OA10708A - Carbamoyloxy derivatives of mutiline and their useas antibacterials. - Google Patents

Carbamoyloxy derivatives of mutiline and their useas antibacterials. Download PDF

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Publication number
OA10708A
OA10708A OA9800101A OA9800101A OA10708A OA 10708 A OA10708 A OA 10708A OA 9800101 A OA9800101 A OA 9800101A OA 9800101 A OA9800101 A OA 9800101A OA 10708 A OA10708 A OA 10708A
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OA
OAPI
Prior art keywords
mutilin
mmol
carbamate
solution
group
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OA9800101A
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English (en)
Inventor
Jeremy David Hinks
Andrew Kenneth Takle
Eric Hunt
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Smithkline Beecham Plc
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Priority claimed from GBGB9600048.4A external-priority patent/GB9600048D0/en
Priority claimed from GBGB9616305.0A external-priority patent/GB9616305D0/en
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of OA10708A publication Critical patent/OA10708A/en

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/325—Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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OA9800101A 1996-01-03 1998-07-02 Carbamoyloxy derivatives of mutiline and their useas antibacterials. OA10708A (en)

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Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6753006B1 (en) 1993-02-22 2004-06-22 American Bioscience, Inc. Paclitaxel-containing formulations
CZ212498A3 (cs) * 1996-01-03 1998-12-16 Smithkline Beecham P. L. C. Karbamoyloxyderiváty mutilinu, způsob výroby a farmaceutický prosředek
HUP0001741A3 (en) * 1996-08-02 2000-11-28 Smithkline Beecham Plc Azabicyclic carbamoyloxy mutilin derivatives for antibacterial use, process for preparing them, pharmaceuticals contg. them and their use
GB9719187D0 (en) 1997-09-09 1997-11-12 Glaxo Group Ltd Compounds
UY25225A1 (es) * 1997-10-29 2000-12-29 Smithkline Beecham Plc Derivados de pleuromutilina utiles como agentes antimicrobianos
GB9817029D0 (en) * 1998-08-05 1998-09-30 Smithkline Beecham Plc Novel compounds
WO2000037074A1 (en) * 1998-12-18 2000-06-29 Smithkline Beecham Plc Mutilin 14-ester derivatives having antibacterial activity
GB9912657D0 (en) * 1999-06-01 1999-07-28 Smithkline Beecham Plc Novel compounds
TWI260220B (en) * 1999-11-22 2006-08-21 Novartis Ag A pharmaceutical composition for the transdermal treatment of bacterial infections in animals
CA2405132A1 (en) 2000-04-04 2001-10-11 Smithkline Beecham Plc 2-hydroxy-mutilin carbamate derivatives for antibacterial use
GB0018951D0 (en) 2000-08-03 2000-09-20 Smithkline Beecham Plc Novel compounds
PE20020676A1 (es) * 2000-09-13 2002-08-27 Biochemie Gmbh Compuestos de mutilina como antibacterianos
GB0024811D0 (en) 2000-10-10 2000-11-22 Smithkline Beecham Plc Novel compounds
US20030054042A1 (en) * 2001-09-14 2003-03-20 Elaine Liversidge Stabilization of chemical compounds using nanoparticulate formulations
FR2835186B1 (fr) * 2002-01-28 2006-10-20 Aventis Pharma Sa Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases
ATE343376T1 (de) * 2002-03-20 2006-11-15 Elan Pharma Int Ltd Nanopartikelzusammensetzungen von angiogeneseinhibitoren
US20080220075A1 (en) * 2002-03-20 2008-09-11 Elan Pharma International Ltd. Nanoparticulate compositions of angiogenesis inhibitors
GB0218578D0 (en) * 2002-08-09 2002-09-18 Glaxo Group Ltd Novel method
GB0308114D0 (en) * 2003-04-08 2003-05-14 Glaxo Group Ltd Novel compounds
US7521386B2 (en) 2004-02-07 2009-04-21 Milliken & Company Moldable heat shield
KR20070094786A (ko) * 2004-12-27 2007-09-21 교린 세이야꾸 가부시키 가이샤 12번 위치가 치환된 무틸린 유도체
GB0504314D0 (en) 2005-03-02 2005-04-06 Glaxo Group Ltd Novel polymorph
US7696112B2 (en) 2005-05-17 2010-04-13 Milliken & Company Non-woven material with barrier skin
US7651964B2 (en) 2005-08-17 2010-01-26 Milliken & Company Fiber-containing composite and method for making the same
US7605097B2 (en) 2006-05-26 2009-10-20 Milliken & Company Fiber-containing composite and method for making the same
US7825050B2 (en) 2006-12-22 2010-11-02 Milliken & Company VOC-absorbing nonwoven composites
US8222407B2 (en) * 2007-05-24 2012-07-17 Kyorin Pharmaceutical Co., Ltd. Mutilin derivative having heterocyclic aromatic ring carboxylic acid structure in substituent at 14-position
TWM384453U (en) * 2010-03-02 2010-07-11 Winharbor Technology Co Ltd Pull-resistant illuminating/heat generating structure capable of being charged in wireless manner
CN102249982B (zh) * 2010-05-18 2013-10-23 中国科学院上海药物研究所 新型截短侧耳素类化合物、其药物组合物及其制备方法和用途
WO2012006276A1 (en) * 2010-07-06 2012-01-12 North Carolina State University Inhibition of bacterial biofilms with aryl carbamates
US9125408B2 (en) 2010-09-01 2015-09-08 North Carolina State University Use of aryl carbamates in agriculture and other plant-related areas
MY166866A (en) 2011-08-18 2018-07-24 Nippon Shinyaku Co Ltd Heterocyclic derivative and pharmaceutical drug
CZ307500B6 (cs) * 2012-08-15 2018-10-24 Zentiva, K.S. Způsob přípravy derivátu 2-methyl-2´-fenylpropionové kyseliny využívající nové intermediáty
CN113563368A (zh) * 2016-03-02 2021-10-29 比尔及梅琳达盖茨基金会 含硼小分子
US10874679B2 (en) * 2016-03-02 2020-12-29 Bill & Melinda Gates Foundation Boron-containing small molecules
CN109152932B (zh) * 2016-03-02 2021-09-28 比尔及梅琳达盖茨基金会 含硼小分子
CN106699690B (zh) * 2016-12-07 2019-09-10 华南农业大学 一种具有酰基哌嗪基侧链的截短侧耳素衍生物及其制备方法和用途
TWI762573B (zh) 2017-02-10 2022-05-01 奧地利商納畢瓦治療有限責任公司 截短側耳素之純化
CN111574395B (zh) * 2020-06-18 2021-07-02 华南农业大学 一种具有酰胺侧链的截短侧耳素衍生物及制备与应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT301752B (de) * 1969-07-21 1972-09-25 Biochemie Gmbh Verfahren zur Herstellung neuer Pleuromutilin-Derivate
US3979423A (en) * 1969-07-25 1976-09-07 Biochemie Gesellschaft M.B.H. 14-Desoxy-14-tosyloxyacetoxy-mutilin
BE789629A (fr) * 1971-10-05 1973-04-03 Sandoz Sa Nouveaux derives de la pleuromutiline, leur preparation et leurapplication en therapeutique
US3919290A (en) * 1972-10-03 1975-11-11 Sandoz Ltd Substituted 14-desoxy-mutilins
CH627940A5 (de) * 1976-12-23 1982-02-15 Sandoz Ag Kokzidiostatisches kombinationspraeparat.
DE2966635D1 (en) * 1979-01-12 1984-03-08 Sandoz Ag New pleuromutilin derivatives, their production and pharmaceutical compositions containing them
CZ212498A3 (cs) * 1996-01-03 1998-12-16 Smithkline Beecham P. L. C. Karbamoyloxyderiváty mutilinu, způsob výroby a farmaceutický prosředek

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US6020368A (en) 2000-02-01
AP9801283A0 (en) 1998-09-30
NO983074D0 (no) 1998-07-02
NZ325837A (en) 1999-11-29
HUP9900973A2 (hu) 1999-08-30
ATE248143T1 (de) 2003-09-15
HUP9900973A3 (en) 2000-04-28
KR19990076988A (ko) 1999-10-25
AR005357A1 (es) 1999-04-28
CN1214039A (zh) 1999-04-14
CZ212498A3 (cs) 1998-12-16
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CA2240467A1 (en) 1997-07-17
MX9805416A (es) 1998-10-31
BR9612426A (pt) 1999-07-13
EP0874809B1 (de) 2003-08-27
AU1307897A (en) 1997-08-01
IL124912A0 (en) 1999-01-26
WO1997025309A1 (en) 1997-07-17
EA199800525A1 (ru) 1999-02-25
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EP0874809A1 (de) 1998-11-04
US6239175B1 (en) 2001-05-29

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