitis
DE19639817A1 (de)	1996-09-27	1998-04-02	Hoechst Ag	Verwendung von 1-Hydroxy-2-pyridonen zur Behandlung von Hautinfektionen
DE19639816A1 (de) *	1996-09-27	1998-04-02	Hoechst Ag	Antimykotische Mittel mit hoher Wirkstofffreisetzung
RO118174B1 (ro) *	1997-08-21	2003-03-28	Aventis Pharma Deutschland Gmbh	Lac de unghii şi utilizarea acestuia
US6401724B1 (en) *	1999-10-11	2002-06-11	Par Pharmaceuticals Incorporated	Method of applying a cosmetic nail lacquer or polish to a nail
DE10011081A1 (de) *	2000-03-09	2001-09-13	Aventis Pharma Gmbh	Antiinfektive Wirkstoffkombinationen und ihre Verwendung zur topischen Behandlung von Pilzerkrankungen der Fuß- und Fingernägel
US6664292B2 (en) *	2001-06-04	2003-12-16	Mark H. Bogart	Methods for the treatment of nail fungus and other microbial and mycotic conditions and compositions useful therefor
US8404751B2 (en) *	2002-09-27	2013-03-26	Hallux, Inc.	Subunguicide, and method for treating onychomycosis
US7135194B2 (en) *	2002-09-27	2006-11-14	Birnbaum Jay E	Subunguicide, and method for treating onychomycosis
WO2009087474A2 (en) *	2008-01-08	2009-07-16	Akthelia Pharmaceuticals	Agonists for antimicrobial peptide systems
DE102008041049A1 (de) *	2008-08-06	2010-02-11	Sonja Spohler	Verwendung einer antimykotischen Zusammensetzung zur topischen Behandlung von Pilzerkrankungen von Fuß- und Fingernägeln
CN103110566A (zh) *	2013-01-31	2013-05-22	巫国谊	一种纠正婴幼儿吮吸手指不良习惯的外用涂剂
US8697753B1 (en)	2013-02-07	2014-04-15	Polichem Sa	Method of treating onychomycosis
CN105377355A (zh)	2013-03-14	2016-03-02	拇趾公司	治疗甲单元的感染、疾病或病症的方法
CN110693754B (zh) *	2019-11-16	2022-08-23	烟台东方化学有限公司	一种抗菌消炎的吡啶酮组合物及包含其的化妆品

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3544983A1 (de) *	1985-12-19	1987-06-25	Hoechst Ag	Antimykotisch wirksamer nagellack
DE3720147A1 (de) *	1987-06-16	1988-12-29	Hoechst Ag	Antimykotisch wirksamer nagellack sowie verfahren zu dessen herstellung
CA2008775C (en) *	1989-02-24	1998-12-22	Alberto Ferro	Nail lacquer
US5066484A (en) *	1990-04-30	1991-11-19	Revlon, Inc.	Nail enamels containing glyceryl, glycol or citrate esters
DE4212105A1 (de) *	1992-04-10	1993-10-14	Roehm Pharma Gmbh	Nagellack zur Behandlung von Onychomykosen
FR2697749B1 (fr) *	1992-11-12	1995-01-13	Oreal	Composition cosmétique filmogène à base d'un copolymère chloré greffé résultant du greffage d'une polyoléfine chlorée et de monomères insaturés du type acrylique, styrénique et/ou vinylique.
FR2718349B1 (fr) *	1994-04-07	1996-05-31	Oreal	Compositions cosmétiques à appliquer sur l'ongle.

1995
- 1995-05-18 DE DE19518262A patent/DE19518262A1/de not_active Withdrawn
1996
- 1996-03-05 UA UA97020678A patent/UA44280C2/uk unknown
- 1996-05-03 JP JP53450296A patent/JP3653098B2/ja not_active Expired - Lifetime
- 1996-05-03 CN CNB961906561A patent/CN1193730C/zh not_active Expired - Fee Related
- 1996-05-03 WO PCT/EP1996/001855 patent/WO1996036311A1/de not_active Ceased
- 1996-05-03 AU AU56936/96A patent/AU699323B2/en not_active Ceased
- 1996-05-03 RO RO97-00045A patent/RO120039B1/ro unknown
- 1996-05-03 HU HU9700153A patent/HU226246B1/hu not_active IP Right Cessation
- 1996-05-03 AT AT96915016T patent/ATE221763T1/de active
- 1996-05-03 ES ES96915016T patent/ES2180774T3/es not_active Expired - Lifetime
- 1996-05-03 EP EP96915016A patent/EP0777457B1/de not_active Expired - Lifetime
- 1996-05-03 NZ NZ307555A patent/NZ307555A/en not_active IP Right Cessation
- 1996-05-03 MX MX9700470A patent/MX9700470A/es unknown
- 1996-05-03 BR BRPI9606662-8A patent/BR9606662B1/pt not_active IP Right Cessation
- 1996-05-03 PT PT96915016T patent/PT777457E/pt unknown
- 1996-05-03 DK DK96915016T patent/DK0777457T3/da active
- 1996-05-03 PL PL96318312A patent/PL184648B1/pl not_active IP Right Cessation
- 1996-05-03 DE DE59609538T patent/DE59609538D1/de not_active Expired - Lifetime
- 1996-05-03 CZ CZ1997141A patent/CZ290526B6/cs not_active IP Right Cessation
- 1996-05-03 US US08/776,101 patent/US6162420A/en not_active Expired - Lifetime
- 1996-05-03 KR KR1019970700298A patent/KR100442161B1/ko not_active Expired - Fee Related
- 1996-05-03 CA CA002195455A patent/CA2195455A1/en not_active Abandoned
- 1996-05-14 MA MA24237A patent/MA23870A1/fr unknown
- 1996-05-16 IL IL11828996A patent/IL118289A/xx not_active IP Right Cessation
- 1996-05-16 MY MYPI96001850A patent/MY124480A/en unknown
- 1996-05-16 AR ARP960102600A patent/AR002743A1/es active IP Right Grant
- 1996-05-17 ZA ZA963935A patent/ZA963935B/xx unknown
- 1996-05-22 TW TW085106017A patent/TW496738B/zh not_active IP Right Cessation
1997
- 1997-01-16 BG BG101138A patent/BG63589B1/bg unknown
- 1997-01-16 NO NO19970198A patent/NO312395B1/no not_active IP Right Cessation
- 1997-01-17 OA OA60953A patent/OA10395A/fr unknown
2003
- 2003-06-30 CY CY0300049A patent/CY2386B1/xx unknown

Also Published As

Publication number	Publication date
PT777457E (pt)	2002-12-31
AR002743A1 (es)	1998-04-29
DE19518262A1 (de)	1996-11-21
DK0777457T3 (da)	2002-11-11
ATE221763T1 (de)	2002-08-15
AU5693696A (en)	1996-11-29
CY2386B1 (en)	2004-09-10
AU699323B2 (en)	1998-12-03
EP0777457B1 (de)	2002-08-07
JP3653098B2 (ja)	2005-05-25
IL118289A0 (en)	1996-09-12
US6162420A (en)	2000-12-19
CN1193730C (zh)	2005-03-23
HUP9700153A2 (hu)	1998-03-02
MA23870A1 (fr)	1996-12-31
WO1996036311A1 (de)	1996-11-21
PL184648B1 (pl)	2002-11-29
IL118289A (en)	2000-08-31
CN1156958A (zh)	1997-08-13
BG101138A (en)	1998-03-31
HU226246B1 (en)	2008-07-28
NO312395B1 (no)	2002-05-06
UA44280C2 (uk)	2002-02-15
BR9606662A (pt)	1997-10-28
ES2180774T3 (es)	2003-02-16
JPH10503219A (ja)	1998-03-24
KR970704413A (ko)	1997-09-06
CZ290526B6 (cs)	2002-08-14
RO120039B1 (ro)	2005-08-30
HK1011936A1 (en)	1999-07-23
NO970198D0 (no)	1997-01-16
CZ14197A3 (en)	1997-04-16
HUP9700153A3 (en)	1999-01-28
BR9606662B1 (pt)	2010-08-10
MY124480A (en)	2006-06-30
NZ307555A (en)	1998-01-26
KR100442161B1 (ko)	2004-10-02
CA2195455A1 (en)	1996-11-21
TW496738B (en)	2002-08-01
ZA963935B (en)	1996-11-25
PL318312A1 (en)	1997-06-09
NO970198L (no)	1997-01-16
MX9700470A (es)	1998-05-31
HU9700153D0 (en)	1997-03-28
DE59609538D1 (de)	2002-09-12
EP0777457A1 (de)	1997-06-11
BG63589B1 (bg)	2002-06-28

Publication	Publication Date	Title
OA10395A (fr)	2001-12-04	Utilisation du triacétate de glycéryle pour le traitement d'onychomycoses
CA2005695C (fr)	1998-02-10	Utilisation de derives salicyles pour le traitement du vieillissement de la peau
US4957730A (en)	1990-09-18	Antimycotic nail varnish
EP0971687B1 (fr)	2004-04-07	Solutions aqueuses de derives d'acide salicylique
EP1172091B1 (fr)	2006-06-07	Utilisation du 4',5,7-trihydroxyflavylium pour colorer la peau
EP0793476A1 (fr)	1997-09-10	Compositions cosmetiques ou pharmaceutiques contenant de la mangiferine ou ses derives
FR2719481A1 (fr)	1995-11-10	Composition à base de composés antifongiques et de composés antibactériens halogènes pour diminuer la chute des cheveux.
CA1166162A (fr)	1984-04-24	Utilisation de l'huile de cafe comme agent filtrant solaire, composition et procede de protection la mettant en oeuvre
OA10829A (fr)	2003-01-29	Préparations stimulant la croissance des ongles
EP0390682A1 (fr)	1990-10-03	Compositions cosmétiques et pharmaceutiques contenant des dérivés hydrophiles du benzylidène camphre et nouveaux dérivés sulfonés hydrophilesdu benzylidène camphre
FR2811554A1 (fr)	2002-01-18	Composition comprenant au moins un filtre uv et un sel de flavylium non substitue en position 3 pour la coloration de la peau et utilisations
EP1172090B1 (fr)	2005-03-09	Compositions pour la coloration de la peau comprenant la dihydroxyacétone et un sel de flavylium non substitué en position 3
EP0948313B1 (fr)	2002-04-17	Utilisation d'un extrait de resine d'okoume, dans les domaines cosmetique et pharmaceutique, notamment dermatologiques
CA2462579A1 (fr)	2003-04-17	Utilisation du tazarotene pour la preparation d'un vernis a ongles pour le traitement et/ou la prevention du psoriasis et un vernis a ongles le contenant
FR2755015A1 (fr)	1998-04-30	Utilisation d'un extrait flavonoidique de ginkgo biloba substantiellement depourvu de terpenes, dans le domaine buccodentaire, et composition contenant un tel extrait
EP0946140B1 (fr)	2002-03-20	Utilisation d'un extrait de cordia dichotoma
FR2714054A1 (fr)	1995-06-23	Procédé de fabrication de la 4-hydroxy-5-méthyl-3[2H]-furanone et utilisations de cette dernière.
FR2787711A1 (fr)	2000-06-30	Composition cosmetique a activite depigmentante et son utilisation
CA2533720A1 (fr)	2005-02-10	Vernis a ongles a action antimycosique
WO1996002226A1 (fr)	1996-02-01	Nouveau produit de combinaison comprenant un agent antifongique et du crotamiton comme potentialisateur de l'activite de l'agent antifongique, et compositions dermatologiques et/ou cosmetiques le comprenant
EP1591101A1 (fr)	2005-11-02	Dissolvant gel sans acetone
FR3132433A1 (fr)	2023-08-11	Composition cosmétique comprenant un ou plusieurs tensioactifs anioniques particuliers, un ou plusieurs hydroxyhydrocarbyl (poly)glycosides et un ou plusieurs acides carboxyliques spécifiques
FR2834454A1 (fr)	2003-07-11	Compositions pour la coloration de la peau comprenant un extrait de sorgho et utilisations
FR2735695A1 (fr)	1996-12-27	Compositions cosmetiques ou pharmaceutiques contenant a titre de principe actif, de la mangiferine ou ses derives
FR2834455A1 (fr)	2003-07-11	Composition pour la coloration de la peau comprenant au moins un autobronzant mono ou polycarbonyle et un extrait de sorgho et utilisations