OA10727A - Methods of producing effective recombinant serine protease inhibitors and uses of these inhibitors - Google Patents

Methods of producing effective recombinant serine protease inhibitors and uses of these inhibitors Download PDF

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Publication number
OA10727A
OA10727A OA60903A OA60903A OA10727A OA 10727 A OA10727 A OA 10727A OA 60903 A OA60903 A OA 60903A OA 60903 A OA60903 A OA 60903A OA 10727 A OA10727 A OA 10727A
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OA
OAPI
Prior art keywords
ala
thr
leu
ile
val
Prior art date
Application number
OA60903A
Other languages
English (en)
Inventor
Harvey Rubin
Barry Cooperman
Norman Schechter
Michael Plotnick
Zhi Mei Wang
Original Assignee
Univ Pennsylvania
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pennsylvania filed Critical Univ Pennsylvania
Publication of OA10727A publication Critical patent/OA10727A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8125—Alpha-1-antitrypsin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
OA60903A 1994-04-18 1996-10-17 Methods of producing effective recombinant serine protease inhibitors and uses of these inhibitors OA10727A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22928694A 1994-04-18 1994-04-18
US08/276,936 US5612194A (en) 1989-06-23 1994-07-19 Methods of producing effective recombinant serine protease inhibitors and uses of these inhibitors

Publications (1)

Publication Number Publication Date
OA10727A true OA10727A (en) 2002-12-09

Family

ID=26923159

Family Applications (1)

Application Number Title Priority Date Filing Date
OA60903A OA10727A (en) 1994-04-18 1996-10-17 Methods of producing effective recombinant serine protease inhibitors and uses of these inhibitors

Country Status (19)

Country Link
US (1) US5612194A (de)
EP (1) EP0765342A1 (de)
JP (1) JPH10501404A (de)
CN (1) CN1146207A (de)
AP (1) AP9600905A0 (de)
AU (1) AU2382195A (de)
BG (1) BG100981A (de)
BR (1) BR9507467A (de)
CA (1) CA2188180A1 (de)
CZ (1) CZ300396A3 (de)
FI (1) FI964174A0 (de)
HU (1) HUT75358A (de)
LV (1) LV11801A (de)
NO (1) NO964416D0 (de)
OA (1) OA10727A (de)
PL (1) PL316949A1 (de)
SI (1) SI9520043A (de)
SK (1) SK130696A3 (de)
WO (1) WO1995028422A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5827662A (en) * 1989-06-23 1998-10-27 The Trustees Of The University Of Pennsylvania Methods for detecting genetic mutations resulting in protease inhibitor insufficiencies
US7171016B1 (en) 1993-11-18 2007-01-30 Digimarc Corporation Method for monitoring internet dissemination of image, video and/or audio files
DE19543750C2 (de) * 1995-11-24 1997-10-23 Crinos Industria Farmaco Cathepsin G inhibierende Aptamere
AU3866799A (en) * 1998-05-04 1999-11-23 Zymogenetics Inc. Cytoplasmic antiproteinase-3 coding sequence in gene therapy
AU3731400A (en) 1999-03-05 2000-09-21 Trustees Of University Technology Corporation, The Methods and compositions useful in inhibiting apoptosis
AU3511500A (en) 1999-03-05 2000-09-21 Trustees Of University Technology Corporation, The Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide-induced clinical conditions
US6849605B1 (en) 1999-03-05 2005-02-01 The Trustees Of University Technology Corporation Inhibitors of serine protease activity, methods and compositions for treatment of viral infections
WO2002053172A2 (en) * 2000-12-29 2002-07-11 Kimberly-Clark Worldwide, Inc. Use of matrix metalloproteinase peptide substrate to lower the rate of extracellular matrix turnover
JP4754478B2 (ja) * 2003-04-04 2011-08-24 ユニバーシティ オブ ローザンヌ プロテアーゼに対するインヒビタータンパク質およびその利用
USPP15990P3 (en) * 2003-04-23 2005-09-20 J. C. Bakker & Sons Limited Lilac plant named ‘Golden Eclipse’
US7850970B2 (en) * 2003-08-26 2010-12-14 The Regents Of The University Of Colorado Inhibitors of serine protease activity and their use in methods and compositions for treatment of bacterial infections
KR101231126B1 (ko) * 2004-09-29 2013-02-07 가부시키가이샤 라이토 브락쿠 복2배체 수서동물과 그 육종법
US20070104699A1 (en) * 2005-09-29 2007-05-10 University Of Alberta Compositions for and methods of granzyme B inhibition
WO2012178102A2 (en) 2011-06-24 2012-12-27 The Regents Of The Unversity Of Colorado, A Body Corporate Compositions, methods and uses for alpha-1 antitrypsin fusion molecules
CA2896951A1 (en) 2012-01-10 2013-07-18 The Regents Of The University Of Colorado, A Body Corporate Compositions, methods and uses for alpha-1 antitrypsin fusion molecules
JP2015111050A (ja) * 2012-03-28 2015-06-18 国立大学法人九州大学 Ｋａｌｌｉｓｔａｔｉｎ蛋白質による脳梗塞検査方法
CN103243105B (zh) * 2013-05-19 2018-11-02 中国农业科学院兰州兽医研究所 一种旋毛虫重组蛋白及应用
CN103275214A (zh) * 2013-06-08 2013-09-04 天津师范大学 对虾丝氨酸蛋白酶抑制剂的基因工程制备与鉴定方法
GB201322091D0 (en) 2013-12-13 2014-01-29 Cambridge Entpr Ltd Modified serpins for the treatment of bleeding disorders
CN104628845B (zh) * 2015-01-21 2017-12-08 中国人民解放军第二军医大学 一种发形霞水母丝氨酸蛋白酶抑制剂及其编码基因与应用
CN106478812B (zh) * 2016-10-21 2020-11-20 沈阳药科大学 丝氨酸蛋白酶抑制剂-3及其功能、制备方法和应用
CN110068676A (zh) * 2019-03-22 2019-07-30 同济大学 分泌蛋白Serpin A3在预测心肌损伤诊断试剂中的应用
CN110330564B (zh) * 2019-08-06 2022-09-20 上海景晗生物科技有限公司 丝氨酸蛋白酶抑制剂及其最小功能片段和免疫抑制作用
WO2026021603A1 (zh) * 2024-07-25 2026-01-29 吉林大学第一医院 Serpina3蛋白变异体或其编码序列以及它们的应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5252725A (en) * 1989-06-23 1993-10-12 The Trustees Of The University Of Pennsylvania α-1-antichymotrypsin, analogues and methods of production

Also Published As

Publication number Publication date
NO964416L (no) 1996-10-17
CN1146207A (zh) 1997-03-26
US5612194A (en) 1997-03-18
AU2382195A (en) 1995-11-10
FI964174A7 (fi) 1996-10-17
BR9507467A (pt) 1997-09-23
LV11801A (lv) 1997-06-20
HU9602886D0 (en) 1996-12-30
FI964174L (fi) 1996-10-17
FI964174A0 (fi) 1996-10-17
WO1995028422A1 (en) 1995-10-26
BG100981A (en) 1998-01-30
CZ300396A3 (en) 1997-08-13
AP9600905A0 (en) 1997-01-31
SI9520043A (en) 1997-08-31
HUT75358A (en) 1997-05-28
NO964416D0 (no) 1996-10-17
CA2188180A1 (en) 1995-10-26
EP0765342A1 (de) 1997-04-02
SK130696A3 (en) 1997-07-09
PL316949A1 (en) 1997-02-17
JPH10501404A (ja) 1998-02-10

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